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Beh et's disease complicated by multiple aseptic abscesses of the liver and spleen 被引量:3
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作者 Keisuke Maeshima Koji Ishii +2 位作者 Megumi Inoue Katsuro Himeno Masataka Seike 《World Journal of Gastroenterology》 SCIE CAS 2013年第20期3165-3168,共4页
Aseptic abscesses are an emergent entity and have been described in inflammatory bowel disease,especially in Crohn's disease,and in other diseases.However,aseptic abscesses associated with Beh et's disease are... Aseptic abscesses are an emergent entity and have been described in inflammatory bowel disease,especially in Crohn's disease,and in other diseases.However,aseptic abscesses associated with Beh et's disease are extremely rare.We report a Japanese male diagnosed with an incomplete type of Beh et's disease who developed multiple aseptic abscesses of the spleen and liver.In 2002,the spleen abscesses were accompanied by paroxysmal oral aphthous ulcers and erythema nodosum.As the patient's response to antibiotic treatment was inadequate,a splenectomy was performed.Severe inflammatory cell infiltration,largely of polymorphonuclear neutrophils,was observed without evidence of bacterial or fungal growth.Although the patient had no history of ocular symptoms or genital ulcers,a diagnosis of incomplete Beh et's disease was made according to the Japanese diagnostic criteria because of the presence of paroxysmal arthritis and epididymitis since 2002.In 2005,multiple liver abscesses developed with right hypochondrial pain and seemed to be attributed to Beh et's disease because the abscesses yielded negative results during a microbiologic investigation and failed to go into remission under antibiotic therapy.Oral prednisone(15 mg/d) was started in May 2006,and the abscesses dramatically disappeared 4 wk after treatment.Although the patient had a relapse of the liver abscesses in association with the tapering of prednisone,the augmentation of prednisone dosage yielded a response.The abscesses of the liver and spleen were strongly suggested to be attributed to Beh et's disease.Clinician should be aware of the existence of aseptic abscesses as uncommon manifestations of Beh et's disease. 展开更多
关键词 beh ets disease AsEPTIC ABsCEss sPLEEN Liver PREDNIsONE
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Diagnostic dilemma between intestinal Behet disease and inflammatory bowel disease with pyoderma gangrenosum
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作者 Cem Evereklioglu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第35期5748-5751,共4页
TO THE EDITOR I have read with great interest the very recent article rifled "Intestinal Behcet's disease with pyoderma gangrenosum: A case report" of Nakamura T et al that was published in your journal. The autho... TO THE EDITOR I have read with great interest the very recent article rifled "Intestinal Behcet's disease with pyoderma gangrenosum: A case report" of Nakamura T et al that was published in your journal. The authors stated that they presented a very rare case of intestinal Behcet's disease with pyoderma gangrenosum in a 16-year old patient. However, I would like to make some important contributions and suggestions to the presented case and have a few questions to ask the authors. 展开更多
