Therapeutic effect of traditional Chinese medicine on coagulation disorder and accompanying intractable jaundice in hepatitis B virus-related liver cirrhosis patients

AIM： TO observe the therapeutic effects of new traditional Chinese medicine （TClVl） therapy on coagulation disorder and accompanying intractable jaundice in HBV-related liver cirrhosis patients. METHODS： Using stratified random sampling according to fibrinogen （Fib） levels, 145 liver cirrhosis patients due to hepatitis B complicated by coagulation disorder were treated. Of them, 70 in research group were treated with TCM by ＂nourishing yin, cooling blood and invigorating blood circulation＂ and Western medicine, 75 in control group were treated with conventional Western medicine. The indexes of liver function, coagulation function and bleeding events were observed and compared. RESULTS： The prothrombin time （PT） was shorter and the fibrinogen （Fib） level was higher in the research group than in the control group （Fib = 1.6-2.0 g/L, 1.1-1.5 g/L, and ≤ 1.0 g/L）. The total bilirubin （TBIL） level was significantly lower in the research group than in the control group, except for the subgroup of FIB ≤ 1.0 g/L. CONCLUSION： TCM therapy can improve coagulation fuction and decrease TBIL.

Efficacy of integrative medicine in deficiency of both qi and yin in the rat model of type 2 diabetes

Objective:To establish a rat model of type 2 diabetes(T2DM)manifesting the Chinese medicine syndrome pattern of both qi and yin deficiency for evaluating the efficacy of a Chinese herbal formula(CHF),integrative medicine(IM),and pioglitazone(PIO)on T2DM indicators in the animal model.Methods:The rat model was induced by a high-fat diet(HFD)and streptozotocin(STZ,30 mg/kg).CHF(3.4 g/kg),PIO(2.7 mg/kg),and IM(3.4 g CHF+2.7 mg PIO)were administered to rats once daily for 14 days.Related laboratory parameters were observed.Results:Diabetic rats showed unsmooth fur,alopecia,reduced activity,huddling,somnolence,depression,pale or reddened tongue,damp/dark red tail,and high levels of water and food intake,urine volume,and stool weight,but weakened grip strength.Low levels of serum SOD,Nat-Kt-ATPase,cAMP/cGMP,and a high level of iNOS were observed.Hyperglycemia,hyperinsulinemia,insulin resistance,high levels of serum glucagon/IDE and pancreatic amylin,and low serum and pancreatic SS levels were evident as well.Conclusions:A rat model of T2DM with both qi and yin deficiency was successfully replicated.CHF appeared to be more efficacious than IM and PIO in the rat model of qi and yin deficiency pattern of T2DM,though IM and PIO were each found to have their merits and drawbacks in attenuating T2DM indicators in the rat model.

Effect of Chinese Herbal Medicine for Nourishing Yin,Supplementing Qi,and Activating Blood on the Th1/Th2 Immune Balance in Peripheral Blood in Patients with Primary Sjogren's Syndrome

Objective： To observe the effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the expression of interferen- γ （IFN-γ,）/interleukin-4 （IL-4） in peripheral blood and disease activity in primary Sjogren＇s syndrome （pSS） patients, and to study the relationship between the immune balance of Th1/Th2 and the disease activity. Methods： A total of 66 pSS patients were randomized with tossing coins method into two groups： the integrative therapy group （34 cases） and the control group （32 cases）; and 28 healthy subjects were taken as the normal group. The integrative therapy group was treated by Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with hydroxychloroquine sulfate tablets and the control group was treated with hydroxychloroquine sulfate tablets. The treatment course was 3 months for both groups. The levels of serum immunoglobulin G （IgG）, erythrocyte sedimentation rate （ESR）, IFN-γand IL-4 in peripheral blood were measured before and after treatment. Results： Compared with the normal group, the levels of IgG, ESR, IFN- γ and IL-4 were significantly increased in pSS patients （P〈0.05）. Remarkably, after 3 months of treatment, these levels were dramatically decreased in both the integrative therapy group and the control group, although still higher than the normal group. The levels of IgG, ESR, IFN- and IL-4 in the integrative therapy group were lower than the control group and the same group before treatment （P〈0.05）. The ratio of IFN-γ/IL-4 also significantly decreased after treatment. Moreover, the level of IFN- γ, and the ratio of IFN- γ/IL-4 in the integrative theraphy group were significantly lower than the control group （P〈0.05）. For all patients the ratio of IFN-γ/IL-4 before and after treatment was positive correlated with the levels of IgG and ESR. Conclusion： Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood can alleviate the disease activity of pSS by regulating the immune balance of Th1/Th2.

