The era of Precision Medicine （PM） has entered its execution phase where acquisition of human genome variation data is already leading the charge [1,2]. PM has come a long way to this phase from the Human Genome Pro...The era of Precision Medicine （PM） has entered its execution phase where acquisition of human genome variation data is already leading the charge [1,2]. PM has come a long way to this phase from the Human Genome Project started some 25 years ago [3,4]; it marks the beginning of disease-centric research in the field of biomedical sciences. Other than deliver- ing high-coverage human genomes by millions--of course tai- lored to patients and common diseases--in the next decade or so, what else do we expect to have and what should we be doing to make the best out of PM projects beyond the current expectation of genetics？展开更多
INFORMATION FOR AUTHORS Biomedical and Environmental Sciences, an international journal with special emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmenta...INFORMATION FOR AUTHORS Biomedical and Environmental Sciences, an international journal with special emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and展开更多
Biomedical and Environmental Sciences,an international journal with special emphasis on scientificfindings in China,publishes articles dealing with biologic and toxic effects of environmental pollutants onman and othe...Biomedical and Environmental Sciences,an international journal with special emphasis on scientificfindings in China,publishes articles dealing with biologic and toxic effects of environmental pollutants onman and other forms of life.The effects may be measured with pharmacological,biochemical,pathological,and immunological techniques.The journal also publishes reports dealing with the entry,transport,andfate of natural and anthropogenic chemicals in the biosphere,and their impact on human health andwell-being.Papers describing biochemical,pharmacological,pathological,and immunological studies ofpharmaceuticals that might facilitate the interpretation of toxic effects of environmental pollutants are alsowelcome.展开更多
Biomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other fo...Biomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, toxicological and immunological studies of pharmaceuticals （biotechnological products） are also welcome.展开更多
Biomedical and Environmental Sciences, an international journal with special emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and ...Biomedical and Environmental Sciences, an international journal with special emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical. pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport. and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, and immunological studies of展开更多
Biomedical and Environmental Sciences. an international journal with special emphasis on scientific findings in China.publishes articles dealing with biologic and toxic effects of environmental pollutants on man and o...Biomedical and Environmental Sciences. an international journal with special emphasis on scientific findings in China.publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry. transport. and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological. pathological, and immunological studies of Pharmaceuticals that might facilitate the interpretation of toxic effects of environmental pollutants are also welcome.展开更多
Biomedical and Environmental Sciences, an intemational journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other for...Biomedical and Environmental Sciences, an intemational journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, toxicological and immunological studies of pharmaceuticals （biotechnological products） are also welcome.展开更多
Biomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other fo...Biomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing ~ith the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, toxicological and immunological studies of pharmaceuticals （biotechnological products） are also welcome.展开更多
INFORMATION FOR AUTHORSBiomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental polluta...INFORMATION FOR AUTHORSBiomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, toxicological and immunological studies of Pharmaceuticals (biotechnological products) are also welcome.展开更多
Biomedical and Environmental Sciences, an intemational journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other for...Biomedical and Environmental Sciences, an intemational journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, toxicological and immunological studies of pharmaceuticals （biotechnological products） are also welcome.展开更多
Biomedical and Environmental Sciences, an international journal with special emphasis on scientific findings in China. publishes articles dealing with biologic and toxic effects of environmental pollutants on man and ...Biomedical and Environmental Sciences, an international journal with special emphasis on scientific findings in China. publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, and immunological studies of pharmaceuticals that might facilitate the interpretation of toxic effects of environmental pollutants are also展开更多
Biomedical and Environmental Sciences,an international journal with special emphasis on scientificfindings in China,publishes articles dealing with biologic and toxic effects of environmental pollutants onman and othe...Biomedical and Environmental Sciences,an international journal with special emphasis on scientificfindings in China,publishes articles dealing with biologic and toxic effects of environmental pollutants onman and other forms of life.The effects may be measured with pharmacological,biochemical,pathological,and immunological techniques.The journal also publishes reports dealing with the entry,transport,andfate of natural and anthropogenic chemicals in the biosphere,and their impact on human health andwell-being.Papers describing biochemical,pharmacological,pathological,and immunological studies ofpharmaceuticals that might facilitate the interpretation of toxic effects of environmental pollutants are also展开更多
