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Analysis of herbs-combination of Professor Yang Su-qing in the treatment of psoriasis vulgaris with blood stasis syndrome
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作者 Xue Xiao Su-Qing Yang 《Journal of Hainan Medical University》 2021年第20期55-59,共5页
Objective:To explore Professor Yang Suqing’s experience in treating blood stasis syndrome of psoriasis vulgaris and analyze the characteristics of its prescription;Methods:Outpatient prescriptions for the treatment o... Objective:To explore Professor Yang Suqing’s experience in treating blood stasis syndrome of psoriasis vulgaris and analyze the characteristics of its prescription;Methods:Outpatient prescriptions for the treatment of psoriasis vulgaris with blood stasis syndrome were selected and extracted traditional Chinese medicine for standardized processing.Then analyze the data by using set visualization analysis and Apriori algorithm.Results:A total of 149 traditional Chinese herbs were extracted.Among them,and the top 12 commonly used herbs with frequency>30 were Licorice,Saposhnikovia,Schizonepeta tenuifolia,Angelica sinensis,Paeonia lactiflora,Ligusticum chuanxiong,Rehmannia glutinosa,Cicada slough,Oyster and Keel through the set visualization analysis,herbs association rules analysis,and herbs combination analysis.Saposhnikovia,Liquorice,Schizonepeta tenuifolia,Angelica sinensis and Paeonia Alba are the most commonly used combination of herbs by Professor Yang Suqing in the treatment of blood stasis syndrome of psoriasis vulgaris.Conclusion:In addition to invigorating blood circulation and removing blood stasis herbs,which are preferred for the treatment of blood stasis syndromes,Saposhnikovia and Schizonepeta tenuifolia,etc.,are used to synergistically exert the functions of invigorating blood circulation and removing blood stasis and eliminating wind expression,with remarkable efficacy. 展开更多
关键词 psoriasis vulgaris blood stasis syndrome Herbs-combination
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Literature Research of Chinese Medicine Recipes for the Treatment of Psoriasis Vulgaris with Blood-heat Syndrome Type 被引量:5
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作者 谭亚琦 刘久利 +1 位作者 白彦萍 张立新 《Chinese Journal of Integrative Medicine》 SCIE CAS 2011年第3期150-153,共4页
Objective:To analyze and investigate the rules for drug utilization of Chinese medicine for the treatment of psoriasis vulgaris with blood-heat syndrome.Methods:The literatures that met the following inclusion crite... Objective:To analyze and investigate the rules for drug utilization of Chinese medicine for the treatment of psoriasis vulgaris with blood-heat syndrome.Methods:The literatures that met the following inclusion criteria were screened out from China National Knowledge Infrastructure(CNKI) from January 1998 to December 2008,including the compositions and dosages of the recipes reported completely and accurately, the sample size being30 cases and the total effective rate being70%.Results:In total,289 papers meeting the inclusion criteria were retrieved,involving 301 recipes;in which 111 recipes consisting of 145 individual drugs were the function for clearing the heat,accounting for 52.84%.The three drugs with the highest utilized frequency were Radix Rehmanniae,Radix Arnebiae seu Lithospermi and Cortex Moutan.Meridian adscription of the drugs was mainly the Gan(肝)-meridian.Conclusion:There were rules for the treatment of psoriasis vulgaris of blood-heat syndrome with Chinese medicine prescriptions. 展开更多
