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The First National Conference on Chemical and Biochemical Engineering
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《China Particuology》 SCIE EI CAS CSCD 2004年第6期278-278,共1页
关键词 ORAL The First National Conference on Chemical and biochemical engineering
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Tissue Engineering of Ligament/tendon-Part II-Importance of Biochemical and Mechanical Factors on the Neogenesis of Ligament
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作者 Sylvaine Muller Shalaw Fawzi-Grancher Said Slimani 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2005年第S1期27-28,共2页
关键词 Tissue engineering of Ligament/tendon-Part II-Importance of biochemical and Mechanical Factors on the Neogenesis of Ligament
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Recent progress in enzymatic functionalization of carbon-hydrogen bonds for the green synthesis of chemicals
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作者 Zheyu Wang Yupei Jian +4 位作者 Yilei Han Zhongwang Fu Diannan Lu Jianzhong Wu Zheng Liu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2020年第10期2499-2506,共8页
Enzymatic reactions take place with high chemo-, regio-, and stereo-selectivity, appealing for the direct functionalization of abundant and inexpensive compounds with C-H bonds to make fine chemicals such as high-valu... Enzymatic reactions take place with high chemo-, regio-, and stereo-selectivity, appealing for the direct functionalization of abundant and inexpensive compounds with C-H bonds to make fine chemicals such as high-value intermediates and pharmaceuticals. This review summarizes recent progress in the enzymatic functionalization of C-H bonds with an emphasis on heme enzymes such as cytochrome P450 s, chloroperoxidase and unspecific peroxygenases. Specific examples are discussed to elucidate the applications of the molecular and process engineering approaches to overcome the challenges hindering enzymatic C-H functionalization. Also discussed is the recent development of the chemo-enzymatic cascade as an effective way to integrate the power of metal catalysis and enzymatic catalysis for C-H functionalization. 展开更多
关键词 BIOCATALYSIS biochemical engineering ENZYME C-H functionalization CHLOROPEROXIDASE
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Effects of Samarium Chloride on Porcine Thyroid Cells in Vitro
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作者 周莉 聂毓秀 +3 位作者 陈玉兰 牛春吉 张树功 倪嘉缵 《Journal of Rare Earths》 SCIE EI CAS CSCD 1994年第4期283-287,共5页
To study the effects of various concentrations of SmCl3 on the morphology and functions of porcine thyroid cells in vitro, the methods of the electron microscope and radioimmunoassay were used. The investigation showe... To study the effects of various concentrations of SmCl3 on the morphology and functions of porcine thyroid cells in vitro, the methods of the electron microscope and radioimmunoassay were used. The investigation showed that when the thyroid cells were cultured in the presence of 0.001 and 0.01 mmol/L SmCl3, the measured levels of tetraiodothyronine (T4) were much higher than those in control cells and iodine uptake by thyroid cells increased, and the cells appeared to be active functional morphology under the electron microscope. When the thyroid cells were cultured in the presence of 0.1 mmol/L SmCl3, the levels of T4 and iodine uptake by cells decreased as compared with those in control cells, and the morphological changes of the cells presented an inactive functional state. From the evidences mentioned above, it demonstrates that very low concentrations (0.001 and 0.01 mmol/L) of SmCl3 promote synthesis and secretion of thyroid hormone, whereas a higher concentration (0.1 mmol/L of SmCl3) inhibits the synthesis and secretion of thyroid hormone. 展开更多
关键词 Animal cell culture biochemical engineering Chlorine compounds
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Multi-functional engineered polypeptide-based drug delivery systems for improved cancer therapy
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作者 Xiaobin Li Junyu Liu +4 位作者 Haihong Chen Yaxin Chen Yi Wang Can Yang Zhang Xin-Hui Xing 《Green Chemical Engineering》 EI CSCD 2023年第2期173-188,共16页
With the rapid development of chemical engineering and biotechnology,polypeptide,as a promising candidate in the biomedical field,has been thoroughly investigated and extensively used as the drug delivery vehicle for ... With the rapid development of chemical engineering and biotechnology,polypeptide,as a promising candidate in the biomedical field,has been thoroughly investigated and extensively used as the drug delivery vehicle for diseases treatment,especially cancer,owing to the high biocompatibility,good biodegradability,versatile con-structions,and diverse functions.Engineered polypeptide-based drug delivery system(so-called EPP-DDS)can deliver the cargos to the target site via a specific recognition effect,followed by overcoming the barriers like blood brain barrier(BBB)and releasing them by responding to the microenvironment cues,to improve the therapeutic efficacy and reduce the side-effect.Herein,it's of great importance to conclude and summarize the updates on EPP-DDS developed by chemical engineering methods.In this review,we first summarized the recent updates in the manufacturing of polypeptide and preparation of EPP-DDS based on green biochemical engineering and/or synthetic processes for cancer therapy,including chemotherapy,immunotherapy,photodynamic therapy(PDT),gene therapy,and combination therapy.Then,we surveyed the research progress of inflammation-mediated cancer treatment strategies based on EPP-DDS with high anti-inflammation activity.Finally,we concluded the discovery and green production process of engineered polypeptide,challenges,and perspectives of EPP-DDS.Overall,the EPP-DDS has great potential for cancer therapy in the clinic with improved therapeutic efficacy and reduced adverse effect,which needs the innovation of green biochemical engineering for customized design and production of polypeptides. 展开更多
关键词 POLYPEPTIDE Drug delivery system Cancer therapy BIOPHARMACEUTICS Green biochemical engineering
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