Objective: To explore the effect of Bifidobacterium triple live bacteria on inflammatory factors, oxidative stress and T lymphocyte subsets in patients with ulcerative colitis (UC). Method: A total of 90 patients with...Objective: To explore the effect of Bifidobacterium triple live bacteria on inflammatory factors, oxidative stress and T lymphocyte subsets in patients with ulcerative colitis (UC). Method: A total of 90 patients with UC treated in our hospital were selected and randomly divided into the observation group and the control group each with 45 cases. The control group was given Mesalazin Enteric-coated Tablets 1 g/times, 4 times/d, continuous treatment for 1 months:when the clinical symptoms were stable, switched to 500 mg/times, 3 times/d, continuous treatment for 3 months. The observation group on the basis of conventional treatment to give Bifidobacterium triple live bacteria scattered adjuvant therapy (Bifico capsule), 0.84 g/time, 2 times/d, continuous treatment for 3 months. In the two groups, the levels of inflammatory factors (IL-6, IL-10, CRP, TNF-α), oxidative stress markers (MDA, SOD) and T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) were compared pre and post treatment. Results: The levels of IL-6, CRP, MDA, TNF-α, CD8+ in both two groups were significantly decreased compared with treatment before;the levels of IL-10, SOD, CD3+, CD4+ and CD4+/CD8+were significantly increased compared with treatment before. After treatment, the levels of serum IL-6, CRP, TNF-α, MDA and CD8+ in observation group with the data (72.17±15.18) pg/mL, (21.52±10.21) mg/mL, (15.98±4.12) pg/mL respectively were decreased more significantly than those data in control group which were (86.55±17.26) pg/mL, (43.02±12.27) mg/L, (22.35±3.67) pg/mL, MDA level (5.89±0.56) nmol/mL in observation group was decreased more significantly than the level in the control group (6.75±0.68) nmol/mL;CD8+level (17.24±3.06)% in observation group was decreased more significantly than the level (19.01±2.62)% in the control group. After treatment, IL-10 level (70.21±6.03) pg/mL in observation group was increased more significantly than the level in the control group (56.48+ 8.67) pg/mL;SOD level (1.84±0.06) U/mL in observation group was increased more significantly than the level in the control group (1.32±0.05) U/mL;the levels of CD3+, CD4+, CD4+/CD8+ in the observation group (57.84±6.07)%;(36.78±4.32)%;(1.92±0.29) were increased more significantly than the level in the control group (54.93±6.87)%;(35.42±5.27)%;(1.89±0.12). Conclusion: Bifidobacterium triple live bacteria scattered adjuvant treatment of ulcerative colitis helps regulate oxidative stress and inflammatory cytokines inhibiting inflammatory reaction and improving enhance function, and can effectively improve the clinical symptoms of patients with UC.展开更多
目的研究双歧杆菌三联活菌辅助蓝光照射对新生儿黄疸的价值。方法选取南京市高淳人民医院于2022年5月—2023年7月收治的136例黄疸新生儿为研究对象,以随机数表法分为两组,各68例。对照组采用蓝光照射治疗,研究组在对照组基础上采用双歧...目的研究双歧杆菌三联活菌辅助蓝光照射对新生儿黄疸的价值。方法选取南京市高淳人民医院于2022年5月—2023年7月收治的136例黄疸新生儿为研究对象,以随机数表法分为两组,各68例。对照组采用蓝光照射治疗,研究组在对照组基础上采用双歧杆菌三联活菌治疗。治疗前及治疗6 d后,比较两组血清总胆红素水平(Total Serum Bilirubin,TSB)、直接胆红素(Direct Bilirubin,DBIL)、经皮黄疸指数、总胆红素与白蛋白比值(Bilirubin to Albumin Ratio,TSB/ALB)、乳酸脱氢酶水平(Lactate Dehydrogenase,LDH)水平以及不良反应发生情况。结果治疗前,两组机体胆红素水平比较,差异无统计学意义(P>0.05);治疗后,研究组TSB、DBIL及经皮黄疸指数水平低于对照组,差异有统计学意义(P均<0.05)。治疗前,两组TSB/ALB及LDH水平比较,差异无统计学意义(P均>0.05);治疗后,研究组TSB/ALB及LDH水平低于对照组,差异有统计学意义(P均<0.05)。研究组不良反应发生率为2.94%,与对照组的4.41%对比,差异无统计学意义(χ^(2)=0.208,P=0.649)。结论新生儿黄疸使用双歧杆菌三联活菌辅助蓝光照射能够降低胆红素水平,减少胆红素脑病发生风险,且不会增加不良反应。展开更多
基金Beijing Natural Science Foundation of China(7151729).