关键词 Intestinal beh(c)et disease Inflammatory bowel disease DIAGNOsIs HIsTOLOGY Pyoderma gangrenosum sURGERY TREATMENT VAsCULITIs
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Muscular atrophy and weakness in the lower extremities in Behçet’s disease: A case report and review of literature
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作者 Koh-Woon Kim Jae-Heung Cho 《World Journal of Clinical Cases》 SCIE 2021年第20期5647-5654,共8页
BACKGROUND In Behçet’s disease(BD),very few cases of muscular involvement have been reported previously.The natural history and therapeutic protocol for muscular involvement in BD are obscure due to the low inci... BACKGROUND In Behçet’s disease(BD),very few cases of muscular involvement have been reported previously.The natural history and therapeutic protocol for muscular involvement in BD are obscure due to the low incidence of peripheral neuropathy or myopathy in BD.The purpose of our study was to report a rare case of BD with chronic,focal forms of neuromyopathy and review the relevant literature.CASE SUMMARY We herein report the case of a 54-year-old man who presented with progressive muscular atrophy and weakness of both thighs 2 years after the presentation of the cardinal symptoms of BD.The past medical history,electrophysiological study,neurological examination,blood tests,magnetic resonance imaging study,and histological exam were performed for the differential diagnosis.Relevant literature on muscular involvement in BD was reviewed.Neurological examination revealed that muscular involvement was predominantly localized in the proximal parts of the lower extremities.Heterogeneous enhancement of several thigh muscles was observed on magnetic resonance imaging,which corresponded with the clinical manifestations.Histological study of one of the enhanced muscles showed denervation atrophy of the muscle with superimposed myopathic changes,while electrophysiological studies only suggested denervation.CONCLUSION To our knowledge,this is the first case of neurogenic muscular atrophy with a specific set of clinical,radiological,electrophysiological,and histological findings reported in BD. 展开更多
关键词 behçets disease Muscular atrophy Muscular weakness NEUROPATHY MYOPATHY Case report
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Management and outcomes of surgical patients with intestinal Behçet’s disease and Crohn’s disease in southwest China
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作者 Li Zeng Wen-Jian Meng +3 位作者 Zhong-Hui Wen Yi-Long Chen Yu-Fang Wang Cheng-Wei Tang 《World Journal of Clinical Cases》 SCIE 2021年第16期3858-3868,共11页