Therapeutic Effect of Chinese Herbal Medicine for Strengthening Qi,Nourishing Yin,and Removing Stasis on Serum Osteopontin and Quality of Life of Patients with Primary Sjogren's Syndrome

Objective：To observe the therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin,and removing stasis on serum osteopontin（OPN） and quality of life（QOL） in patients with primary Sjogren＇s syndrome（pSS） and to study the correlation between OPN level and the disease.Methods：Sixtyeight pSS patients were randomly assigned to two groups：the treatment group（35 cases） treated by Chinese herbal medicine for strengthening qi,nourishing yin,and removing stasis combined with hydroxychloroquine sulfate tablet（HCQ） and the control group（33 cases） treated by HCQ only.Both were treated for 3 months. Before and after treatment,immunoglobulin G（IgG） level,erythrocyte sedimentation rate（ESR）,and OPN level were measured.The QOL in patients was evaluated using the Short Form-36 Health Survey（SF-36） before and after treatment.Thirty healthy females were taken as the normal control.Results：Before treatment,levels of IgG,ESR,and OPN in patients were higher than those in the normal control.After 3 months of treatment, those in both treatment groups decreased but were lower in the treatment group than those in the control group （P0.05）.The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control （P0.05） and higher in the treatment group than in the control group after treatment（P0.05）.Furthermore, there was a positive correlation between the levels of OPN and the levels of IgG and ESR,and a negative correlation between OPN levels and the overall score of SF-36（P0.05）.Conclusions：Chinese herbal medicine for strengthening qi,nourishing yin,and removing stasis could alleviate pSS disease and improve the QOL.In addition,the OPN level might be used as an evaluating index for pSS disease.

Effect of Chinese Herbal Medicines for Nourishing Yin,Supplementing Qi,and Activating Blood on Reproductive Endocrine Activity and Immune Functions in Patients with Primary Sjogren's Syndrome

ABSTRACT Objective： To investigate the effect of Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood on the reproductive endocrine-immune network and its mechanisms in patients with primary Sjogren＇s syndrome （pSS）. Methods： Seventy pSS patients were randomly assigned to two groups using a randomized digital table： the integrative therapy group （36 cases） and the control group （34 cases）. Thirty healthy subjects were taken as a normal group. The control group was treated with hydroxychloroquine sulfate tablets alone, and the integrative therapy group was treated by Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with hydroxychloroquine sulfate tablets. The treatment course was 6 months for both groups. Before and after treatment, serum estradiol （E2）, testosterone （T）, luteinizing hormone （LH）, prolactin （PRL） by radioimmunoassay and immunoglobulin （IgG） by immunodiffusion, erythrocyte sedimentation rate （ESR） by Westergren, interferon-γ （IFN-γ） and interleukin-4 （IL-4） by enzyme linked immunosorbent assay were determined. Results： E2 and T levels in all patients were lower than those of normal subjects before treatment （P〈0.05） and were increased significantly after 6-month treatment （P〈0.05）. ESR, FSH, LH, IgG, IFN - γ, IL - 4 and ratios of E2/T, and IFN --γ/IL in the patients were higher than those of normal subjects before the treatments （P〈0.05）, and were reduced significantly after the treatments （P〈0.05）. The T and IFN -γ levels and E2/T ratio in the patients treated with integrative therapy were reduced significantly compared with the control group （P〈0.05）. However, the PRL levels before and after treatment were not significantly changed in the two groups （P〉0.05）. The ratios of E2/T and IFN -γ/IL-4, and levels of IgG and ESR were positively correlated before and after treatment （P〈0.05）. Conclusions： The ratios of E2/T and IFN - γ/ IL-4 might be used as indicators of pSS activity. Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with Western medicine could improve the therapeutic effect by regulating the reproductive endocrine-immune network in pSS patients.

