Eleven recently completed toxicological studies were critically reviewed to identify toxicologically significant endpoints and dose-response information. Dose-response data were compiled and entered into the USEPA＇s ...Eleven recently completed toxicological studies were critically reviewed to identify toxicologically significant endpoints and dose-response information. Dose-response data were compiled and entered into the USEPA＇s benchmark dose software （BMDS） for calculation of a benchmark dose （BMD） and a benchmark dose low （BMDL）. After assessing 91 endpoints across the nine studies, a total of 23 of these endpoints were identified for BMD modeling, and BMDL estimates corresponding to various dose-response models were compiled for these separate endpoints. Thyroid, neurobehavior and reproductive endpoints for BDE-47, -99, -209 were quantitatively evaluated. According to methods and feature of each study, different uncertainty factor （UF） value was decided and subsequently reference doses （RfDs） were proposed. Consistent with USEPA, the lowest BMDLs of 2.10, 81.77, and 1698 I^g/kg were used to develop RfDs for BDE-47, -99, and -209, respectively. RfDs for BDE-99 and BDE-209 were comparable to EPA results, and however, RfD of BDE-47 was much lower than that of EPA, which may result from that reproductive/developmental proves to be more sensitive than neurobehavior for BDE-47 and the principal study uses very-low-dose exposure.展开更多
In this paper, we present the results of our numerical seakeeping analyses of a 6750-TEU containership, which were subjected to the benchmark test of the 2 nd ITTC–ISSC Joint Workshop held in 2014. We performed the s...In this paper, we present the results of our numerical seakeeping analyses of a 6750-TEU containership, which were subjected to the benchmark test of the 2 nd ITTC–ISSC Joint Workshop held in 2014. We performed the seakeeping analyses using three different methods based on a 3D Rankine panel method, including 1) a rigid-body solver, 2) a flexible-body solver using a beam model, and 3) a flexible-body solver using the eigenvectors of a 3D Finite Element Model(FEM). The flexible-body solvers adopt a fully coupled approach between the fluid and structure. We consider the nonlinear Froude–Krylov and restoring forces using a weakly nonlinear approach. In addition, we calculate the slamming loads on the bow flare and stern using a 2D generalized Wagner model. We compare the numerical and experimental results in terms of the linear response, the time series of the nonlinear response, and the longitudinal distribution of the sagging and hogging moments. The flexible-body solvers show good agreement with the experimental model with respect to both the linear and nonlinear results, including the high-frequency oscillations due to springing and whipping vibrations. The rigid-body solver gives similar results except for the springing and whipping.展开更多
The paper aims to give a comprehensive investigation of the two dimensional deformation of a single bubble in a straight duct and a 90° bend under the zero gravity condition. For this, the two phase flow lattice ...The paper aims to give a comprehensive investigation of the two dimensional deformation of a single bubble in a straight duct and a 90° bend under the zero gravity condition. For this, the two phase flow lattice Boltzmann equation (LBE) model is used. An averaging scheme of boundary condition implementation has been applied and validated. A generalized deformation benchmark has been introduced. By presenting and analyzing the shape of the bubbles moving through the channels, the effects of the all important nondimensional numbers on the bubble deformation are examined thoroughly. It is seen that by increasing the Weber number the rate of the deformation enhances. Besides, because of the velocity dissimilarity between the particles constructing the bubble, the initial coordinates and the diameter of the bubble play a great role in the future behavior of the bubble. The density ratio has a little effect on the shape of the bubble within the assumed range of the density ratio. Moreover, as the Reynolds number or the viscosity ratio is decreased, higher rate of deformation is exhibited. Finally it is found that there is an inverse proportionality between the amplitude and frequency of the bubble deformation.展开更多
The selection of suitable models and solutions is a fundamental requirement for con-ducting energy flow analysis in integrated energy systems(IES).However,this task is challenging due to the vast number of existing mo...The selection of suitable models and solutions is a fundamental requirement for con-ducting energy flow analysis in integrated energy systems(IES).However,this task is challenging due to the vast number of existing models and solutions,making it difficult to comprehensively compare scholars'studies with current work.In this paper,we aim to address this issue by presenting a comprehensive overview of mainstream IES models and clarifying their relationships,thereby providing guidance for scholars in selecting appro-priate models.Additionally,we introduce several widely used solvers for solving algebraic and differential equations,along with their detailed implementations in the energy flow analysis of IES.Furthermore,we conduct extensive testing and demonstration of these models and methods in various cases to establish benchmarking datasets.To facilitate reproducibility,verification and comparisons,we provide open‐source access to these datasets,including system data,analysis settings and implementations of the various solvers in the mainstream models.Scholars can utilise the provided datasets to reproduce the results,verify the findings and perform comparative analyses.Moreover,they have the flexibility to customise these settings according to their specific requirements.展开更多
基金financially supported by the Natural Science Foundation of China(Grant 81072263,to Y.Z.)Chun Tsung Scholarship of Fudan University(to D.C.)
