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Improved super-elastic Ti-Ni alloy wire for the angle class III patient with anterior open bite:A case report
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作者 Yu Fan Jian-Hong Yu Yuan-Hou Chen 《World Journal of Clinical Cases》 2025年第15期32-41,共10页
BACKGROUND Orthodontic treatment for open bite and crossbite cases is always challenging.In this paper,we demonstrate a skeletal class III patient with anterior open bite and crossbite whose problem was successfully c... BACKGROUND Orthodontic treatment for open bite and crossbite cases is always challenging.In this paper,we demonstrate a skeletal class III patient with anterior open bite and crossbite whose problem was successfully corrected with improved super-elastic Ti-Ni alloy wire(ISW).CASE SUMMARY A 19 years old male came to our clinic with a chief complaint of anterior open bite and crossbite and not able to chew food well.Clinical examination revealed an angle class III malocclusion with anterior open bite,crossbite and spaced arch.Ra-diographic and clinical examination showed a skeletal class III pattern.We used ISW to level the upper and lower arch and to correct the anterior open bite and crossbite.Intermaxillary elastics were also used to achieve a better interdigitation.Finally,adequate overbite,overjet and a desirable occlusion were achieved.The active treatment time took 2 years and 2 months.CONCLUSION In a case of class III angular malocclusion with open bite and crossbite in the ante-rior teeth,ideal results were achieved using the ISW technique and the patient was satisfied with the outcome. 展开更多
关键词 Dentistry Orthodontics Angle class III malocclusion Anterior open bite Anterior open bite Improved super-elastic Ti-Ni alloy wire Case report
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Application progresses of ultrasound for snakebites and relative complications
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作者 ZHENG Yiyin SHEN Yanyan BIN Wenkai 《中国医学影像技术》 CSCD 北大核心 2024年第8期1258-1261,共4页
Snakebite has become a serious public health problem with high mortality and disability rates.Ultrasound can provide imaging basis for diagnosis and treatment of snakebites and relative complications.The application p... Snakebite has become a serious public health problem with high mortality and disability rates.Ultrasound can provide imaging basis for diagnosis and treatment of snakebites and relative complications.The application progresses of ultrasound in snakebites and complications were reviewed in this article. 展开更多
关键词 snake bites ULTRASONOGRAPHY DIAGNOSIS
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A 10-year review and epidemiology of animal bite cases in Gerash city, south of Iran: A retrospective cross-sectional study
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作者 Mohammad-Rafi Bazrafshan Esmaeil Kavi +3 位作者 Negar Shahkarami Mohammad Nowrouzi Fereidoun Jahangir Hajar Haghshenas 《Journal of Acute Disease》 2024年第1期20-25,共6页