Effects on type 2 diabetes complicated with pulmonary tuberculosis:regiment of insulin,isoniazid,rifampicin,pyrazinamide and ethambutol versus the regiment plus Qi-boosting and Yin-nourishing decoction of Traditional Chinese Medicine

OBjECTIVE:To observe the clinical effect on type 2diabetes mellitus(T2DM) complicated with pulmonary tuberculosis(TB) of insulin,isoniazid,rifampicin,pyrazinamide and ethambutol(conventional medication) administered together with Qi-boosting and Yin-nourishing decoction derived from Traditional Chinese Medicine(TCM).METHODS:A total of 60 patients with T2 DM complicated with pulmonary TB were randomly and equally divided into positive control group and treatment group.The control group was treated with Western conventional regiment(WCR):insulin,isoniazid,rifampicin,pyrazinamide,and ethambutol,whereas the treatment group was given both WCR and Qi-boosting and V/n-nourishing decoction prepared from TCM.RESULTS:After the treatment,20(66.7%) and 11(36.7%) cases showed sputum bacteria negative conversion in the WCR plus TCM group and WCM group respectively(P < 0.05).A total of 25(83.3%)and 18(60%) cases showed improvement in lung lesion in the WCR plus TCM group and WCM group respectively(P < 0.05).Compared with WCR group,fasting plasma glucose and 2-hour postprandial blood glucose levels in the WCR plus TCM group significantly decreased(P < 0.05 and P < 0.01,respectively).CONCLUSION:Qi-boosting and Yin-nourishing decoction combined with the Western medication showed better curative effect in treating T2 DM complicated with pulmonary TB compared with the group using the conventional Western Medicine alone.

中药滋阴补阳方剂治疗肾气亏虚型多囊卵巢综合征不孕症对患者超声动态多参数的影响评价

目的评价中药滋阴补阳方剂治疗肾气亏虚型多囊卵巢综合征不孕症对患者超声动态多参数的影响。方法选取2022年1月至2023年1月江西省妇幼保健院收治的80例肾气亏虚型多囊卵巢综合征患者作为研究对象,按照随机数字法将其分为观察组(40例)与对照组(40例)。对照组采用枸橼酸氯米芬片治疗,观察组在对照组方法的基础上联合中药滋阴补阳方剂治疗。比较两组患者的治疗效果、卵泡发育情况、激素水平、子宫动脉血流灌注情况及子宫内膜厚度。结果观察组的有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后的卵泡及优势卵泡数目多于对照组,差异有统计学意义(P<0.05);观察组治疗后的黄体生成素(LH)、促卵泡激素(FSH)、睾酮(T)均低于对照组,雌二醇(E2)高于对照组,差异有统计学意义(P<0.05);观察组治疗后的搏动指数(PI)、阻力指数(RI)均低于对照组,差异有统计学意义(P<0.05);观察组治疗后的子宫内膜厚度高于对照组,差异有统计学意义(P<0.05)。结论将中药滋阴补阳方剂应用于肾气亏虚型多囊卵巢综合征不孕症患者治疗中,可积极改善患者的激素水平及子宫动脉血流灌注情况,同时能够促进卵泡发育,增加子宫内膜厚度,改善症状,值得推广。

芪蛭益肾胶囊治疗早期糖尿病肾病的多中心前瞻性临床观察

目的:评价芪蛭益肾胶囊治疗糖尿病肾病(DKD)(气阴两虚型)的临床疗效与安全性。方法:采取多中心、区组随机、双盲、安慰剂对照前瞻性研究方法,选取2013年04月—2014年11月全国11所医院478例受试者。采用随机编码表法将患者分为试验组和对照组。试验组口服芪蛭益肾胶囊(1次5粒,1日3次),对照组口服芪蛭益肾胶囊模拟剂(1次5粒,1日3次),共治疗24周,以24 h尿白蛋白排泄率(UAER)作为主要观察指标,并观察24 h尿蛋白定量、肾功能、中医证候评分及不良事件发生情况。结果:治疗后两组UAER均有不同程度下降,但治疗12周、24周后试验组显著低于对照组(P<0.05,P<0.01)。试验组与对照组的UAER下降率在12周末分别为35.81%vs 20.36%(P<0.05),24周后分别为46.08%vs 27.28%(P<0.01),试验组UAER下降率优于对照组。观察结束时试验组UAER较基线下降超过50%的患者比例较对照组多(P<0.05),分别为120(46.51%)vs 30(31.58%)。治疗后试验组24 h尿蛋白定量90.00 mg显著低于对照组131.68 mg(P<0.01)。治疗24周后试验组中医证候疗效为84.5%,显著优于对照组45.26%(P<0.01)。但两组的肾小球滤过率差异无统计学意义(P>0.05),治疗期间两组不良事件发生率差异无统计学意义(P>0.05)。结论:芪蛭益肾胶囊能有效控制DKD(气阴两虚型)尿蛋白,临床使用安全。

