Objective:To compare the clinical effects of thick-needle therapy(TNT)and acupuncture therapy(AT)on patients with Bell's palsy(BP)at the recovery stage.Methods:A total of 146 eligible participants from 3 hospitals...Objective:To compare the clinical effects of thick-needle therapy(TNT)and acupuncture therapy(AT)on patients with Bell's palsy(BP)at the recovery stage.Methods:A total of 146 eligible participants from 3 hospitals in China were randomized into the TNT group(73 cases)and the AT group(73 cases)using a central randomization.Both groups received Western medicine thrice a day for 4 weeks.Moreover,patients in the TNT group received subcutaneous insertion of a thick needle into Shendao(GV 11)acupoint,while patients in the AT group received AT at acupoints of Cuanzhu(BL 2),Yangbai(GB 14),Dicang(ST 4),Xiaguan(ST 7),Jiache(ST 6),Yingxiang(LI 20)and Hegu(LI 4),4 times a week,for 4 weeks.Both groups received 2 follow-up visits,which were arranged at 1 month and 3 months after treatment,respectively.The primary outcome measure was House-Brackmann Facial Nerve Grading System(HBFNGS)grade.And the clinical recovery rates of both groups were evaluated according to the HBFNGS grades after treatment.The secondary outcome measures included the facial disability index(FDI)and electroneurogram(EnoG).The adverse events were observed and recorded in both groups.Results:Three cases withdrew from the trial,2 in the TNT group and 1 in the AT group.There was no significant difference in the clinical recovery rates between the TNT and AT groups after 4-week treatment[40.85%(29/71)vs.34.72%(25/72),P>0.05].At the 2nd follow-up visit,more patients in the TNT group showed reduced HBFNGS grades than those in the AT group(P<0.01).No significant difference was observed between the two groups in FDI score,EnoG latency and maximum amplitude ratio at all time points(all P>0.05).Conclusion:The clinical effect of TNT was equivalent to that of AT in patients with BP at recovery stage,while the post-treatment effect of TNT was superior to that of AT.展开更多
目的基于脑电频谱技术,观察头针配合低频重复经颅磁刺激治疗痉挛性脑性瘫痪的临床疗效。方法将90例痉挛性脑性瘫痪患者和20例健康儿童分为病例组和正常组,通过采集静息态脑电信号比较各频谱(δ、θ、α、β、γ)密度。再将病例组随机分...目的基于脑电频谱技术,观察头针配合低频重复经颅磁刺激治疗痉挛性脑性瘫痪的临床疗效。方法将90例痉挛性脑性瘫痪患者和20例健康儿童分为病例组和正常组,通过采集静息态脑电信号比较各频谱(δ、θ、α、β、γ)密度。再将病例组随机分为A组、B组和C组,每组30例。在接受常规康复训练的基础上,A组采用头针治疗,B组采用低频重复经颅磁刺激治疗,C组采用头针配合低频重复经颅磁刺激治疗。观察3组治疗前后粗大运动功能测试量表-88(gross motor function measure-88,GMFM-88)评分(D区、E区)、Gesell发育诊断量表各项评分、颅内椎基底节动脉血流状态各项指标[左侧椎动脉(left vertebral artery,LVA)、右侧椎动脉(right vertebral,RLA)、基底动脉(basilar artery,BA)平均流速]、各项炎症因子[血清白细胞介素-6(interleukin-6,IL-6)、白细胞介素-33(interleukin-33,IL-33)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)]水平及脑电信号各频谱密度的变化情况,比较3组临床疗效。结果C组治疗后D区、E区GMFM-88评分及Gesell发育诊断量表各项评分较同组治疗前显著上升,LVA、RLA、BA平均流速显著加快,各项炎症因子水平显著降低,差异均具有统计学意义(P<0.05)。C组治疗后D区、E区GMFM-88评分及Gesell发育诊断量表各项评分均明显高于A组和B组,LVA、RLA、BA平均流速明显快于A组和B组,各项炎症因子水平明显低于A组和B组,差异均具有统计学意义(P<0.05)。病例组治疗前脑电信号δ、θ频谱密度明显高于正常组(P<0.05);3组治疗后脑电信号δ、θ频谱密度均较同组治疗前显著降低(P<0.05)。C组总有效率为83.3%,明显高于A组的63.3%和B组的56.7%,差异均具有统计学意义(P<0.05)。结论在常规康复训练的基础上,头针配合低频重复经颅磁刺激治疗痉挛性脑性瘫痪疗效确切,能改善患者运动功能和认知功能,其机制主要与该方法能下调炎症因子表达、调节颅内椎基底节动脉血流状态有关。展开更多
