Studies have indicated that night lights interfere with the circadian rhythm in the human body and threaten human health. Our previous studies indicated that continuous light exposure severely damages the reproductive...Studies have indicated that night lights interfere with the circadian rhythm in the human body and threaten human health. Our previous studies indicated that continuous light exposure severely damages the reproductive endocrine system of female rats resembles polycystic ovary syndrome in women. In this study, we used the continuous measurement method to observe changes in the basal physiological indicators of female rats in an abnormal light exposure environment. Our study results indicated that in female rats: 1) the body temperature first continuously and gradually increased followed by a gradually decrease;2) the increase in body weight slowed down at the late stage of the experimental process;3) the random blood glucose level increased, and the fasting serum insulin level decreased;and 4) the serum C-reactive protein level increased. Our study investigated for the first time the correlation between the duration of continuous light exposure in female rats and the continuously measured basal physiological indicators and preliminarily discussed the effect of continuous light exposure on female basal metabolism and the possible inflammation mechanism. We propose that long-term continuous exposure to night lights in females severely damages their immune and metabolic systems.展开更多
Objective To examine the change of body weight (BW) and blood pressure (BP) in obese rats, clarify relationships between BP and BW and other factors. Methods Male Spraque-Dawley rats were fed either with normal diet (...Objective To examine the change of body weight (BW) and blood pressure (BP) in obese rats, clarify relationships between BP and BW and other factors. Methods Male Spraque-Dawley rats were fed either with normal diet (ND) or high calorie diet (HC) for 20 weeks. BW and BP of tail artery were observed biweekly and tetraweekly respectively; serum leptin and fasting insulin (FINS) were detected by enzyme-linked immunoadsordent assay (ELISA) and radioimmunoassay (RIA) respectively. Fasting plasma glucose (FPG) and free fatty acid(FFA) were measured by conventional means. Results BW, abdominal fat weight (AFW), ratio of abdominal fat weight to body weight (R_ F/W), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum levels of leptin and FINS, FPG, FFA increased in the HD group after 20 weeks diet intervention (P<0.05 or P<0.01). SBP was strongly correlated with BW, leptin, FINS and FFA (P<0.05), DBP was correlated with FFA (r=0.47, P<0.05). In addition, leptin was positively correlated with BW, AFW, R_ F/W, FINS and FFA (P<0.05 or P<0.01). Conclusion In this study of high calorie-diet induced rats, the gain of BW is accompanied by increased BP. The obese rats have hyperleptinemia, hyperinsulinemia, hyperglycemia and dyslipidemia which may have important effects on the development of obesity-related hypertension. R_ F/W is the key factor in which affect serum leptin level.展开更多
Sedentary lifestyles promote adipose tissue accumulation that generates systemic inflammation and oxidative damage. Physical activity induces cardiovascular fitness, increases muscle mass, and healthy blood glucose re...Sedentary lifestyles promote adipose tissue accumulation that generates systemic inflammation and oxidative damage. Physical activity induces cardiovascular fitness, increases muscle mass, and healthy blood glucose regulation, while reducing visceral fat, triglycerides and low-density lipoproteins. It is theoretically possible to develop a long-term multi-exercise regimen for health management and enhancement. Pragmatically, time and career restraints, individual choices, genetic factors, or demoralization due to the draconian commitment involved in weight loss, have rendered over a billion of individuals obese, or overweight, burdened by excess lipids, insulin resistance, elevated glucose levels, and inflammation, that foster a number of medical conditions including diabetes. Strenuous overtraining has ensued adverse effects, including an upsurge of proinflammatory cytokines, and hyperglycemia. We implemented