Background: Ecologists are interested in assessing the spatial and temporal variation in ecological surveys repeated over time. This paper compares the 1985 and 2015 surveys of the Barro Colorado Forest Dynamics plot(...Background: Ecologists are interested in assessing the spatial and temporal variation in ecological surveys repeated over time. This paper compares the 1985 and 2015 surveys of the Barro Colorado Forest Dynamics plot(BCI), Panama,divided into 1250(20 m × 20 m) quadrats.Methods, spatial analysis: Total beta diversity was measured as the total variance of the Hellinger-transformed community data throughout the BCI plot. Total beta was partitioned into contributions of individual sites(LCBD indices), which were tested for significance and mapped.Results, spatial analysis: LCBD indices indicated the sites with exceptional community composition. In 1985,they were mostly found in the swamp habitat. In the 2015 survey, none of the swamp quadrats had significant LCBDs.What happened to the tree community in the interval?Methods, temporal analysis: The dissimilarity in community composition in each quadrat was measured between time 1(1985) and time 2(2015). Temporal Beta Indices(TBI) were computed from abundance and presence-absence data and tested for significance. TBI indices can be decomposed into B = species(or abundances-per-species) losses and C = species(or abundances-per-species) gains. B-C plots were produced; they display visually the relative importance of the loss and gain components, through time, across the sites.Results, temporal analysis: In BCI, quadrats with significant TBI indices were found in the swamp area, which is shrinking in importance due to changes to the local climate. A published habitat classification divided the BCI forest plot into six habitat zones. Graphs of the B and C components were produced for each habitat group. Group 4(the swamp) was dominated by species(and abundances-per-species) gains whereas the five other habitat groups were dominated by losses, some groups more than others.Conclusions: We identified the species that had changed the most in abundances in the swamp between T1 and T2.This analysis supported the hypothesis that the swamp is drying out and is invaded by species from the surrounding area. Analysis of the B and C components of temporal beta diversity bring us to the heart of the mechanisms of community change through time: losses(B) and gains(C) of species, losses and gains of individuals of various species. TBI analysis is especially interesting in species-rich communities where we cannot examine the changes in every species individually.展开更多
Lipopeptides are currently re-emerging as an interesting subgroup in the peptide research field, having historical applications as antibacterial and antifungal agents and new potential applications as antiviral, antit...Lipopeptides are currently re-emerging as an interesting subgroup in the peptide research field, having historical applications as antibacterial and antifungal agents and new potential applications as antiviral, antitumor, immune-modulating and cell-penetrating compounds. However, due to their specific structure, chromatographic analysis often requires special buffer systems or the use of trifluoroacetic acid, limiting mass spectrometry detection. Therefore, we used a traditional aqueous/acetonitrile based gradient system, containing 0.1% (m/v) formic acid, to separate four pharmaceutically relevant lipopeptides (polymyxin B1, caspofungin, daptomycin and gramicidin A1), which were selected based upon hierarchical cluster analysis (HCA) and principal component analysis (PCA).In total, the performance of four different C18 columns, including one UPLC column, were evaluated using two parallel approaches. First, a Derringer desirability function was used, whereby six single and multiple chromatographic response values were rescaled into one overall D-value per column. Using this approach, the YMC Pack Pro C18 column was ranked as the best column for general MS-compatible lipopeptide separation. Secondly, the kinetic plot approach was used to compare the different columns at different flow rate ranges. As the optimal kinetic column performance is obtained at its maximal pressure, the length elongation factor λ(Pmax/Pexp) was used to transform the obtained experimental data (retention times and peak capacities) and construct kinetic performance limit (KPL) curves, allowing a direct visual and unbiased comparison of the selected columns, whereby the YMC Triart C18 UPLC and ACE C18 columns performed as best. Finally, differences in column performance and the (dis)advantages of both approaches are discussed.展开更多