文摘Eleven recently completed toxicological studies were critically reviewed to identify toxicologically significant endpoints and dose-response information. Dose-response data were compiled and entered into the USEPA＇s benchmark dose software （BMDS） for calculation of a benchmark dose （BMD） and a benchmark dose low （BMDL）. After assessing 91 endpoints across the nine studies, a total of 23 of these endpoints were identified for BMD modeling, and BMDL estimates corresponding to various dose-response models were compiled for these separate endpoints. Thyroid, neurobehavior and reproductive endpoints for BDE-47, -99, -209 were quantitatively evaluated. According to methods and feature of each study, different uncertainty factor （UF） value was decided and subsequently reference doses （RfDs） were proposed. Consistent with USEPA, the lowest BMDLs of 2.10, 81.77, and 1698 I^g/kg were used to develop RfDs for BDE-47, -99, and -209, respectively. RfDs for BDE-99 and BDE-209 were comparable to EPA results, and however, RfD of BDE-47 was much lower than that of EPA, which may result from that reproductive/developmental proves to be more sensitive than neurobehavior for BDE-47 and the principal study uses very-low-dose exposure.
基金Supported by Lloyd’s Register Foundation(LRF)-Funded Research Center at SNU(LRFC)
文摘In this paper, we present the results of our numerical seakeeping analyses of a 6750-TEU containership, which were subjected to the benchmark test of the 2 nd ITTC–ISSC Joint Workshop held in 2014. We performed the seakeeping analyses using three different methods based on a 3D Rankine panel method, including 1) a rigid-body solver, 2) a flexible-body solver using a beam model, and 3) a flexible-body solver using the eigenvectors of a 3D Finite Element Model(FEM). The flexible-body solvers adopt a fully coupled approach between the fluid and structure. We consider the nonlinear Froude–Krylov and restoring forces using a weakly nonlinear approach. In addition, we calculate the slamming loads on the bow flare and stern using a 2D generalized Wagner model. We compare the numerical and experimental results in terms of the linear response, the time series of the nonlinear response, and the longitudinal distribution of the sagging and hogging moments. The flexible-body solvers show good agreement with the experimental model with respect to both the linear and nonlinear results, including the high-frequency oscillations due to springing and whipping vibrations. The rigid-body solver gives similar results except for the springing and whipping.
文摘The paper aims to give a comprehensive investigation of the two dimensional deformation of a single bubble in a straight duct and a 90° bend under the zero gravity condition. For this, the two phase flow lattice Boltzmann equation (LBE) model is used. An averaging scheme of boundary condition implementation has been applied and validated. A generalized deformation benchmark has been introduced. By presenting and analyzing the shape of the bubbles moving through the channels, the effects of the all important nondimensional numbers on the bubble deformation are examined thoroughly. It is seen that by increasing the Weber number the rate of the deformation enhances. Besides, because of the velocity dissimilarity between the particles constructing the bubble, the initial coordinates and the diameter of the bubble play a great role in the future behavior of the bubble. The density ratio has a little effect on the shape of the bubble within the assumed range of the density ratio. Moreover, as the Reynolds number or the viscosity ratio is decreased, higher rate of deformation is exhibited. Finally it is found that there is an inverse proportionality between the amplitude and frequency of the bubble deformation.
基金The National Science Fund for Distinguished Young Scholars,Grant/Award Number:52325703IEEE Power and Energy Society Working Group on Test Systems for Economic Analysis。
文摘The selection of suitable models and solutions is a fundamental requirement for con-ducting energy flow analysis in integrated energy systems(IES).However,this task is challenging due to the vast number of existing models and solutions,making it difficult to comprehensively compare scholars'studies with current work.In this paper,we aim to address this issue by presenting a comprehensive overview of mainstream IES models and clarifying their relationships,thereby providing guidance for scholars in selecting appro-priate models.Additionally,we introduce several widely used solvers for solving algebraic and differential equations,along with their detailed implementations in the energy flow analysis of IES.Furthermore,we conduct extensive testing and demonstration of these models and methods in various cases to establish benchmarking datasets.To facilitate reproducibility,verification and comparisons,we provide open‐source access to these datasets,including system data,analysis settings and implementations of the various solvers in the mainstream models.Scholars can utilise the provided datasets to reproduce the results,verify the findings and perform comparative analyses.Moreover,they have the flexibility to customise these settings according to their specific requirements.
