We investigated the feasibility of applying polymethylmethacrylate bone cement composited with biomimetic bone-mineralizsed collagen to percutaneous kyphoplasty(PKP).We performed PKP in 95 patients diagnosed with oste...We investigated the feasibility of applying polymethylmethacrylate bone cement composited with biomimetic bone-mineralizsed collagen to percutaneous kyphoplasty(PKP).We performed PKP in 95 patients diagnosed with osteoporotic vertebral compression fracture.All patients had fractures of a single vertebral body,and they were divided randomly into control(group A,47 patients)and experimental(group B,48 patients)groups.Patients in group A were treated with acrylic cement,and those in group B were treated with acrylic cement composited with the bone graft material.All patients were evaluated by a visual analogue scale(VAS),Oswestry disability index(ODI),Cobb angle and anterior vertebral body height preoperatively,and 3 days and 3 months postoperatively.All patients successfully completed surgery and were followed up thereafter.The VAS score,ODI index,Cobb angle and anterior vertebral body height compression rate in both groups had significant changes(P<0.05)preoperatively,and at 3 days and 3 months postoperatively.There was no significant difference between the two groups at different times(P>0.05).The analgesic effects of bone cement composited with bone-mineralized collagen are similar to those of bone cement only.Mineralized collagen has excellent promotion prospects by inducing new bone formation and reducing the incidence of adverse reactions caused by bone cement.展开更多
目的:探讨含重组人碱性成纤维细胞生长因子(recombinant human basic fibroblast growth factor,rhbFGF)和重组人骨形态发生蛋白-2(recombinant human bone morphogenetic protein-2,rhBMP-2)骨水泥在骨质疏松性腰椎压缩性骨折(osteopor...目的:探讨含重组人碱性成纤维细胞生长因子(recombinant human basic fibroblast growth factor,rhbFGF)和重组人骨形态发生蛋白-2(recombinant human bone morphogenetic protein-2,rhBMP-2)骨水泥在骨质疏松性腰椎压缩性骨折(osteoporotic vertebral compression fracture,OVCF)患者经皮椎体后凸成形术(percutaneous kyphoplasty,PKP)治疗的应用价值。方法:回顾性分析2018年1月至2021年1月收治的103例行PKP手术治疗的OVCF患者,男40例,女63例;年龄61~78(65.72±3.29)岁。受伤原因:滑倒33例,跌倒42例,提重物受伤28例。根据填充骨水泥不同分为3组:磷酸钙组34例,男14例,女20例,年龄(65.1±3.3)岁,填充磷酸钙骨水泥;rhBMP-2组34例,男12例,女22例,年龄(64.8±3.2)岁,填充含rhBMP-2的骨水泥;rhbFGF+rhBMP-2组35例,男14例,女21例,年龄(65.1±3.6)岁,填充含rhbFGF和rhBMP-2的骨水泥。比较3组Oswestry功能障碍指数(Oswestry dysfunction index,ODI)、骨密度、椎体前缘丢失高度、伤椎前缘压缩率、疼痛视觉模拟评分(visual simulation score,VAS)及再骨折发生率。结果:所有患者获得12个月随访。3组术后ODI、VAS呈下降(P<0.001),骨密度增高(P<0.001),椎体前缘丢失高度、伤椎前缘压缩率呈先下降后缓慢上升趋势(P<0.001),rhbFGF+rhBMP-2组术后第1、6、12个月ODI、VAS均低于rhBMP-2组和磷酸钙组(P<0.05),术后第6、12个月骨密度大于rhBMP-2组和磷酸钙组(P<0.05)。rhbFGF+rhBMP-2组术后第6、12个月椎体前缘丢失高度、伤椎前缘压缩率均低于rhBMP-2组和磷酸钙组(P<0.05)。3组再骨折发生率比较差异无统计学意义(P>0.05)。结论:含rhbFGF和rhBMP-2骨水泥可更有效地增加OVCF患者骨密度,获得术后满意的临床和放射学效果,显著改善临床症状。展开更多
基金This work is in part supported by NSFC No.51402176the Inner Mongolia autonomous region natural science fund No.20070501.
文摘We investigated the feasibility of applying polymethylmethacrylate bone cement composited with biomimetic bone-mineralizsed collagen to percutaneous kyphoplasty(PKP).We performed PKP in 95 patients diagnosed with osteoporotic vertebral compression fracture.All patients had fractures of a single vertebral body,and they were divided randomly into control(group A,47 patients)and experimental(group B,48 patients)groups.Patients in group A were treated with acrylic cement,and those in group B were treated with acrylic cement composited with the bone graft material.All patients were evaluated by a visual analogue scale(VAS),Oswestry disability index(ODI),Cobb angle and anterior vertebral body height preoperatively,and 3 days and 3 months postoperatively.All patients successfully completed surgery and were followed up thereafter.The VAS score,ODI index,Cobb angle and anterior vertebral body height compression rate in both groups had significant changes(P<0.05)preoperatively,and at 3 days and 3 months postoperatively.There was no significant difference between the two groups at different times(P>0.05).The analgesic effects of bone cement composited with bone-mineralized collagen are similar to those of bone cement only.Mineralized collagen has excellent promotion prospects by inducing new bone formation and reducing the incidence of adverse reactions caused by bone cement.
