目的在上海市闵行区高血压人群中,探究年龄和体重指数(body mass index,BMI)对癌症发生的共同作用。方法研究对象为2007—2015年进入上海市闵行区电子健康信息系统的未患癌症的212394名高血压患者。将年龄、BMI以平滑函数形式纳入广义加...目的在上海市闵行区高血压人群中,探究年龄和体重指数(body mass index,BMI)对癌症发生的共同作用。方法研究对象为2007—2015年进入上海市闵行区电子健康信息系统的未患癌症的212394名高血压患者。将年龄、BMI以平滑函数形式纳入广义加性Cox比例风险模型,用双变量响应模型构建曲面图使结果可视化,全面分析两者对癌症发生的联合效应。结果截至2018年12月31日,累计22141名高血压患者新发癌症。年龄与癌症发生风险整体呈线性趋势,而BMI与癌症发生风险整体呈“U”型,BMI在26 kg/m^(2)左右时癌症发生风险最低。不同BMI下,随着年龄增大,癌症发生风险均增加;不同年龄下,BMI与癌症发生风险的关联不同:青年人群(20~44岁)中BMI与癌症发生风险无明显关联,中老年人群(≥45岁)中BMI与癌症发生风险呈“U”型关联,BMI在26 kg/m^(2)左右时癌症发生风险最低。结论建议高血压人群控制BMI在合理范围内,特别是中老年人群,以减少癌症发生。展开更多
目的应用双变量响应模型分析高血压人群中体质指数(body mass index,BMI)和年龄两个因素对心血管死亡(cardiovascular death,CVD)的共同作用。方法使用上海市闵行区2007-2015年高血压患者随访数据,建立可加COX比例风险模型,分析BMI、年...目的应用双变量响应模型分析高血压人群中体质指数(body mass index,BMI)和年龄两个因素对心血管死亡(cardiovascular death,CVD)的共同作用。方法使用上海市闵行区2007-2015年高血压患者随访数据,建立可加COX比例风险模型,分析BMI、年龄与CVD之间的非线性关联以及两变量的共同作用。结果BMI、年龄与CVD的关联分别呈“U”型和“J”型。不同年龄,BMI对CVD的影响略有差异。青年和老年群体的死亡风险随BMI的增加而降低,中年群体的死亡风险与BMI的关联略微呈“U”型。结论双变量响应模型是一种全面了解两变量共同作用的有效的方法。展开更多
China’s 13 th 5-year forestry plan explicitly requires the end of commercial harvesting and the improved management of natural forests by means of adjusting and optimizing forest structure and developing high-quality...China’s 13 th 5-year forestry plan explicitly requires the end of commercial harvesting and the improved management of natural forests by means of adjusting and optimizing forest structure and developing high-quality forest production.This requires the quantification of stand structure and species diversity.In this study,species distribution,association and size differentiation in a mixed broad-leaved/Korean pine(Pinus koraiensis Siebold&Zucc.)forest in Mudanfeng National Nature Reserve were analyzed using three spatial structure indices:uniform angle index,complete mingling index,and size differentiation index.The results show that the species were randomly distributed,with a moderate size differentiation and high mixed structure.Three dominant species exhibited different patterns in terms of the three indices and their bivariate distribution.Overall,Korean pine showed an opposite trend to Manchurian maple(Acer mandshuricum Maxim.),whereas the distribution pattern of Manchurian linden(Tilia mandshurica Rupr.&Maxim.)was similar to that of the entire stand.Our work contributes to further the knowledge of population structure in order to optimize the structure of secondary forests and plantations.展开更多
文摘目的在上海市闵行区高血压人群中,探究年龄和体重指数(body mass index,BMI)对癌症发生的共同作用。方法研究对象为2007—2015年进入上海市闵行区电子健康信息系统的未患癌症的212394名高血压患者。将年龄、BMI以平滑函数形式纳入广义加性Cox比例风险模型,用双变量响应模型构建曲面图使结果可视化,全面分析两者对癌症发生的联合效应。结果截至2018年12月31日,累计22141名高血压患者新发癌症。年龄与癌症发生风险整体呈线性趋势,而BMI与癌症发生风险整体呈“U”型,BMI在26 kg/m^(2)左右时癌症发生风险最低。不同BMI下,随着年龄增大,癌症发生风险均增加;不同年龄下,BMI与癌症发生风险的关联不同:青年人群(20~44岁)中BMI与癌症发生风险无明显关联,中老年人群(≥45岁)中BMI与癌症发生风险呈“U”型关联,BMI在26 kg/m^(2)左右时癌症发生风险最低。结论建议高血压人群控制BMI在合理范围内,特别是中老年人群,以减少癌症发生。
文摘目的应用双变量响应模型分析高血压人群中体质指数(body mass index,BMI)和年龄两个因素对心血管死亡(cardiovascular death,CVD)的共同作用。方法使用上海市闵行区2007-2015年高血压患者随访数据,建立可加COX比例风险模型,分析BMI、年龄与CVD之间的非线性关联以及两变量的共同作用。结果BMI、年龄与CVD的关联分别呈“U”型和“J”型。不同年龄,BMI对CVD的影响略有差异。青年和老年群体的死亡风险随BMI的增加而降低,中年群体的死亡风险与BMI的关联略微呈“U”型。结论双变量响应模型是一种全面了解两变量共同作用的有效的方法。
基金financially supported by the National Key R&D Program of China(2018YFC0507302-2)the CFERN and BEIJING TECHNO SOLUTIONS Award Funds for excellent academic achievement
文摘China’s 13 th 5-year forestry plan explicitly requires the end of commercial harvesting and the improved management of natural forests by means of adjusting and optimizing forest structure and developing high-quality forest production.This requires the quantification of stand structure and species diversity.In this study,species distribution,association and size differentiation in a mixed broad-leaved/Korean pine(Pinus koraiensis Siebold&Zucc.)forest in Mudanfeng National Nature Reserve were analyzed using three spatial structure indices:uniform angle index,complete mingling index,and size differentiation index.The results show that the species were randomly distributed,with a moderate size differentiation and high mixed structure.Three dominant species exhibited different patterns in terms of the three indices and their bivariate distribution.Overall,Korean pine showed an opposite trend to Manchurian maple(Acer mandshuricum Maxim.),whereas the distribution pattern of Manchurian linden(Tilia mandshurica Rupr.&Maxim.)was similar to that of the entire stand.Our work contributes to further the knowledge of population structure in order to optimize the structure of secondary forests and plantations.
