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Application of Bioengineered Bacteria in Allergic Diseases
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作者 Yu-Wen Gao Xu Yao Xue-Yuan Yang 《International Journal of Dermatology and Venereology》 CSCD 2023年第1期43-48,共6页
In recent years,increasing attention has been paid to bioengineered bacteria as vectors for the treatment of allergic diseases.The methods for preparing bioengineered bacteria that can express exogenous genes are impr... In recent years,increasing attention has been paid to bioengineered bacteria as vectors for the treatment of allergic diseases.The methods for preparing bioengineered bacteria that can express exogenous genes are improving.Research has focused mainly on application of bioengineered bacteria expressing recombinant allergens,hypoallergenic derivatives of allergens,T-cell epitope derivatives,cytokines,or as mucosal adjuvants to enhance immunotherapy effects.This strategy offers new ideas for the treatment of allergic diseases.This review summarizes recent advances in use of live bioengineered bacteria in allergic diseases as well as the challenges of using microorganisms(or their components)in immunotherapy. 展开更多
关键词 bioengineered bacteria recombinant probiotics ALLERGY allergen-specific immunotherapy
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