Although many sensitivity analyses using the soil and water assessment tool(SWAT) in a complex watershed have been conducted, little attention has been paid to the application potential of the model in unique plots. I...Although many sensitivity analyses using the soil and water assessment tool(SWAT) in a complex watershed have been conducted, little attention has been paid to the application potential of the model in unique plots. In addition, sensitivity analysis of percolation and evapotranspiration with SWAT has seldom been undertaken. In this study, SWAT99.2 was calibrated to simulate water balance components for unique plots in Southern China from 2000 to 2001, which included surface runoff, percolation, and evapotranspiration. Twenty-one parameters classified into four categories, including meteorological conditions, topographical characteristics, soil properties, and vegetation attributes, were used for sensitivity analysis through one-at-a-time(OAT) sampling to identify the factor that contributed most to the variance in water balance components. The results were shown to be different for different plots, with parameter sensitivity indices and ranks varying for different water balance components. Water balance components in the broad-leaved forest and natural grass plots were most sensitive to meteorological conditions, less sensitive to vegetation attributes and soil properties, and least sensitive to topographical characteristics. Compared to those in the natural grass plot, water balance components in the broad-leaved forest plot demonstrated higher sensitivity to the maximum stomatal conductance(GSI) and maximum leaf area index(BLAI).展开更多
In order to study the dynamics of uneven-aged stands of interior Douglas-fir, Pseudotsuga menzesii var.glouca (Mirb.) Franco in future, six permanent sample plots wer set up on the Knife Creek Block of the Alex Fraser...In order to study the dynamics of uneven-aged stands of interior Douglas-fir, Pseudotsuga menzesii var.glouca (Mirb.) Franco in future, six permanent sample plots wer set up on the Knife Creek Block of the Alex Fraser Researh Forcst of University of British Columbia. The measurements and observations for all living trees within theboundaries of a plot wer madc, including DBH(diameter at breast height), TTH(total tree height), height to lowest livingbranch, crown diameter, tree vigor, angle of lean, distance of lean, direction of lean and tree location. Based on the data,some stand characteristics of the plots were analyzed simply and preliminarily. Results showed that most of the interiortrees on the plots are ranged 10-20 cm in distribution of DBH class, and 2-6 m in distribution of rm class. Trees withdifferent fors, however, are distributed unevenly. The relationship between total tree height and diameter at breast heightfollows a quadratic distribution, Y=a+bX+cX2.展开更多
Aquifer test methods have greatly improved in recent years with the advent of inverse analysis, derivative analysis, and diagnostic plots. Updated analyses of past aquifer tests allow for improved interpretations of t...Aquifer test methods have greatly improved in recent years with the advent of inverse analysis, derivative analysis, and diagnostic plots. Updated analyses of past aquifer tests allow for improved interpretations of the data to enhance the knowledge and the predictive capabilities of the flow system. This work thoroughly reanalyzes a series of pre- and post-hydraulic fracturing, single-well aquifer tests conducted in two crystalline rock wells in New Hampshire as part of an early 1970’s study. Previous analyses of the data had relied on older manual type-curve methods for predicting the possible effects of hydraulic fracturing. This work applies inverse analysis, derivative analysis, and diagnostic plots to reanalyze the 1970’s aquifer test data. Our results demonstrate that the aquifer tests were affected by changes in flow regimes, dewatering of the aquifer and discrete fractures, and changes due to well development. Increases in transmissivities are related to well development prior to hydraulic fracturing, propagation of a single, vertical fracture hydraulically connecting the two wells after stimulation and expansion of troughs of depression. After hydraulic fracturing, the estimated total yield of the individual wells increased by 2.5 times due to the hydraulic fracturing. However, the wells may be receiving water from the same source, and well interference may affect any significant increase in their combined yield. Our analyses demonstrate the value in applying inverse analysis, derivative analysis, and diagnostic plots over the conventional method of manual type-curve analysis. In addition, our improvement in the aquifer test interpretation of the 1970’s test data has implications for more reliable estimates of sustained well yields.展开更多
The use of Recurrence plots have been extensively used in various fields. In this work, Recurrence Plots (RPs) investigates the changes in the non-linear behaviour of urban air pollution using large datasets of raw da...The use of Recurrence plots have been extensively used in various fields. In this work, Recurrence Plots (RPs) investigates the changes in the non-linear behaviour of urban air pollution using large datasets of raw data (hourly). This analysis has not been used before to extract information from large datasets for this type non-linear problem. Two different approaches have been used to tackle this problem. The first approach is to show results according to monitoring network. The second approach is to show the results by particle type. This analysis shows the feasibility of using Recurrence Analysis for pollution monitoring and control.展开更多