The use of an electrical probe is forned by whispering gallery modes(WGMs)of light within the coated microring circuits,in which the electrical signal is generated by trapped electron tunneling along the circular path...The use of an electrical probe is forned by whispering gallery modes(WGMs)of light within the coated microring circuits,in which the electrical signal is generated by trapped electron tunneling along the circular path of the coa ted microring circuit.The ollection of electrons is formed within the WGMs,where in this study,a modifed nonlinear microring resonator known as a PANDA ring resonator is coated by gold material and forms the mirroring circuit.The induced current(magnetic field)within the circuit occurs by the coupling ffects between trapped electrons and coated ring,which can penetrate into the brain cells and transform to the required signals via the terahertz carier for peychiatric investigations.The use of WGMs for 3D image construction using a PANDA conjugate mirror is also discussed,which is useful for thermal and imaging sensons.展开更多
In this paper, the AC-excited helium discharges generated between the powered needle electrode enclosed in a conical quartz tube and the grounded de-ionized water electrode are investigated. The current and voltage wa...In this paper, the AC-excited helium discharges generated between the powered needle electrode enclosed in a conical quartz tube and the grounded de-ionized water electrode are investigated. The current and voltage waveforms exhibit a transition from the glow-like to streamer-like mode discharges, which forms a stable cone-shaped structure at the gas-liquid interface. In this region, the air and water vapor diffusion initiate various physical-chemical processes leading to substantial changes of the primary species emission intensities （e.g., OH, N2, NO, and O） and the rotational temperatures. The experimentally measured rotational temperature at the gas-liquid interface is 870 K from the Nz（C-B） band with a power input of 26 W. With the prolongation of the discharge time, significant changes in the discharge voltage and current, discharge emission patterns, instantaneous concentrations of the secondary species （e.g., H202, NO2, and NO3） in the liquid phase, pH values and electrical conductivities of the liquids are observed experimentally. The present study is helpful for deepening the understandings to the basic physical-chemical processes in the discharges in contact with liquids, especially to those occurring in the vicinity of the gas-liquid interface, and also for promoting existing and potential applications of such type of discharges in the fields of environmental protection, biomedicine, agriculture, and so on.展开更多
The launch of the World Journal of Nephrology （WJN） has distinct purposes. Its main purpose is to incorporate the fields of diabetes, hypertension, urology, cardiol-ogy and neurology, which are related to kidney di...The launch of the World Journal of Nephrology （WJN） has distinct purposes. Its main purpose is to incorporate the fields of diabetes, hypertension, urology, cardiol-ogy and neurology, which are related to kidney disease, and to make all of our readers, contributors and allied health professionals feel at home with the WJN. The WJN aims to rapidly report new theories, methods and techniques for prevention, diagnosis, treatment, reha-bilitation and nursing skill in the feld of nephrology. The WJN will cover diagnostic imaging, disorders of kidney development, renal obstruction, atrophy and regenera-tion, kidney tumors, renal pharmacology and therapy, renal replacement therapies including transplantation, and Chinese herbal medicine. The WJN issues will in-clude an editorial, frontier, invited review of articles and commentaries in addition to original articles submitted. The WJN will solicit articles from investigators in areas of diabetes and hypertension, and high priority will be given to those articles with an emphasis on the pre-vention of dialysis. Final decision for publication will be based on the merit of the article, language and lucidity.展开更多
Biomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other fo...Biomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, toxicological and immunological studies of pharmaceuticals （biotechnological products） are also welcome.展开更多
Biomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other fo...Biomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life.展开更多
An educational intervention targeting medical students and aiming to develop skills useful to the writing of a health science research protocol over a short period of time has been developed in the Shanghai Jiao Tong ...An educational intervention targeting medical students and aiming to develop skills useful to the writing of a health science research protocol over a short period of time has been developed in the Shanghai Jiao Tong University School of Medicine. The methodology blending the principles of PBL and TBL is detailed and key issues of this implementation are discussed. Twenty-one students were enrolled in a research master degree and participated to three mandatory 180-minutes sessions. Beyond classical skills useful to solve a problem, this new intervention focused on the transformation of knowledge to create an authentic content, which is a feature of the project-based learning(PBL). The training process was designed according to team-based learning(TBL) procedure except that work sharing between groups and pooling resources and outcomes of each group allowed the construction of one final class original research project in the field of respiratory pharmacology. The combination of both learning methods allowed promoting individual and group accountability necessary to improve self-learning and the quality of the final joint project. The peer reviewing was an essential factor in creating the students' motivation and improving of team discussion. The grades individually assigned for skills and quality of the project by an external teacher suggested that key objectives of the intervention were reached. In conclusion, the educational intervention described in this paper appears as an appropriate method to develop specific skills necessary to write and discuss a research project within a research team.Further works are necessary to measure the degree of satisfaction of students and improvement of performance.展开更多
