Summary： The effects of oligosaccharide and creatine （Cr） supplementation on glucose, lactic acid and urea nitrogen levels in blood and activity of serum creatine kinase （CK） were explored. Twenty CUBA male athle...Summary： The effects of oligosaccharide and creatine （Cr） supplementation on glucose, lactic acid and urea nitrogen levels in blood and activity of serum creatine kinase （CK） were explored. Twenty CUBA male athletes were divided into 4 groups： group A （supplementation of Cr alone）, group B （supplementation of oligosaccharide）, group C （supplementation of oligosaccharide and Cr） and group D （placebo control group）. By using orthogonal L4 table （2a ）, the experiment was performed. There were factors including oligosaccharide （carbohydrate, CHO）, Cr and their correlation. Each factor had two levels： supplementation and no-supplementation. The results showed that the supplementation of CliO or Cr alone, combined supplementation of CHO and Cr could significantly reduce the glucose, urea nitrogen levels in blood and serum CK activity after competition in the athletes. Moreover, the effects of combined supplementation of CHO and Cr were more satisfactory. It was concluded that supplementation of CliO and Cr could promote the recovery of physical performance and athletic abilities after athletics in basketball athletes.展开更多
In order to investigate the feasibility of serum creatine kinase （CK） and blood urea nitrogen （BUN） in monitoring pre-competition training of badminton athletes, the pre-competition training load of 20 badminton a...In order to investigate the feasibility of serum creatine kinase （CK） and blood urea nitrogen （BUN） in monitoring pre-competition training of badminton athletes, the pre-competition training load of 20 badminton athletes was studied, and serum CK and BUN were determined before, immediate and next morning after training. The results showed that after intensive training for one week, serum CK levels were significantly increased by 57.53 mmol/L （P〈0.05）. After regulation of the training intensity, average serum CK levels were increased by 21.79 mmol/L （P〈0.05）. BUN contents were increased by 0.83 mmol/L on average with the difference being not significant （P〉0.05）. After intermittent training, there was significant difference in the average increased levels of serum CK in athletes （P〈0.05）. There was significant difference before and after regulation of training （P〈0.05）. The increased levels of BUN were 0.78 mmol/L without significant difference （P〉0.05）. It was concluded that serum CK was one of the biochemical indicators monitoring the training load sensitivity of badminton athletes, but BUN was of little value in monitoring the training load. Both serum CK and BUN recovered slowly after one-week intensive training and intermittent training, suggesting the metabolic mechanism of human body in training needs further study.展开更多