Throughout Oscar Wilde’s farcical comedy,The Importance of Being Ernest,there are two story lines.The lines are both independent to each other,but are connected with each other.With the author’s thoughtful arrangeme...Throughout Oscar Wilde’s farcical comedy,The Importance of Being Ernest,there are two story lines.The lines are both independent to each other,but are connected with each other.With the author’s thoughtful arrangement and distinctive technology,the two lines push the development of plot;intensify the depth of conflict and make the structure complete.It seems the author told us a story,but indeed it gives us a lot of inspiration and education.展开更多
Objectives: Recent reports on venous blood gas analysis have shown that venous bicarbonate concentration is useful in the evaluation of the body acid-base status. Most of these reports have been based on the Bland-Alt...Objectives: Recent reports on venous blood gas analysis have shown that venous bicarbonate concentration is useful in the evaluation of the body acid-base status. Most of these reports have been based on the Bland-Altman analysis comparing arterial and venous blood gas values. We intended to elucidate any factors that decrease the agreement between venous and arterial bicarbonate concentrations, which might impair the usefulness of venous blood gas analysis. Methods: Healthy volunteers and patients with various diseases (n = 141) were evaluated by simultaneous arterial and venous blood sampling and Bland-Altman analysis. The venous-arterial bicarbonate concentration difference was compared between healthy volunteers and untreated respiratory alkalosis patients. Intentional hyperventilation (30 or 60 breaths/min, for 3 min) was also performed on 6 healthy volunteers and the venous-arterial bicarbonate concentration difference was evaluated. Results: The relative average bias in bicarbonate concentration was 2.00 mEq/l with venous bicarbonate higher than arterial bicarbonate with 95% limits of agreement of ±4.15 mEq/l. Hyperventilation challenges increased the venous-arterial bicarbonate concentration difference in an intensity-dependent manner. The venous-arterial bicarbonate concentration difference was higher in untreated respiratory alkalosis patients than in healthy volunteers (P Conclusion: Although venous bicarbonate may be useful to evaluate the body acid-base status, hyperventilation increases the venous-arterial bicarbonate concentration difference. Physicians should keep this phenomenon in mind.展开更多
Survival studies mainly deal with distribution of time to event. Often in such studies researchers are interested in comparing several treatment or prognostic groups. At the time of analysis, there is an unmeasured ch...Survival studies mainly deal with distribution of time to event. Often in such studies researchers are interested in comparing several treatment or prognostic groups. At the time of analysis, there is an unmeasured chance of making type I error, or finding a falsely significant difference between any two groups. The chance of making type I error is increased, if multiple groups are compared simultaneously. In this paper, survival analysis with Bonferroni correction is explained in easy way to cope up with this issue. The DLHS-3 data are taken to explain this methodology in the context of neonatal survival. Kaplan-meier plot with three survival comparison test is used to elaborate the application of Bonferroni correction.展开更多
The objectives of the study were as follows: 1) to evaluate the GxExM for wheat genotypes;2) to predict yield performance and identify high stable wheat genotypes in different management practices;and 3) to make genot...The objectives of the study were as follows: 1) to evaluate the GxExM for wheat genotypes;2) to predict yield performance and identify high stable wheat genotypes in different management practices;and 3) to make genotype-specific management and high performing genotype recommendations within and across agro-ecological regions. A diverse set of twenty-one genotypes was evaluated over three years (2012, 2013 and 2014) under two levels of crop management practices (CT and ZT) across three agro-ecological regions (BR, MP and PB) of India in replicated trials. Data were analyzed with SASGxE and RGxE programs using SAS and R programming languages, respectively. Across and within a location(s), the pattern of GxExM and GxMxY interactions (respectively) among univariate and multivariate stability statistics, grouping of genotypes in divisive clusters and estimates (with a prediction interval) of genotype varied in management practice CT and ZT. Across locations, the genotypes “Munal” and “HD-2967” were the best performers and high stable in CT and ZT, respectively. Genotypes “HD-2824” and “DPW-621-50”, and “Munal” may serve as diverse parents for developing high quality, climate smart, locally adapted genotypes for BR in CT and ZT, respectively. Genotypes “HD-2932”, “BAZ” and “JW-3288”, and “GW-322” and “HD-2967” are suitable for developing locally adapted stress tolerant genotypes for MP in management practices CT and ZT, respectively. Relatively small GxM and GxExM interactions in PB preclude in making definitive conclusions.展开更多