吕晓东论治肺结节经验撷菁

总结吕晓东教授运用中医药治疗肺结节的临床经验和学术思想。吕晓东教授基于阳化气,阴成形的两个基本生理功能观,考察肺结节的发生、发展的病理环节,认为肺结节形成之机理复杂,病因纷繁,为阴分邪气积聚为肺,但病性基础变化总体以阳虚为关键,病理以气滞痰瘀胶着于肺络为核心。在肺络病的指导原则下,运用扶阳抑阴、通补肺络的手段,恢复阳主阴从,一气周流,肺络调和的生理状态,从而调复肺脏的异常功能状态、消弭肺结节的病理改变,恢复身心健康的目的,临床每获良效,具有推广应用的价值。

Effect of Chinese Drugs for Supplementing Qi,Nourishing Yin and Activating Blood Circulation on Myocardial Perfusion in Patients with Acute Myocardial Infarction after Revascularization

Objective:To observe the effects of Chinese drugs for supplementing qi,nourishing yin and activating blood circulation on the myocardial perfusion in acute myocardial infarction(AMI) patients after revascularization.Methods:Eighty patients with anterior or inferior ventricular wall AMI,who had received revascularization by intravenous thrombolysis or coronary bypass,were randomized into the treated group and the control group equally,both treated with conventional Western medical treatment,but combined,resp...

滋阴泻火中药治疗女童功能性卵巢囊肿的临床疗效分析

目的:分析滋阴泻火中药治疗女童功能性卵巢囊肿的临床疗效。方法:选择2021年1月—2022年12月收治的卵巢囊肿患儿40例,所有患儿均给予滋阴泻火中药治疗,连续治疗3个月。比较患儿治疗前、治疗3个月后发育情况(身高、体质量、骨龄、乳房发育Tanner分期)、性激素水平、子宫与卵巢容积、卵巢囊肿体积及不良反应情况。结果:治疗前后患儿身高、体质量、骨龄比较,差异无统计学意义(P>0.05);治疗后患儿乳房发育Tanner分期较治疗前改善显著,差异有统计学意义(P<0.05);治疗后患儿黄体生成素(LH)、促卵泡激素(FSH)、雌二醇(E2)水平较治疗前均降低,差异有统计学意义(P<0.05);治疗后患儿子宫大小、卵巢容积、卵巢囊肿体积较治疗前降低,差异有统计学意义(P<0.05);患儿治疗期间未见严重不良反应。结论:滋阴泻火中药治疗女童功能性卵巢囊肿效果较佳,可调节患儿E2水平,抑制外周性性早熟,利于卵巢囊肿缩小。

单味中药有效成分治疗溃疡性结肠炎研究进展

研究表明,中药治疗溃疡性结肠炎不良反应少且复发率低,临床常用益气健脾、清热祛湿、活血化瘀、补血养阴类中药组方治疗,其主要药物的有效成分具有减轻炎症反应、修复黏膜损伤、调节肠道微生态、调节免疫反应等作用。本文对常用单味中药有效成分治疗溃疡性结肠炎的作用机制进行综述,为其临床治疗与中药新药研发提供参考。

国医大师王晞星基于阴火理论辨治癌性发热经验

癌性发热是恶性肿瘤在发病过程中出现的与肿瘤直接相关或因肿瘤治疗而引起的非感染性发热。国医大师王晞星教授从“阴火理论”出发,认为脾胃气虚、阴火上冲为癌性发热之关键病机,病变脏腑涉及肝、脾、肾三脏,当以甘温益气、健脾升阳、清泻阴火为首要治则;同时应重视“土木关系”,通过养血解郁、疏肝散火之法以调和肝脾;并通过滋阴清热、引火归元之法阻断阴火的传变。王晞星教授根据多年临床经验,在补中益气汤基础上化裁创制补中调肝汤(药物组成包括黄芪、党参、白术、升麻、柴胡、当归、白芍、麦冬、五味子、陈皮、蜈蚣、石见穿、八月札、炙甘草等),通过益中气、补肝血、调肝气、消癥散结,以调和人体寒热阴阳,可有效改善肿瘤患者癌性发热症状。

