期刊文献+
共找到4篇文章
< 1 >
每页显示 20 50 100
Structural and Theoretical Studies of a New Cu^I-Cu^I Complex Bearing Bulky Unsymmetrical Benzamidinate Ligand
1
作者 PAN Chengling TANG Guodong +2 位作者 CAO Zhi XU Jiqing SHENG Shaoding 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2015年第1期112-116,共5页
Density functional theory(DFT) calculations unambiguously verify that there is little or no direct metalmetal bonding in the dinuclear copper(I) benzamidinate complex [Cu2(LRW)2](2){LRR=[PhC(NR)(NR')]-(R... Density functional theory(DFT) calculations unambiguously verify that there is little or no direct metalmetal bonding in the dinuclear copper(I) benzamidinate complex [Cu2(LRW)2](2){LRR=[PhC(NR)(NR')]-(R= 2,6-iPr2C6H3, R'=SiMe3)} with a short Cu-Cu distance[0.24454(4) nm]. 展开更多
关键词 Copper(I) complex Cu-Cu interaction benzamidinate N-LIGAND Density functional theory
原文传递
抑制剂Benzamidine与胰岛素作用机制的分子动力学和结合自由能计算研究 被引量:2
2
作者 王青 梁志强 +3 位作者 王伟 伊长虹 李洪云 赵娟 《原子与分子物理学报》 CAS CSCD 北大核心 2016年第5期951-956,共6页
氢键和极性相互作用在抑制剂-蛋白结合专一性识别过程中起到重要作用.抑制剂Benzamidine(BEN)与胰岛素trypsin相互作用机制的阐明有助于胰岛素高效抑制剂的研发.本文采用分子动力学模拟和MM-PBSA(molecular mechanics-Poisson Boltzmann... 氢键和极性相互作用在抑制剂-蛋白结合专一性识别过程中起到重要作用.抑制剂Benzamidine(BEN)与胰岛素trypsin相互作用机制的阐明有助于胰岛素高效抑制剂的研发.本文采用分子动力学模拟和MM-PBSA(molecular mechanics-Poisson Boltzmann surface area)从原子层次上研究BEN与胰岛素的结合模式.结果表明抑制剂BEN的脒基不仅与Asp189的羰基产生静电相互作用,而且与残基Ser190和Gly214形成氢键相互作用.基于残基能量分解的计算表明抑制剂的苯基与残基His58,Cys191,Gln192,Trp211,Gly212和Cys215形成有利于抑制剂结合的疏水性相互作用.期望当前的研究能为胰岛素有效抑制剂的研发提供重要的理论指导. 展开更多
关键词 胰岛素trypsin 分子动力学 结合自由能 抑制剂Benzamidine.
下载PDF
Separation and Purification of Thrombin-like Enzymes by Affinity Adsorbents 被引量:2
3
作者 杨青 Xu Xiaoming +4 位作者 Hu Xuejun Gao Xiaorong Dong Xinyan Su Zhiguo An Lijia 《High Technology Letters》 EI CAS 2001年第4期13-15,共3页
An affinity adsorbent, benzamidine Sepharose 4B, was used to separate and purify thrombin like enzymes. The p aminobenzamidine as a specific ligand was coupled to the matrix-Sepharose 4B. The recombinant thrombin like... An affinity adsorbent, benzamidine Sepharose 4B, was used to separate and purify thrombin like enzymes. The p aminobenzamidine as a specific ligand was coupled to the matrix-Sepharose 4B. The recombinant thrombin like enzyme-defibrase was used as a model in order to evaluate the efficiency of this biospecific affinity adsorbent. The homogeneity of the enzyme preparation was comfirmed as one band on sodium dodecyl sulfate polyacrylamide gel electrophoresis. 展开更多
关键词 Affinity chromatography LIGAND Benzamidine PURIFICATION Thrombin like enzyme
下载PDF
A Transition-Metal-Free Synthesis of Multisubstituted Imidazoles
4
作者 Ping Wu Lutao Zhang +2 位作者 Xueguo Zhang Xin Guo Baohua Chen 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2016年第4期363-367,共5页
A novel and simple t-BuOLi/I2-mediated synthesis of 1,2,4-trisubstituted imidazoles was developed without transition-metal added. The transition-metal-free strategy tolerated a range of sdbstrates and provided product... A novel and simple t-BuOLi/I2-mediated synthesis of 1,2,4-trisubstituted imidazoles was developed without transition-metal added. The transition-metal-free strategy tolerated a range of sdbstrates and provided products in moderate to good yields with 100% regioselectivity. 展开更多
关键词 multisubstituted imidazoles CYCLIZATION benzamidine N-tosyl-hydrazone HETEROCYCLES
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部