In this paper, we are interested to find the most sensitive parameter, local and global stability of ovarian tumor growth model. For sensitivity analysis, we use Latin Hypercube Sampling (LHS) method to generate sampl...In this paper, we are interested to find the most sensitive parameter, local and global stability of ovarian tumor growth model. For sensitivity analysis, we use Latin Hypercube Sampling (LHS) method to generate sample points and Partial Rank Correlation Coefficient (PRCC) method, uses those sample points to find out which parameters are important for the model. Based on our findings, we suggest some treatment strategies. We investigate the sensitivity of the parameters for tumor volume, <em>y</em>, cell nutrient density, <em>Q</em> and maximum tumor size, <em>ymax</em>. We also use Scatter Plot method using LHS samples to show the consistency of the results obtained by using PRCC. Moreover, we discuss the qualitative analysis of ovarian tumor growth model investigating the local and global stability.展开更多
This paper describes a novel approach to explore a multidimensional design space and guide multi-actor decision making in the design of sustainable buildings.The aim is to provide proactive and holistic guidance of th...This paper describes a novel approach to explore a multidimensional design space and guide multi-actor decision making in the design of sustainable buildings.The aim is to provide proactive and holistic guidance of the design team.We propose to perform exhaustive Monte Carlo simulations in an iterative design approach that consists of tw o steps:1) preparation by the modeler,and 2) a multi-collaborator meeting.In the preparation phase,the simulation modeler performs Morris sensitivity analysis to fixate insignificant model inputs and to identify non-linearity and interaction effects.Next,a representation of the global design space is obtained from thousands of simulations using low-discrepancysequences(LPτ) for sampling.From these simulations,the modeler constructs fast metamodels and performs quantitative sensitivity analysis.During the meeting,the design team explores the global design space by filtering the thousands of simulations.Variable filter criteria are easily applied using an interactive parallel coordinate plot w hich provide immediate feedback on requirements and design choices.Sensitivity measures and metamodels show the combined effects of changing a single input and how to remedy unw anted output changes.The proposed methodology has been developed and tested through real building cases using a normative model to assess energy demand,thermal comfort,and daylight.展开更多
基金support of the U.S. National Science Foundation (awards 8206992, 8906869, 9405933, 9909947, 0948585 to S.P. Hubbell)the John D. and Catherine D. McArthur Foundation+1 种基金the Smithsonian Tropical Research Institutesupported by research grant #7738 from the Natural Sciences and Engineering Research Council of Canada (NSERC) to P. Legendre
文摘Background: Ecologists are interested in assessing the spatial and temporal variation in ecological surveys repeated over time. This paper compares the 1985 and 2015 surveys of the Barro Colorado Forest Dynamics plot(BCI), Panama,divided into 1250(20 m × 20 m) quadrats.Methods, spatial analysis: Total beta diversity was measured as the total variance of the Hellinger-transformed community data throughout the BCI plot. Total beta was partitioned into contributions of individual sites(LCBD indices), which were tested for significance and mapped.Results, spatial analysis: LCBD indices indicated the sites with exceptional community composition. In 1985,they were mostly found in the swamp habitat. In the 2015 survey, none of the swamp quadrats had significant LCBDs.What happened to the tree community in the interval?Methods, temporal analysis: The dissimilarity in community composition in each quadrat was measured between time 1(1985) and time 2(2015). Temporal Beta Indices(TBI) were computed from abundance and presence-absence data and tested for significance. TBI indices can be decomposed into B = species(or abundances-per-species) losses and C = species(or abundances-per-species) gains. B-C plots were produced; they display visually the relative importance of the loss and gain components, through time, across the sites.Results, temporal analysis: In BCI, quadrats with significant TBI indices were found in the swamp area, which is shrinking in importance due to changes to the local climate. A published habitat classification divided the BCI forest plot into six habitat zones. Graphs of the B and C components were produced for each habitat group. Group 4(the swamp) was dominated by species(and abundances-per-species) gains whereas the five other habitat groups were dominated by losses, some groups more than others.Conclusions: We identified the species that had changed the most in abundances in the swamp between T1 and T2.This analysis supported the hypothesis that the swamp is drying out and is invaded by species from the surrounding area. Analysis of the B and C components of temporal beta diversity bring us to the heart of the mechanisms of community change through time: losses(B) and gains(C) of species, losses and gains of individuals of various species. TBI analysis is especially interesting in species-rich communities where we cannot examine the changes in every species individually.