Objective:To determine the temporal trend and epidemiology of animal bite cases in Gerash City,Iran.Methods:This retrospective cross-sectional study analyzed 630 cases of people with animal bites between 2011 and 2021... Objective:To determine the temporal trend and epidemiology of animal bite cases in Gerash City,Iran.Methods:This retrospective cross-sectional study analyzed 630 cases of people with animal bites between 2011 and 2021 in Gerash City.The collected data were analyzed using Chi-square test.Results:The mean age of victims was(30.9±17.5)years.80.54%Of victims were male,39.70%were self-employed,and 64.60%were adults(≥18 years).Most cases of bites occurred in 2019(91 cases),2020(74 cases)and 2021(87 cases),and most of the bites were related to the upper limbs(62.70%).Most of the wounds were superficial(78%),most of the biting animals were domestic animals(91.74%),and most of the victims had Iranian nationality(97.62%).Conclusions:Given the increasing trend of animal bites in Gerash City,health authorities should carry out basic measures such as education and awareness among the public,especially at-risk groups such as adult males.Additionally,since most cases of bites are due to dogs,it seems necessary to plan for vaccination of dogs,especially those with owners. 展开更多
关键词 Animal bite Gerash Time trend Disease EPIDEMIOLOGY RABIES
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Spatial analysis of animal bites in Iran(2015-2020):A cross-sectional study
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作者 Hoda Amiri Khadijeh Yazdanparast +1 位作者 Mohsen Pourkhosravani Maryam Rastegar 《Journal of Acute Disease》 2024年第2期67-73,共7页
Objective:To investigate the distribution pattern of animal bites in Mirjaveh,Iran from 2015 to 2020.Methods:The data on animal bites were collected from the Department of Infectious Diseases,the provincial health cen... Objective:To investigate the distribution pattern of animal bites in Mirjaveh,Iran from 2015 to 2020.Methods:The data on animal bites were collected from the Department of Infectious Diseases,the provincial health center.Monthly climatic data on precipitation and temperature during the study period were also collected.The correlation between incidence and temperature,precipitation rate,land type,and altitude was also analyzed.Results:The results showed that men were more affected by animal bites than women(76.4%,P<0.001),and the highest incidence rate occurred in the age group of 5-19 years.The incidence rate of animal bites was found to be correlated with temperature and altitude.An increase in temperature was associated with a rise in the incidence rate of animal bites.The number of animal bites increased until 2019,possibly due to an increase in the number of dogs in the area.Conclusions:Targeted interventions should be implemented to reduce the incidence of animal bites,particularly among children,housewives,and students.Improving access to appropriate treatments,increasing public awareness of the hazards of animal bites,and increasing the number of vaccinated dogs in the area are essential strategies to be considered. 展开更多