Objective:To examine the effects of hydroalcoholic extract and fractions of Hordeum vulgare Linn.(H.vulgare,Da Mai)on streptozotocin(STZ)-induced diabetic nephropathy in Sprague-Dawley rat models.Methods:The study inv...Objective:To examine the effects of hydroalcoholic extract and fractions of Hordeum vulgare Linn.(H.vulgare,Da Mai)on streptozotocin(STZ)-induced diabetic nephropathy in Sprague-Dawley rat models.Methods:The study involved preliminary phytochemical screening of extract and fractions,estimation of secondary metabolites,chromatographic studies using high performance liquid chromatography(HPLC),antioxidant potential using 1,1-diphenyl-2-picrylhydrazyl(DPPH),nitric oxide radical scavenging and reducing power methods along with the determination of potential against diabetic nephropathy in STZ-induced rat models.Results:The phytochemical evaluation of the hydroalcoholic extract of H.vulgare and fractions revealed the presence of various phytoconstituents such as alkaloids,saponins,tannins,flavonoids,and glycosides.The chromatographic analysis indicated the peak complementing marker compound epicatechin and significant antioxidant activity in the extract and aqueous fraction.STZ-induced rats showed abnormal levels of serum albumin,creatinine,total cholesterol,blood urea nitrogen(BUN),and triglycerides,and urine albumin and creatinine,which returned to normal after 8 weeks of treatment with hydroalcoholic extract(400 mg/kg)and aqueous fraction(50 mg/kg)of H.vulgare.Conclusion:Hydroalcoholic extract(400 mg/kg)and aqueous fraction(50 mg/kg)of H.vulgare have significant antioxidant potential and positive effects on diabetic nephropathy.The fractionation and optimization increase the concentration of polyphenols in aqueous extract,causing a decrease in the dose required for effects against diabetic nephropathy.展开更多
目的:探究尿素氮与白蛋白比值(blood urea nitrogen to serum albumin ratio,B/A)对老年慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)合并肾功能不全患者,无创机械通气(non-invasi...目的:探究尿素氮与白蛋白比值(blood urea nitrogen to serum albumin ratio,B/A)对老年慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)合并肾功能不全患者,无创机械通气(non-invasive mechanical ventilation,NIV)预后的预测价值。方法:选择2021年1月至2023年1月,在连云港市第二人民医院肾内科,收治的老年AECOPD合并肾功能不全患者接受NIV患者220例,依据患者住院NIV治疗后28 d的生存情况分为:生存组(180例)和死亡组(40例),比较两组患者的B/A,运用Logistic回归性分析和受试者工作特征曲线ROC评价入院初24 h的B/A预测AECOPD合并肾功能不全患者NIV治疗后28 d预后的价值。结果:生存组白蛋白、血红蛋白和血小板显著高于死亡组患者(P <0.05),生存组尿素氮、B/A、急性生理和慢性健康评分(acutephysiology and chronic health evaluationⅡ,APACHEⅡ)显著低于死亡组患者(P <0.05)。Logistic回归分析结果显示B/A和APACHEⅡ评分是导致患者死亡的危险因素(P <0.05)。ROC分析显示,B/A的曲线下面积、敏感度、特异度均较APACHEⅡ评分增高,B/A与APACHEⅡ评分的AUC差异无统计学意义(t=1.686,P=0.093)。结论:B/A和APACHEⅡ评分均可用于评估老年AECOPD合并肾功能不全患者NIV预后,与APACHEⅡ评分比,B/A在评估老年AECOPD患者NIV预后的效能更高。展开更多
【目的】系统评价益气养阴法联合西药治疗肾病综合征的有效性及安全性。【方法】检索中国知网(CNKI)、中国生物医学文献数据库(CBM)、万方(Wangfang)、维普(VIP)、PubMed、Web of Science、Cochrane Library、Embase等国内外主要文献数...【目的】系统评价益气养阴法联合西药治疗肾病综合征的有效性及安全性。【方法】检索中国知网(CNKI)、中国生物医学文献数据库(CBM)、万方(Wangfang)、维普(VIP)、PubMed、Web of Science、Cochrane Library、Embase等国内外主要文献数据库,筛选其中有关益气养阴法联合西药(试验组)对比单纯西药(对照组)治疗肾病综合征的临床随机对照试验(RCTs),采用Cochrane手册中的偏倚风险工具进行文献的质量评价,运用RevMan 5.3软件进行Meta分析。【结果】共纳入18个RCTs,包含1334例患者。Meta分析结果显示,益气养阴法联合西药在提高临床有效率(RR=1.24,95%CI[1.16,1.32],P<0.00001),改善24 h尿蛋白定量(24hUPRO)(MD=-0.92,95%CI[-1.09,-0.75],P<0.00001)、血清白蛋白(ALB)(MD=7.06,95%CI[4.73,9.39],P<0.00001)、尿素氮(BUN)(MD=-1.57,95%CI[-2.01,-1.13],P<0.00001)、血肌酐(SCr)(MD=-12.23,95%CI[-16.58,-7.88],P<0.00001)、总胆固醇(TC)(MD=-1.06,95%CI[-1.69,-0.43],P=0.0009)、甘油三酯(TG)(MD=-0.58,95%CI[-0.94,-0.21],P=0.002)水平,以及降低不良反应发生率(RR=0.50,95%CI[0.40,0.64],P<0.00001)方面优于单纯西药治疗。【结论】益气养阴法联合西药治疗肾病综合征在提高临床疗效及改善24hUPRO、ALB、BUN、SCr、TC、TG方面优于单纯西药治疗,且能降低激素产生的不良反应。因纳入文献较少,文献质量较低,潜在疗效需更多的高质量研究进行验证。展开更多
