Aim: To investigate the relation between change in systemic blood pressures an d change in intraocular pressure. Methods: This was a population based study of people 43-86 years old living in Beaver Dam, Wisconsin. Me...Aim: To investigate the relation between change in systemic blood pressures an d change in intraocular pressure. Methods: This was a population based study of people 43-86 years old living in Beaver Dam, Wisconsin. Measurements at baselin e (1988-90) and 5 year follow up of systemic blood pressures, intraocular press ures, and history of use of blood pressure medications. Results: Intraocular pre ssures were significantly correlated with systolic and diastolic blood pressures at both baseline and follow up. There were significant direct correlations betw een changes in systemic blood pressures and changes in intraocular pressure. The re was a 0.21 (95%CI: 0.16 to 0.27) mm Hg increase in IOP for a 10 mm Hg increa se in systolic and 0.43 (0.35 to 0.52) mm Hg increase in IOP for a 10 mm Hg incr ease in diastolic blood pressure. Further adjustment for diabetes and medication use did not alter these associations. Decreased systolic or diastolic blood pre ssures of more than 10 mm Hg over 5 years were significantly associated with dec reased IOP. Conclusions: Reduced systemic blood pressure is associated with redu ced intraocular pressure. T5his finding should be evaluated in other studies, es pecially with respect to the possibility of resultant decreased risk of open ang le glaucoma.展开更多
PURPOSE: To investigate the associations of measures of frailty to prevalent age-related maculopathy (ARM). DESIGN: Cross-sectional population-based study. METHODS: Time to walk a measured course (gait-time), handgrip...PURPOSE: To investigate the associations of measures of frailty to prevalent age-related maculopathy (ARM). DESIGN: Cross-sectional population-based study. METHODS: Time to walk a measured course (gait-time), handgrip strength, peak expiratory flow rate, ability to stand from a sitting position without using arms, self-reported co-morbidities, and ARM were assessed at the third examination of the Beaver Dam Eye Study (n=2,962). ARM was determined by grading stereoscopic color fundus photographs. RESULTS: While controlling for age, smoking, and the number of co-morbid conditions, weaker handgrip strength was associated with early ARM (odds ratio [OR]10 kg decrease 1.28, confidence interval [CI]1.08, 1.52, P = .004) and late ARM(OR 1.55, 95% CI 1.02, 2.36) in men but not women. Othermeasures of frailty were not related to ARM. CONCLUSIONS: A weak cross-sectional association of handgrip strength with ARM (in men) was found after controlling for co-morbid conditions. These data suggest that ARM is due to a specific disease process, albeit age-related, rather than to biologic aging, as reflected by measures of frailty.展开更多
文摘Aim: To investigate the relation between change in systemic blood pressures an d change in intraocular pressure. Methods: This was a population based study of people 43-86 years old living in Beaver Dam, Wisconsin. Measurements at baselin e (1988-90) and 5 year follow up of systemic blood pressures, intraocular press ures, and history of use of blood pressure medications. Results: Intraocular pre ssures were significantly correlated with systolic and diastolic blood pressures at both baseline and follow up. There were significant direct correlations betw een changes in systemic blood pressures and changes in intraocular pressure. The re was a 0.21 (95%CI: 0.16 to 0.27) mm Hg increase in IOP for a 10 mm Hg increa se in systolic and 0.43 (0.35 to 0.52) mm Hg increase in IOP for a 10 mm Hg incr ease in diastolic blood pressure. Further adjustment for diabetes and medication use did not alter these associations. Decreased systolic or diastolic blood pre ssures of more than 10 mm Hg over 5 years were significantly associated with dec reased IOP. Conclusions: Reduced systemic blood pressure is associated with redu ced intraocular pressure. T5his finding should be evaluated in other studies, es pecially with respect to the possibility of resultant decreased risk of open ang le glaucoma.
文摘PURPOSE: To investigate the associations of measures of frailty to prevalent age-related maculopathy (ARM). DESIGN: Cross-sectional population-based study. METHODS: Time to walk a measured course (gait-time), handgrip strength, peak expiratory flow rate, ability to stand from a sitting position without using arms, self-reported co-morbidities, and ARM were assessed at the third examination of the Beaver Dam Eye Study (n=2,962). ARM was determined by grading stereoscopic color fundus photographs. RESULTS: While controlling for age, smoking, and the number of co-morbid conditions, weaker handgrip strength was associated with early ARM (odds ratio [OR]10 kg decrease 1.28, confidence interval [CI]1.08, 1.52, P = .004) and late ARM(OR 1.55, 95% CI 1.02, 2.36) in men but not women. Othermeasures of frailty were not related to ARM. CONCLUSIONS: A weak cross-sectional association of handgrip strength with ARM (in men) was found after controlling for co-morbid conditions. These data suggest that ARM is due to a specific disease process, albeit age-related, rather than to biologic aging, as reflected by measures of frailty.