关键词 psoriasis vulgaris blood-heat syndrome rule for drug utilization Chinese medicine
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Expression of T-Helper 17 Cells and Signal Transducers in Patients with Psoriasis Vulgaris of Blood-Heat Syndrome and Blood-Stasis Syndrome 被引量:6
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作者 范斌 李欣 +7 位作者 迮侃 徐蓉 施若非 耿琳 李福伦 王一飞 陈洁 李斌 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2015年第1期10-16,共7页
Objective: To investigate the levels of cytokines related to T-helper (Th) 17 cells in serum and signal transducers in the psoriatic lesions of patients with psoriasis vulgaris of blood-heat syndrome (BHS) and bl... Objective: To investigate the levels of cytokines related to T-helper (Th) 17 cells in serum and signal transducers in the psoriatic lesions of patients with psoriasis vulgaris of blood-heat syndrome (BHS) and blood-stasis syndrome (BSS). Methods: Sixty patients with psoriasis vulgaris were divided into the BHS and BSS groups according to the syndrome differentiation of Chinese medicine (CM). Ten healthy subjects were considered as the control group. Cytokine levels of interleukin (IL)-17, IL-23 and IL-6 in serum were determined by enzyme-linked immunosorbent assay. Expression levels of signal transducer and activator of transcription 3 (STAT3), p38-mitogen-activated protein kinase (MAPK) and STAT6 in the psoriatic lesions were determined using immunohistochemistry (IHC), Western blot, and real-time quantitative reverse transcription polymerase chain reaction, respectively. Results: Production of IL-17, IL-23 and IL-6 in the BHS group and BSS group were significantly increased compared with those in the control group (P〈0.05). Levels of IL-17 and IL-23 in the BHS group were higher than those in the BSS group (P〈0.05). Compared with the control group, IHC positive expressions and protein expressions of STAT3 and p38-MAPK, and the STAT3 mRNA expressions in the BHS and BSS groups were significantly higher (P〈0.05 or P〈0.01). The protein expression of STAT3 in the BHS group was significantly higher than that in the BSS group (P〈0.05). Conclusions: Cytokines in serum and signal transducers in the psoriatic lesions alter with various CM syndromes of psoriasis. The results provide scientific basis for the treatment based on syndrome differentiation of CM in treating psoriasis vulgaris. 展开更多
关键词 psoriasis T-helper 17 cells signal transducers blood-heat syndrome blood-stasis syndrome Chinese medicine
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Effect of New Pulian Ointment (新普连膏) in Treating Psoriasis of Blood-Heat Syndrome:A Randomized Controlled Trial 被引量:6
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作者 周宁 白彦萍 +4 位作者 蔓小红 张云璧 孔宇虹 鞠海 常明 《Chinese Journal of Integrative Medicine》 SCIE CAS 2009年第6期409-414,共6页