BACKGROUND Gastrointestinal involvement in Behçet's disease(GIBD)and Crohn’s disease(CD)are inflammatory diseases sharing a considerable number of similarities.However,different from CD,the operative and pos... BACKGROUND Gastrointestinal involvement in Behçet's disease(GIBD)and Crohn’s disease(CD)are inflammatory diseases sharing a considerable number of similarities.However,different from CD,the operative and postoperative management of GIBD remains largely empirical because of the lack of comprehensive treatment guidelines.AIM To compare surgical patients with GIBD and those with CD in a medical center and identify notable clinical features and effective postoperative treatment for surgical patients with GIBD.METHODS We searched patients diagnosed with CD and GIBD who underwent operations for gastrointestinal complications from 2009 to 2015 at West China Hospital of Sichuan University.A total of 10 surgical patients with GIBD and 106 surgical patients with CD were recruited.Information including demographic data,medication,and operative and postoperative parameters were collected and analyzed.As the incidence of surgical GIBD is low,their detailed medical records were reviewed and compared to previous studies.Moreover,the prognoses of CD and GIBD were evaluated respectively between groups treated with biological and non-biological agents.RESULTS Indication for first surgery was often acute intestinal perforation for GIBDpatients (7/10 vs 0/106, P < 0.001), whereas intestinal fistulae (0/10 vs 44/106, P =0.013) and ileus (0/10 vs 40/106, P = 0.015) were the indications for surgical CDpatients. Approximately 40% of patients with GIBD and 23.6% of patients withCD developed postoperative complications, 50% of patients with GIBD and 38.7%of patients with CD had recurrence postoperatively, and 40% (4/10) of patientswith GIBD and 26.4% (28/106) of patients with CD underwent reoperations. Theaverage period of postoperative recurrence was 7.87 mo in patients with Behçet'sdisease (BD) and 10.43 mo in patients with CD, whereas the mean duration fromfirst surgery to reoperation was 5.75 mo in BD patients and 18.04 mo in CDpatients. Surgical patients with GIBD more often used corticosteroids (6/10 vs7/106, P < 0.001) and thalidomide (7/10 vs 9/106, P < 0.001) postoperatively,whereas surgical patients with CD often used infliximab (27/106), azathioprine,or 6-mercaptopurine (74/106) for maintenance therapy.CONCLUSIONPatients suffering GIBD require surgery mostly under emergency situations,which may be more susceptible to recurrence and reoperation and need moreaggressive postoperative treatment than patients with CD. 展开更多
关键词 Gastrointestinal involvement in behçet's disease Crohn’s disease sURGERY Postoperative treatment Biological agents Real-world study
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Clinic Analysis of Behet Disease
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作者 JingjunLin HongniLi YixiaHuang KangkengZheng ZhongxiaZhou XiaofengLin 《Eye Science》 CAS 2004年第3期155-157,共3页
