BACKGROUND: Aluminum phosphide(Al P) poisoning is common in the developing countries. There is no specifi c antidote for the treatment of acute Al P poisoning. Early diagnosis of poisoning and outcome predictors may f...BACKGROUND: Aluminum phosphide(Al P) poisoning is common in the developing countries. There is no specifi c antidote for the treatment of acute Al P poisoning. Early diagnosis of poisoning and outcome predictors may facilitate treatment decisions. The objective of this study was to determine the trend of blood lactate level in acute Al P poisoning to evaluate its role as a prognostic factor.METHODS: This was a prospective study on acute Al P intoxicated patients during one year. Demographic data, clinical and laboratory data on admission, and outcome were recorded in a selfmade questionnaire. Blood lactate levels were analyzed every two hours for 24 hours.RESULTS: Thirty-nine(27 male, 12 female) patients were included in the study. The mortality rate was 38.5%. The mean blood pressure, pulse rate, blood p H and serum bicarbonate level were significantly different between the survivors and non-survivors groups. Blood lactate level was signifi cantly higher in the non-survivors group during 8 to 16 hours post ingestion.CONCLUSION: Blood lactate level could be used as an index of severity of acute Al P poisoning.展开更多
目的探讨职业性铝接触与工人空腹血糖水平的关系。方法采用整群抽样方法,选择山西省某大型铝厂178名职业性铝接触工人为接触组,以该厂无职业性铝接触的178名工人为对照组,采用葡萄糖氧化酶法测定2组工人空腹血糖水平,采用电感耦合等离子...目的探讨职业性铝接触与工人空腹血糖水平的关系。方法采用整群抽样方法,选择山西省某大型铝厂178名职业性铝接触工人为接触组,以该厂无职业性铝接触的178名工人为对照组,采用葡萄糖氧化酶法测定2组工人空腹血糖水平,采用电感耦合等离子体-质谱法检测其血浆铝水平,采用广义线性模型分析其血浆铝接触水平与其空腹血糖的关联性。结果接触组工人血铝水平高于对照组[中位数:39.58 vs 16.67μg/L,P<0.01];接触组工人空腹血糖水平高于对照组[(5.33±0.79)vs(5.15±0.41) mmol/L,P<0.01]。广义线性模型分析结果显示:调整年龄、体质量指数、吸烟、饮酒、锻炼、糖尿病家族史和糖尿病患病情况等混杂因素后,工人血铝水平与其空腹血糖水平呈正相关(P<0.05);初中及以下组和高中组工人的血铝水平均与空腹血糖水平存在剂量-效应关系(P_(趋势)值均<0.01);在大学专科及以上组中,未发现血铝水平与空腹血糖水平存在关联性(P_(趋势)>0.05);不锻炼组工人血铝水平与空腹血糖水平存在剂量-效应关系(P_(趋势)<0.01),在锻炼组工人中未发现血铝水平与空腹血糖水平存在关联性(P_(趋势)>0.05)。结论职业性铝接触工人血铅水平与其空腹血糖水平呈正相关;文化程度较高或锻炼可适度降低血铝水平对空腹血糖水平的影响。展开更多
基金supported by a grant from Toxicological Research Center of Shahid Beheshti University of Medical Sciences
文摘BACKGROUND: Aluminum phosphide(Al P) poisoning is common in the developing countries. There is no specifi c antidote for the treatment of acute Al P poisoning. Early diagnosis of poisoning and outcome predictors may facilitate treatment decisions. The objective of this study was to determine the trend of blood lactate level in acute Al P poisoning to evaluate its role as a prognostic factor.METHODS: This was a prospective study on acute Al P intoxicated patients during one year. Demographic data, clinical and laboratory data on admission, and outcome were recorded in a selfmade questionnaire. Blood lactate levels were analyzed every two hours for 24 hours.RESULTS: Thirty-nine(27 male, 12 female) patients were included in the study. The mortality rate was 38.5%. The mean blood pressure, pulse rate, blood p H and serum bicarbonate level were significantly different between the survivors and non-survivors groups. Blood lactate level was signifi cantly higher in the non-survivors group during 8 to 16 hours post ingestion.CONCLUSION: Blood lactate level could be used as an index of severity of acute Al P poisoning.
文摘目的探讨职业性铝接触与工人空腹血糖水平的关系。方法采用整群抽样方法,选择山西省某大型铝厂178名职业性铝接触工人为接触组,以该厂无职业性铝接触的178名工人为对照组,采用葡萄糖氧化酶法测定2组工人空腹血糖水平,采用电感耦合等离子体-质谱法检测其血浆铝水平,采用广义线性模型分析其血浆铝接触水平与其空腹血糖的关联性。结果接触组工人血铝水平高于对照组[中位数:39.58 vs 16.67μg/L,P<0.01];接触组工人空腹血糖水平高于对照组[(5.33±0.79)vs(5.15±0.41) mmol/L,P<0.01]。广义线性模型分析结果显示:调整年龄、体质量指数、吸烟、饮酒、锻炼、糖尿病家族史和糖尿病患病情况等混杂因素后,工人血铝水平与其空腹血糖水平呈正相关(P<0.05);初中及以下组和高中组工人的血铝水平均与空腹血糖水平存在剂量-效应关系(P_(趋势)值均<0.01);在大学专科及以上组中,未发现血铝水平与空腹血糖水平存在关联性(P_(趋势)>0.05);不锻炼组工人血铝水平与空腹血糖水平存在剂量-效应关系(P_(趋势)<0.01),在锻炼组工人中未发现血铝水平与空腹血糖水平存在关联性(P_(趋势)>0.05)。结论职业性铝接触工人血铅水平与其空腹血糖水平呈正相关;文化程度较高或锻炼可适度降低血铝水平对空腹血糖水平的影响。