基金supported by the‘‘Strategic Priority Research Program"of the Chinese Academy of Sciences(Grant No.XDA08010304)awarded to JY
文摘The era of Precision Medicine （PM） has entered its execution phase where acquisition of human genome variation data is already leading the charge [1,2]. PM has come a long way to this phase from the Human Genome Project started some 25 years ago [3,4]; it marks the beginning of disease-centric research in the field of biomedical sciences. Other than deliver- ing high-coverage human genomes by millions--of course tai- lored to patients and common diseases--in the next decade or so, what else do we expect to have and what should we be doing to make the best out of PM projects beyond the current expectation of genetics？
文摘INFORMATION FOR AUTHORS Biomedical and Environmental Sciences, an international journal with special emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and
文摘Biomedical and Environmental Sciences,an international journal with special emphasis on scientificfindings in China,publishes articles dealing with biologic and toxic effects of environmental pollutants onman and other forms of life.The effects may be measured with pharmacological,biochemical,pathological,and immunological techniques.The journal also publishes reports dealing with the entry,transport,andfate of natural and anthropogenic chemicals in the biosphere,and their impact on human health andwell-being.Papers describing biochemical,pharmacological,pathological,and immunological studies ofpharmaceuticals that might facilitate the interpretation of toxic effects of environmental pollutants are alsowelcome.
文摘Biomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, toxicological and immunological studies of pharmaceuticals （biotechnological products） are also welcome.
文摘Biomedical and Environmental Sciences, an international journal with special emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical. pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport. and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, and immunological studies of
文摘Biomedical and Environmental Sciences. an international journal with special emphasis on scientific findings in China.publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry. transport. and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological. pathological, and immunological studies of Pharmaceuticals that might facilitate the interpretation of toxic effects of environmental pollutants are also welcome.
文摘Biomedical and Environmental Sciences, an intemational journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, toxicological and immunological studies of pharmaceuticals （biotechnological products） are also welcome.
文摘Biomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing ~ith the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, toxicological and immunological studies of pharmaceuticals （biotechnological products） are also welcome.
文摘INFORMATION FOR AUTHORSBiomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, toxicological and immunological studies of Pharmaceuticals (biotechnological products) are also welcome.
文摘Biomedical and Environmental Sciences, an intemational journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, toxicological and immunological studies of pharmaceuticals （biotechnological products） are also welcome.
文摘Biomedical and Environmental Sciences, an international journal with special emphasis on scientific findings in China. publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, and immunological studies of pharmaceuticals that might facilitate the interpretation of toxic effects of environmental pollutants are also
文摘Biomedical and Environmental Sciences,an international journal with special emphasis on scientificfindings in China,publishes articles dealing with biologic and toxic effects of environmental pollutants onman and other forms of life.The effects may be measured with pharmacological,biochemical,pathological,and immunological techniques.The journal also publishes reports dealing with the entry,transport,andfate of natural and anthropogenic chemicals in the biosphere,and their impact on human health andwell-being.Papers describing biochemical,pharmacological,pathological,and immunological studies ofpharmaceuticals that might facilitate the interpretation of toxic effects of environmental pollutants are also
文摘The use of an electrical probe is forned by whispering gallery modes(WGMs)of light within the coated microring circuits,in which the electrical signal is generated by trapped electron tunneling along the circular path of the coa ted microring circuit.The ollection of electrons is formed within the WGMs,where in this study,a modifed nonlinear microring resonator known as a PANDA ring resonator is coated by gold material and forms the mirroring circuit.The induced current(magnetic field)within the circuit occurs by the coupling ffects between trapped electrons and coated ring,which can penetrate into the brain cells and transform to the required signals via the terahertz carier for peychiatric investigations.The use of WGMs for 3D image construction using a PANDA conjugate mirror is also discussed,which is useful for thermal and imaging sensons.