an one-month long innovative method with 20 diabetic and prediabetic patients. Results demonstrated a statistically significant reduction of both fasting and PP blood glucose. Fasting and PP insulin reached optimal levels. There was a substantial decline in dyslipidemia, reflecting a reverse relationship of elevated HDL versus triglycerides descending towards the normal range. The notable visceral fat reduction was validated by sonography reports that indicated no evidence of fatty liver in seven patients previously diagnosed with hepatic steatosis. These findings have important implications in improving the health status of obese diabetic and prediabetic individuals, by helping them jumpstart an active lifestyle, or by serving as an exercise alternative to reduce lipids, blood glucose levels and insulin resistance.展开更多
目的探讨达格列净联合胰岛素泵强化治疗对老年2型糖尿病(T_(2)DM)患者胰岛功能的影响。方法选取2019年8月至2022年8月接受治疗的80例老年T_(2)DM患者作为研究对象,按照抽签法将其分为对照组和研究组,每组40例。对照组给予二甲双胍联合...目的探讨达格列净联合胰岛素泵强化治疗对老年2型糖尿病(T_(2)DM)患者胰岛功能的影响。方法选取2019年8月至2022年8月接受治疗的80例老年T_(2)DM患者作为研究对象,按照抽签法将其分为对照组和研究组,每组40例。对照组给予二甲双胍联合胰岛素泵强化治疗,研究组给予达格列净联合胰岛素泵强化治疗。比较两组的治疗效果。结果治疗后,研究组的空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平及糖化血红蛋白(HbA1c)低于对照组(P<0.05)。治疗后,研究组的体重、体质指数(BMI)低于对照组(P<0.05)。治疗后,研究组的空腹胰岛素(FINS)水平与稳态模型胰岛β细胞分泌指数(HOMA-β)高于对照组,稳态模型胰岛素抵抗指数(HOMA-IR)低于对照组(P<0.05)。治疗后,研究组的谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)水平高于对照组,丙二醛(MDA)水平低于对照组(P<0.05)。结论达格列净联合胰岛素泵强化治疗老年T_(2)DM患者的效果显著,可有效降低血糖指标、体重以及BMI,并改善胰岛功能。展开更多
AIM: To investigate the effectiveness of insulin on decreasing serum potassium concentration during anhepatic stage of orthotopic liver transplantation.METHODS: Sixteen patients with serum potassium concentrations gre...AIM: To investigate the effectiveness of insulin on decreasing serum potassium concentration during anhepatic stage of orthotopic liver transplantation.METHODS: Sixteen patients with serum potassium concentrations greater than 4.0 mmol/L at the onset of anhepatic stage were randomized into two groups. The patients in control group (n = 8) received no treatment,while those in treatment group (n = 8) received an intravenous bolus injection of regular insulin (20 U) 10 min into the anhepatic stage, followed by a glucose infusion(500 mL 50 g/L dextrose) over 15 min.RESULTS: In control group, potassium concentration underwent no changes whereas in treatment group, it decreased from 4.8±0.48 mmol/L to 4.19±0.55 mmol/L(mean±SD) within 15 min and to 3.62±0.45 mmol/L 60 min after the therapy. The potassium concentration was lower in treatment group than in control group within 30 min of treatment (3.94+0.57 vs 4.47±0.42 mmol/L,respectively; P<0.05), and increased similarly 30 s after graft reperfusion in both groups of patients, but remained lower in treatment group (5.81±1.78 vs7.44±1.75 mmol/L,respectively; P<0.05). The potassium concentration returned to pre-reperfusion levels within 5 min after graft reperfusion.CONCLUSION: In patients undergoing orthotopic liver transplantation, the administration of insulin rapidly decreases serum potassium concentration even in the absence of the liver, suggesting an important contribution by extrahepatic tissues in insulin-stimulated uptake of potassium.展开更多
目的：评价利拉鲁肽和甘精胰岛素治疗2型糖尿病（T2DM）的临床疗效,并进行药物经济学分析,为治疗T2DM提供经济、合理的治疗方案。方法：将80例T2DM患者按照随机数字表法分为利拉鲁肽组和甘精胰岛素组,各40例。两组患者在停用原治疗方案...目的：评价利拉鲁肽和甘精胰岛素治疗2型糖尿病（T2DM）的临床疗效,并进行药物经济学分析,为治疗T2DM提供经济、合理的治疗方案。方法：将80例T2DM患者按照随机数字表法分为利拉鲁肽组和甘精胰岛素组,各40例。两组患者在停用原治疗方案的其他口服降糖药后,给予盐酸二甲双胍缓释片口服,0.5~2.0 g/d,并给予糖尿病膳食和运动训练指导。在此基础上,利拉鲁肽组患者给予利拉鲁肽注射液皮下注射,每次0.6~1.2 mg,qd;甘精胰岛素组患者于每晚22：00给予甘精胰岛素皮下注射,起始剂量为0.2 IU/（kg·d）,两组患者均根据餐后血糖、空腹及夜间血糖水平调整用量,直至患者的空腹血糖（FBG）≤7 mmo1/L、餐后2 h血糖（2 h PG）≤10 mmol/L。两组疗程均为12周。观察两组患者治疗前后FBG、2 h PG、糖化血红蛋白（Hb A1c）和体质量指数（BMI）的变化。采用最小成本分析法对两种药物治疗方案进行比较评价。结果：治疗后两组患者的FBG、2 h PG、Hb A1c水平均较治疗前明显下降,差异均有统计学意义（P〈0.05）,但组间比较差异无统计学意义（P〉0.05）。治疗后利拉鲁肽组患者的BMI较治疗前及甘精胰岛素组明显降低,差异均有统计学意义（P〈0.05）;甘精胰岛素组患者的BMI治疗前后比较差异无统计学意义（P〉0.05）。最小成本分析结果显示,甘精胰岛素组方案在降低FBG、2 h PG和Hb Alc方面所需成本均小于利拉鲁肽组,但在降低BMI方面所需成本则大于利拉鲁肽组。敏感度分析结果验证了最小成本分析结果的稳定性和可靠性。结论：利拉鲁肽和甘精胰岛素具有基本相当的临床疗效,但甘精胰岛素在控制血糖水平方面具有较佳的成本优势,而利拉鲁肽是控制体质量较佳的治疗方案。展开更多
