Z and E configuration 4-aryl-but-2-en-1-ols were isolated from several terrestrial plants, and （Z）-4-aryl-but-2- en-l-ols were found to have choleretic activity. Strategies have been reported to synthesize （E）-4-a...Z and E configuration 4-aryl-but-2-en-1-ols were isolated from several terrestrial plants, and （Z）-4-aryl-but-2- en-l-ols were found to have choleretic activity. Strategies have been reported to synthesize （E）-4-aryl-but-2-en-l- ols with high selectivity. However, there is no method to obtain （Z）-4-aryl-but-2-en-1-ols with high selectivity now. We developed a Suzuki-Miyaura cross-coupling reaction of 1,2-oxaborol-2（5H）-ols with benzyl bromides to synthesize （Z）-4-aryl-but-2-en-1-ols, the products were obtained in up to 94% isolated yield.展开更多
基金support from National Natural Science Foundation of China （Nos. 20802088, 91017006, 90917017） and the Fundamental Research Funds for the Central Universities.
文摘Z and E configuration 4-aryl-but-2-en-1-ols were isolated from several terrestrial plants, and （Z）-4-aryl-but-2- en-l-ols were found to have choleretic activity. Strategies have been reported to synthesize （E）-4-aryl-but-2-en-l- ols with high selectivity. However, there is no method to obtain （Z）-4-aryl-but-2-en-1-ols with high selectivity now. We developed a Suzuki-Miyaura cross-coupling reaction of 1,2-oxaborol-2（5H）-ols with benzyl bromides to synthesize （Z）-4-aryl-but-2-en-1-ols, the products were obtained in up to 94% isolated yield.