从“药类法象”角度解读气机的升降浮沉

“药类法象”之理由张元素首次提出,是根据每种药物气味各异而升降、功用不同,法象于自然,将药物分为五大类,即风升生、热浮长、湿化成、燥降收、寒沉藏。而人与天地相参,人药相关,人体及药物皆依赖于自然界而存在,是以人体脏腑气机升降及药性升降应遵循自然规律,即顺应“神机气立”而得以正常运行。因此“药类法象”是药性升降浮沉的理论基础,可应人体脏腑气机升降,促进对脏腑生理病理的认识,引出对临证用药的启发,为理解气机升降理论提供思路。

缺铁性贫血孕妇的中医体质分布及影响因素研究

【目的】分析缺铁性贫血(iron deficiency anemia,IDA)孕妇的中医体质分布规律及相关影响因素,为中医药防治妊娠期IDA提供指导方案。【方法】纳入109例符合条件的妊娠期IDA患者,收集孕妇的一般资料、中医体质鉴别结果和相关实验室指标,包括血清铁蛋白(Fer)、血红蛋白(Hb)及平均红细胞体积(MCV)。对IDA孕妇的中医体质分布规律及相关影响因素、妊娠结局进行统计分析。【结果】(1)109例IDA孕妇中医体质以偏颇质为主,有60例(55.05%),各体质分布人数和比例从高到低依次为:平和质49例(44.95%)>湿热质13例(11.93%)>阳虚质12例(11.01%)>阴虚质11例(10.09%)>气虚质10例(9.17%)>气郁质9例(8.26%)>血瘀质3例(2.75%)>痰湿质2例(1.83%)。(2)不同体质类型IDA孕妇的Hb和MCV水平比较,差异均无统计学意义(P>0.05),但湿热质IDA孕妇的Fer水平显著高于平和质(P<0.01),湿热质IDA孕妇发生羊水混浊的概率显著高于平和质及其他偏颇体质(P<0.05)。【结论】湿热质是IDA孕妇最常见的偏颇体质,其次是阳虚质、阴虚质和气虚质,湿热质可能是IDA孕妇的易感体质,此体质类型IDA孕妇的Fer水平显著高于平和质,而其发生羊水混浊的概率显著高于平和质及其他偏颇体质。

基于数据挖掘探讨中药治疗妊娠恶阻的用药规律

目的:借助于中医传承辅助平台系统(V2.5)与数据挖掘技术,探讨现代临床研究文献中,中药治疗妊娠恶阻的用药规律,为临床实践诊疗提供理论依据。方法:检索中文数据库中临床研究文献,提取文献数据,建立数据库,通过中医传承辅助平台系统(V2.5)对用药进行频次统计、关联规则分析、聚类分析等。结果:本研究共纳入文献121篇,纳入处方139首,涉及中药99味;平均使用频次为12.22次,使用频次≥13次的中药有22味,前5味中药分别是半夏、陈皮、甘草、竹茹、白术;使用中药四气顺序为:温性、寒性、平性、凉性、热性;五味顺序为:甘、辛、苦、酸、涩、咸;归经顺序为:脾经、胃经、肺经、心经、肾经、肝经、大肠经、胆经、小肠经和三焦经。通过关联规则对组方规律进行分析,得出常见药对及药物组合,其中核心药物组合为“半夏,陈皮,甘草”;通过复杂系统熵层次聚类分析得出潜在核心药物组合16个(8组),在此基础上进行无监督的熵层次聚类分析得出潜在新方组合8个。结论:治疗妊娠恶阻的高频中药多以补虚、化痰、理气、化湿药为主,且多具有止呕、保护胃黏膜、调节肠道菌群、调节胃肠道功能等作用;核心药物组合及潜在新方多以健脾益气、清热泻火、化痰行滞、养阴生津安胎为主。

