A tri-block copolymer coupling agent polystyreneblock-poly （n-butyl-acrylate）-block-poly （y-methacryloxypro pylt rimethoxysilane）（PS-b-PnBA-b-PMPS） was synthesized by atom transfer radical polymerization （ATRP...A tri-block copolymer coupling agent polystyreneblock-poly （n-butyl-acrylate）-block-poly （y-methacryloxypro pylt rimethoxysilane）（PS-b-PnBA-b-PMPS） was synthesized by atom transfer radical polymerization （ATRP）, and its molecular structure was characterized by fourier-transform infrared spectra, hydrogen nuclear magnetic resonance and gel permeation chromatography. The glass bead was treated with the block copolymer coupling agent, and then studied by transmission electron microscopy. The result showed that strong interaction was formed between the block copolymer coupling agent and the surface of glass bead, and then the block of poly（n-butylacrylate） formed a layer of film on the surface.展开更多
BACKGROUND Donepezil is an acetylcholinesterase inhibitor used to improve cognition and delay disease progression in dementia patients by increasing acetylcholine levels.This drug may potentially interact with neuromu...BACKGROUND Donepezil is an acetylcholinesterase inhibitor used to improve cognition and delay disease progression in dementia patients by increasing acetylcholine levels.This drug may potentially interact with neuromuscular blocking agents(NMBAs)that act on muscular acetylcholine receptors during general anesthesia.Herein,we present a case of inadequate neuromuscular blockade with rocuronium,a nondepolarizing NMBA,in a dementia patient who had taken donepezil.CASE SUMMARY A 71-year-old man was scheduled for laparoscopic gastrectomy.He had been taking donepezil 5 mg for dementia.General anesthesia was induced with propofol and remifentanil.The depth of neuromuscular blockade was monitored by train-of-four(TOF)stimulation.After the administration of rocuronium,the TOF ratio decreased at an unusually slow rate,and a TOF count of 0 was detected 7 min later.After intubation,a TOF count of 1 was detected within 1 min,and a TOF ratio of 12%was detected within 2 min.The TOF count remained at 4 even with an additional bolus and continuous infusion of rocuronium,suggesting resistance to this NMBA.Instead of propofol,an inhalation anesthetic was administered alongside another NMBA(cisatracurium).Then,the quality of neuromuscular blockade improved,and the TOF count remained at 0-1 for the next 70 min.No further problems were encountered with respect to surgery or anesthesia.CONCLUSION Donepezil may be responsible for inadequate neuromuscular blockade during anesthesia,especially when total intravenous anesthesia is used.展开更多
文摘A tri-block copolymer coupling agent polystyreneblock-poly （n-butyl-acrylate）-block-poly （y-methacryloxypro pylt rimethoxysilane）（PS-b-PnBA-b-PMPS） was synthesized by atom transfer radical polymerization （ATRP）, and its molecular structure was characterized by fourier-transform infrared spectra, hydrogen nuclear magnetic resonance and gel permeation chromatography. The glass bead was treated with the block copolymer coupling agent, and then studied by transmission electron microscopy. The result showed that strong interaction was formed between the block copolymer coupling agent and the surface of glass bead, and then the block of poly（n-butylacrylate） formed a layer of film on the surface.
文摘BACKGROUND Donepezil is an acetylcholinesterase inhibitor used to improve cognition and delay disease progression in dementia patients by increasing acetylcholine levels.This drug may potentially interact with neuromuscular blocking agents(NMBAs)that act on muscular acetylcholine receptors during general anesthesia.Herein,we present a case of inadequate neuromuscular blockade with rocuronium,a nondepolarizing NMBA,in a dementia patient who had taken donepezil.CASE SUMMARY A 71-year-old man was scheduled for laparoscopic gastrectomy.He had been taking donepezil 5 mg for dementia.General anesthesia was induced with propofol and remifentanil.The depth of neuromuscular blockade was monitored by train-of-four(TOF)stimulation.After the administration of rocuronium,the TOF ratio decreased at an unusually slow rate,and a TOF count of 0 was detected 7 min later.After intubation,a TOF count of 1 was detected within 1 min,and a TOF ratio of 12%was detected within 2 min.The TOF count remained at 4 even with an additional bolus and continuous infusion of rocuronium,suggesting resistance to this NMBA.Instead of propofol,an inhalation anesthetic was administered alongside another NMBA(cisatracurium).Then,the quality of neuromuscular blockade improved,and the TOF count remained at 0-1 for the next 70 min.No further problems were encountered with respect to surgery or anesthesia.CONCLUSION Donepezil may be responsible for inadequate neuromuscular blockade during anesthesia,especially when total intravenous anesthesia is used.