基金funded by PhD grants of ‘Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen)’ (Nos. 101529 (MD) and 121512 (BG))The Special Research Fund (BOF) of Ghent University (01J22510 (EW) and 01D38811 (SS))
文摘Lipopeptides are currently re-emerging as an interesting subgroup in the peptide research field, having historical applications as antibacterial and antifungal agents and new potential applications as antiviral, antitumor, immune-modulating and cell-penetrating compounds. However, due to their specific structure, chromatographic analysis often requires special buffer systems or the use of trifluoroacetic acid, limiting mass spectrometry detection. Therefore, we used a traditional aqueous/acetonitrile based gradient system, containing 0.1% (m/v) formic acid, to separate four pharmaceutically relevant lipopeptides (polymyxin B1, caspofungin, daptomycin and gramicidin A1), which were selected based upon hierarchical cluster analysis (HCA) and principal component analysis (PCA).In total, the performance of four different C18 columns, including one UPLC column, were evaluated using two parallel approaches. First, a Derringer desirability function was used, whereby six single and multiple chromatographic response values were rescaled into one overall D-value per column. Using this approach, the YMC Pack Pro C18 column was ranked as the best column for general MS-compatible lipopeptide separation. Secondly, the kinetic plot approach was used to compare the different columns at different flow rate ranges. As the optimal kinetic column performance is obtained at its maximal pressure, the length elongation factor λ(Pmax/Pexp) was used to transform the obtained experimental data (retention times and peak capacities) and construct kinetic performance limit (KPL) curves, allowing a direct visual and unbiased comparison of the selected columns, whereby the YMC Triart C18 UPLC and ACE C18 columns performed as best. Finally, differences in column performance and the (dis)advantages of both approaches are discussed.
基金supported by the National Natural Science Foundation of China(Grants No.51569007 and 41301289)the Natural Science Foundation of Guangxi Province,China(Grant No.2015GXNSFCA139004)+1 种基金the Fund of the IRCK by UNESCO(Grant No.KDL201601)the Project of High Level Innovation Team and Outstanding Scholar in Guangxi Colleges and Universities(Grant No.002401013001)
文摘Although many sensitivity analyses using the soil and water assessment tool(SWAT) in a complex watershed have been conducted, little attention has been paid to the application potential of the model in unique plots. In addition, sensitivity analysis of percolation and evapotranspiration with SWAT has seldom been undertaken. In this study, SWAT99.2 was calibrated to simulate water balance components for unique plots in Southern China from 2000 to 2001, which included surface runoff, percolation, and evapotranspiration. Twenty-one parameters classified into four categories, including meteorological conditions, topographical characteristics, soil properties, and vegetation attributes, were used for sensitivity analysis through one-at-a-time(OAT) sampling to identify the factor that contributed most to the variance in water balance components. The results were shown to be different for different plots, with parameter sensitivity indices and ranks varying for different water balance components. Water balance components in the broad-leaved forest and natural grass plots were most sensitive to meteorological conditions, less sensitive to vegetation attributes and soil properties, and least sensitive to topographical characteristics. Compared to those in the natural grass plot, water balance components in the broad-leaved forest plot demonstrated higher sensitivity to the maximum stomatal conductance(GSI) and maximum leaf area index(BLAI).