Purpose: To analyze the clinic manifestation and prognosis of Behet disease. Method: Twenty patients requiring inpatient treatment with Beh?觭et disease were retrosp-ectively analyzed. Results: The morbidity of Beh?... Purpose: To analyze the clinic manifestation and prognosis of Behet disease. Method: Twenty patients requiring inpatient treatment with Beh?觭et disease were retrosp-ectively analyzed. Results: The morbidity of Beh?觭et disease is 5.5/100 000. In the systemic damage, stom-atocace and skin lesion are 95%, eye lesion and genital ulcer 50%, joint lesion 45%, gastrointestinal lesion 35%, Uveitis is the major disease in eye lesion, and followed in order by retinal vasculitis and obstruction of retinal artery. Attack age average 30.3 years old. Diagnosis age average 34.8 years old. The patients stay in hospital for 41 days on the average. Cure rate is 55%, improvement rate 40%, blinding rate of eye lesion is 36%. Conclusions: Beh?觭et disease is a multisystem lesion disease. Stomatocace and skin lesion is the major lesion, the next in common occurrence are eye and genital lesions. Repeated attack of uveitis, complicated cataract and secondary glaucoma are the major causes of blindness. 展开更多
关键词 临床分析 贝切特疾病 发病率 系统损害
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Right Ventricular Thrombus and Tricuspid Valve Dysfunction in a Patient with Behçet’s Disease
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作者 Federica Valente Christian Motet +1 位作者 Stefan Rusu Frederic Vandergheynst 《Case Reports in Clinical Medicine》 2020年第10期319-328,共10页
<strong>Background:</strong> Beh<span style="white-space:nowrap;">&ccedil;</span>et’s disease (BD) is a multisystemic, chronic inflammatory disorder with a broad range of manifes... <strong>Background:</strong> Beh<span style="white-space:nowrap;">&ccedil;</span>et’s disease (BD) is a multisystemic, chronic inflammatory disorder with a broad range of manifestations including within the cardiovascular system. Cardiac involvement like intracardiac thrombus (ICT) and valvular involvement in BD are rarely seen entities and often associated with poor prognosis. <strong>Case Presentation: </strong>We present the case of a young patient with vascular-Beh<span style="white-space:nowrap;">&ccedil;</span>et diagnosed by the presence of intracardiac thrombus in the right ventricle, unresponsive to medical treatment. Even though the intracardiac lesion was successfully treated by surgical excision, he presented a severe tricuspid dysfunction some years later due to the extension of fibrosis with no surgical therapeutic option. <strong>Conclusion:</strong> Intracardiac thrombosis is a rare but early manifestation of Beh<span style="white-space:nowrap;">&ccedil;</span>et’s disease, which is difficult to diagnose and has a poor prognosis. 展开更多
关键词 behçets disease Cardiac Involvement Intracardiac Thrombosis Tricuspid Valve Regurgitation Endomyocardial Fibrosis
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Successful splenic artery embolization in a patient with Behçet’s syndrome-associated splenic rupture:A case report
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作者 Guang-Zhao Zhu Dong-Hua Ji 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第4期1184-1188,共5页