文摘Studies have indicated that night lights interfere with the circadian rhythm in the human body and threaten human health. Our previous studies indicated that continuous light exposure severely damages the reproductive endocrine system of female rats resembles polycystic ovary syndrome in women. In this study, we used the continuous measurement method to observe changes in the basal physiological indicators of female rats in an abnormal light exposure environment. Our study results indicated that in female rats: 1) the body temperature first continuously and gradually increased followed by a gradually decrease;2) the increase in body weight slowed down at the late stage of the experimental process;3) the random blood glucose level increased, and the fasting serum insulin level decreased;and 4) the serum C-reactive protein level increased. Our study investigated for the first time the correlation between the duration of continuous light exposure in female rats and the continuously measured basal physiological indicators and preliminarily discussed the effect of continuous light exposure on female basal metabolism and the possible inflammation mechanism. We propose that long-term continuous exposure to night lights in females severely damages their immune and metabolic systems.
文摘Objective To examine the change of body weight (BW) and blood pressure (BP) in obese rats, clarify relationships between BP and BW and other factors. Methods Male Spraque-Dawley rats were fed either with normal diet (ND) or high calorie diet (HC) for 20 weeks. BW and BP of tail artery were observed biweekly and tetraweekly respectively; serum leptin and fasting insulin (FINS) were detected by enzyme-linked immunoadsordent assay (ELISA) and radioimmunoassay (RIA) respectively. Fasting plasma glucose (FPG) and free fatty acid(FFA) were measured by conventional means. Results BW, abdominal fat weight (AFW), ratio of abdominal fat weight to body weight (R_ F/W), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum levels of leptin and FINS, FPG, FFA increased in the HD group after 20 weeks diet intervention (P<0.05 or P<0.01). SBP was strongly correlated with BW, leptin, FINS and FFA (P<0.05), DBP was correlated with FFA (r=0.47, P<0.05). In addition, leptin was positively correlated with BW, AFW, R_ F/W, FINS and FFA (P<0.05 or P<0.01). Conclusion In this study of high calorie-diet induced rats, the gain of BW is accompanied by increased BP. The obese rats have hyperleptinemia, hyperinsulinemia, hyperglycemia and dyslipidemia which may have important effects on the development of obesity-related hypertension. R_ F/W is the key factor in which affect serum leptin level.
文摘Sedentary lifestyles promote adipose tissue accumulation that generates systemic inflammation and oxidative damage. Physical activity induces cardiovascular fitness, increases muscle mass, and healthy blood glucose regulation, while reducing visceral fat, triglycerides and low-density lipoproteins. It is theoretically possible to develop a long-term multi-exercise regimen for health management and enhancement. Pragmatically, time and career restraints, individual choices, genetic factors, or demoralization due to the draconian commitment involved in weight loss, have rendered over a billion of individuals obese, or overweight, burdened by excess lipids, insulin resistance, elevated glucose levels, and inflammation, that foster a number of medical conditions including diabetes. Strenuous overtraining has ensued adverse effects, including an upsurge of proinflammatory cytokines, and hyperglycemia. We implemented an one-month long innovative method with 20 diabetic and prediabetic patients. Results demonstrated a statistically significant reduction of both fasting and PP blood glucose. Fasting and PP insulin reached optimal levels. There was a substantial decline in dyslipidemia, reflecting a reverse relationship of elevated HDL versus triglycerides descending towards the normal range. The notable visceral fat reduction was validated by sonography reports that indicated no evidence of fatty liver in seven patients previously diagnosed with hepatic steatosis. These findings have important implications in improving the health status of obese diabetic and prediabetic individuals, by helping them jumpstart an active lifestyle, or by serving as an exercise alternative to reduce lipids, blood glucose levels and insulin resistance.
