The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive impairment.However,most previous microbiome-based inte...The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive impairment.However,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive improvements.Here,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)training.In this study,we found that compared with EE or B.breve treatment alone,B.breve intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic function.Moreover,using microbiome and metabolome profiling,we found that the combination of B.breve and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite changes.Finally,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain interactions.Collectively,combined B.breve intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut microbiome.Our findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.展开更多
The aim of this study is to demonstrate the influence of Spirulina platensis on the growth of Bifidobacteium breve in the infantile milk. The authors used a stump of Bifidobacterium breve isolated from the new saddles...The aim of this study is to demonstrate the influence of Spirulina platensis on the growth of Bifidobacteium breve in the infantile milk. The authors used a stump of Bifidobacterium breve isolated from the new saddles which was born after identification and characterization. The follow-up of the kinetics of growth of B. breve in the milk enriched by various concentrations of Spirulina （0, 1, 5 and 10 mg/mL） was realized, and the authors estimated the antimicrobial effect of the cultures realised on three pathogenic bacteria： a bacteria isolated from saddles ＂Salmonella ssp.＂, two reference stumps ＂Staphylococcus aureus ATCC25923＂ and ＂Escherichia coli ATCC25922＂. The growth rate was 0.11 hl for the culture of B. breve associated with Spirulina （10 mg/mL）, 0.09 hl for the culture of B. breve enriched with Spirulina （5 mg/mL） and 0.08 hl for the culture of B. breve enriched with Spirulina （1 mg/mL）. In the case of the pure culture of B. breve, the growth rate was 0.07 h1. The authors observed inhibitory effects of B. breve in the various cultures towards the considered pathogenic bacteria. The optimal antimicrobial activity was observed in the preculture bifid with the algae culture （10 mg/mL） towards Salmonella ssp. （Zi = 25 mm）, S. aureus ATCC25923 （Zi = 26 mm） and E. coli ATCC25922 （Zi = 28 mm）.展开更多
During this COVID-19 pandemic’s,scientists and researchers are developing vaccines and with help of country's health ministry and WHO.They try to reach out vaccination throughout the country but this process shou...During this COVID-19 pandemic’s,scientists and researchers are developing vaccines and with help of country's health ministry and WHO.They try to reach out vaccination throughout the country but this process should take some time.Therefore,until vaccination can done we have to protect our immune system.In the year,2021 people may also get an infection of the third wave of COVID,which is a chance to arrive.Therefore,protecting our immunity and decreasing the severity of infection is the priority for that developing a new approach is necessary.Therefore,probiotics(Lactobacillus plantarum&Bifidobacterium breve)are good option for the person having post Covid Symptoms without side effects.Those probiotics can help people for developing immunity against COVID-19 infection.Those probiotics dosages are useful to patient because these probiotics are easily available,easy to administrate and it is useful in severe condition as well as in mild condition.展开更多
基金supported by the National Natural Science Foundation of China(31972052,32021005,31820103010)the Fundamental Research Funds for the Central Universities(JUSRP22006,JUSRP51501)the Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province。
文摘The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive impairment.However,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive improvements.Here,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)training.In this study,we found that compared with EE or B.breve treatment alone,B.breve intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic function.Moreover,using microbiome and metabolome profiling,we found that the combination of B.breve and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite changes.Finally,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain interactions.Collectively,combined B.breve intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut microbiome.Our findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.
文摘The aim of this study is to demonstrate the influence of Spirulina platensis on the growth of Bifidobacteium breve in the infantile milk. The authors used a stump of Bifidobacterium breve isolated from the new saddles which was born after identification and characterization. The follow-up of the kinetics of growth of B. breve in the milk enriched by various concentrations of Spirulina （0, 1, 5 and 10 mg/mL） was realized, and the authors estimated the antimicrobial effect of the cultures realised on three pathogenic bacteria： a bacteria isolated from saddles ＂Salmonella ssp.＂, two reference stumps ＂Staphylococcus aureus ATCC25923＂ and ＂Escherichia coli ATCC25922＂. The growth rate was 0.11 hl for the culture of B. breve associated with Spirulina （10 mg/mL）, 0.09 hl for the culture of B. breve enriched with Spirulina （5 mg/mL） and 0.08 hl for the culture of B. breve enriched with Spirulina （1 mg/mL）. In the case of the pure culture of B. breve, the growth rate was 0.07 h1. The authors observed inhibitory effects of B. breve in the various cultures towards the considered pathogenic bacteria. The optimal antimicrobial activity was observed in the preculture bifid with the algae culture （10 mg/mL） towards Salmonella ssp. （Zi = 25 mm）, S. aureus ATCC25923 （Zi = 26 mm） and E. coli ATCC25922 （Zi = 28 mm）.
文摘During this COVID-19 pandemic’s,scientists and researchers are developing vaccines and with help of country's health ministry and WHO.They try to reach out vaccination throughout the country but this process should take some time.Therefore,until vaccination can done we have to protect our immune system.In the year,2021 people may also get an infection of the third wave of COVID,which is a chance to arrive.Therefore,protecting our immunity and decreasing the severity of infection is the priority for that developing a new approach is necessary.Therefore,probiotics(Lactobacillus plantarum&Bifidobacterium breve)are good option for the person having post Covid Symptoms without side effects.Those probiotics can help people for developing immunity against COVID-19 infection.Those probiotics dosages are useful to patient because these probiotics are easily available,easy to administrate and it is useful in severe condition as well as in mild condition.