BACKGROUND Splenic rupture associated with Behçet’s syndrome(BS)is extremely rare,and there is no consensus on its management.In this case report,a patient with BSassociated splenic rupture was successfully trea... BACKGROUND Splenic rupture associated with Behçet’s syndrome(BS)is extremely rare,and there is no consensus on its management.In this case report,a patient with BSassociated splenic rupture was successfully treated with splenic artery embolization(SAE)and had a good prognosis after the intervention.CASE SUMMARY The patient was admitted for pain in the left upper abdominal quadrant.He was diagnosed with splenic rupture.Multiple oral and genital aphthous ulcers were observed,and acne scars were found on his back.He had a 2-year history of BS diagnosis,with symptoms of oral and genital ulcers.At that time,he was treated with oral corticosteroids for 1 month,but the symptoms did not alleviate.He underwent SAE to treat the rupture.On the first day after SAE,the patient reported a complete resolution of abdominal pain and was discharged 5 d later.Three months after the intervention,a computed tomography examination showed that the splenic hematoma had formed a stable cystic effusion,suggesting a good prognosis.CONCLUSION SAE might be a good choice for BS-associated splenic rupture based on good surgical practice and material selection. 展开更多
关键词 splenic artery embolization behçets syndrome splenic rupture Case report
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手术对Vogt-小柳原田综合征和Beh(c)et病并发性白内障患者的影响
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作者 母开红 杨志英 殷显辉 《医学综述》 2016年第24期4986-4988,共3页
目的探讨手术对Vogt-小柳原田综合征和Beh(c)et病并发性白内障患者的影响。方法选择2012年4月至2014年4月西昌市人民医院采用超声乳化白内障吸除联合囊袋内人工晶状体植入术治疗的20例(25眼)Vogt-小柳原田综合征和Beh(c)et病并发性白内... 目的探讨手术对Vogt-小柳原田综合征和Beh(c)et病并发性白内障患者的影响。方法选择2012年4月至2014年4月西昌市人民医院采用超声乳化白内障吸除联合囊袋内人工晶状体植入术治疗的20例(25眼)Vogt-小柳原田综合征和Beh(c)et病并发性白内障患者作为并发性白内障组。同时选取同期接受相同术式的年龄相关性白内障患者20例(26眼)作为年龄相关性白内障组。两组患者均给予1 mg万古霉素注入前房预防感染,并发性白内障组在此基础上给予非甾体类抗炎药滴眼液滴眼、术后前5日口服泼尼松(1 mg/kg)治疗。比较两组患者术前以及术后1 d、7 d、30 d及90 d的房水闪辉值及炎性细胞个数。结果并发性白内障组患者术前及术后1 d、7 d、30 d及90 d的房水闪辉值和炎性细胞个数均多于年龄相关性白内障组[(19.9±6.5)pc/ms、(44.3±18.5)pc/ms、(35.6±12.7)pc/ms、(23.9±8.4)pc/ms、(13.9±4.3)pc/ms比(5.6±1.1)pc/ms、(13.6±2.6)pc/ms、(8.5±2.7)pc/ms、(5.3±1.6)pc/ms、(4.0±1.3)pc/ms;(6.5±1.9)个/0.5 mm^3、(83.5±17.1)个/0.5 mm^3、(27.5±8.3)个/0.5 mm^3、(11.4±2.8)个/0.5 mm^3、(4.8±1.3)个/0.5 mm^3比(4.9±1.4)个/0.5 mm^3、(33.6±11.1)个/0.5 mm^3、(9.5±2.8)个/0.5 mm^3、(2.5±0.8)个/0.5 mm^3、(3.7±1.1)个/0.5mm^3],且均随着手术后时间的延长,逐渐降低,直至低于术前,两组患者房水闪辉值及炎性细胞个数在组间、时点间以及组间·时点间交互作用比较差异均有统计学意义(P<0.05),结论 Vogt-小柳原田综合征和Beh(c)et病并发性白内障患者采用超声乳化白内障吸除联合囊袋内人工晶状体植入术后早期前房内活动性炎症较为严重,术后3个月可恢复到术前水平,甚至低于术前水平。 展开更多
关键词 VOGT-小柳原田综合征 beh(c)et 年龄相关性白内障 炎症反应
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Behçet Disease with Generalized Polymorphous Cutaneous Lesions:A Case Report
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作者 Li-Wei Wang Ling-Ling Luo +2 位作者 Wei Zhang Xue-Si Zeng Pan-Gen Cui 《International Journal of Dermatology and Venereology》 2022年第3期175-177,共3页
