Marsupenaeusjaponicus Bate is one of the most valuable cultured shrimp species in China and outdoor earthen pond farming is the most common method of culturing this organism. The need to increase soil usage efficiency...Marsupenaeusjaponicus Bate is one of the most valuable cultured shrimp species in China and outdoor earthen pond farming is the most common method of culturing this organism. The need to increase soil usage efficiency in aquaculture has been recognized and a great deal of research effort has been directed toward development of super-intensive farming systems. However, current research and development in this field is largely devoted to Litopenaeus vannamei Boone, while to M.japonicus Bate it has been neglected. In this study, a layered fanning system was designed and a 66-day study was conducted in M.japonicus Bate culture. The system comprised bracket and sand layers that divided a shrimp tank filled to a depth of 1.2 m into four water layers. Conventional tank culture （unlayered） was used as a control. The results show that survival rate, feed conversion efficiency and production of M.japonicus Bate in the layered farming system were 68%, 18%, and 0.59 kg/m^2, respectively, all of which are significantly higher than in the unlayered fanning system （P〈0.01）. These findings confirmed the possibility of using a layered system to culture M. japonicus Bate.展开更多
“Through our walk in Zhejiang,the kindness of the people,the beauty of the scenery and the richness of its culture have left many footprints on our heart and our soul.Our hope is that through our Walk of Friendship w...“Through our walk in Zhejiang,the kindness of the people,the beauty of the scenery and the richness of its culture have left many footprints on our heart and our soul.Our hope is that through our Walk of Friendship we may have left behind a few positive British footprints in the lives and understanding and contributed in a small way to the‘golden era’of friendship between the people of China and the United Kingdom,”remarked British Lord Michael Bates at the premiere of The New Stories of Zhejiang,a documentary following his recentlycompleted walk across China’s coastal province of Zhejiang.The documentary was released to celebrate the 70th anniversary of the founding of the People’s Republic of China.Bates’walk event and the accompanying documentary were intended to help people better understand Zhejiang and Chinese culture and build a bridge of friendship through cultural exchange.展开更多
基于Jain提出的高阶紧致有限差分格式(high order compact of Jain,HOCJ),结合卷积积分(convolution integral)与快速傅里叶变换(FFT),构建了一种新颖的数值方法,简称HOCJ-CF,并用于Bates模型下美式看跌期权定价.针对期权定价偏积分微...基于Jain提出的高阶紧致有限差分格式(high order compact of Jain,HOCJ),结合卷积积分(convolution integral)与快速傅里叶变换(FFT),构建了一种新颖的数值方法,简称HOCJ-CF,并用于Bates模型下美式看跌期权定价.针对期权定价偏积分微分方程(PIDE)的微分项,首先将其拆分成三个子偏微分方程(sub-PDE),然后分别应用Numerov离散方法,衍生出具有空间四阶精度和时间二阶精度的HOCJ格式;积分项则将其转化成卷积积分,并运用FFT.在相同模型参数设置下,数值结果验证了新方法在精度、收敛率及效率相比IMEX格式的优越性.展开更多
鸡球虫病是一种由艾美耳属原生动物寄生虫引起的肠道疾病,是影响家禽业的最重要疾病之一。目前,球虫病的控制主要依赖于抗球虫药物的使用,但由于药物的长期广泛使用导致了球虫的严重耐药性。为研究其耐药性机制,本实验室前期对柔嫩艾美...鸡球虫病是一种由艾美耳属原生动物寄生虫引起的肠道疾病,是影响家禽业的最重要疾病之一。目前,球虫病的控制主要依赖于抗球虫药物的使用,但由于药物的长期广泛使用导致了球虫的严重耐药性。为研究其耐药性机制,本实验室前期对柔嫩艾美耳球虫敏感株、地克珠利耐药株、马杜拉霉素耐药株、盐霉素耐药株进行了转录组测序分析,发现与敏感株相比,柔嫩艾美耳球虫微管蛋白β链(Et TBC)仅在地克珠利耐药株高表达。本研究在此基础上,克隆、表达了EtTBC,并初步分析了其功能及与地克珠利的关系;以柔嫩艾美耳球虫敏感株cDNA为模板成功克隆了EtTBC基因,构建了原核表达重组质粒pET28a-Et TBC,并成功诱导表达了重组蛋白r Et TBC;利用qPCR对柔嫩艾美耳球虫敏感株不同发育阶段以及不同虫株(耐药株、敏感株和田间耐药株)的mRNA转录水平进行了分析,结果显示,该基因的转录水平在敏感株未孢子化卵囊阶段最高,且其mRNA转录水平仅在地克珠利耐药株上调;间接免疫荧光定位结果表明该蛋白主要分布在子孢子除折光体外的细胞质和表面,第二代裂殖子的细胞质和表面。展开更多
In this paper, for time-to-event data, we propose a new statistical framework for casual inference in evaluating clinical utility of predictive biomarkers and in selecting an optimal treatment for a particular patient...In this paper, for time-to-event data, we propose a new statistical framework for casual inference in evaluating clinical utility of predictive biomarkers and in selecting an optimal treatment for a particular patient. This new casual framework is based on a new concept, called Biomarker Adjusted Treatment Effect （BATE） curve. The BATE curve can be used for assessing clinical utility of a predictive biomarker, for designing a subsequent confirmation trial, and for guiding clinical practice. We then propose semi-p^rametric methods for estimating the BATE curves of biomarkers and establish asymptotic results of the proposed estimators for the BATE curves. We also conduct extensive simulation studies to evaluate finite-sample properties of the proposed estimation methods. Finally, we illustrate the application of the proposed method in a real-world data set.展开更多
基金Supported by the Science and Technology Plan of Qingdao(No.103-4-5-6-jch)the National Natural Science Foundation of China(No.31101916)+1 种基金the Natural Science Foundation of Shandong Province,China(No.ZR2010CM060)the University Student Innovation Plan of Qingdao Agricultural University(No.201030)
文摘Marsupenaeusjaponicus Bate is one of the most valuable cultured shrimp species in China and outdoor earthen pond farming is the most common method of culturing this organism. The need to increase soil usage efficiency in aquaculture has been recognized and a great deal of research effort has been directed toward development of super-intensive farming systems. However, current research and development in this field is largely devoted to Litopenaeus vannamei Boone, while to M.japonicus Bate it has been neglected. In this study, a layered fanning system was designed and a 66-day study was conducted in M.japonicus Bate culture. The system comprised bracket and sand layers that divided a shrimp tank filled to a depth of 1.2 m into four water layers. Conventional tank culture （unlayered） was used as a control. The results show that survival rate, feed conversion efficiency and production of M.japonicus Bate in the layered farming system were 68%, 18%, and 0.59 kg/m^2, respectively, all of which are significantly higher than in the unlayered fanning system （P〈0.01）. These findings confirmed the possibility of using a layered system to culture M. japonicus Bate.