Objective:To objectively assess the clinical efficacy and safety of a new Pulian Ointment(新普连膏,NPLO) in treating psoriasis of blood-heat syndrome of Chinese medicine.Methods:A total of 108 patients with psoriasis ... Objective:To objectively assess the clinical efficacy and safety of a new Pulian Ointment(新普连膏,NPLO) in treating psoriasis of blood-heat syndrome of Chinese medicine.Methods:A total of 108 patients with psoriasis of blood-heat syndrome were equally assigned,using a randomizing digital table,to the test group treated externally with NPLO and the control group treated with placebo;the medication was done using a single-blinded method twice a day.Meanwhile,all patients received by oral intake a conventional Ch... 展开更多
关键词 curative efficacy assessment new Pulian Ointment blood heat syndrome psoriasis
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Circulating Levels of Inflammatory Cytokines in Patients with Psoriasis Vulgaris of Different Chinese Medicine Syndromes 被引量:7
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作者 禤美玲 卢传坚 +1 位作者 韩凌 项瑜 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2015年第2期108-114,共7页
Objective: To investigate whether the serum levels of inflammation-related cytokines might be different between the healthy individuals and the psoriatic patients diagnosed of three varied Chinese medicine (CM) syn... Objective: To investigate whether the serum levels of inflammation-related cytokines might be different between the healthy individuals and the psoriatic patients diagnosed of three varied Chinese medicine (CM) syndromes [blood-stasis syndrome (BSS), blood-dryness syndrome (BDS) and wind-heat syndrome (WHS)]. Methods: A total of 62 psoriatic patients were recruited and assigned to 3 groups according to their CM syndromes, including 27 patients of BSS, 21 of BDS and 14 of WHS. Another 20 sex- and age- matched healthy subjects were enrolled into the control group. Serum concentrations of multiple cytokines, including monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), soluble CD40 ligand (SCD40L), tumor necrosis factor-α (TNF-α), epidermal growth factor (EGF), interleukin-8 (IL-8), interleukin-17 (IL-17), interferon γ inducible protein-10 (IP-10) and vascular endothelial growth factor (VEGF), were measured by a multiplexed flow cytometric assay. Results: The circulating levels of MIP-1α, TNF-α, IL-8, and IP-10 were significantly increased in the psoriatic patients compared with the healthy controls (P〈0.01). Male and female patients tended to have higher serum levels of MCP-1 and IP-10, respectively (P〈0.05). Interestingly, compared with the control group, 6 out of the 9 cytokines (MCP-1, MIP-1α, TNF-α, EGF, IL-8 and IP-10) were substantially increased in the BSS group (P〈0.05 or P〈0.01), whereas only MIP-1α and IL-8 levels were elevated in the BDS group (P〈0.05 or P〈0.01) concurrent with lowered concentrations of SCD40L and IL-17 (P〈0.05). In the WHS group, MIP-1α was the only cytokine whose level was evidently increased (P〈0.01), in contrast to IL-17 which was decreased as compared with the control (P〈0.05). The psoriatic patients