Bioflavonoids as Important Component of Biological Protection from Ionizing Radiation

New advances in the area of deciphering the mechanism for a possible modification of the biological effects of radiation exposure at the genetic level make it possible to distinguish the group of radiation protective agents having their own specific features in the implementation of their beneficial effects. The mechanism of the radioprotective action of bioflavonoids is worthy of a detailed analysis in view of their great biological importance. Radiobiological studies show that antioxidants can reduce the radiation damage to membranes and favor more adequate energy dependent adaptive and reparative processes after the exposure to radiation. Bioflavonoids are significant component of “biological protection” for a enhance of resistance of the body to environmental factors that are adverse for human health, including ionizing radiation, with reducing the risk of carcinogenic effects and decreasing the biological age. The best practical value of bioflavonoids, can be considered as the agents for prophylaxis against the development of oxidative stress. These are the reasons why the administration of natural antioxidants have a pathogenetic justification for exposures to chronic (months, years) low-rate-dose ionizing radiation. These agents were previously and are currently being developed for use during long-term, low-ratedose exposures to radiation, under conditions of long space missions. Acting as low-dose stressors through a hormetic mechanism and a “substrate” support of adaptive shifts radiomodulators results in an increase in the antioxidant defense of the body and the rearrangement of its functioning in the new environment with the modulation of gene expression of antioxidant response elements by activation of Nrd2/KeapI and Sirtuin/FoxO pathways and a decrease in the transcription factor NF-κB.

Vitamin C, Grape Seed Extract and Citrus Bioflavonoids Protect the Skin against Photoaging: A Review

The skin is a major protective organ of the body. It is constantly exposed to the environment and is very resilient. But exposure to ultraviolet (UV) rays from the sun results in the production of reactive oxygen species (ROS) and subsequent inflammatory responses that can overwhelm the innate protective mechanisms of the skin. This results in damage and premature aging. Strategies to mitigate this premature photoaging might include avoidance of sunlight. However, some sunlight exposure is beneficial to health. One notable example of this is the production of vitamin D. A more practical approach to preventing adverse effects of UV light in the skin is antioxidant supplementation. Dietary antioxidants may help control ROS propagation following UV light exposure. To further evaluate the utility of antioxidants in protecting the skin, in vitro, in vivo and human studies of three well known dietary antioxidants are reviewed and discussed. The data clearly demonstrate that vitamin C, grape seed extract and citrus bioflavonoids have the potential to reduce the damaging effects of excess sun exposure via antioxidant, anti-inflammatory and immunomodulating mechanisms. As such, regular ingestion of dietary antioxidants appears to be a useful strategy for protecting the skin against photoaging.

Biochemical Mechanisms of Therapeutic and Prophylactic Effects of Bioflavonoids

In the present study to investigate the biochemical mechanisms of therapeutic and prophylactic action of bioflavonoids, carried out a comparative evaluation of antioxidant and antiproteinase properties of certain bioflavonoids standards in vitro. Therapeutic and prophylactic efficacy of individual bioflavonoids as well as herbal medicines with bioflavonoids, was examined at an experimental pathology （toxic hepatitis, dental caries, periodontitis, stomatitis, dysbiosis, diabetes Types 1 and 2, gastric ulcer, osteopenia） in Wistar line rats. Condition of organs and tissues was assessed by biochemical markers of inflammation, antioxidant and antimicrobial defense systems of animals. Research has shown the ability ofbioflavonoids in varying degrees inhibit the formation of superoxide anion radicals and malondialdehyde, recover free radicals, bind ions of Fe2＋, inhibiting the activity of proteases, such as leukocyte elastase. Established partially competitive type of trypsin and elastase activity inhibition by bioflavonoids. Was revealed a positive effect of bioflavonoids in experimental pathology on animals. Therapeutic and prophylactic effects of bioflavonoids, in our opinion, are realized through a strong antioxidant and antiprotease properties of these compounds.

Lipoflavonoid Benefits in Patients with Tinnitus

Background: Otolaryngologists are regularly presented with patients experiencing tinnitus who are seeking treatment to help with resuming active and productive lives. Lemon bioflavonoid complexes are known to be safe nutritional supplements;however, data on patient satisfaction are limited. Objectives: The primary objectives were to better understand symptom severity reduction, symptom improvement, and patient satisfaction when lemon bioflavonoid complexes are taken at the recommended dose and duration of treatment. Methods: The SILENT experience study was conducted from January 2017 to January 2018, with 504 otolaryngologists from six states, identified from a purchased list. Each physician provided a free, 500-caplet sample of Lipo-Flavonoid®, a lemon bioflavonoid complex, to three patients who experienced tinnitus and completed a survey detailing patient demographics and symptoms. In total, 719 patients received the sample;51 patients followed through and completed a baseline symptom assessment and five surveys over 10 weeks. IRB approval was deemed unnecessary and the study was overseen by a practicing otolaryngologist. Statistical analysis was conducted on the reduction of symptom severity and symptom improvement over 10-weeks. Results: Bothersomeness of ringing or other noises in the ear(s) was reduced by 32% and patients reported a 55% improvement of all symptoms, which correlated with product satisfaction. Patient satisfaction scores were strong: 33% extremely satisfied, 49% somewhat satisfied, and 18% not satisfied. Compliance was high, with 86% of participants taking the product as directed for 60 days. The top reasons for physician recommendations (selected by >30%) were positive clinical experience (71%), good safety profile (66%), supported by data for over 50 years (37%), and efficacy (35%). Implications for Practice: These data support the use of this lemon bioflavonoid complex for symptoms of tinnitus, for 60 days (and beyond for those who derive benefit) to provide the best chance of relief. For clinicians looking for a safe and beneficial intervention for patients, lemon bioflavonoid complexes offer a good first-line option.