关键词 Animal bites EPIDEMIOLOGY Zoonotic disease Iran
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Classification and a decade-long follow-up of rat bite injuries in the nasal region
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作者 Chu-Hsin Chen Yahong Chen +1 位作者 Peng Xu Kai Liu 《Chinese Journal of Plastic and Reconstructive Surgery》 2024年第1期28-33,共6页
Background:Nasal defects due to rat bites are frequently encountered in rural regions of China.In addition to serving as disease vectors,rats can also inflict bite injuries.In this study,we delineated the characterist... Background:Nasal defects due to rat bites are frequently encountered in rural regions of China.In addition to serving as disease vectors,rats can also inflict bite injuries.In this study,we delineated the characteristics of rat bite injuries in the nasal region and discussed the clinical features observed during a 10-year follow-up period.Methods:We retrospectively reviewed hospital records for patients admitted due to rat bites.This study outlines the demographics,clinical features,and follow-up outcomes supported by comprehensive photo documentation of the patients’progress.Results:Twenty-five patients,with a mean age of 29 years,were admitted due to rat bites.Treatment was provided for three distinct types of injuries:nasal tip defect(type Ⅰ),nasal defect(type Ⅱ),and full-thickness nasal defect with loss of surrounding tissues(type Ⅲ).All patients recovered fully.Conclusions:The treatment for rat bites should be based on the wound type.The long-term follow-up outcomes are more favorable when fewer subunits of the nose affected.We recommend early surgical intervention,along with psychological therapy,to prevent interference with growth and development. 展开更多
关键词 Rat bite Wound classification Nasal reconstruction
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Osteoarticular Lesions of the Shoulder Girdle by Hippopotamus Bite: Highly Septic Lesion
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作者 Jr Pierre Germain Ochou Achié Jean Régis Akobe +11 位作者 Yao Aboh Ganyn Robert Arnaud Assere Kouamé Jean-Eric Kouassi Adelaïde Aya Natacha Kouassi Ibrahim Soumahoro Zolopégué Marcel Soro Sédi Loues De Randolphe Akpro Gbalé Yannick Blé Kouamé Innocent M’bra Loukou Blaise Yao Bada Juste Léopold NiaoréSery Koffi Léopold Krah Michel Kodo 《Open Journal of Orthopedics》 2024年第2期114-121,共8页
Hippopotamus bites are rare in medical consultations, despite several studies exposing their aggressive character. A case of a hippopotamus bite on the shoulder of a fisherman has been reported. In addition to the ost... Hippopotamus bites are rare in medical consultations, despite several studies exposing their aggressive character. A case of a hippopotamus bite on the shoulder of a fisherman has been reported. In addition to the osteoarticular aspect representing a therapeutic problem, the infectious aspect was marked by sepsis, with a death in less than 48 hours. Based on this observation, a protocol for the initial management of large animal bites was submitted. 展开更多