基于滋阴相关理论探讨甲状腺功能亢进症

甲状腺功能亢进症(简称甲亢)是临床常见的内分泌代谢疾病,其主要特征为甲状腺激素过多引起的一系列临床症状,如汗多、烦躁、手颤和消瘦快等。尽管西药治疗在控制甲亢方面取得了一定成效,但其常见的不良反应和高复发率限制了其长期应用。与此相比,中医药治疗甲亢的独特优势逐渐受到重视。文章以古代文献和现代研究为理论基础,从滋阴出发,核心思想为“阴常不足,阳常有余”,重在探讨滋补肝肾阴的治疗策略在甲亢中的应用。肝肾同源理论认为肝阴为血,肾阴为精,二者相互滋养,共同维持阴阳平衡和气血循环。肝肾阴虚会导致甲亢的发展和症状的加重。因此,在甲亢的防治中注重滋养肝肾之阴具有重要意义。研究显示,应用具有滋养肝肾阴之功效的中药,如加味二至方、六味地黄丸等,能够有效改善甲状腺功能、减轻症状,降低血清甲状腺相关指标和甲状腺内血管形成。这些药物通过打破肝肾阴虚状态使机体达到阴阳平衡,从而更有效地控制甲亢的进展。综上所述,滋补肝肾阴类中药在甲亢治疗中具有潜在优势。但目前其相关机制研究还不够明确,仍需更多的实验研究及临床多中心、随机对照、大样本研究作为理论支撑,将有助于临床实践中更好地应用中医药治疗甲亢。

基于数据挖掘探讨益气养阴类中成药治疗糖尿病用药规律

目的:采用数据挖掘方法探讨益气养阴类中成药治疗糖尿病用药规律。方法:筛选2020年版《国家医保目录》、2020年版《中华人民共和国药典》、2018年版《国家基本药物目录》以及相关糖尿病防治指南中治疗糖尿病的益气养阴类中成药,利用古今医案云平台对中成药的使用频次、性味归经、关联规则、聚类和复杂网络进行分析。结果:共纳入38个益气养阴类中成药,涉及92味中药。治疗糖尿病的高频药物有黄芪、地黄、五味子、天花粉等,性味以甘、(微)寒为主,主入肺、肾经。益气养阴类中成药治疗糖尿病的常用药物组合有地黄-麦冬、麦冬-五味子、葛根-黄芪等;聚类分析得到枸杞子-五倍子-人参-知母-丹参-天花粉-黄芪-地黄-葛根-五味子-麦冬、牡丹皮-女贞子-山药-山茱萸-茯苓-泽泻、玉竹-牛膝-石膏-玄参-党参、黄连-苍术-黄精-荔枝核、水蛭-太子参、甘草-红参等6首新处方;复杂网络分析得到黄芪-地黄-五味子核心中药组合。结论:益气养阴类中成药治疗糖尿病的核心药物为黄芪、地黄、五味子,其用药以益气养阴药为主,常兼清热、活血以治疗糖尿病肾病及糖尿病视网膜病变等多种并发症,临床常选择消渴方、津立达、渴络欣等中成药对症治疗。

亚健康失眠的中医辨证分型及临床用药思路

失眠是亚健康状态的主要表现之一。在病因病机上可归于劳逸失度、阴血亏耗,情志不舒、肝郁化火,饮食偏嗜、痰湿内生3方面。在中医证型上可分为心神失养证、火扰心神证、气郁痰阻证3型。针对亚健康失眠的中医保健,应以辨证保健为主结合对症保健。辨证保健上以利尿导热、滋阴降火法清心安神缩短入睡时间,以补虚敛神、益精养血法养心安神维持睡眠深度,以理气化痰、利胆和胃法疏泄通滞调节寐寤表现;对症保健上以重镇与甘缓类药物改善烦躁不宁、心神不安的表现,以导阳入阴药物改善节律紊乱症状,实现辨证、对症相结合。

中医药益气温阳、活血利水法治疗慢性心力衰竭作用机制的研究进展

综述中医药益气温阳、活血利水法治疗慢性心力衰竭作用机制的研究进展。慢性心力衰竭可依据阳气虚弱、心血瘀阻、水饮内停的病机,采用中医药益气温阳、活血利水法治疗。研究显示,该法治疗慢性心力衰竭的临床疗效显著,其机制主要与改善心肌纤维化及心室重构、调节氧化应激反应、改善血流动力学障碍与心肌能量代谢、干预相关信号通路、缓解利尿剂抵抗等有关。