Dependablity study on near-infrared parameters of blood oxygen and microvessel density of mammary gland phyma

Objective:To detect the reliability of near-infrared parameters of blood oxygen of mammary gland phyma from the microvessel density of tumor.Methods:181 cases of mammary gland phyma who had accepted the examination of the near-infrared TBO-I dual-wave length mammary gland phyma detector were classified by near-infrared parameters of blood oxygen,and were performed the pathologic examination to ascertain whether the tumor was benign or malignant.Among these cases,intratumoral microvessel density of 20 cases of malignant phyma and 20 cases of benign phyma were confirmed by S-P immunohistochemical method,then the relationship between near-infrared parameters and microvessel density were analyzed by medical statistics.Results:(1)The microvessel density and blood concentration of 28 cases of the"high blood" tumor were 24.56±8.110 and 1.891±0.850 respectively.The microvessel density and blood concentration of 12 cases of the"low blood"tumor were 17.98±8.729 and 0.698±0.283 respectively.There was significant difference between the"high blood"and"low blood"tumors(P<0.05).(2)The intratumoral microvessel density and blood concentration were linearly correlated respectively,and the linear correlation coefficient r=0.4208(P<0.05)in 40 cases of mammary gland phyma. Conclusion:The intratumoral microvessel density and blood concentration of benign or malignant mammary gland phyma were linearly correlated.Blood concentration(one of near-infrared parameters)is reliable to be used as diagnosis criterion of malignant mammary gland phyma.

乳腺肿块微血管密度与血氧近红外光参数的实验研究

目的从组织微血管分布密度初探乳腺肿块血氧近红外光参数的可靠性。方法用近红外光TBO-I型双波长乳腺肿瘤检测仪,对检测的181例乳腺肿块进行近红外光血氧参数分类和病理切片检查明确肿块性质,并对其中20例恶性肿块和20例良性肿块进行免疫组织化学SP法检测乳腺肿块微血管密度,运用医学统计学方法分析近红外光血氧参数与微血管密度的相关性。结果(1)28例高血乳腺肿块微血管密度值和血含量值分别为24.56±8.110和1.891±0.850,12例低血乳腺肿块微血管密度值和血含量值分别为17.98±8.729和0.698±0.283,两者比较存在显著性差异(P<0.05);(2)40例乳腺肿块的微血管密度值与近红外光血含量值直线相关系数为r=0.4208(P<0.05)。结论乳腺良、恶性肿块局部微血管密度与其血含量近红外检测参数存在相关性,说明了近红外光血含量检测参数作为诊断乳腺癌标准的可靠性。

血氧检测与彩超检查对乳腺癌诊断的比较分析

目的探讨乳腺血氧检测对乳腺癌的诊断价值。方法对45例乳腺肿块患者分别采用乳腺血氧检测及乳腺彩色多普勒超声检查,并对结果进行对比分析。结果乳腺血氧检测对乳腺癌诊断的准确性为91.1%、特异性92.3%、敏感性89.4%。彩色多普勒检查对乳腺癌诊断的准确性为80.0%、特异性76.9%、敏感性84.2%。两组比较差异无统计学意义(P>0.05)。结论乳腺血氧检测对乳腺癌诊断具有较高的准确性、特异性及敏感性,对乳腺癌有较高的诊断价值,临床上可将乳腺血氧检测与彩色多普勒超声检查两种方法有效结合,综合诊断乳腺癌。

多波长近红外乳腺血氧检测影像特征在乳腺癌诊断中的应用

目的:分析多波长近红外乳腺血氧检测影像特征在乳腺癌诊断中的应用价值。方法:选择医院收治的146例乳腺疾病患者,其中病理诊断乳腺癌62例,乳腺良性病变84例,均行多波长近红外乳腺血氧功能影像检测,并将其检测结果与病理结果、血含量、氧含量及微血管密度(MVD)进行对比。结果:乳腺癌患者血含量显著高于乳腺良性病变患者,且氧含量显著低于乳腺良性病变患者,差异有统计学意义(t=5.223,t=2.907;P<0.05);血氧检测对乳腺癌的灵敏度、特异度及准确率分别为93.55%、80.95%和86.30%,阳性预测值和阴性预测值分别为78.37%和94.44%;乳腺癌患者MVD值显著高于乳腺良性病变患者,差异有统计学意义(t=2.084,P<0.05);Person相关性分析显示,乳腺良性病变患者及乳腺癌患者血氧含量与MVD值之间无明显相关性(r=0.105,r=-0.228;P>0.05)。结论:高血含量低氧含量诊断是乳腺癌的多波长近红外乳腺血氧检测影像特征,应用该技术诊断乳腺癌具有一定临床指导价值。