关键词 bite HIPPOPOTAMUS Septic Shock
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新型双特异性单链抗体BiTEs及其在肿瘤治疗中的应用前景 被引量:2
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作者 于蕊 陈昭烈 《中国生物工程杂志》 CAS CSCD 2004年第4期1-6,共6页
BiTEs(bispecificTcellengagers)是一种以T细胞作为效应细胞的双特异性单链抗体 ,它具有两个抗原结合臂 ,可以同时和T细胞及靶细胞结合 ,并激活细胞毒性T细胞杀伤病变细胞。和其它双特异性抗体相比 ,BiTEs的分子柔韧性更好 ,能更好地促... BiTEs(bispecificTcellengagers)是一种以T细胞作为效应细胞的双特异性单链抗体 ,它具有两个抗原结合臂 ,可以同时和T细胞及靶细胞结合 ,并激活细胞毒性T细胞杀伤病变细胞。和其它双特异性抗体相比 ,BiTEs的分子柔韧性更好 ,能更好地促进CD3复合体和肿瘤靶标的连接 ,并且它不受T细胞受体和靶细胞上MHCⅠ类分子的约束 ,不需要共刺激分子的参与 ,是一种极具应用潜力的抗体形式。就BiTEs的结构、作用机理及其在肿瘤临床上的应用前景几个方面做一综述。 展开更多
关键词 biteS 双特异性单链抗体 细胞毒性T细胞 肿瘤 临床治疗
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基于MSFG的机载BITE故障定位算法研究 被引量:1
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作者 刘家学 杨梦娜 耿宏 《科学技术与工程》 北大核心 2016年第8期132-136,170,共6页
故障定位是机载BITE的重要功能,定位结果的准确性对维修测试有着重要影响。基于多信号流图模型,在构造故障-测试关联矩阵和故障-故障关联矩阵的基础上,引入故障信息矢量和故障定位矩阵,并给出适用于机载BITE故障定位的矢量描述和矩阵定... 故障定位是机载BITE的重要功能,定位结果的准确性对维修测试有着重要影响。基于多信号流图模型,在构造故障-测试关联矩阵和故障-故障关联矩阵的基础上,引入故障信息矢量和故障定位矩阵,并给出适用于机载BITE故障定位的矢量描述和矩阵定义,进而提出一种简单、有效的故障定位算法。实例验证表明,该算法能够对系统中的故障源进行准确定位。 展开更多
关键词 故障定位 多信号流图模型 机载bite系统 故障定位矩阵
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微环DNA表达抗EpCAM/抗CD3双特异BiTE分子的抗卵巢癌细胞体外实验研究 被引量:1
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作者 陈远群 谌平 +1 位作者 陈国创 韦枝红 《中国医药导报》 CAS 2019年第30期12-16,共5页
目的探讨抗EpCAM/抗CD3 BsAb分子蛋白对体外卵巢癌细胞生长的抑制效果。方法采用非病毒载体微环DNA表达抗EpCAM/抗CD3 BsAb分子蛋白。观察不同浓度(1×10^-3、1×10^-4、1×10^-5、1×10^-6、1×10^-7、1×10^-... 目的探讨抗EpCAM/抗CD3 BsAb分子蛋白对体外卵巢癌细胞生长的抑制效果。方法采用非病毒载体微环DNA表达抗EpCAM/抗CD3 BsAb分子蛋白。观察不同浓度(1×10^-3、1×10^-4、1×10^-5、1×10^-6、1×10^-7、1×10^-8μg/mL)抗EpCAM/抗CD3 BsAb分子蛋白加至卵巢癌细胞及T细胞中,经6 h和12 h培育后,利用倒置荧光显微镜观察活细胞与死亡细胞数量及形态变化。结果倒置显微镜下可见加抗体后卵巢癌细胞与T细胞明显聚集成块,周围见大量死亡细胞。相同时间下,随着浓度的增加,T细胞介导的卵巢癌肿瘤细胞的杀伤效果并不会一直增强。当浓度达到1×10^-4μg/mL时,培育6 h和12 h时的杀伤均达到最大,差异均有统计学意义(P<0.05)。结论新型的微环DNA表达系统所表达的抗EpCAM/抗CD3 BsAb对体外卵巢癌细胞生长具有抑制作用,未来可作为一种有效的抗卵巢癌肿瘤的靶向治疗药物。 展开更多
关键词 EPCAM CD3 双特异bite分子蛋白 卵巢癌 靶向治疗
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Bite turbo配合早期牵引治疗前牙反牙合的疗效分析
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作者 薛楠 赵阳 +1 位作者 戚琳 张扬 《口腔医学》 CAS 2016年第7期624-627,共4页
目的分析Bite turbo配合早期Ⅲ类牵引治疗前牙反牙合的临床效果。方法 16例恒牙期前牙反牙合且反覆牙合深的病例,下前牙舌侧粘接Bite turbo,并同时进行早期Ⅲ类牵引,观察其疗程及疗效。结果 16例病例均快速打开咬合并解除前牙反牙合。... 目的分析Bite turbo配合早期Ⅲ类牵引治疗前牙反牙合的临床效果。方法 16例恒牙期前牙反牙合且反覆牙合深的病例,下前牙舌侧粘接Bite turbo,并同时进行早期Ⅲ类牵引,观察其疗程及疗效。结果 16例病例均快速打开咬合并解除前牙反牙合。咬合打开后SNB减小、ANB增大,下颌平面角、下面高、下面高/全面高增大,上下磨牙均伸长、下切牙被压低,反覆盖解除,覆牙合减小。结论 Bite turbo配合早期Ⅲ类牵引可以快速打开咬合,解除前牙反牙合。 展开更多
关键词 bite TURBO 前牙反牙合 早期牵引
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对空情报雷达BITE定量指标的确定方法研究 被引量:1
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作者 刘辉 王红 《电子对抗》 2008年第2期38-41,共4页
机内测试(BIT)是现代对空情报雷达设计中的一项非常重要的功能。文章在对BITE主要定量指标建立数学模型的基础上,分析了BITE定量指标确定的流程图以及具体的确定方法,详尽地阐述了定量指标验证试验的截尾序贯试验方法,并用具体的... 机内测试(BIT)是现代对空情报雷达设计中的一项非常重要的功能。文章在对BITE主要定量指标建立数学模型的基础上,分析了BITE定量指标确定的流程图以及具体的确定方法,详尽地阐述了定量指标验证试验的截尾序贯试验方法,并用具体的实例进行了分析。 展开更多
关键词 bite 故障检测率 故障隔离率 虚警率