overall owned higher levels of MIP-1 a and IL-8 in the circulation which were comparable among the 3 groups of CM syndromes (P〈0.01). In contrast, TNF-α level of the BSS group was the highest among the three (P〈0.01), followed by the BDS and the WHS groups. Conclusions: The expression profiles of cytokines in the circulation might not be necessarily identical for psoriatic patients with different CM syndromes. Accordingly, the serum concentrations of certain cytokines could potentially be used as the ancillary indices for the clinical classification of psoriatic CM syndromes. 展开更多
关键词 psoriasis vulgaris blood-stasis syndrome blood-dryness syndrome wind-heat syndrome CYTOKINES Chinese medicine syndrome
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血热型寻常性银屑病辨治思考
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作者 徐胜东 刘占河 《新中医》 CAS 2024年第6期166-169,共4页
在审证求机的中医思维指导下,发现血热型寻常性银屑病的“血热”只是表象,其背后隐藏着不同的病因病机,风热蕴毒入血、肝经郁热入血是其主要的两种证候,故确立以解毒和疏肝解郁治本、以清热凉血治标的总原则,可选翘根犀角地黄汤解毒凉... 在审证求机的中医思维指导下,发现血热型寻常性银屑病的“血热”只是表象,其背后隐藏着不同的病因病机,风热蕴毒入血、肝经郁热入血是其主要的两种证候,故确立以解毒和疏肝解郁治本、以清热凉血治标的总原则,可选翘根犀角地黄汤解毒凉血、丹栀逍遥散疏肝解郁,随证治之。 展开更多
关键词 银屑病 血热型 辨证论治 风热蕴毒入血 肝经郁热入血 解毒凉血 疏肝解郁
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中药熏洗治疗头部银屑病血热证临床观察
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作者 张亚丽 吴开举 《光明中医》 2024年第13期2623-2626,共4页
目的观察自拟中药熏洗方治疗头部银屑病血热证的临床疗效。方法选取2020年6月—2022年12月收治的60例头部银屑病血热证患者,按照随机分配原则分为对照组和观察组,每组30例。2组均给予盐酸左西替利嗪片、复方甘草酸苷片口服,观察组同时... 目的观察自拟中药熏洗方治疗头部银屑病血热证的临床疗效。方法选取2020年6月—2022年12月收治的60例头部银屑病血热证患者,按照随机分配原则分为对照组和观察组,每组30例。2组均给予盐酸左西替利嗪片、复方甘草酸苷片口服,观察组同时外用中药熏洗方,疗程均为4周。比较2组患者治疗前后头部PASI评分、瘙痒评分及治疗效果。结果治疗后,观察组总有效率显著优于对照组,差异具有统计学意义(P<0.05)。2组患者PASI评分和瘙痒评分均较治疗前下降(P<0.05),且观察组较对照组降低更明显(P<0.05)。结论采用中药熏洗方治疗头部银屑病血热证疗效显著,可明显改善皮损严重程度、缓解瘙痒,值得临床推广和应用。 展开更多
关键词 白疕 银屑病 血热证 中药熏洗疗法
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新银灵颗粒对寻常型银屑病血热证患者外周血Th22细胞及其细胞因子的影响 被引量:2
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作者 李晓莉 邱芳 +3 位作者 刘栋 闫学文 贾婧 赵丽园 《中国中西医结合皮肤性病学杂志》 CAS 2024年第3期193-196,共4页
目的观察新银灵颗粒对寻常型银屑病(PsV)血热证患者外周血辅助性T细胞22(Th22)及其细胞因子的影响。方法选取2019年12月—2020年12月在天津市中医药研究院附属医院皮肤科门诊就诊的30例PsV血热证患者为研究组,10例健康志愿者为对照组。... 目的观察新银灵颗粒对寻常型银屑病(PsV)血热证患者外周血辅助性T细胞22(Th22)及其细胞因子的影响。方法选取2019年12月—2020年12月在天津市中医药研究院附属医院皮肤科门诊就诊的30例PsV血热证患者为研究组,10例健康志愿者为对照组。研究组采用新银灵颗粒治疗8周,分别于治疗前后采取外周血,流式细胞术检测外周血Th22细胞比例,酶联免疫吸附测定(ELISA)法检测白细胞介素-22(IL-22)水平,实时荧光定量聚合酶链反应(RT-qPCR)检测IL-22 mRNA表达。结果经过新银灵颗粒治疗,研究组与治疗前比较,银屑病面积及严重程度指数(PASI)评分、中医证候评分和皮肤病生活质量指数评分(DLQI)均显著下降(均P<0.01);治疗后外周血中Th22细胞比例、IL-22及IL-22信使RNA(mRNA)表达水平均显著降低(P<0.01)。结论新银灵颗粒可能通过抑制Th22细胞活化、降低Th22细胞因子表达,从而治疗PsV血热证。 展开更多
关键词 寻常型银屑病 血热证 新银灵颗粒 辅助性T细胞22
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李树君治疗寻常型银屑病经验介绍
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作者 潘之 张玉琴 +2 位作者 李艳萍 雒玉辉 李树君(指导) 《新中医》 CAS 2024年第24期215-218,共4页
介绍李树君主任医师治疗寻常型银屑病的临床经验。李树君认为寻常型银屑病的基本病机是血热内蕴,且贯穿病程始终,故将其基本病证分为血热和血燥两种证型,同时主张有侧重地运用从血辨证、从卫气营血辨证、从脏腑辨证、从经络辨证,治疗上... 介绍李树君主任医师治疗寻常型银屑病的临床经验。李树君认为寻常型银屑病的基本病机是血热内蕴,且贯穿病程始终,故将其基本病证分为血热和血燥两种证型,同时主张有侧重地运用从血辨证、从卫气营血辨证、从脏腑辨证、从经络辨证,治疗上重视调脾胃、护阴液、调冲任,辨证用药,并借鉴现代中药药理学研究成果针对性用药。 展开更多
关键词 寻常型银屑病 血热内蕴 辨证用药 李树君
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秦艽丸联合刺络拔罐疗法治疗寻常型银屑病血热证的疗效评价及对血清炎症因子的影响