文摘Objective: To explore the effect of Bifidobacterium triple live bacteria on inflammatory factors, oxidative stress and T lymphocyte subsets in patients with ulcerative colitis (UC). Method: A total of 90 patients with UC treated in our hospital were selected and randomly divided into the observation group and the control group each with 45 cases. The control group was given Mesalazin Enteric-coated Tablets 1 g/times, 4 times/d, continuous treatment for 1 months:when the clinical symptoms were stable, switched to 500 mg/times, 3 times/d, continuous treatment for 3 months. The observation group on the basis of conventional treatment to give Bifidobacterium triple live bacteria scattered adjuvant therapy (Bifico capsule), 0.84 g/time, 2 times/d, continuous treatment for 3 months. In the two groups, the levels of inflammatory factors (IL-6, IL-10, CRP, TNF-α), oxidative stress markers (MDA, SOD) and T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) were compared pre and post treatment. Results: The levels of IL-6, CRP, MDA, TNF-α, CD8+ in both two groups were significantly decreased compared with treatment before;the levels of IL-10, SOD, CD3+, CD4+ and CD4+/CD8+were significantly increased compared with treatment before. After treatment, the levels of serum IL-6, CRP, TNF-α, MDA and CD8+ in observation group with the data (72.17±15.18) pg/mL, (21.52±10.21) mg/mL, (15.98±4.12) pg/mL respectively were decreased more significantly than those data in control group which were (86.55±17.26) pg/mL, (43.02±12.27) mg/L, (22.35±3.67) pg/mL, MDA level (5.89±0.56) nmol/mL in observation group was decreased more significantly than the level in the control group (6.75±0.68) nmol/mL;CD8+level (17.24±3.06)% in observation group was decreased more significantly than the level (19.01±2.62)% in the control group. After treatment, IL-10 level (70.21±6.03) pg/mL in observation group was increased more significantly than the level in the control group (56.48+ 8.67) pg/mL;SOD level (1.84±0.06) U/mL in observation group was increased more significantly than the level in the control group (1.32±0.05) U/mL;the levels of CD3+, CD4+, CD4+/CD8+ in the observation group (57.84±6.07)%;(36.78±4.32)%;(1.92±0.29) were increased more significantly than the level in the control group (54.93±6.87)%;(35.42±5.27)%;(1.89±0.12). Conclusion: Bifidobacterium triple live bacteria scattered adjuvant treatment of ulcerative colitis helps regulate oxidative stress and inflammatory cytokines inhibiting inflammatory reaction and improving enhance function, and can effectively improve the clinical symptoms of patients with UC.
文摘目的研究双歧杆菌三联活菌辅助蓝光照射对新生儿黄疸的价值。方法选取南京市高淳人民医院于2022年5月—2023年7月收治的136例黄疸新生儿为研究对象,以随机数表法分为两组,各68例。对照组采用蓝光照射治疗,研究组在对照组基础上采用双歧杆菌三联活菌治疗。治疗前及治疗6 d后,比较两组血清总胆红素水平(Total Serum Bilirubin,TSB)、直接胆红素(Direct Bilirubin,DBIL)、经皮黄疸指数、总胆红素与白蛋白比值(Bilirubin to Albumin Ratio,TSB/ALB)、乳酸脱氢酶水平(Lactate Dehydrogenase,LDH)水平以及不良反应发生情况。结果治疗前,两组机体胆红素水平比较,差异无统计学意义(P>0.05);治疗后,研究组TSB、DBIL及经皮黄疸指数水平低于对照组,差异有统计学意义(P均<0.05)。治疗前,两组TSB/ALB及LDH水平比较,差异无统计学意义(P均>0.05);治疗后,研究组TSB/ALB及LDH水平低于对照组,差异有统计学意义(P均<0.05)。研究组不良反应发生率为2.94%,与对照组的4.41%对比,差异无统计学意义(χ^(2)=0.208,P=0.649)。结论新生儿黄疸使用双歧杆菌三联活菌辅助蓝光照射能够降低胆红素水平,减少胆红素脑病发生风险,且不会增加不良反应。