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双特异性单链抗体BiTE在肿瘤靶向治疗中的研究进展
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作者 董琼娜 蒋华 李宗海 《中国科技论文》 CAS 北大核心 2012年第12期963-966,共4页
BiTE(bispecificTcellengager)是一种以T细胞作为效应细胞的双特异性单链抗体,它具有2个抗原结合部位,可以同时结合T细胞及病变细胞表面的抗原分子,从而有效地激活静止的T细胞,达到杀伤病变细胞的目的。其分子量小,易穿透肿瘤组织,缺乏F... BiTE(bispecificTcellengager)是一种以T细胞作为效应细胞的双特异性单链抗体,它具有2个抗原结合部位,可以同时结合T细胞及病变细胞表面的抗原分子,从而有效地激活静止的T细胞,达到杀伤病变细胞的目的。其分子量小,易穿透肿瘤组织,缺乏Fc段,免疫源性低,是一种极具发展潜力的新型抗体形式。对BiTE的发展历程、结构和作用机制以及在肿瘤靶向治疗中的应用做简要综述。 展开更多
关键词 双特异性抗体 bite 定向杀伤 肿瘤靶向治疗
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共表达BiTE的溶瘤病毒对胶质瘤的抗肿瘤活性研究
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作者 许琼冠 欧阳一彬 谢镇明 《现代肿瘤医学》 CAS 北大核心 2022年第8期1354-1359,共6页
目的:探索编码BiTE的溶瘤病毒[分泌双特异性T细胞衔接器的单纯性孢疹病毒(herpes simplex virus-Bi-specific T-cell engagers,HSV-BiTE)]是否可以对胶质瘤产生显著的抗肿瘤活性。方法:荧光显微镜观察及Western blot检测HSV-BiTE对胶质... 目的:探索编码BiTE的溶瘤病毒[分泌双特异性T细胞衔接器的单纯性孢疹病毒(herpes simplex virus-Bi-specific T-cell engagers,HSV-BiTE)]是否可以对胶质瘤产生显著的抗肿瘤活性。方法:荧光显微镜观察及Western blot检测HSV-BiTE对胶质瘤细胞U118的感染能力及BiTE的表达情况;流式细胞术检测HSV-BiTE感染后U118的凋亡情况;小鼠移植瘤模型验证HSV-BiTE的体内抑瘤活性;免疫组化法检测肿瘤组织中Ki67和Cleaved Caspase3(Cl-Cas3)的表达;流式细胞术检测肿瘤浸润T细胞中IFN-γ和Granzyme B的表达情况。结果:HSV-BiTE可以有效感染U118细胞并表达BiTE;感染HSV-BiTE可以显著诱导U118细胞凋亡(P<0.001);HSV-BiTE较HSV而言可以有效抑制小鼠体内的肿瘤生长(P<0.001);HSV-BiTE治疗的小鼠较HSV治疗组可以降低肿瘤中Ki67的表达(P<0.01),同时增加Cl-Cas3的表达(P<0.01);HSV-BiTE治疗的小鼠较HSV治疗组可以显著提升肿瘤浸润T细胞中IFN-γ(P<0.001)和Granzyme B(P<0.0001)的表达水平。结论:HSV-BiTE在小鼠皮下移植瘤模型中显著抑制肿瘤生长,同时诱导肿瘤部位的T细胞发挥抗肿瘤功能。这种治疗方法优于未经改造的HSV治疗,支持进一步研究其在胶质瘤中的应用。 展开更多
关键词 胶质瘤 HSV bite 溶瘤病毒
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双特异性单链抗体BiTE的研究进展 被引量:2
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作者 周冲 于峰 +3 位作者 韩邦兴 周阳 刘黎琼 施海峰 《生物学杂志》 CAS CSCD 北大核心 2018年第4期76-80,共5页
癌症是严重威胁人类生存的重大疾病。BiTE(bispecific T-cell engager)所代表的一类具有显著抗肿瘤效应的双特异抗体,能够靶向性激活自身T细胞杀伤肿瘤细胞。BiTE由两个单链可变片段(scFv)组成,通过柔性融合接头串联连接。一个scFv识别... 癌症是严重威胁人类生存的重大疾病。BiTE(bispecific T-cell engager)所代表的一类具有显著抗肿瘤效应的双特异抗体,能够靶向性激活自身T细胞杀伤肿瘤细胞。BiTE由两个单链可变片段(scFv)组成,通过柔性融合接头串联连接。一个scFv识别T细胞表面蛋白CD3ε,而另一个scFv识别特异性肿瘤细胞表面抗原。BiTE的这种结构和特异性结合蛋白能力允许它将T细胞物理性地桥接肿瘤细胞而形成T细胞-BiTE-肿瘤细胞复合物,诱导免疫突触形成,刺激T细胞活化,产生杀伤肿瘤的细胞因子。近年来,BiTE在抗肿瘤研究中取得了显著进展,在临床上取得了理想的治疗效果。因此,对BiTE的结构、作用机制、临床应用以及创新性运用进行阐述。 展开更多
关键词 双特异性单链抗体 bite 免疫治疗
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The bonding bite plate combined with the face mask protracting maxilla to treat skeletal crossbite in the early mixed dentition
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作者 夜文敏 段银钟 +1 位作者 武俊杰 郭涛 《Journal of Medical Colleges of PLA(China)》 CAS 2007年第4期221-225,共5页
Objective: To evaluate the orthopedic effects of a new method to treat skeletal crossbite in the early mixed dentition. Methods :Twenty cases (5.8-7. 5 years old ) with skeletal crossbite were treated by bonding t... Objective: To evaluate the orthopedic effects of a new method to treat skeletal crossbite in the early mixed dentition. Methods :Twenty cases (5.8-7. 