Heterogeneous catalyst aluminium oxide(acidic) is found to be an effective catalyst for the solvent-free condensation reaction of indole with aldehydes in microwave irradiation with shorter reaction time and higher yi...Heterogeneous catalyst aluminium oxide(acidic) is found to be an effective catalyst for the solvent-free condensation reaction of indole with aldehydes in microwave irradiation with shorter reaction time and higher yields.展开更多
Benzyltriphenylphosphonium tribromide（BTPTB） has been applied as an efficient catalyst for the preparation of bis（indolyl）-methanes （BIMs） via electrophilic substitution of indoles with aldehydes in the absence ...Benzyltriphenylphosphonium tribromide（BTPTB） has been applied as an efficient catalyst for the preparation of bis（indolyl）-methanes （BIMs） via electrophilic substitution of indoles with aldehydes in the absence of solvent.展开更多
A clean and efficient method for the synthesis of bis（indolyl）alkanes with antimony trichloride（SbCl3） as the catalyst under solvent-free grinding conditions is described. This method provides several advantages, ...A clean and efficient method for the synthesis of bis（indolyl）alkanes with antimony trichloride（SbCl3） as the catalyst under solvent-free grinding conditions is described. This method provides several advantages, such as simple work-up procedure, neutral conditions and high yields.展开更多
A simple, efficient, and environment benign route was developed for the preparation of bis-（indolyl）methanes and 14-aryl-14H- dibenzo[aj]xanthenes from condensation of various aromatic aldehydes or ketones with indo...A simple, efficient, and environment benign route was developed for the preparation of bis-（indolyl）methanes and 14-aryl-14H- dibenzo[aj]xanthenes from condensation of various aromatic aldehydes or ketones with indole, and 2-naphthol, respectively, using oxalic acid catalyst in aqueous medium. Use of cheap and easily available catalyst, better yields and simple reaction protocol are the advantages of the present method.展开更多
n-Dodecylbenzene sulfonic acid (DBSA) as a novel, biodegradable, and efficient Br?nsted acid catalyst used for the reaction of indoles/4-hydroxy coumarin with aldehydes to obtain a bis(indolyl)methanes/bis(4-hydroxyco...n-Dodecylbenzene sulfonic acid (DBSA) as a novel, biodegradable, and efficient Br?nsted acid catalyst used for the reaction of indoles/4-hydroxy coumarin with aldehydes to obtain a bis(indolyl)methanes/bis(4-hydroxycoumarin-3-yl)methanes, respectively. The catalyst exhibited remarkable activity, and tolerated a wide variety of functional groups providing the desired bis(indolyl)methanes and bis(4-hydroxycoumarin-3-yl)methanes in good to excellent yield (70%-96%) in water.展开更多
Efficient electrophilic substitution reaction of indoles with various aromatic aldehydes were carried out with a catalytic amount of sodium hydrogensulfate monohydrate （NaHSO4·H20） in ionic liquid n-butylpyridi...Efficient electrophilic substitution reaction of indoles with various aromatic aldehydes were carried out with a catalytic amount of sodium hydrogensulfate monohydrate （NaHSO4·H20） in ionic liquid n-butylpyridinium tetrafluoroborate （[Bpy]BF4） to afford the corresponding bi（indolyl）methanes in excellent yields. The notable advantages of this protocol in terms of low cost of catalyst and ionic liquid, mild conditions, simple operation, short reaction time, high yields and recycling of the ionic liquid.展开更多
t-BuOK-promoted synthesis of bis（indolyl）arylmethunes from aromatic aldehydes and indoles wasachieved. Substrates bearing different functional groups, especially groups which are sensitive to acidic media, arewell t...t-BuOK-promoted synthesis of bis（indolyl）arylmethunes from aromatic aldehydes and indoles wasachieved. Substrates bearing different functional groups, especially groups which are sensitive to acidic media, arewell tolerated under the optimal condition, making this reaction particularly attractive for expanding the scope of thepresent protocols that provides bis（1H-indol-3-yl）arylmethanes.展开更多
Practical BF3.Et20 catalyzed reactions between indoles and a series of carbonyl compounds at room temperature are described, which afford bis（indolyl）methanes with isolated yields up to 96%,
文摘Heterogeneous catalyst aluminium oxide(acidic) is found to be an effective catalyst for the solvent-free condensation reaction of indole with aldehydes in microwave irradiation with shorter reaction time and higher yields.
文摘Benzyltriphenylphosphonium tribromide（BTPTB） has been applied as an efficient catalyst for the preparation of bis（indolyl）-methanes （BIMs） via electrophilic substitution of indoles with aldehydes in the absence of solvent.
基金Supported by the Natural Science Foundation of Shandong Province,China(No.Y2008B33)
文摘A clean and efficient method for the synthesis of bis（indolyl）alkanes with antimony trichloride（SbCl3） as the catalyst under solvent-free grinding conditions is described. This method provides several advantages, such as simple work-up procedure, neutral conditions and high yields.
文摘A simple, efficient, and environment benign route was developed for the preparation of bis-（indolyl）methanes and 14-aryl-14H- dibenzo[aj]xanthenes from condensation of various aromatic aldehydes or ketones with indole, and 2-naphthol, respectively, using oxalic acid catalyst in aqueous medium. Use of cheap and easily available catalyst, better yields and simple reaction protocol are the advantages of the present method.
文摘n-Dodecylbenzene sulfonic acid (DBSA) as a novel, biodegradable, and efficient Br?nsted acid catalyst used for the reaction of indoles/4-hydroxy coumarin with aldehydes to obtain a bis(indolyl)methanes/bis(4-hydroxycoumarin-3-yl)methanes, respectively. The catalyst exhibited remarkable activity, and tolerated a wide variety of functional groups providing the desired bis(indolyl)methanes and bis(4-hydroxycoumarin-3-yl)methanes in good to excellent yield (70%-96%) in water.
基金The project was supported by the National Natural Science Foundation of China （No. 20272018） the Guangdong Natural Science Foundation （No. 04010458, 021166）.
文摘Efficient electrophilic substitution reaction of indoles with various aromatic aldehydes were carried out with a catalytic amount of sodium hydrogensulfate monohydrate （NaHSO4·H20） in ionic liquid n-butylpyridinium tetrafluoroborate （[Bpy]BF4） to afford the corresponding bi（indolyl）methanes in excellent yields. The notable advantages of this protocol in terms of low cost of catalyst and ionic liquid, mild conditions, simple operation, short reaction time, high yields and recycling of the ionic liquid.
文摘t-BuOK-promoted synthesis of bis（indolyl）arylmethunes from aromatic aldehydes and indoles wasachieved. Substrates bearing different functional groups, especially groups which are sensitive to acidic media, arewell tolerated under the optimal condition, making this reaction particularly attractive for expanding the scope of thepresent protocols that provides bis（1H-indol-3-yl）arylmethanes.
基金fundings from the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, Partenariats Hubert Curien Xu Guangqi 2012 (No. 27967RE)Fundamental Research Funds for the Central Universities (Nos. CDJRC10220004 and CDJZR11220005)Natural Science Foundation Project of CQ CSTC (Nos. 2010BB5064 and cstc2013jcyjA0217) for financial support
文摘Practical BF3.Et20 catalyzed reactions between indoles and a series of carbonyl compounds at room temperature are described, which afford bis（indolyl）methanes with isolated yields up to 96%,
