Gastric mucosal damage in water immersion stress:Mechanism and prevention with GHRP-6

AIM:To investigate the mechanism of gastric mucosal demage induced by water immersion restraint stress(WRS) and its prevention by growth hormone releasing peptide-6(GHRP-6).METHODS:Male Wistar rats were subjected to conscious or unconscious(anesthetized) WRS,simple restraint(SR),free swimming(FS),non-water fluid immersion,immersion without water contact,or rats were placed in a cage surrounded by sand.To explore the sensitivity structures that influence the stress reaction besides skin stimuli,a group the rats had their eyes occluded.Cervical bilateral trunk vagotomy or atropine injection was performed in some rats to assess the parasympathetic role in mucosal damage.Gastric mucosal lesions,acid output and heart rate variability were measured.Plasma renin,endothelin-1 and thromboxane B2 and gastric heat shock protein 70 were also assayed.GHRP-6 was injected [intraperitoneal(IP) or intracerebroventricular(ICV)] 2 h before the onset of stress to observe its potential prevention of the mucosal lesion.RESULTS:WRS for 6 h induced serious gastric mucosal lesion [lesion area,WRS 81.8 ± 6.4 mm 2 vs normal control 0.0 ± 0.0 mm 2,P < 0.01],decreased the heart rate,and increased the heart rate variability and gastric acid secretion,suggesting an increase in vagal nervecarrying stimuli.The mucosal injury was inversely correlated with water temperature(lesion area,WRS at 35 ℃ 56.4 ± 5.2 mm 2 vs WRS at 23 ℃ 81.8 ± 6.4 mm 2,P < 0.01) and was consciousness-dependent.The injury could not be prevented by eye occlusion,but could be prevented by avoiding contact of the rat body with the water by dressing it in an impermeable plastic suit.When water was replaced by vegetable oil or liquid paraffin,there were gastric lesions in the same grade of water immersion.When rat were placed in a cage surrounded by sand,there were no gastric lesions.All these data point to a remarkable importance of cutenuous information transmitted to the high neural center that by vagal nerves reaching the gastric mucosa.FS alone also induced serious gastric injury,but SR could not induce gastric injury.Bilateral vagotomy or atropine prevented the WRS-induced mucosal lesion,indicating that increased outflow from the vagal center is a decisive factor in WRS-induced gastric injury.The mucosal lesions were prevented by prior injection of GHRP-6 via IP did,but not via ICV,suggesting that the protection is peripheral,although a sudden injection is not equivalent to a physiological release and uptake,which eventually may affect the vagal center.CONCLUSION:From the central nervous system,vagal nerves carry the cutaneous stimuli brought about by the immersion restraint,an experimental model for inducing acute gastric erosions.GHRP-6 prevents the occurrence of these lesions.

Viscous Cahn-Hilliard Equation with Concentration Dependent Mobility

This paper is devoted to viscous Cahn-Hiliiard equation with concentration dependent mobility. Some results on the existence, uniqueness and large time behavior are established.

Seismic sentinel? An analysis of captive giant panda behavior in response to the Lushan earthquake in China

It is widely believed that various animal species can sense and respond to the geophysical stimuli that precede earthquakes,especially electromagnetic fields,although supporting field evidence is mostly anecdotal.Here we report on the reactions of four female giant pandas under observation over the three days prior to the Lushan(30.1°N,103.0°E)magnitude 7.0 earthquake that occurred in Sichuan province,China,on April 20,2013.We observed no significant generalized behavioral anomalies indicative of them perceiving an impending earthquake.We also observed no startle behaviors in the 5 s prior to tremors commencing,indicating that these pandas either did not detect or did not respond to precursor P-waves.Our findings suggest that although giant pandas have evolved in,and continue to occupy exclusively,a seismically active range in central China,they do not appear to perceive pre-earthquake geophysical warning signs.

Observation and Study of Fracture Behaviour for Fiber Reinforced Cement

Polypropylene, carbon, aramid and polyethylene fibers reinforced cement composites were fabricated respectively. Their fracture behaviors were observed using scanning electron microscopy and the bonding between fiber and matrix was observed in detail.

Values of medical-grade smart wearable device onimprovement of individual healthTaking philips health watch as an example

Health is an inevitable demand to promote people's all-round development and to make foundation for economic and social development. Health and longevity of citizens is not only important symbols of national development and prosperity but also the common wish of the Chinese people. Actually,smart wearable technology is an emerging one and the application of some smart wearable devices such as health watch is the most promising one in the health industry. As new psychotherapy,cognitive behavioral therapy( CBT) can change the poor awareness by means of changing one's way of thinking,thus eliminating the unhealthy emotions and behaviors. In terms of health management,CBT enjoys such advantages as guidance,motivation,integrity and short therapy time. This paper introduces the improvement of smart wearable device guided by professional health management solutions on individual health by taking Philips health watch as an example,and the users can therefrom get full understanding of the relationship between smart wearable devices and health,thus improving their individual health.

A behavior-aware SLA-based framework for guaranteeing the security conformance of cloud service

As cloud computing technology turning to mature,cloud services have become a trust-based service.Users'distrust of the security and performance of cloud services will hinder the rapid deployment and development of cloud services.So cloud service providers(CSPs)urgently need a way to prove that the infrastructure and the behavior of cloud services they provided can be trusted.The challenge here is how to construct a novel framework that can effective verify the security conformance of cloud services,which focuses on fine-grained descriptions of cloud service behavior and security service level aggreements(SLAs).In this paper,we propose a novel approach to verify cloud service security conformance,which reduces the description gap between the CSP and users through modeling cloud service behavior and security SLA,these models enable a systematic integration of security constraints and service behavior into cloud while using UPPAAL to check the performance and security conformance.The proposed approach is validated through case study and experiments with real cloud service based on Open-Stack,which illustrates CloudSec approach effectiveness and can be applied on realistic cloud scenario.

A Study of the Behavioral Controllability for Superposed Kuznetsov–Ma Soliton of the (3+1)-Dimensional Generalized Nonlinear Schr?dinger Equation

Abstract The （3＋1 ）-dimensional variable-coetfficient nonlinear SchrSdinger equation with linear and parabolic traps is studied, and an exact Kuznetsov-Ma soliton solution in certain parameter conditions is derived. These precise expressions indicate that diffraction and chirp factors influence phase, center and widths, while the gain/loss parameter only affects peaks. By adjusting the relation between the maximum accumulated time Tm and the accumulated time To based on maximum amplitude of Kuznetsov Ma soliton, postpone, maintenance and restraint of superposed Kuznetsov-Ma solitons are investigated.