5 years old ) with skeletal crossbite were treated by bonding the bite plate combined with the face mask protracting the upper jaw. Cephalometric radiographs were taken and analyzed before and after treatments. Results: On average, in all 20 cases the maxilla was moved by 2.06 mm forwards the mandible was turned 2.45° downward and backwards the skeletal crossbites were corrected and the facial profiles were improved satisfactorily. The period of treatment was conducted for 1.7 months on average. Conclusion: A good effect can be achieved by bonding bite plate combined with the face mask protracting the upper jaw to treat skeletal crossbite in the early mixed dentition, which will benefit the craniofacial growth and the development of young children. 展开更多
关键词 bite plate face mask protracting upper jaw skeletal crossbite mixed dentition
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Culture Negative Disseminated Septic Polyarthritis Complicating Rat-Bite Fever in an Immunocompetent Adult
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作者 Mohammed Reda Sewilam Nasser Alhadhood 《Open Journal of Rheumatology and Autoimmune Diseases》 CAS 2022年第3期71-82,共12页
Rat-bite is uncommon worldwide, excluding developing countries. The history of a bite is usually missed if not meticulously asked for in history, proper exposure and examination. Today we report a case of culture-nega... Rat-bite is uncommon worldwide, excluding developing countries. The history of a bite is usually missed if not meticulously asked for in history, proper exposure and examination. Today we report a case of culture-negative rat-bite fever with poly septic arthritis resembling a rheumatoid arthritis-like picture in a 64-year-old gentleman. The presentation at first imitated an arthritis-like picture which was polyarthritis affecting the right ankle, right knee, right wrist, right proximal interphalangeal, left metacarpophalangeal and proximal interphalangeal joints. 展开更多
关键词 Rat-bite Fever Rat-bite Fever POLYARTHRITIS Culture-Negative Rheumatoid Arthritis Mimickers
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Root Resorption in Anterior Open Bite Malocclusions Due to Vertical Correction: A Radiometric Pilot Study
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作者 Suhina Kapoor David Briss +1 位作者 Shuying Jiang Thomas J. Cangialosi 《Open Journal of Orthopedics》 2023年第6期233-245,共13页
Introduction: One of the most common risks of fixed orthodontic therapy is the evidence of root resorption post orthodontic treatment ranging from mild root blunting to severe root resorption of significant portions o... Introduction: One of the most common risks of fixed orthodontic therapy is the evidence of root resorption post orthodontic treatment ranging from mild root blunting to severe root resorption of significant portions of the root structure. The etiology of apical root resorption is multifactorial but largely depends upon the type of orthodontic tooth movement and treatment duration. Study Objective: The primary aim of this study is to examine the association of external apical root resorption and vertical correction in anterior open bite malocclusions using panoramic radiographs