基金supported by the Major Science and Technology Program for Water Pollution Control and Treatment(No.2014ZX07215-001)partly by National Natural Science Foundation of China(Nos.11475103,51578309)the Chinese Scholarship Council for the financial assistance of my PhD program in Tsinghua University of China
文摘In this paper, the AC-excited helium discharges generated between the powered needle electrode enclosed in a conical quartz tube and the grounded de-ionized water electrode are investigated. The current and voltage waveforms exhibit a transition from the glow-like to streamer-like mode discharges, which forms a stable cone-shaped structure at the gas-liquid interface. In this region, the air and water vapor diffusion initiate various physical-chemical processes leading to substantial changes of the primary species emission intensities （e.g., OH, N2, NO, and O） and the rotational temperatures. The experimentally measured rotational temperature at the gas-liquid interface is 870 K from the Nz（C-B） band with a power input of 26 W. With the prolongation of the discharge time, significant changes in the discharge voltage and current, discharge emission patterns, instantaneous concentrations of the secondary species （e.g., H202, NO2, and NO3） in the liquid phase, pH values and electrical conductivities of the liquids are observed experimentally. The present study is helpful for deepening the understandings to the basic physical-chemical processes in the discharges in contact with liquids, especially to those occurring in the vicinity of the gas-liquid interface, and also for promoting existing and potential applications of such type of discharges in the fields of environmental protection, biomedicine, agriculture, and so on.
文摘The launch of the World Journal of Nephrology （WJN） has distinct purposes. Its main purpose is to incorporate the fields of diabetes, hypertension, urology, cardiol-ogy and neurology, which are related to kidney disease, and to make all of our readers, contributors and allied health professionals feel at home with the WJN. The WJN aims to rapidly report new theories, methods and techniques for prevention, diagnosis, treatment, reha-bilitation and nursing skill in the feld of nephrology. The WJN will cover diagnostic imaging, disorders of kidney development, renal obstruction, atrophy and regenera-tion, kidney tumors, renal pharmacology and therapy, renal replacement therapies including transplantation, and Chinese herbal medicine. The WJN issues will in-clude an editorial, frontier, invited review of articles and commentaries in addition to original articles submitted. The WJN will solicit articles from investigators in areas of diabetes and hypertension, and high priority will be given to those articles with an emphasis on the pre-vention of dialysis. Final decision for publication will be based on the merit of the article, language and lucidity.
文摘Biomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being. Papers describing biochemical, pharmacological, pathological, toxicological and immunological studies of pharmaceuticals （biotechnological products） are also welcome.
文摘Biomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life.
文摘An educational intervention targeting medical students and aiming to develop skills useful to the writing of a health science research protocol over a short period of time has been developed in the Shanghai Jiao Tong University School of Medicine. The methodology blending the principles of PBL and TBL is detailed and key issues of this implementation are discussed. Twenty-one students were enrolled in a research master degree and participated to three mandatory 180-minutes sessions. Beyond classical skills useful to solve a problem, this new intervention focused on the transformation of knowledge to create an authentic content, which is a feature of the project-based learning(PBL). The training process was designed according to team-based learning(TBL) procedure except that work sharing between groups and pooling resources and outcomes of each group allowed the construction of one final class original research project in the field of respiratory pharmacology. The combination of both learning methods allowed promoting individual and group accountability necessary to improve self-learning and the quality of the final joint project. The peer reviewing was an essential factor in creating the students' motivation and improving of team discussion. The grades individually assigned for skills and quality of the project by an external teacher suggested that key objectives of the intervention were reached. In conclusion, the educational intervention described in this paper appears as an appropriate method to develop specific skills necessary to write and discuss a research project within a research team.Further works are necessary to measure the degree of satisfaction of students and improvement of performance.