Introduction:Behçet disease is a chronic multisystem vasculitis disease,however generalized polymorphous cutaneous lesions are uncommon.Here,we reported a case of Behçet disease with multiple parts of the bo... Introduction:Behçet disease is a chronic multisystem vasculitis disease,however generalized polymorphous cutaneous lesions are uncommon.Here,we reported a case of Behçet disease with multiple parts of the body and complex lesions,which may lead to misjudging in clinical diagnosis.Case report:A 69-year-old man presented with a seven-year history of recurrent generalized polymorphous mucocutaneous lesions(erythematous papules,nodules,ulcers,and necrosis)over his entire body,and the lesions had been painful for the past three years.Based on the past medical history,clinical presentation,histological examination excluded other diseases,and the 2014-amended International Criteria for Behget disease,the patient had a score of 6 points and was diagnosed as Behçet disease.Discussion:The common clinical feature in patients with Behçet syndrome is the presence of recurrent and usually painful mucocutaneous ulcers.Other clinical manifestations of this disorder are more variable among different patients.A diagnosis of generalized polymorphous cutaneous lesions should remain on the list of differential diagnosis of Behçet disease after excluding other diseases.Conclusion:The mucocutaneous lesions of Behçet disease are often preceded by other manifestations,and timely diagnosis may benefit early treatment and prognosis. 展开更多
关键词 behçet disease cutaneous lesions generalized lesions poloymorphous
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同型半胱氨酸对血管型白塞病动静脉血栓形成危险性的Meta分析 被引量:2
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作者 朱马汗.托克达尔汗 艾则孜.阿不都热依木 +3 位作者 赛力克.马高维亚 王护国 哈尔满.阿吉汗 田野 《中国血管外科杂志(电子版)》 2015年第1期21-25,共5页
目的系统评价白塞病(BD)患者血浆同型半胱氨酸水平与动静脉血栓形成间的关联性。方法检索1950年1月至2014年10月Pubmed、EMBASE、Cochrane Library、Web of Science、CNKI等中外文数据库上所有关于BD合并动静脉血栓形成的研究。按照纳... 目的系统评价白塞病(BD)患者血浆同型半胱氨酸水平与动静脉血栓形成间的关联性。方法检索1950年1月至2014年10月Pubmed、EMBASE、Cochrane Library、Web of Science、CNKI等中外文数据库上所有关于BD合并动静脉血栓形成的研究。按照纳入和排除标准纳入文献,并采用Rev Man5.2软件进行Meta分析。结果最终纳入11个研究,分析结果显示同型半胱氨酸血症在血栓组较无血栓组更普遍(比值比2.61,95%置信区间1.46~4.67,P=0.001),血栓组同型半胱氨酸的平均水平显著高于无血栓组(均数差=2.99,95%置信区间1.81~4.16,P【0.00001]。结论血浆高同型半胱氨酸增加BD患者的动静脉血栓形成风险。 展开更多
关键词 同型半胱氨酸 白塞病 血栓 MetA分析
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英夫利西单抗治疗儿童肠白塞病的疗效分析
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作者 李超 邓江红 +5 位作者 王江 邝伟英 张俊梅 檀晓华 李士朋 李彩凤 《中国临床新医学》 2024年第9期967-971,共5页
目的分析英夫利西单抗治疗儿童肠白塞病的疗效。方法回顾性分析首都医科大学附属北京儿童医院风湿科2017年1月至2020年12月收治的10例肠白塞病患儿的临床资料,均接受英夫利西单抗治疗>3次。探讨肠白塞病患儿消化道及其他系统受累情... 目的分析英夫利西单抗治疗儿童肠白塞病的疗效。方法回顾性分析首都医科大学附属北京儿童医院风湿科2017年1月至2020年12月收治的10例肠白塞病患儿的临床资料,均接受英夫利西单抗治疗>3次。探讨肠白塞病患儿消化道及其他系统受累情况、激素及免疫抑制剂治疗情况、英夫利西单抗应用情况以及随访情况等。结果男性7例,女性3例,起病年龄为(8.18±3.66)岁,病程中位时间为3(1~72)个月。10例患儿均有消化道症状,其中腹泻6例、腹痛5例、血便3例、呕吐1例、腹胀1例,3例肠穿孔。消化道超声和内镜检查提示回盲部溃疡最常见。3例合并血管受累。英夫利西单抗的剂量3~5 mg/(kg·次)。英夫利西单抗治疗时间为(20.9±9.5)个月。10例患儿随访中位时间为17.5(14~54)个月。9例患儿予甲泼尼龙冲击治疗。泼尼松初始剂量为1.6~2.0 mg/(kg·d)。8例使用甲氨蝶呤,5例使用环孢素A,5例使用沙利度胺,1例使用吗替麦考酚酯。治疗后所有患儿均无临床症状,炎症指标及消化道超声无异常,病情稳定。6例停用英夫利西单抗。英夫利西单抗输注过程中无过敏反应及活动性感染。结论英夫利西单抗治疗对儿童肠白塞病是一种耐受性良好且有效的治疗方法。 展开更多
关键词 儿童 肠白塞病 英夫利西单抗
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肠白塞病发病机制研究进展