for evaluation. Materials and Methods: Pre-treatment and post-treatment panoramic radiographs of 16 patients with anterior open bite malocclusions were scored to assess root resorption of anterior teeth (U/L 3-3). Initial and final root length and total tooth length for U/L 3-3 were measured on panoramic radiographs in Dolphin imaging. Results: Of the 24 pairs of measurements, 7 had a significant p-value (p Conclusions: A statistically significant amount of root resorption was observed, from pre-treatment to post-treatment radiographs. All mandibular anterior teeth except the mandibular right lateral incisors showed evidence of root resorption. 展开更多
关键词 Open bite malocclusion External apical root resorption Open bite closure
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高性能N型热压BiTe基材料的研究 被引量:1
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作者 刘勇 张丽丽 张建中 《电源技术》 CAS CSCD 北大核心 2008年第6期379-382,共4页
研究了区熔N型(Bi2Te3)x-(Bi2Se3)1-x晶体通过热压方法制备BiTe基材料及其性能。对所获得样品进行了密度分析、抗弯强度测试、扫描电子显微镜(SEM)分析以及温差电性能测试。实验结果表明由热压工艺制备的BiTe基材料在垂直于压力的方向... 研究了区熔N型(Bi2Te3)x-(Bi2Se3)1-x晶体通过热压方法制备BiTe基材料及其性能。对所获得样品进行了密度分析、抗弯强度测试、扫描电子显微镜(SEM)分析以及温差电性能测试。实验结果表明由热压工艺制备的BiTe基材料在垂直于压力的方向具有良好的取向性和温差电性能。优化的制备工艺条件下获得的热压样品在垂直热压压力方向上的热电性能优于区熔材料。热压材料的机械强度要明显优于区熔材料,且前者的机械强度随着热压压力的增加而增大。 展开更多
关键词 bite基温差电材料 热压 区熔 性能
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Bite ramp和活动式平面导板矫治深覆的机制 被引量:2
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作者 王梦 侯凤春 +3 位作者 高杨 张倩倩 孙君君 于艳玲 《海南医学》 CAS 2017年第11期1867-1869,共3页
目的探讨Bite ramp和活动式平面导板分别结合直丝弓矫治器打开咬合机制的差异。方法选取2014年7月至2016年3月在青岛市口腔医院正畸科就诊的60例深覆患者作为研究对象。按照随机数表法将60例患者随机分成A、B两组,每组30例。A组患者采用... 目的探讨Bite ramp和活动式平面导板分别结合直丝弓矫治器打开咬合机制的差异。方法选取2014年7月至2016年3月在青岛市口腔医院正畸科就诊的60例深覆患者作为研究对象。按照随机数表法将60例患者随机分成A、B两组,每组30例。A组患者采用Bite ramp结合直丝弓矫治器的方法打开咬合,B组患者采用活动式平面导板结合直丝弓矫治器的方法打开咬合。分别对两组患者咬合打开前后的X线头颅侧位片进行头影测量,并对测量结果进行分析。结果两组患者治疗前的颌骨矢状关系(SNA、SNB、ANB)、前后面高度(ANS-Me,S-Go)、下颌平面角(MP-SN)、上下颌切牙和磨牙的高度(U1-PP,L1-MP,L6-MP,U6-PP)以及覆(overbite)比较差异均无统计学意义(P>0.05);咬合打开后,两组患者的MP-SN、ANS-Me、S-Go、U6-PP、L6-MP和overbite均较咬合打开前增大,差异均有统计学意义(P<0.05),但两组间比较差异均无统计学意义(P>0.05),同时,两组患者咬合打开后的SNA、SNB、ANB、U1-PP和LI-MP与咬合打开前比较差异均无统计学意义(P>0.05)。结论 Bite ramp和活动式平面导板结合直丝弓矫治器打开咬合的机制无差异,且都可以有效地矫治深覆。因Bite ramp具有更好的临床性能,因此推荐选择Bite ramp与直丝弓矫治器结合矫治深覆。 展开更多
关键词 bite RAMP 活动式平面导板 深覆 X线头影测量
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BiTE-T:一种应用于实体瘤治疗的新型基因编辑T细胞 被引量:1
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作者 王月弟 骆菲菲 储以微 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2019年第7期725-729,共5页
以嵌合抗原受体T细胞(CAR-T)为代表的基因编辑T细胞在血液肿瘤中取得了卓越的成效,并逐渐应用在肿瘤的临床治疗中。2017年,先后有两款针对血液肿瘤的CAR-T细胞产品在美国获批上市,越来越广泛地应用在于实体肿瘤的治疗。但是利用CAR-T技... 以嵌合抗原受体T细胞(CAR-T)为代表的基因编辑T细胞在血液肿瘤中取得了卓越的成效,并逐渐应用在肿瘤的临床治疗中。2017年,先后有两款针对血液肿瘤的CAR-T细胞产品在美国获批上市,越来越广泛地应用在于实体肿瘤的治疗。但是利用CAR-T技术治疗实体瘤却遇到一些困境,实体瘤特有的微环境和表面肿瘤抗原的限制导致CAR-T细胞治疗效果并不理想,脱靶效应造成的细胞毒性更为棘手。针对这一问题,越来越多的研究人员开始探索新型的基因编辑T细胞用于实体瘤的治疗,其中双特异性T细胞衔接子基因编辑的T细胞(BiTE-T)在体外评估以及体内动物模型中展现出高效的抗肿瘤效果引起了高度关注。本文主要论述目前实体瘤治疗面临的困境以及BiTE-T细胞制备的原理、特点和应用于实体瘤治疗的优势。 展开更多
关键词 肿瘤免疫治疗 实体瘤 bite-T CAR-T
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