<p> Lopinavir is an antiretroviral of the protease inhibitor class (Figure 1 <span style="display:none;" id="__kindeditor_bookmark_end_3__"></span>and Figure 2). It is used agains...<p> Lopinavir is an antiretroviral of the protease inhibitor class (Figure 1 <span style="display:none;" id="__kindeditor_bookmark_end_3__"></span>and Figure 2). It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir). In the current research, the stimulated ATR-FTIR biospectroscopy of liquid sample of Lopinavir was investigated. The stimulated ATR-FTIR diffractions emitted through focusing the second harmonic laser beam Nd:YAG into the sample were recorded by Echelle spectrometer and ICCD detector. Increasing the energy of laser beam from 2.6 (mJ) to 16 (mJ) led to increase in stimulated ATR-FTIR signal but after breakdown threshold of liquid sample, further increasing energy led to the decrease in stimulating ATR-FTIR signals and for energies higher than 20 (mJ), they were disappeared. </p>展开更多
We developed a novel method for real-time monitoring of alteration of the local epithelium vessel/capillary and blood oxygenation spatial pattern in epithelium exploiting a compact fibre sensor system based on spatial...We developed a novel method for real-time monitoring of alteration of the local epithelium vessel/capillary and blood oxygenation spatial pattern in epithelium exploiting a compact fibre sensor system based on spatially and spectrally resolved diffuse reflectance.The method is based on collection of spatially resolved diffuse reflectance Re(λ)by fiber sensors.The spatial resolution is provided as a dependence of Re(λ)on a set of distancesρbetween the source and detector(attenuation curve).It is expected that the new method can reasonably extract the minor spatial deviations of oxygenation and local blood volume fraction-parameters,directly related to the local vessel density and capillary spatial patterns in the epithelium.Light scattering in visible range is naturally taken into account in the proposed method.展开更多
文摘<p> Lopinavir is an antiretroviral of the protease inhibitor class (Figure 1 <span style="display:none;" id="__kindeditor_bookmark_end_3__"></span>and Figure 2). It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir). In the current research, the stimulated ATR-FTIR biospectroscopy of liquid sample of Lopinavir was investigated. The stimulated ATR-FTIR diffractions emitted through focusing the second harmonic laser beam Nd:YAG into the sample were recorded by Echelle spectrometer and ICCD detector. Increasing the energy of laser beam from 2.6 (mJ) to 16 (mJ) led to increase in stimulated ATR-FTIR signal but after breakdown threshold of liquid sample, further increasing energy led to the decrease in stimulating ATR-FTIR signals and for energies higher than 20 (mJ), they were disappeared. </p>
基金The authors gratefully acknowledge funding of the Erlangen Graduate School in Advanced Optical Technologies(SAOT)by the German National Science Foundation(DFG)in the framework of the excellence initiative for support of this study.
文摘We developed a novel method for real-time monitoring of alteration of the local epithelium vessel/capillary and blood oxygenation spatial pattern in epithelium exploiting a compact fibre sensor system based on spatially and spectrally resolved diffuse reflectance.The method is based on collection of spatially resolved diffuse reflectance Re(λ)by fiber sensors.The spatial resolution is provided as a dependence of Re(λ)on a set of distancesρbetween the source and detector(attenuation curve).It is expected that the new method can reasonably extract the minor spatial deviations of oxygenation and local blood volume fraction-parameters,directly related to the local vessel density and capillary spatial patterns in the epithelium.Light scattering in visible range is naturally taken into account in the proposed method.