文摘目的探讨达格列净联合胰岛素泵强化治疗对老年2型糖尿病(T_(2)DM)患者胰岛功能的影响。方法选取2019年8月至2022年8月接受治疗的80例老年T_(2)DM患者作为研究对象,按照抽签法将其分为对照组和研究组,每组40例。对照组给予二甲双胍联合胰岛素泵强化治疗,研究组给予达格列净联合胰岛素泵强化治疗。比较两组的治疗效果。结果治疗后,研究组的空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平及糖化血红蛋白(HbA1c)低于对照组(P<0.05)。治疗后,研究组的体重、体质指数(BMI)低于对照组(P<0.05)。治疗后,研究组的空腹胰岛素(FINS)水平与稳态模型胰岛β细胞分泌指数(HOMA-β)高于对照组,稳态模型胰岛素抵抗指数(HOMA-IR)低于对照组(P<0.05)。治疗后,研究组的谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)水平高于对照组,丙二醛(MDA)水平低于对照组(P<0.05)。结论达格列净联合胰岛素泵强化治疗老年T_(2)DM患者的效果显著,可有效降低血糖指标、体重以及BMI,并改善胰岛功能。
基金Supported by the National Natural Science Foundation of China,No.39900140
文摘AIM: To investigate the effectiveness of insulin on decreasing serum potassium concentration during anhepatic stage of orthotopic liver transplantation.METHODS: Sixteen patients with serum potassium concentrations greater than 4.0 mmol/L at the onset of anhepatic stage were randomized into two groups. The patients in control group (n = 8) received no treatment,while those in treatment group (n = 8) received an intravenous bolus injection of regular insulin (20 U) 10 min into the anhepatic stage, followed by a glucose infusion(500 mL 50 g/L dextrose) over 15 min.RESULTS: In control group, potassium concentration underwent no changes whereas in treatment group, it decreased from 4.8±0.48 mmol/L to 4.19±0.55 mmol/L(mean±SD) within 15 min and to 3.62±0.45 mmol/L 60 min after the therapy. The potassium concentration was lower in treatment group than in control group within 30 min of treatment (3.94+0.57 vs 4.47±0.42 mmol/L,respectively; P<0.05), and increased similarly 30 s after graft reperfusion in both groups of patients, but remained lower in treatment group (5.81±1.78 vs7.44±1.75 mmol/L,respectively; P<0.05). The potassium concentration returned to pre-reperfusion levels within 5 min after graft reperfusion.CONCLUSION: In patients undergoing orthotopic liver transplantation, the administration of insulin rapidly decreases serum potassium concentration even in the absence of the liver, suggesting an important contribution by extrahepatic tissues in insulin-stimulated uptake of potassium.
文摘目的：评价利拉鲁肽和甘精胰岛素治疗2型糖尿病（T2DM）的临床疗效,并进行药物经济学分析,为治疗T2DM提供经济、合理的治疗方案。方法：将80例T2DM患者按照随机数字表法分为利拉鲁肽组和甘精胰岛素组,各40例。两组患者在停用原治疗方案的其他口服降糖药后,给予盐酸二甲双胍缓释片口服,0.5~2.0 g/d,并给予糖尿病膳食和运动训练指导。在此基础上,利拉鲁肽组患者给予利拉鲁肽注射液皮下注射,每次0.6~1.2 mg,qd;甘精胰岛素组患者于每晚22：00给予甘精胰岛素皮下注射,起始剂量为0.2 IU/（kg·d）,两组患者均根据餐后血糖、空腹及夜间血糖水平调整用量,直至患者的空腹血糖（FBG）≤7 mmo1/L、餐后2 h血糖（2 h PG）≤10 mmol/L。两组疗程均为12周。观察两组患者治疗前后FBG、2 h PG、糖化血红蛋白（Hb A1c）和体质量指数（BMI）的变化。采用最小成本分析法对两种药物治疗方案进行比较评价。结果：治疗后两组患者的FBG、2 h PG、Hb A1c水平均较治疗前明显下降,差异均有统计学意义（P〈0.05）,但组间比较差异无统计学意义（P〉0.05）。治疗后利拉鲁肽组患者的BMI较治疗前及甘精胰岛素组明显降低,差异均有统计学意义（P〈0.05）;甘精胰岛素组患者的BMI治疗前后比较差异无统计学意义（P〉0.05）。最小成本分析结果显示,甘精胰岛素组方案在降低FBG、2 h PG和Hb Alc方面所需成本均小于利拉鲁肽组,但在降低BMI方面所需成本则大于利拉鲁肽组。敏感度分析结果验证了最小成本分析结果的稳定性和可靠性。结论：利拉鲁肽和甘精胰岛素具有基本相当的临床疗效,但甘精胰岛素在控制血糖水平方面具有较佳的成本优势,而利拉鲁肽是控制体质量较佳的治疗方案。