背景随着人口老龄化的加剧,心力衰竭(heart failure,HF)患病率呈上升趋势,老年心力衰竭的预警、风险分层研究对改善预后具有重要意义。目的探讨血尿素氮-白蛋白比值(blood urea nitrogen to albumin ratio,BAR)对老年心力衰竭患者1年内...背景随着人口老龄化的加剧,心力衰竭(heart failure,HF)患病率呈上升趋势,老年心力衰竭的预警、风险分层研究对改善预后具有重要意义。目的探讨血尿素氮-白蛋白比值(blood urea nitrogen to albumin ratio,BAR)对老年心力衰竭患者1年内死亡的预测价值;建立包含BAR在内的列线图,并验证其临床价值。方法建模数据来自解放军总医院2016年1月—2021年10月诊断为心力衰竭的1259例老年患者,验证队列来自2021年10月—2022年10月诊断为心力衰竭的314例老年患者。以1年病死率为结局指标,采用Logistic回归分析筛选预后因素,根据预后因素构建列线图;ROC曲线、校准曲线和临床决策曲线分析(decision curve analysis,DCA)用于评估模型的区分度、一致性和临床效益;通过计算ROC曲线下面积和DCA,比较列线图与N端脑钠肽前体(N-terminal pro-B-type natriureticpeptide,NT-proBNP)及BIOSTATCHF预测模型的性能。结果训练队列和验证队列中分别有27.2%(343/1259)和25.2%(79/314)患者在1年内死亡。多因素Logistic回归结果显示,年龄、D-二聚体、NT-proBNP、BAR、血管紧张素转化酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)/血管紧张素受体阻滞剂(angiotensin receptor blockers,ARB)使用与死亡结局独立关联(P<0.05)。基于以上5个因素构建列线图,列线图展现出良好的区分度(AUC=0.838,P<0.001)、一致性(Hosmer-Lemeshowχ2=4.251,P=0.834)和临床效益。列线图模型与NT-proBNP和欧洲BIOSTAT-CHF预测模型相比预测效能均更佳(0.838 vs 0.703和0.825,P<0.05)。DCA结果提示,列线图相比NT-proBNP、BIOSTAT-CHF预测模型均增加了更多的净获益。结论BAR是老年心力衰竭患者1年内死亡的独立预测因子。包含BAR在内的列线图展现出优异的辨别力和校准能力,为预后评估提供有力支持。展开更多
目的通过分析血清胱抑素C(Cys-C)、β2微球蛋白(β2-MG)、尿酸(UA)等联合项目与糖尿病肾病(DN)的相关性,从而找出准确诊断DN的相关因素。方法选取259名糖尿病(DM)患者,收集Cys-C、β2-MG、UA等相关项目指标,运用相应的统计学方法分析相...目的通过分析血清胱抑素C(Cys-C)、β2微球蛋白(β2-MG)、尿酸(UA)等联合项目与糖尿病肾病(DN)的相关性,从而找出准确诊断DN的相关因素。方法选取259名糖尿病(DM)患者,收集Cys-C、β2-MG、UA等相关项目指标,运用相应的统计学方法分析相关项目与尿白蛋白/肌酐比值(UACR)的关系。结果UACR≥30 mg/g作为DN的诊断临界点时,显示Cys-C、β2-MG、UA、收缩压(SBP)、餐后2 h血糖(2 h PG)、病程等6个项目是UACR的独立危险因素,当某一DM患者Cys-C≥1.435 mg/L、β2-MG≥2.055 mg/L、UA≥320μmol/L、SBP≥145 mmHg、2 h PG≥8.5 mmol/L、病程≥4.5年时,患者发展成早期DN的风险较大,相对应的临界值患病概率为81.5%。结论联合检测Cys-C、β2-MG、UA、SBP、2 h PG、病程等6个项目可以较好预测DN的发生。展开更多
文摘Summary： The effects of oligosaccharide and creatine （Cr） supplementation on glucose, lactic acid and urea nitrogen levels in blood and activity of serum creatine kinase （CK） were explored. Twenty CUBA male athletes were divided into 4 groups： group A （supplementation of Cr alone）, group B （supplementation of oligosaccharide）, group C （supplementation of oligosaccharide and Cr） and group D （placebo control group）. By using orthogonal L4 table （2a ）, the experiment was performed. There were factors including oligosaccharide （carbohydrate, CHO）, Cr and their correlation. Each factor had two levels： supplementation and no-supplementation. The results showed that the supplementation of CliO or Cr alone, combined supplementation of CHO and Cr could significantly reduce the glucose, urea nitrogen levels in blood and serum CK activity after competition in the athletes. Moreover, the effects of combined supplementation of CHO and Cr were more satisfactory. It was concluded that supplementation of CliO and Cr could promote the recovery of physical performance and athletic abilities after athletics in basketball athletes.