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作者 薛凯元 吴海源 +1 位作者 贾丽丹 杨素清 《时珍国医国药》 CAS CSCD 北大核心 2024年第8期1911-1914,共4页
目的 探讨秦艽丸联合刺络拔罐疗法治疗寻常型银屑病血热证的临床疗效及对血清炎症因子的干预影响。方法 选取2021年10月至2023年10月该院皮肤科门诊收治的130例寻常型银屑病血热证患者随机分为治疗组和对照组各65例,治疗组给予中药汤剂... 目的 探讨秦艽丸联合刺络拔罐疗法治疗寻常型银屑病血热证的临床疗效及对血清炎症因子的干预影响。方法 选取2021年10月至2023年10月该院皮肤科门诊收治的130例寻常型银屑病血热证患者随机分为治疗组和对照组各65例,治疗组给予中药汤剂秦艽丸加减联合中医特色外治刺络拔罐疗法治疗,对照组仅给予刺络拔罐疗法治疗,记录两组患者治疗前、第2周、第4周皮损PASI评分、生活质量DLQI指数评分、中医证候评分,并酶联免疫吸附实验(ELISA)法检测治疗前后患者血清中肿瘤坏死因子-α(TNF-α)、干扰素-γ(INF-γ)、白介素-6(IL-6)、白介素-17(IL-17)水平。结果 治疗组总有效率96.92%明显高于对照组83.08%(P<0.05),治疗后两组PASI评分、生活质量DLQI指数、中医证候评分明显降低,两组患者血清炎症因子TNF-α、INF-γ、IL-6、IL-17水平均较治疗前显著改善,且治疗组评分明显优于对照组,差异有统计学意义(P<0.05)。结论 秦艽丸联合刺络拔罐疗法可以有效改善寻常型银屑病血热证患者皮损状况及各项中医证候,降低炎症因子水平并提高患者生活质量,疗效确切,展现中医药特色治疗优势,值得临床推广使用。 展开更多
关键词 秦艽丸 刺络拔罐 血热证银屑病 炎症因子
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基于四川地域特色探讨寻常性银屑病的中医治疗
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作者 叶晟桢 凌桂华 +1 位作者 肖敏 陈明岭 《皮肤科学通报》 2024年第3期348-351,共4页
银屑病是常见的慢性炎症性皮肤病,中医又称白疕。历代中医医家非常重视地域因素对疾病造成的影响,强调气候、饮食、体质等因素在患病过程中所发挥的重要作用。结合四川地区独特的地理位置和气候环境,经过长期的临床实践与总结,本文提出... 银屑病是常见的慢性炎症性皮肤病,中医又称白疕。历代中医医家非常重视地域因素对疾病造成的影响,强调气候、饮食、体质等因素在患病过程中所发挥的重要作用。结合四川地区独特的地理位置和气候环境,经过长期的临床实践与总结,本文提出寻常性银屑病以脾虚为本,湿热内蕴为因,皮肤红斑鳞屑为果,提倡以寒温并调、清热利湿、健脾疏肝为治法,以标本兼治、扶正祛邪为目的治疗银屑病,临床常取得较为满意的疗效。本文介绍了川派皮科对银屑病的中医认识及治疗经验,以期为中医治疗寻常性银屑病的提供思路。 展开更多
关键词 湿热气候 湿热证 寻常性银屑病 寒温并调法 脾胃 体质
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走罐联合火针治疗血瘀型白疕临床观察 被引量:3
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作者 卢懿 闵俊英 +2 位作者 赵爱平 宋淑华 刘萍 《中国中医药现代远程教育》 2024年第6期102-104,共3页
目的 观察走罐联合火针治疗血瘀型白疕的临床效果。方法 将2020年1月—2021年3月于江西省中西医结合医院皮肤科住院的80例血瘀型白疕患者随机分为试验组和对照组。试验组在常规护理的基础上使用走罐联合火针治疗,对照组在常规护理的基... 目的 观察走罐联合火针治疗血瘀型白疕的临床效果。方法 将2020年1月—2021年3月于江西省中西医结合医院皮肤科住院的80例血瘀型白疕患者随机分为试验组和对照组。试验组在常规护理的基础上使用走罐联合火针治疗,对照组在常规护理的基础上外擦卡泊三醇软膏和黄连膏治疗,治疗时间均为30 d。对比2组皮损面积和严重程度指数(PASI)评分、瘙痒情况及临床疗效。结果 试验组PASI评分低于对照组(P<0.05);试验组瘙痒情况优于对照组(P<0.05);试验治疗总有效率95.00%(38/40)高于对照组的75.00%(30/40)(P<0.05)。结论 走罐联合火针治疗对血瘀型白疕患者的恢复具有促进作用。 展开更多
关键词 白疕 寻常型银屑病 血瘀证 走罐疗法 火针疗法 中医综合疗法
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自拟解毒凉血汤联合西药治疗寻常型银屑病(血热证)的临床疗效及对生活质量的影响 被引量:1
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作者 卫艳 袁缘 《中医临床研究》 2024年第7期91-95,共5页
目的:观察自拟解毒凉血汤联合西药治疗寻常型银屑病(血热证)的临床疗效及对患者生活质量的影响。方法:将80例寻常型银屑病(血热证)患者随机分为观察组和对照组,每组40例。对照组予以阿维A胶囊20~30 mg/d,卡泊三醇轻柔均匀涂抹于皮损处,2... 目的:观察自拟解毒凉血汤联合西药治疗寻常型银屑病(血热证)的临床疗效及对患者生活质量的影响。方法:将80例寻常型银屑病(血热证)患者随机分为观察组和对照组,每组40例。对照组予以阿维A胶囊20~30 mg/d,卡泊三醇轻柔均匀涂抹于皮损处,2次/d,治疗4周。观察组加用自拟解毒凉血汤,药用生槐花15 g,紫草20 g,生地黄30 g,牡丹皮20 g,白茅根15 g,土茯苓15 g,金银花15 g,白鲜皮15 g,水牛角30 g,板蓝根15 g,龙骨(先煎)30 g,牡蛎(先煎)30 g,远志15 g,由医院统一制成装袋,200 mL/袋,1袋/次,2次/d,治疗4周。比较两组治疗后临床疗效、皮损面积和严重程度、炎性因子水平、瘙痒程度、生活质量评分。结果:治疗后,观察组总有效率高于对照组(P<0.05),炎性因子水平、银屑病皮损面积和严重程度评分、瘙痒评分、生活质量评分均低于对照组(P<0.05)。结论:自拟解毒凉血汤联合西药治疗寻常型银屑病(血热证)能提高临床疗效,改善临床症状,降低炎性反应,提高患者生活质量。 展开更多
关键词 寻常型银屑病 白疕 血热证 解毒凉血汤
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犀角地黄汤加味联合司库奇尤单抗注射液治疗中重度银屑病临床研究 被引量:1
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作者 郑明警 赵东瑞 《新中医》 CAS 2024年第6期18-22,共5页