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作者 杨青林 万俊辰 +1 位作者 张妙心 周琦 《胃肠病学和肝病学杂志》 CAS 2024年第12期1698-1702,1710,共6页
白塞综合征(Behcet’s syndrome,BS)是一种慢性、周期性复发的全身性血管炎疾病,其典型临床表现为反复发作的口腔与生殖器溃疡。其中,肠白塞病作为BS的一种亚型,主要以肠溃疡为临床特征。肠白塞病的临床表现多样,可能并发严重病症,从而... 白塞综合征(Behcet’s syndrome,BS)是一种慢性、周期性复发的全身性血管炎疾病,其典型临床表现为反复发作的口腔与生殖器溃疡。其中,肠白塞病作为BS的一种亚型,主要以肠溃疡为临床特征。肠白塞病的临床表现多样,可能并发严重病症,从而增加死亡风险,加重经济负担,且显著降低患者的生活品质。虽然肠白塞病的发病机理尚未彻底明了,但现有研究揭示其可能与遗传素质、环境因素、免疫调节失衡及肠道微生物群的变化密切相关。对这些病因的深入理解对于提高早期诊断精准度和开发更有效治疗手段具有重大意义。当前,关于BS的病理生理学的研究已较为充分,然而,针对肠白塞病亚型的研究文献相对较少。本文将侧重对肠白塞病涉及的遗传背景、免疫机制、环境因素和肠道微生态失衡等方面的研究进展进行综述。 展开更多
关键词 白塞综合征 肠白塞病 发病机制 肠道微生态
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白塞氏病合并升主动脉瘤和主动脉瓣关闭不全的外科治疗——个案报告与文献复习 被引量:11
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作者 刘愚勇 孙衍庆 蔡克强 《心肺血管病杂志》 CAS 2002年第4期214-216,共3页
目的 :报告 1例Beh et’s病合并升主动脉瘤、主动脉瓣关闭不全的外科治疗 ,结合文献 ,探讨其相关问题和解决方法。方法 :1例Beh et’s患者经激素加免疫抑制剂治疗后进行升主动脉与主动脉瓣替换手术 ,术后给予激素、抗凝、抗炎治疗 ,并随... 目的 :报告 1例Beh et’s病合并升主动脉瘤、主动脉瓣关闭不全的外科治疗 ,结合文献 ,探讨其相关问题和解决方法。方法 :1例Beh et’s患者经激素加免疫抑制剂治疗后进行升主动脉与主动脉瓣替换手术 ,术后给予激素、抗凝、抗炎治疗 ,并随访 ;阅读分析相关文献 ,探讨解决方案。结果 :本例患者术后早期恢复良好 ,彩色多普勒超声心动图示人工瓣情况无异常 ,随访 6个月情况良好 ,后因主动脉人工瓣脱落导致急性心衰而死亡。结论 :Beh et’s合并升主动脉瘤及主动脉瓣关闭不全手术后容易并发瓣周漏或人工瓣脱落 ,尽管已提出了一些预防方法 ,但从根本上尚无有效的防治办法。 展开更多
关键词 白塞氏病 升主动脉瘤 外科治疗 主动脉瓣关闭不全 合并症
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稀土含硫有机配体配合物应用研究(Ⅱ)——N,N-二乙基二硫代氨基甲酸合镧对蔬菜防病促长的作用 被引量:8
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作者 章伟光 朱初耀 +1 位作者 黎华养 胡德广 《稀土》 EI CAS CSCD 北大核心 1998年第4期46-50,共5页
合成了N,N-二乙基二硫代氨基甲酸合镧二乙铵固态配合物(简称ELaDC),研究了ELaDC对蕃茄、辣椒、黄瓜和扁豆的防病促长作用,各小区的土壤肥力相似,pH值约为6.5,ELaDC配制成浓度1‰,2‰和3‰的水溶液,... 合成了N,N-二乙基二硫代氨基甲酸合镧二乙铵固态配合物(简称ELaDC),研究了ELaDC对蕃茄、辣椒、黄瓜和扁豆的防病促长作用,各小区的土壤肥力相似,pH值约为6.5,ELaDC配制成浓度1‰,2‰和3‰的水溶液,对照(CK)为清水,每一块小区在播种、定植期和苗龄期的水肥管理水平一致。蕃茄始果期,辣椒盛花期,黄瓜始花期和豆角结夹期,开始进行叶面喷施。整个生长期喷施二到三次,每次间隔10到15天。实验表明,Vc含量及单株结果数高于对照,亩产量也增加了。实验还发现能提前2~3天收获。ELaDC能防止蔬菜病害,病害发生率比对照减少12~29%。然而,当浓度达3‰时,产量减少。 展开更多
关键词 稀土肥料 镧配合物 蔬菜 ELaDC
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中西药对肿瘤坏死因子α的抑制作用——治疗白塞病的新思路 被引量:4
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作者 杨永升 庄曾渊 《中国中医眼科杂志》 2005年第2期109-113,共5页
白塞病(Beh etdisease,BD)是一种与免疫失调有关的免疫性疾病,现代医学研究发现机体中肿瘤坏死因子α(tumornecrosisfactorα,TNFα)的水平增高与Beh et病的病情密切相关,抑制TNFα可以明显减轻病情,控制疾病的发展及防止进一步组织器... 白塞病(Beh etdisease,BD)是一种与免疫失调有关的免疫性疾病,现代医学研究发现机体中肿瘤坏死因子α(tumornecrosisfactorα,TNFα)的水平增高与Beh et病的病情密切相关,抑制TNFα可以明显减轻病情,控制疾病的发展及防止进一步组织器官的损伤。近年来发现沙度利胺、Infliximab、Etanercept等几种TNFα抑制剂可控制病情发展,从中医药研究中也发现一些中药及方剂有明显抑制TNFα的作用,如雷公藤、丹参、栀子、茯苓、大黄、白芍以及清热解毒汤剂及大承气汤。因此可以从这一角度解释许多中药组方对控制Beh et病的病情,防止疾病复发有明显功效的原因。 展开更多
关键词 beheet 免疫学 肿瘤坏死因子A 中药
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白塞病误诊为化脓性扁桃体炎1例并文献复习 被引量:2
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作者 吴茱萸 唐思源 刘亚 《国际医药卫生导报》 2015年第17期2592-2593,共2页
目的 提高对白塞病临床特点的认识,减少误诊.方法 对我科近期误诊为急性化脓性扁桃体炎最终确诊为白塞病的1例患者的临床资料进行回顾性分析.结果 白塞病的首发表现各异,本例患者以发热、扁桃体化脓为首发症状,抗生素治疗无效,病程中出... 目的 提高对白塞病临床特点的认识,减少误诊.方法 对我科近期误诊为急性化脓性扁桃体炎最终确诊为白塞病的1例患者的临床资料进行回顾性分析.结果 白塞病的首发表现各异,本例患者以发热、扁桃体化脓为首发症状,抗生素治疗无效,病程中出现外阴溃疡,行针刺试验阳性,诊断为白塞病,经激素及免疫抑制剂治疗好转.结论 白塞病的首发表现各异,当出现以发热、扁桃体化脓为首发症状,抗生素治疗无效时,应考虑到白塞病的可能. 展开更多
关键词 白塞病 误诊 化脓性扁桃体炎
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神经白塞氏病的临床诊断
