Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury:focus on the visual system

The retina,as part of the central nervous system is an ideal model to study the response of neurons to injury and disease and to test new treatments.During the last decade is becoming clear that unilateral lesions in bilateral areas of the central nervous system trigger an inflammatory response in the contralateral uninjured site.This effect has been better studied in the visual system where,as a rule,one retina is used as experimental and the other as control.Contralateral retinas in unilateral models of retinal injury show neuronal degeneration and glial activation.The mechanisms by which this adverse response in the central nervous system occurs are discussed in this review,focusing primarily on the visual system.

外伤性颅内多发血肿给予双侧开颅的外科干预效果观察

目的:观察外伤性颅内多发血肿给予双侧开颅的外科干预效果。方法:收治外伤性颅内多发血肿患者80例,分为观察组和对照组。观察组给予Ⅰ期双侧开颅手术,对照组给予分期开颅手术。观察治疗效果,术后半年电话随访,观察病死率、残疾情况。结果:观察组格拉斯哥预后评分、手术时间明显多于对照组,住院时间、病死率、残疾率、并发症明显低(少)于对照组。结论:对于外伤性颅内多发血肿患者,应尽早采取手术治疗,Ⅰ期手术具有明显治疗效果,彻底清除血块及颅内积液,提高患者的存活率。