目的:观察犀角地黄汤加味联合司库奇尤单抗注射液治疗中重度银屑病血热证的临床疗效。方法:选取64例中重度银屑病血热证患者,采用随机数字表法分为对照组和观察组各32例。2组均剔除2例,最终纳入研究各30例。对照组给予司库奇尤单抗注射... 目的:观察犀角地黄汤加味联合司库奇尤单抗注射液治疗中重度银屑病血热证的临床疗效。方法:选取64例中重度银屑病血热证患者,采用随机数字表法分为对照组和观察组各32例。2组均剔除2例,最终纳入研究各30例。对照组给予司库奇尤单抗注射液治疗,观察组在对照组基础上给予犀角地黄汤加味治疗。2组均治疗2个月。比较2组临床疗效、银屑病皮损面积和严重指数(PASI)评分、皮肤病生活质量指数(DLQI)评分、炎症因子水平及不良反应发生率。结果:治疗后,观察组总有效率93.33%,高于对照组73.33%,差异有统计学意义(P<0.05)。2组PASI、DLQI评分均较治疗前降低,观察组PASI、DLQI评分均低于对照组,差异均有统计学意义(P<0.05)。2组血清白细胞介素-6(IL-6)、白细胞介素-17A(IL-17A)、白细胞介素-23(IL-23)水平均较治疗前降低,观察组血清IL-6、IL-17A、IL-23水平均低于对照组,差异均有统计学意义(P<0.05)。不良反应发生率观察组6.67%、对照组3.33%,2组比较,差异无统计学意义(P>0.05)。结论:在司库奇尤单抗注射液基础上加用犀角地黄汤加味治疗中重度银屑病血热证,可提高临床疗效和患者的生活质量,抑制炎症反应,且安全性好。 展开更多
关键词 银屑病 中重度 血热证 犀角地黄汤 司库奇尤单抗注射液 生活质量 炎症因子
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Efficacy and safety of Liangxue Jiedu decoction for the treatment of progressive psoriasis vulgaris: a multicenter, randomized, controlled study 被引量:3
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作者 Sun Liyun Li Tiantian +12 位作者 Zhou Dongmei Yang Xiumin Tian Jing Zhao Junying Xu Wei He Yanling Liu Fang Tong Chunguan Chu Xiaoling Dai Ling Zhu Wei Xu Xuying Wang Ping 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2020年第2期296-304,共9页
OBJECTIVE: To determine the clinical efficacy and safety of Liangxue Jiedu decoction(LJD) for the treatment of progressive psoriasis vulgaris and to provide the basis for the development of a standardized treatment pr... OBJECTIVE: To determine the clinical efficacy and safety of Liangxue Jiedu decoction(LJD) for the treatment of progressive psoriasis vulgaris and to provide the basis for the development of a standardized treatment protocol for psoriasis vulgaris.METHODS: In this multicenter, randomized, controlled study, patients with blood-heat type psoriasis were randomly assigned to receive either Chinese herbal medicine(LJD;treatment group) or Western Medicine(cetirizine hydrochloride, vitamin C, and vitamin B complex;control group). Psoriasis Area and Severity Index(PASI) scores were calculated in addition to the number of patients who achieved ≥ 50% or ≥ 75% improvement in PASI score from baseline. The change in symptoms of Chinese medicine(color of rash, burning sensation,itchiness, severity of irritation, and anger) was evaluated and safety was assessed as adverse events and laboratory analysis. t test, independent sample non-parametric test and χ2 test were used to analyze the results.RESULTS: A total of 238 participants were included in the study [treatment group, n = 122(PP analysis117);control group, n = 116(PP analysis 104)]. LJD treatment was associated with a significant improvement in skin lesions and symptoms com-pared with Western Medicine treatment. At the end of the 8-week treatment period, 23.77%(PP analysis 24.79%) of patients in the treatment group had achieved PASI75 and 57.38%(PP analysis 58.97%)had achieved PASI50;the corresponding figures in the control group were 9.48%(9.62%) and 25.00%(25.00%), respectively. The between-group differences were statistically significant(P < 0.05).CONCLUSION: Treatment of psoriasis vulgaris of the blood-heat type using LJD was associated with significantly better outcomes compared with those achieved using standard Western Medicine. 展开更多
关键词 psoriasis vulgaris blood heat Treatment outcome SAFETY Liangxue Jiedu decoction