文摘In order to study the dynamics of uneven-aged stands of interior Douglas-fir, Pseudotsuga menzesii var.glouca (Mirb.) Franco in future, six permanent sample plots wer set up on the Knife Creek Block of the Alex Fraser Researh Forcst of University of British Columbia. The measurements and observations for all living trees within theboundaries of a plot wer madc, including DBH(diameter at breast height), TTH(total tree height), height to lowest livingbranch, crown diameter, tree vigor, angle of lean, distance of lean, direction of lean and tree location. Based on the data,some stand characteristics of the plots were analyzed simply and preliminarily. Results showed that most of the interiortrees on the plots are ranged 10-20 cm in distribution of DBH class, and 2-6 m in distribution of rm class. Trees withdifferent fors, however, are distributed unevenly. The relationship between total tree height and diameter at breast heightfollows a quadratic distribution, Y=a+bX+cX2.
文摘Aquifer test methods have greatly improved in recent years with the advent of inverse analysis, derivative analysis, and diagnostic plots. Updated analyses of past aquifer tests allow for improved interpretations of the data to enhance the knowledge and the predictive capabilities of the flow system. This work thoroughly reanalyzes a series of pre- and post-hydraulic fracturing, single-well aquifer tests conducted in two crystalline rock wells in New Hampshire as part of an early 1970’s study. Previous analyses of the data had relied on older manual type-curve methods for predicting the possible effects of hydraulic fracturing. This work applies inverse analysis, derivative analysis, and diagnostic plots to reanalyze the 1970’s aquifer test data. Our results demonstrate that the aquifer tests were affected by changes in flow regimes, dewatering of the aquifer and discrete fractures, and changes due to well development. Increases in transmissivities are related to well development prior to hydraulic fracturing, propagation of a single, vertical fracture hydraulically connecting the two wells after stimulation and expansion of troughs of depression. After hydraulic fracturing, the estimated total yield of the individual wells increased by 2.5 times due to the hydraulic fracturing. However, the wells may be receiving water from the same source, and well interference may affect any significant increase in their combined yield. Our analyses demonstrate the value in applying inverse analysis, derivative analysis, and diagnostic plots over the conventional method of manual type-curve analysis. In addition, our improvement in the aquifer test interpretation of the 1970’s test data has implications for more reliable estimates of sustained well yields.
文摘The use of Recurrence plots have been extensively used in various fields. In this work, Recurrence Plots (RPs) investigates the changes in the non-linear behaviour of urban air pollution using large datasets of raw data (hourly). This analysis has not been used before to extract information from large datasets for this type non-linear problem. Two different approaches have been used to tackle this problem. The first approach is to show results according to monitoring network. The second approach is to show the results by particle type. This analysis shows the feasibility of using Recurrence Analysis for pollution monitoring and control.
文摘Throughout Oscar Wilde’s farcical comedy,The Importance of Being Ernest,there are two story lines.The lines are both independent to each other,but are connected with each other.With the author’s thoughtful arrangement and distinctive technology,the two lines push the development of plot;intensify the depth of conflict and make the structure complete.It seems the author told us a story,but indeed it gives us a lot of inspiration and education.
文摘Objectives: Recent reports on venous blood gas analysis have shown that venous bicarbonate concentration is useful in the evaluation of the body acid-base status. Most of these reports have been based on the Bland-Altman analysis comparing arterial and venous blood gas values. We intended to elucidate any factors that decrease the agreement between venous and arterial bicarbonate concentrations, which might impair the usefulness of venous blood gas analysis. Methods: Healthy volunteers and patients with various diseases (n = 141) were evaluated by simultaneous arterial and venous blood sampling and Bland-Altman analysis. The venous-arterial bicarbonate concentration difference was compared between healthy volunteers and untreated respiratory alkalosis patients. Intentional hyperventilation (30 or 60 breaths/min, for 3 min) was also performed on 6 healthy volunteers and the venous-arterial bicarbonate concentration difference was evaluated. Results: The relative average bias in bicarbonate concentration was 2.00 mEq/l with venous bicarbonate higher than arterial bicarbonate with 95% limits of agreement of ±4.15 mEq/l. Hyperventilation challenges increased the venous-arterial bicarbonate concentration difference in an intensity-dependent manner. The venous-arterial bicarbonate concentration difference was higher in untreated respiratory alkalosis patients than in healthy volunteers (P Conclusion: Although venous bicarbonate may be useful to evaluate the body acid-base status, hyperventilation increases the venous-arterial bicarbonate concentration difference. Physicians should keep this phenomenon in mind.
