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Study on two kinds of degradation mechanisms for biomaterials poly(ε-caprolactone)
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作者 陈建海 陈一民 陈志良 《Journal of Medical Colleges of PLA(China)》 CAS 1999年第3期176-179,192,共5页
The in vitro and in vivo degradation behaviour of poly (ε-caprolactone) (PCL) has been examined in terms of degree of degradation and morphological change during an inclibation period of up to 300 d. Gel permeation c... The in vitro and in vivo degradation behaviour of poly (ε-caprolactone) (PCL) has been examined in terms of degree of degradation and morphological change during an inclibation period of up to 300 d. Gel permeation chromatography (GPC) and differential scanning calorimetry (DSC) were employed to character ize their degradation profiles. The observation of the changes in intrinsic viscosity and average molecular weight as well as the crystallinity of PCL leads to the findings that 2 degradation mechanisms of PCL exist. The subcutaneous implant test shows that the rate of degradation in the rabbit body is much higher than in vitro. This illustrated that in vivo, the mechanism of bioerosion is more important than hydrolytic cleavage of ester linkage, especially in the second stage of degradation. Regardless of the initial Mn of specimens, a lin ear relationship between Mn and degradation time has been observed until the Mn decreased to be about 5 ooo D. Above this figure, the main degradation mechanism was hydrolytic cleavage of ester group accompa nied by enzymatic surface erosion, below this point, the bioerosion with weight loss plays a more significant role than hydrolytic reaction in their degradation. Comparison between the morphology of PCL materials af ter and before erosion was made by means of scanning electron microscopy (SEM). 展开更多
关键词 biodegradation poly (ε-caprolactone) biomaterials
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Mechanical Properties and Degradability of Electrospun PCL/PLGA Blended Scaffolds as Vascular Grafts 被引量:3
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作者 Jingchen Gao Siyuan Chen +3 位作者 Di Tang Li Jiang Jie Shi Shufang Wang 《Transactions of Tianjin University》 EI CAS 2019年第2期152-160,共9页
In our study, the mechanical properties and degradability of vascular grafts made from poly(ε-caprolactone)(PCL) and poly(lactic-co-glycolic acid)(PLGA) at different ratios were investigated. The results showed that ... In our study, the mechanical properties and degradability of vascular grafts made from poly(ε-caprolactone)(PCL) and poly(lactic-co-glycolic acid)(PLGA) at different ratios were investigated. The results showed that the electrospun PCL/PLGA grafts possess good mechanical properties and biodegradability. The tensile and burst strength of the scaffolds met the demands of vascular grafts. In vitro degradation tests indicated that the degradation rate of the materials increased with the percentage of PLGA, and in vivo tests showed that increasing the amount of PLGA is an effective way to promote cell infiltration. Particularly, the electrospun PCL/PLGA blended scaffold with 10% PLGA exhibited a balance of mechanical and degradation properties, making it a promising tissue engineering material for vascular grafts. 展开更多
关键词 ELECTROSPINNING poly(ε-caprolactone) poly(lactic-co-glycolic acid) mechanical properties biodegradABILITY
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可吸收性生物材料PCL在体外与动物体内降解机制的研究 被引量:10
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作者 陈建海 马安德 +2 位作者 来永毅 陈一民 崔铭玉 《生物医学工程学杂志》 EI CAS CSCD 北大核心 1997年第4期334-337,共4页
检测了可吸收性生物高分子材料PCL在体外、动物体内的特性粘度[η]、数均分子量Mn及结晶度的变化;探讨该材料在体外与动物体内降解的机制。试验结果表明,降解速率与材料原始分子量无关,降解的临界数均分子量(Mn)。接近于5000;在... 检测了可吸收性生物高分子材料PCL在体外、动物体内的特性粘度[η]、数均分子量Mn及结晶度的变化;探讨该材料在体外与动物体内降解的机制。试验结果表明,降解速率与材料原始分子量无关,降解的临界数均分子量(Mn)。接近于5000;在该分子量以前材料以水解机制为主并伴有表面酶浸蚀机制,在该分子量以后则以浸蚀机制为主.失重明显,并用扫描电镜图片比较了材料浸蚀前后的表面形态. 展开更多
关键词 生物材料 PCL 生物降解 体外 体内
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