文摘“Through our walk in Zhejiang,the kindness of the people,the beauty of the scenery and the richness of its culture have left many footprints on our heart and our soul.Our hope is that through our Walk of Friendship we may have left behind a few positive British footprints in the lives and understanding and contributed in a small way to the‘golden era’of friendship between the people of China and the United Kingdom,”remarked British Lord Michael Bates at the premiere of The New Stories of Zhejiang,a documentary following his recentlycompleted walk across China’s coastal province of Zhejiang.The documentary was released to celebrate the 70th anniversary of the founding of the People’s Republic of China.Bates’walk event and the accompanying documentary were intended to help people better understand Zhejiang and Chinese culture and build a bridge of friendship through cultural exchange.
文摘基于Jain提出的高阶紧致有限差分格式(high order compact of Jain,HOCJ),结合卷积积分(convolution integral)与快速傅里叶变换(FFT),构建了一种新颖的数值方法,简称HOCJ-CF,并用于Bates模型下美式看跌期权定价.针对期权定价偏积分微分方程(PIDE)的微分项,首先将其拆分成三个子偏微分方程(sub-PDE),然后分别应用Numerov离散方法,衍生出具有空间四阶精度和时间二阶精度的HOCJ格式;积分项则将其转化成卷积积分,并运用FFT.在相同模型参数设置下,数值结果验证了新方法在精度、收敛率及效率相比IMEX格式的优越性.
文摘鸡球虫病是一种由艾美耳属原生动物寄生虫引起的肠道疾病,是影响家禽业的最重要疾病之一。目前,球虫病的控制主要依赖于抗球虫药物的使用,但由于药物的长期广泛使用导致了球虫的严重耐药性。为研究其耐药性机制,本实验室前期对柔嫩艾美耳球虫敏感株、地克珠利耐药株、马杜拉霉素耐药株、盐霉素耐药株进行了转录组测序分析,发现与敏感株相比,柔嫩艾美耳球虫微管蛋白β链(Et TBC)仅在地克珠利耐药株高表达。本研究在此基础上,克隆、表达了EtTBC,并初步分析了其功能及与地克珠利的关系;以柔嫩艾美耳球虫敏感株cDNA为模板成功克隆了EtTBC基因,构建了原核表达重组质粒pET28a-Et TBC,并成功诱导表达了重组蛋白r Et TBC;利用qPCR对柔嫩艾美耳球虫敏感株不同发育阶段以及不同虫株(耐药株、敏感株和田间耐药株)的mRNA转录水平进行了分析,结果显示,该基因的转录水平在敏感株未孢子化卵囊阶段最高,且其mRNA转录水平仅在地克珠利耐药株上调;间接免疫荧光定位结果表明该蛋白主要分布在子孢子除折光体外的细胞质和表面,第二代裂殖子的细胞质和表面。
基金supported by a Core Investigator,Research Career Scientist(Grant No.RCS OS-196)Biostatistics Unit Director at the Northwest HSR&D Center of Excellence,Department of Veterans Affairs Medical Center,Seattle,WA and Department of Veterans Affairs,Veterans Health Administration,Health Services Research and Development Service,project(Grant No.XVA61-036)
文摘In this paper, for time-to-event data, we propose a new statistical framework for casual inference in evaluating clinical utility of predictive biomarkers and in selecting an optimal treatment for a particular patient. This new casual framework is based on a new concept, called Biomarker Adjusted Treatment Effect （BATE） curve. The BATE curve can be used for assessing clinical utility of a predictive biomarker, for designing a subsequent confirmation trial, and for guiding clinical practice. We then propose semi-p^rametric methods for estimating the BATE curves of biomarkers and establish asymptotic results of the proposed estimators for the BATE curves. We also conduct extensive simulation studies to evaluate finite-sample properties of the proposed estimation methods. Finally, we illustrate the application of the proposed method in a real-world data set.