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作者 王晔 王德生 《中风与神经疾病杂志》 CAS 2023年第7期652-654,共3页
目的分析神经白塞氏病的临床表现及影像学特征。方法采用回顾性研究方法分析51例患者的临床资料,51例患者均符合白塞氏病国际研究小组1990年提出的诊断标准,并有不同程度的神经系统受损表现。结果常见头痛、感觉障碍、运动障碍、脑膜刺... 目的分析神经白塞氏病的临床表现及影像学特征。方法采用回顾性研究方法分析51例患者的临床资料,51例患者均符合白塞氏病国际研究小组1990年提出的诊断标准,并有不同程度的神经系统受损表现。结果常见头痛、感觉障碍、运动障碍、脑膜刺激征、共济失调;阵发性抽搐、精神障碍、偏盲、失语症等少见。磁共振检查急性期常见基底节区或脑干片状高信号,半球白质、脑室周围散在高信号,呈圆形、线形或新月状。脑脊液典型改变可见淋巴细胞、总蛋白量升高。诱发电位改变不明显。结论神经白塞氏病一般急性起病,呈缓解与复发或持续进展病程。神经白塞氏病临床可见脑干综合征、脑卒中样类型、精神异常型和弥漫型等类型。目前诊断以临床为主,在白塞氏病基础上出现神经系统症状和体征即可诊断。治疗主要用激素、细胞毒素类药物及血浆置换方法。 展开更多
关键词 白塞氏病 神经白塞氏病 临床特征 皮质类固醇 免疫抑制剂
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人类白细胞抗原-B51与Behet病葡萄膜炎的相关性研究 被引量:5
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作者 汪运山 姜莉华 +4 位作者 申红 牟国营 潘光锦 亓同钢 张源潮 《中华眼底病杂志》 CAS CSCD 2004年第4期203-205,共3页
目的 探讨人类白细胞抗原 (HL A) - B5 1与 Behcet  ) 病葡萄膜炎间的相关性。 方法 应用微量淋巴细胞毒试验 ,对 2 7例 Behcet  ) 病患者和 30例健康人的 HL A- A和 HL A- B抗原进行研究。应用聚合酶链式反应 -序列特异性引物 (PC... 目的 探讨人类白细胞抗原 (HL A) - B5 1与 Behcet  ) 病葡萄膜炎间的相关性。 方法 应用微量淋巴细胞毒试验 ,对 2 7例 Behcet  ) 病患者和 30例健康人的 HL A- A和 HL A- B抗原进行研究。应用聚合酶链式反应 -序列特异性引物 (PCR- SSP)技术测定 HL A- B5 1抗原阳性的 Behcet  ) 病患者和对照组人群中的HL A- B5 1等位基因 (HL A- B* 5 10 1- B* 5 10 7)。 结果  Behcet  ) 病患者和对照组 HL A- B5 1的阳性频率分别为 6 3%和 16 .7% [χ2 =12 .9,P<0 .0 0 1,Pc<0 .0 5 ,相对危险度 (RR) =8.5 ]。在 Behcet  ) 病患者中 ,葡萄膜炎的患病率为 4 0 .7% (11/ 2 7) ;72 .7% (8/ 11) Behcet  ) 病葡萄膜炎中存在 HL A- B5 1(均为 HL A- B* 5 10 1)。HL A- B5 1和 HL A- B* 5 10 1与 Behcet  ) 病葡萄膜炎存在弱相关性 ,但均未见统计学差异 (分别为 RR=2 .0 7,χ2 =0 .75 9,P >0 .2 5 ;RR =2 .6 7,χ2 =1.395 ,P >0 .10 )。 结论 提示 HL A- B5 1(HL A- B* 5 10 1)是Behcet  ) 病的易感基因 。 展开更多
关键词 人类白细胞抗原-B51 behCet 葡萄膜炎 测定 等位基因
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白塞病葡萄膜炎的治疗与展望 被引量:3
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作者 白琳 杨培增 《中华实验眼科杂志》 CAS CSCD 北大核心 2016年第8期761-764,共4页
白塞病葡萄膜炎是葡萄膜炎中难治的类型之一,多表现为全葡萄膜炎,对视力影响大,病情易反复,通常需要传统免疫抑制剂,如糖皮质激素、环孢素、苯丁酸氮芥、环磷酰胺等联合使用控制病情,长期使用毒性作用和不良反应大.干扰素、抗肿瘤坏死... 白塞病葡萄膜炎是葡萄膜炎中难治的类型之一,多表现为全葡萄膜炎,对视力影响大,病情易反复,通常需要传统免疫抑制剂,如糖皮质激素、环孢素、苯丁酸氮芥、环磷酰胺等联合使用控制病情,长期使用毒性作用和不良反应大.干扰素、抗肿瘤坏死因子、抗白细胞介素及其受体等新型生物制剂为白塞病葡萄膜炎的治疗提供了新的治疗手段.本文就白塞病葡萄膜炎的传统免疫抑制剂治疗、生物制剂治疗以及二者的治疗效果比较进行综述. 展开更多
关键词 白塞病葡萄膜炎 治疗 免疫抑制剂 生物制剂
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生物制剂治疗以心脏瓣膜病变为主要表现的白塞病8例 被引量:3
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作者 丁艳霞 李超然 +7 位作者 刘金晶 史婧 李璐 赵岩 曾小峰 张奉春 许尚栋 郑文洁 《中华临床免疫和变态反应杂志》 2019年第2期108-112,共5页
目的探讨生物制剂治疗以心脏瓣膜病变为主要表现的白塞病患者的疗效。方法收集北京协和医院2016年6月至2018年9月以心脏瓣膜病变为主要表现并应用生物制剂治疗的8例患者的临床资料,回顾性分析其临床表现、超声心动图资料、手术情况及应... 目的探讨生物制剂治疗以心脏瓣膜病变为主要表现的白塞病患者的疗效。方法收集北京协和医院2016年6月至2018年9月以心脏瓣膜病变为主要表现并应用生物制剂治疗的8例患者的临床资料,回顾性分析其临床表现、超声心动图资料、手术情况及应用生物制剂后的疗效。结果 8例均为男性,平均年龄(39.9±7.7)岁,平均病程(11.8±6.0)年。瓣膜病变均以主动脉瓣受累为主,超声心动图均表现为重度主动脉瓣关闭不全。8例均在围手术期应用了生物制剂,包括英夫利昔单抗、阿达木单抗和托珠单抗。8例患者共行18例次手术,其中6例手术≥2次,先后出现瓣周漏10例次,均为单纯主动脉瓣置换术后,且术前未用激素/免疫抑制剂治疗者8例次;经围手术期积极治疗(激素联合免疫抑制剂及生物制剂),改用Carbrol术、Bentall术及瓣周漏封堵后,随访平均13(6~24)个月无明显术后并发症。应用生物制剂后,8例患者激素用量显著下降[从(41.3±15.3)mg降至(14.7±3.9)] mg(P<0.05)。结论白塞病瓣膜病变诊治困难,应加强激素和免疫抑制剂治疗,注意改良手术方式,对疗效欠佳或需要尽快手术的患者加用生物制剂能快速控制炎症,尽快创造手术时机,并减少术后并发症的发生。 展开更多
关键词 白塞病 心脏瓣膜受累 生物制剂
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