基金Supported by the Scientific Research Special Fund of Traditional Chinese Medicine Industry(No.201507006-01)。
文摘Objective:To compare the clinical effects of thick-needle therapy(TNT)and acupuncture therapy(AT)on patients with Bell's palsy(BP)at the recovery stage.Methods:A total of 146 eligible participants from 3 hospitals in China were randomized into the TNT group(73 cases)and the AT group(73 cases)using a central randomization.Both groups received Western medicine thrice a day for 4 weeks.Moreover,patients in the TNT group received subcutaneous insertion of a thick needle into Shendao(GV 11)acupoint,while patients in the AT group received AT at acupoints of Cuanzhu(BL 2),Yangbai(GB 14),Dicang(ST 4),Xiaguan(ST 7),Jiache(ST 6),Yingxiang(LI 20)and Hegu(LI 4),4 times a week,for 4 weeks.Both groups received 2 follow-up visits,which were arranged at 1 month and 3 months after treatment,respectively.The primary outcome measure was House-Brackmann Facial Nerve Grading System(HBFNGS)grade.And the clinical recovery rates of both groups were evaluated according to the HBFNGS grades after treatment.The secondary outcome measures included the facial disability index(FDI)and electroneurogram(EnoG).The adverse events were observed and recorded in both groups.Results:Three cases withdrew from the trial,2 in the TNT group and 1 in the AT group.There was no significant difference in the clinical recovery rates between the TNT and AT groups after 4-week treatment[40.85%(29/71)vs.34.72%(25/72),P>0.05].At the 2nd follow-up visit,more patients in the TNT group showed reduced HBFNGS grades than those in the AT group(P<0.01).No significant difference was observed between the two groups in FDI score,EnoG latency and maximum amplitude ratio at all time points(all P>0.05).Conclusion:The clinical effect of TNT was equivalent to that of AT in patients with BP at recovery stage,while the post-treatment effect of TNT was superior to that of AT.
文摘目的基于脑电频谱技术,观察头针配合低频重复经颅磁刺激治疗痉挛性脑性瘫痪的临床疗效。方法将90例痉挛性脑性瘫痪患者和20例健康儿童分为病例组和正常组,通过采集静息态脑电信号比较各频谱(δ、θ、α、β、γ)密度。再将病例组随机分为A组、B组和C组,每组30例。在接受常规康复训练的基础上,A组采用头针治疗,B组采用低频重复经颅磁刺激治疗,C组采用头针配合低频重复经颅磁刺激治疗。观察3组治疗前后粗大运动功能测试量表-88(gross motor function measure-88,GMFM-88)评分(D区、E区)、Gesell发育诊断量表各项评分、颅内椎基底节动脉血流状态各项指标[左侧椎动脉(left vertebral artery,LVA)、右侧椎动脉(right vertebral,RLA)、基底动脉(basilar artery,BA)平均流速]、各项炎症因子[血清白细胞介素-6(interleukin-6,IL-6)、白细胞介素-33(interleukin-33,IL-33)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)]水平及脑电信号各频谱密度的变化情况,比较3组临床疗效。结果C组治疗后D区、E区GMFM-88评分及Gesell发育诊断量表各项评分较同组治疗前显著上升,LVA、RLA、BA平均流速显著加快,各项炎症因子水平显著降低,差异均具有统计学意义(P<0.05)。C组治疗后D区、E区GMFM-88评分及Gesell发育诊断量表各项评分均明显高于A组和B组,LVA、RLA、BA平均流速明显快于A组和B组,各项炎症因子水平明显低于A组和B组,差异均具有统计学意义(P<0.05)。病例组治疗前脑电信号δ、θ频谱密度明显高于正常组(P<0.05);3组治疗后脑电信号δ、θ频谱密度均较同组治疗前显著降低(P<0.05)。C组总有效率为83.3%,明显高于A组的63.3%和B组的56.7%,差异均具有统计学意义(P<0.05)。结论在常规康复训练的基础上,头针配合低频重复经颅磁刺激治疗痉挛性脑性瘫痪疗效确切,能改善患者运动功能和认知功能,其机制主要与该方法能下调炎症因子表达、调节颅内椎基底节动脉血流状态有关。
