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The Berlin Patient
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作者 Maya Reid 《ChinAfrica》 2011年第2期55-55,共1页
LAST December,the science journal Blood published a paper claiming a cure for HIV had been found.While the announcement breathes new life into the AIDS research community,it’s not without caveats. The paper’s author... LAST December,the science journal Blood published a paper claiming a cure for HIV had been found.While the announcement breathes new life into the AIDS research community,it’s not without caveats. The paper’s authors’ evidence came in the form of a 44-year-old man referred to as "The Berlin Patient." An American living in Germany,the man,whose real name is Timothy Ray Brown, was diagnosed with HIV around age 30.He spent a decade following a traditional drug regimen for the disease with success; he was healthy and had a high T-cell count.Then,in 2006, Brown was diagnosed with acute leukemia.His doctor,Gero H(u|¨)tter,decided to use the cancer as an opportunity to also rid Brown of his HIV. 展开更多
关键词 HIV The berlin patient
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基因治疗的双重考察
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作者 丁敏 虞法 《中国医学伦理学》 北大核心 2024年第2期138-144,共7页
从生物学上看,基因是人之为人的关键。随着人类对基因技术的不断推进,基因治疗成为当前生命科学领域极富活力也面临巨大争议的前沿话题:在给人类带来更多疾病治愈希望的同时,它也引发了诸多伦理争论。整理了基因治疗所面临的伦理质疑,... 从生物学上看,基因是人之为人的关键。随着人类对基因技术的不断推进,基因治疗成为当前生命科学领域极富活力也面临巨大争议的前沿话题:在给人类带来更多疾病治愈希望的同时,它也引发了诸多伦理争论。整理了基因治疗所面临的伦理质疑,从中提炼出个人权利、社会公平、自然秩序等多个方面所受到的挑战,并一一进行回应,由此说明基因治疗的开展在原则上并不违背这些伦理价值。然而,基因编辑事件的发生,为我们敲响警钟:基因治疗的实施边界究竟应在何处?通过对基因编辑事件与“柏林病人”案件的对比分析指出:技术安全层面的考察才是基因治疗安全应用于临床应用的关键所在。 展开更多
关键词 基因治疗 伦理审查 技术安全 “柏林病人”案
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HIV感染真的被“治愈”了吗? 被引量:3
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作者 秦岭 李太生 《协和医学杂志》 CSCD 2019年第3期197-200,共4页
人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染靶细胞需要识别细胞表面CD4分子及其辅助受体,C-C趋化因子受体5 (C-C chemokine receptor type 5,CCR5)和C-X-C趋化因子受体4 (C-X-C-motif receptor 4,CXCR4)是HIV识别靶细胞... 人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染靶细胞需要识别细胞表面CD4分子及其辅助受体,C-C趋化因子受体5 (C-C chemokine receptor type 5,CCR5)和C-X-C趋化因子受体4 (C-X-C-motif receptor 4,CXCR4)是HIV识别靶细胞的两种重要辅助受体。CCR5Δ32基因突变使得HIV无法识别CCR5受体,从而阻止嗜CCR5的HIV病毒株入侵靶细胞。"柏林病人"和"伦敦病人"正是利用这一原理,通过移植携带纯合子CCR5Δ32突变基因的异基因骨髓,实现了停用抗病毒药物后病毒无反弹的目标,故而被誉为HIV感染"治愈"案例。然而,这一成功是否存在偶然性?事实上,人群中携带CCR5Δ32纯合子基因突变概率极低、异基因骨髓配型十分困难、骨髓移植医疗费用昂贵、移植后HIV病毒株嗜性迁移等客观因素的存在,使得通过携带纯合子CCR5Δ32基因突变异基因骨髓移植法实现HIV感染者停用抗病毒药物且保持病毒不反弹的目标困难重重。因此,"柏林病人"和"伦敦病人"的成功经验为治疗HIV感染提供了新的方向和希望,但如认为HIV感染已被"治愈"为时尚早,需进一步研究证实。 展开更多
关键词 人类免疫缺陷病毒 柏林病人 伦敦病人 CCR5Δ32突变
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Identification of surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverse respiratory events in post anesthesia care unit 被引量:1
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作者 Fei Liu Li Liu +3 位作者 Fang Zheng Xiangdong Tang Yongxin Bao Yunxia Zuo 《Frontiers of Medicine》 SCIE CAS CSCD 2018年第2期189-195,共7页
Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to... Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post anesthesia care unit (PACU). Results indicated that only 11.4% of the patients were considered at a high risk of OSAS. Age and body mass index are the key factors for the risk of OSAS prevalence in China and also gender specific. Furthermore, the incidence of adverse respiratory events in the PACU was higher in patients with high risk of OSAS than others (6.8% vs. 0.9%, P 〈 0.001). They also stayed longer than others in the PACU (95 ~ 28 min vs. 62 ~ 19 min, P 〈 0.001). Age, high risk for OSAS, and smoking were independent risk factors for the occurrence of adverse respiratory events in the PACU. The BQ may be adopted as a screening tool for anesthesiologists in China to identify patients who are at high risk of OSAS and determine the potential risk of developing postoperative respiratory complications in the PACU. 展开更多
关键词 obstructive sleep apnea berlin Questionnaire Chinese surgical patients adverse respiratory event
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