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Correlation analysis of Treg/Th17 cells and related cytokines in patients with psoriasis vulgaris 被引量:8
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作者 Qu Tiange Mei Chencheng +2 位作者 Zeng Yajun Li Lingling Duan Xingwu 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2019年第5期700-706,共7页
OBJECTIVE: To investigate potential differences in circulating levels of T regulatory (Treg)/T helper 17 (Th17) cells, related inflammatory cytokines and specific transcription factors in healthy individuals and patie... OBJECTIVE: To investigate potential differences in circulating levels of T regulatory (Treg)/T helper 17 (Th17) cells, related inflammatory cytokines and specific transcription factors in healthy individuals and patients with psoriasis conforming to one of three Traditional Chinese Medicine (TCM) syndromes: blood-heat syndrome (BHS), blood-stasis syndrome (BSS) and blood-dryness syndrome (BDS). METHODS: Sixty-seven patients with psoriasis were recruited and assigned to one of three corresponding TCM syndrome groups: BHS (n = 40), BSS (n = 14) and BDS (n = 13 patients). The control group comprised 21 healthy individuals. The circulating levels of Treg/Th17 cells in peripheral blood were assessed using flow cytometry;the levels of inflammatory cytokines interleukin (IL)-10 and tumor necrosis factor (TNF)-α by enzyme-linked immunosorbent assay;and the mRNA expression of T cell-specific transcription factors retinoic acid-related orphan receptor γt (RORγt) and forkhead box P3 (Foxp3) by quantitative real-time PCR. RESULTS: The ratio of Th17 cells and the levels of TNF-α and RORγt were all significantly higher in the BHS and BSS groups than the control group (P < 0.05), while the ratio of Treg cells and the levels of IL-10 and Foxp3 mRNA in the BHS group were significantly lower compared with the control group (P < 0.05). No significant differences were seen between the BSS group and the control group. The ratio of Th17 cells and the levels of TNF-α and RORγt in the BDS group were not significantly different from those of the control group;however, the ratio of Treg cells and the levels of IL-10 and Foxp3 were all lower than those in the healthy controls (P < 0.05). CONCLUSION: Compared with healthy individuals, the ratio of Th17 cells and the levels of related cytokines were higher, while the ratio of Treg cells and the levels of related cytokines were lower, in the peripheral blood of psoriasis/BHS patients;corresponding results for the BSS and BDS groups also showed differences. We propose that patterns of differentiation of immunological cells in psoriasis patients are reflected in corresponding TCM blood syndromes. 展开更多
关键词 psoriasis vulgaris blood-heat blood STASIS T-Lymphocytes regulatory Th17 cells Medical informatics
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62例并发血脂异常的血热证白疕患者临床分析
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作者 孙雨欣 卢益萍 《智慧健康》 2024年第2期72-75,共4页
