Six new meroterpe no ids,bipolarinoids A-F(1-6),and two known congen ers(7-8)were isolated from a soil-derived fungus Bipolaris zeicola.Their structures were elucidated based on extensive spectroscopic techniques(inel...Six new meroterpe no ids,bipolarinoids A-F(1-6),and two known congen ers(7-8)were isolated from a soil-derived fungus Bipolaris zeicola.Their structures were elucidated based on extensive spectroscopic techniques(ineluding HRESIMS and ID and 2D NMR data),and the absolute configurations of 1-4 were further confirmed viasingle-crystal X-ray diffraction an alysis and comparis on of experimental electronic circular dichroism(ECD)data.Structurally,compound 1 represents the first case of cochlioquinone derivatives featuring a formaldehyde group at C-11, and compou nd 3 features a rareamino group at C-11.In the immunosuppressive activity assay,compounds 5-8 showed potent inhibitory activity against concanavalin A(ConA)-induced T lymphocyte proliferation with IC50 values of 78.3,81.1,48.3,and 48.0 nmol/L,respectively,which provided promising leads for designing and developing new im-muno suppressive agents to treat auto-immunological diseases.展开更多
基金supported by the National Natural Science Foundation of China(Nos.81573316 and 32000045)the National Science Fund for Distinguished Young Scholars(No.81725021)+2 种基金the Innovative Research Groups of the National Natural Science Foundation of China(No.81721005)the Tongji-Rongcheng Center for Biomedici ne,Huazhong University of Science and Technology(No.0231514141)the Research and Development Program of Hubei Provinee(No.2020BCA058).
文摘Six new meroterpe no ids,bipolarinoids A-F(1-6),and two known congen ers(7-8)were isolated from a soil-derived fungus Bipolaris zeicola.Their structures were elucidated based on extensive spectroscopic techniques(ineluding HRESIMS and ID and 2D NMR data),and the absolute configurations of 1-4 were further confirmed viasingle-crystal X-ray diffraction an alysis and comparis on of experimental electronic circular dichroism(ECD)data.Structurally,compound 1 represents the first case of cochlioquinone derivatives featuring a formaldehyde group at C-11, and compou nd 3 features a rareamino group at C-11.In the immunosuppressive activity assay,compounds 5-8 showed potent inhibitory activity against concanavalin A(ConA)-induced T lymphocyte proliferation with IC50 values of 78.3,81.1,48.3,and 48.0 nmol/L,respectively,which provided promising leads for designing and developing new im-muno suppressive agents to treat auto-immunological diseases.