文摘Survival studies mainly deal with distribution of time to event. Often in such studies researchers are interested in comparing several treatment or prognostic groups. At the time of analysis, there is an unmeasured chance of making type I error, or finding a falsely significant difference between any two groups. The chance of making type I error is increased, if multiple groups are compared simultaneously. In this paper, survival analysis with Bonferroni correction is explained in easy way to cope up with this issue. The DLHS-3 data are taken to explain this methodology in the context of neonatal survival. Kaplan-meier plot with three survival comparison test is used to elaborate the application of Bonferroni correction.
文摘The objectives of the study were as follows: 1) to evaluate the GxExM for wheat genotypes;2) to predict yield performance and identify high stable wheat genotypes in different management practices;and 3) to make genotype-specific management and high performing genotype recommendations within and across agro-ecological regions. A diverse set of twenty-one genotypes was evaluated over three years (2012, 2013 and 2014) under two levels of crop management practices (CT and ZT) across three agro-ecological regions (BR, MP and PB) of India in replicated trials. Data were analyzed with SASGxE and RGxE programs using SAS and R programming languages, respectively. Across and within a location(s), the pattern of GxExM and GxMxY interactions (respectively) among univariate and multivariate stability statistics, grouping of genotypes in divisive clusters and estimates (with a prediction interval) of genotype varied in management practice CT and ZT. Across locations, the genotypes “Munal” and “HD-2967” were the best performers and high stable in CT and ZT, respectively. Genotypes “HD-2824” and “DPW-621-50”, and “Munal” may serve as diverse parents for developing high quality, climate smart, locally adapted genotypes for BR in CT and ZT, respectively. Genotypes “HD-2932”, “BAZ” and “JW-3288”, and “GW-322” and “HD-2967” are suitable for developing locally adapted stress tolerant genotypes for MP in management practices CT and ZT, respectively. Relatively small GxM and GxExM interactions in PB preclude in making definitive conclusions.
文摘In this paper, we are interested to find the most sensitive parameter, local and global stability of ovarian tumor growth model. For sensitivity analysis, we use Latin Hypercube Sampling (LHS) method to generate sample points and Partial Rank Correlation Coefficient (PRCC) method, uses those sample points to find out which parameters are important for the model. Based on our findings, we suggest some treatment strategies. We investigate the sensitivity of the parameters for tumor volume, <em>y</em>, cell nutrient density, <em>Q</em> and maximum tumor size, <em>ymax</em>. We also use Scatter Plot method using LHS samples to show the consistency of the results obtained by using PRCC. Moreover, we discuss the qualitative analysis of ovarian tumor growth model investigating the local and global stability.
文摘This paper describes a novel approach to explore a multidimensional design space and guide multi-actor decision making in the design of sustainable buildings.The aim is to provide proactive and holistic guidance of the design team.We propose to perform exhaustive Monte Carlo simulations in an iterative design approach that consists of tw o steps:1) preparation by the modeler,and 2) a multi-collaborator meeting.In the preparation phase,the simulation modeler performs Morris sensitivity analysis to fixate insignificant model inputs and to identify non-linearity and interaction effects.Next,a representation of the global design space is obtained from thousands of simulations using low-discrepancysequences(LPτ) for sampling.From these simulations,the modeler constructs fast metamodels and performs quantitative sensitivity analysis.During the meeting,the design team explores the global design space by filtering the thousands of simulations.Variable filter criteria are easily applied using an interactive parallel coordinate plot w hich provide immediate feedback on requirements and design choices.Sensitivity measures and metamodels show the combined effects of changing a single input and how to remedy unw anted output changes.The proposed methodology has been developed and tested through real building cases using a normative model to assess energy demand,thermal comfort,and daylight.