目的 探讨并发血脂异常的血热证白疕患者的临床相关性。方法 收录2020年1月—2022年12月在辽宁中医药大学附属医院皮肤科住院治疗的并发血脂异常的血热证白疕患者的相关资料,包括一般资料、伴随症状、中医舌脉情况、皮损严重程度,运用SP... 目的 探讨并发血脂异常的血热证白疕患者的临床相关性。方法 收录2020年1月—2022年12月在辽宁中医药大学附属医院皮肤科住院治疗的并发血脂异常的血热证白疕患者的相关资料,包括一般资料、伴随症状、中医舌脉情况、皮损严重程度,运用SPSS 26.0统计学软件进行分析。结果 本次研究中最常见舌象为舌红苔黄腻,最常见脉象为滑脉。甲损伤组PASI评分高于无甲损伤组,甲损伤组高密度脂蛋白水平低于无甲损伤组,差异有统计学意义(P<0.05)。结论 白疕和血脂异常可能存在共同致病因素,或与痰湿相关,中医治疗上需兼顾祛痰化湿。临床中需警惕伴有甲损伤的患者出现高密度脂蛋白降低的风险。 展开更多
关键词 银屑病 血脂异常 血热证
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四藤合剂联合中药浴治疗寻常型银屑病血热证的临床研究
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作者 张丹露 褚美琴 +4 位作者 祝英 胡凯舒 郭韫懿 季梅 孙忠辉 《中国中西医结合皮肤性病学杂志》 CAS 2024年第3期216-220,共5页
目的观察四藤合剂、自制清热消银药浴方单用和联合治疗血热证寻常型银屑病(PsV)的临床疗效及相关炎性因子的变化。方法收集2021年1月—2023年6月就诊于本院,符合纳入标准的血热证PsV患者120例,随机分为药浴组、中药组和联合组,每组40例... 目的观察四藤合剂、自制清热消银药浴方单用和联合治疗血热证寻常型银屑病(PsV)的临床疗效及相关炎性因子的变化。方法收集2021年1月—2023年6月就诊于本院,符合纳入标准的血热证PsV患者120例,随机分为药浴组、中药组和联合组,每组40例,共治疗4周。于第0周和第4周记录患者银屑病面积和严重程度指数(PASI)评分和采用酶联免疫吸附测定(ELISA)法检测血清白细胞介素-17(IL-17)、IL-22、肿瘤坏死因子-α(TNF-α)和血管内皮生长因子(VEGF)血清浓度变化。结果治疗4周时,药浴组(38例)治疗总有效率为31.58%,中药组(36例)为41.67%,联合组(38例)为68.42%,联合组治疗总有效率显著高于其他2组(P<0.01);3组患者治疗后PASI评分与治疗前比较均显著降低(均P<0.01);联合组PASI评分(6.16±2.25)下降程度显著大于药浴组的(3.13±1.61)和中药组的(5.47±2.26,P<0.01)。治疗后,3组患者血清中IL-17、IL-22、TNF-α和VEGF浓度均显著低于治疗前(P<0.01);联合组血清浓度水平降低更为显著[IL-17(40.74±12.70)、IL-22(35.17±2.93)、TNF-α(22.22±1.72)和VEGF(266.00±11.45)],显著低于药浴组[IL-17(57.02±12.57)、IL-22(54.55±0.56)、TNF-α(28.05±2.56)和VEGF(287.60±11.33)]以及中药组[IL-17(57.61±15.04)、IL-22(54.45±0.63)、TNF-α(27.43±2.15)和VEGF(285.10±10.33,P<0.01)]。3组都有因安全性退出的患者,其中:药浴组2例,中药组4例,联合组2例。结论四藤合剂与自制清热消银药浴方治疗血热证PsV都有一定疗效,二者联用能显著提高治疗有效率,并且针对血热证PsV患者的炎性因子,也较单用有显著抑制作用。四藤合剂联合自制清热消银药浴方治疗血热证PsV值得临床使用和推广。 展开更多
关键词 银屑病 血热证 清热消银药浴方 四藤合剂 炎性因子
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雷公藤多苷片辅助治疗寻常型银屑病血热证临床研究
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作者 马琳 祝美洁 《新中医》 CAS 2024年第17期93-97,共5页
目的:观察雷公藤多苷片辅助治疗寻常型银屑病血热证的临床疗效。方法:按随机数字表法将82例血热证银屑病患者分为联合组和对照组各41例。对照组给予窄谱中波紫外线(NB-UVB)全身照射治疗,联合组在对照组基础上加用雷公藤多苷片治疗。比较... 目的:观察雷公藤多苷片辅助治疗寻常型银屑病血热证的临床疗效。方法:按随机数字表法将82例血热证银屑病患者分为联合组和对照组各41例。对照组给予窄谱中波紫外线(NB-UVB)全身照射治疗,联合组在对照组基础上加用雷公藤多苷片治疗。比较2组治疗前后中医证候积分、皮损面积与严重程度指数量表(PASI)评分、生活质量指数量表(DLQI)评分、皮肤屏障功能、炎性因子,统计临床疗效及不良反应发生率。结果:联合组总有效率为90.24%,高于对照组73.17%(P<0.05)。治疗后,2组各项中医证候评分均较治疗前降低(P<0.05),且联合组各项中医证候评分低于对照组(P<0.05)。治疗后,2组PASI、DLQI评分较治疗前降低(P<0.05),且联合组PASI、DLQI评分低于对照组(P<0.05)。治疗后,2组角质层含水量、皮脂含量较治疗前增高,经表皮水分丢失率(TEWL)较治疗前降低(P<0.05);且联合组角质层含水量、皮脂含量高于对照组,TEWL低于对照组(P<0.05)。治疗后,2组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)水平较治疗前降低(P<0.05),且联合组血清TNF-α、IL-17水平低于对照组(P<0.05)。结论:雷公藤多苷片辅助治疗寻常型银屑病血热证患者疗效更佳,能降低皮损严重程度与炎症反应、调节皮肤屏障功能,提高生活质量,且安全性较高。 展开更多
关键词 寻常型银屑病 血热证 雷公藤多苷片 皮肤屏障功能 炎症因子 生活质量
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毫火针联合耳尖刺血及枇杷清肺饮加减治疗寻常型痤疮肺经风热证的临床效果
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作者 黎娟 张少铃 +1 位作者 邹秋菊 孙世明 《中外医药研究》 2024年第28期79-81,共3页
目的:观察毫火针联合耳尖刺血及枇杷清肺饮加减治疗寻常型痤疮肺经风热证的临床效果。方法:选取2023年1—10月韶关市慢性病防治院收治的60例寻常型痤疮肺经风热证患者,按随机数字表法分为观察组和对照组,各30例。观察组给予毫火针联合... 目的:观察毫火针联合耳尖刺血及枇杷清肺饮加减治疗寻常型痤疮肺经风热证的临床效果。方法:选取2023年1—10月韶关市慢性病防治院收治的60例寻常型痤疮肺经风热证患者,按随机数字表法分为观察组和对照组,各30例。观察组给予毫火针联合耳尖刺血及枇杷清肺饮加减治疗,对照组给予红蓝光、面膜及枇杷清肺饮加减治疗,两组均涂抹克林霉素甲硝唑搽剂、维A酸乳膏。对比两组皮损积分、不良反应发生率、临床疗效。结果:治疗后,两组皮损积分较治疗前下降,观察组低于对照组(P<0.05);观察组治疗总有效率高于对照组(P=0.028);观察组不良反应发生率低于对照组(P=0.037)。结论:毫火针联合耳尖刺血及枇杷清肺饮加减治疗寻常型痤疮肺经风热证患者的效果较好,能够改善皮损症状,减少不良反应。 展开更多
关键词 毫火针 耳尖刺血 枇杷清肺饮 寻常型痤疮 肺经风热证
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