SHANGHAI INSTITUTE OF BIOLOGICAL SCIENCES

The Shanghai Institute of Biological Sciences(SIBS) under the Chinese Academy of Sciences(CAS) was formally founded on July 3, 1999. It wasbased on eight CAS research institutes and tworesearch centers in the Shanghai area, namely, theShanghai institutes of Biochemistry, Cell Biology,Materia Medica, Physiology, Brain Research, PlantPhysiology, Entomology, and Biotechnology, aswell as the Shanghai Life Sciences Research

The SOOS Asian Workshop on Southern Ocean research and observations

1 Background and purpose of workshop The Southern Ocean plays a fundamental role in the function of the Earth System, influencing climate, sea level, biogeochemical cycles, and biological productivity on a variety of scalesIll. Observations from the Southern Ocean suggest that dramatic changes are taking place, which are of global concern, yet because of its remote location, seasonal sea ice, and harsh environment, the Southern Ocean remains one of the least sampled zones in the world.

Comparative Study on Polarization of DNA and CdSe Quantum Dots

The polarizabilities of DNA in transverse direction and CdSe semiconductor quantum dots （QDs） deposited on mica surface are compared by means of electrostatic force microscopy （EFM）. We observe clear EFM-phase shift over CdSe QDs, while no obvious signal on DNA is detected, suggesting that DNA molecules is an electrical insulator.

School of Chemical and Biological Science and Engineering of YTU

The school consists of four first-level interdisciplines： chemistry, biological science, chemical engineering and technology, and food science and engineering. There are three basic teaching divisions： chemistry, biological science and chemical engineering; four research institutes： biological science and technology, food science and technology, chemical materials, and applied chemistry; four basic experimental teaching centers： biology, chemistry, chemical engineering and technique, and food science and engineering; and one food quality and safety testing and detecting center.

PLZF restricts intestinal ILC3 function in gut defense

Group 3 innate lymphoid cells(ILC3s)play important roles in maintaining intestinal homeostasis by protecting the host from pathogen infections and tissue inflammation.The transcription factor PLZF(promyelocytic leukemia zinc finger),encoded by zinc finger BTB domain containing 16(Zbtb16),is highly and transiently expressed in ILC precursors(ILCPs).However,the role of PLZF in regulating ILC3 development and function remains unknown.Here,we show that PLZF was specifically expressed in mature intestinal ILC3s compared with other ILC subsets.PLZF was dispensable for ILC3 development.However,PLZF deficiency in ILC3s resulted in increased innate interleukin-22(IL-22)secretion and protection against gut infection and inflammation.Mechanistically,PLZF negatively regulated IL-22 expression by ILC3s in a cell-intrinsic manner by binding to the IL-22 promoter region for transcriptional repression.Together,our data suggest that PLZF restricts intestinal ILC3 function to regulate gut immune homeostasis.

Research Advance on Metasequoia:Applications of New Technology

The plant genus Metasequoia Miki,1941 and its sole living relict species Metasequoia glyptostroboides Hu et Cheng,1948 have been of special interest for both the public and scientists since 1941 when the genus was established.Due to its unique discovery history（fossils discovered earlier than the living species） and incomparable scientific value in the research of plant evolution and its relationship with environmental and climatic changes, Metasequoia becomes arguably the most comprehensively studied higher plant in both fossil and living forms.This paper summarized recent advance in Metasequoia research by reviewing the research history of Metasequoia and the scientific value of this genus,while paid special attention to the application of new methods and techniques in the research field of Metasequoia in the recent decades.The application of biogeochemical（organic geochemistry and stable isotope） analysis as well as the new and innova ted methods of preparing large-sized cuticular membrane from leaves with originally thin and fragile cuticles further secure Metasequoia＇s super star status for the research of palaeoclimatic reconstruction.