文摘In order to investigate the feasibility of serum creatine kinase （CK） and blood urea nitrogen （BUN） in monitoring pre-competition training of badminton athletes, the pre-competition training load of 20 badminton athletes was studied, and serum CK and BUN were determined before, immediate and next morning after training. The results showed that after intensive training for one week, serum CK levels were significantly increased by 57.53 mmol/L （P〈0.05）. After regulation of the training intensity, average serum CK levels were increased by 21.79 mmol/L （P〈0.05）. BUN contents were increased by 0.83 mmol/L on average with the difference being not significant （P〉0.05）. After intermittent training, there was significant difference in the average increased levels of serum CK in athletes （P〈0.05）. There was significant difference before and after regulation of training （P〈0.05）. The increased levels of BUN were 0.78 mmol/L without significant difference （P〉0.05）. It was concluded that serum CK was one of the biochemical indicators monitoring the training load sensitivity of badminton athletes, but BUN was of little value in monitoring the training load. Both serum CK and BUN recovered slowly after one-week intensive training and intermittent training, suggesting the metabolic mechanism of human body in training needs further study.
基金supported by Rashtrsant Tukadoji Maharaj Memorial Fellowship from Rashtrasant Tukadoji Maharaj Nagpur University。
文摘Objective:To examine the effects of hydroalcoholic extract and fractions of Hordeum vulgare Linn.(H.vulgare,Da Mai)on streptozotocin(STZ)-induced diabetic nephropathy in Sprague-Dawley rat models.Methods:The study involved preliminary phytochemical screening of extract and fractions,estimation of secondary metabolites,chromatographic studies using high performance liquid chromatography(HPLC),antioxidant potential using 1,1-diphenyl-2-picrylhydrazyl(DPPH),nitric oxide radical scavenging and reducing power methods along with the determination of potential against diabetic nephropathy in STZ-induced rat models.Results:The phytochemical evaluation of the hydroalcoholic extract of H.vulgare and fractions revealed the presence of various phytoconstituents such as alkaloids,saponins,tannins,flavonoids,and glycosides.The chromatographic analysis indicated the peak complementing marker compound epicatechin and significant antioxidant activity in the extract and aqueous fraction.STZ-induced rats showed abnormal levels of serum albumin,creatinine,total cholesterol,blood urea nitrogen(BUN),and triglycerides,and urine albumin and creatinine,which returned to normal after 8 weeks of treatment with hydroalcoholic extract(400 mg/kg)and aqueous fraction(50 mg/kg)of H.vulgare.Conclusion:Hydroalcoholic extract(400 mg/kg)and aqueous fraction(50 mg/kg)of H.vulgare have significant antioxidant potential and positive effects on diabetic nephropathy.The fractionation and optimization increase the concentration of polyphenols in aqueous extract,causing a decrease in the dose required for effects against diabetic nephropathy.
文摘目的:探究尿素氮与白蛋白比值(blood urea nitrogen to serum albumin ratio,B/A)对老年慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)合并肾功能不全患者,无创机械通气(non-invasive mechanical ventilation,NIV)预后的预测价值。方法:选择2021年1月至2023年1月,在连云港市第二人民医院肾内科,收治的老年AECOPD合并肾功能不全患者接受NIV患者220例,依据患者住院NIV治疗后28 d的生存情况分为:生存组(180例)和死亡组(40例),比较两组患者的B/A,运用Logistic回归性分析和受试者工作特征曲线ROC评价入院初24 h的B/A预测AECOPD合并肾功能不全患者NIV治疗后28 d预后的价值。结果:生存组白蛋白、血红蛋白和血小板显著高于死亡组患者(P <0.05),生存组尿素氮、B/A、急性生理和慢性健康评分(acutephysiology and chronic health evaluationⅡ,APACHEⅡ)显著低于死亡组患者(P <0.05)。Logistic回归分析结果显示B/A和APACHEⅡ评分是导致患者死亡的危险因素(P <0.05)。ROC分析显示,B/A的曲线下面积、敏感度、特异度均较APACHEⅡ评分增高,B/A与APACHEⅡ评分的AUC差异无统计学意义(t=1.686,P=0.093)。结论:B/A和APACHEⅡ评分均可用于评估老年AECOPD合并肾功能不全患者NIV预后,与APACHEⅡ评分比,B/A在评估老年AECOPD患者NIV预后的效能更高。
文摘目的通过分析血清胱抑素C(Cys-C)、β2微球蛋白(β2-MG)、尿酸(UA)等联合项目与糖尿病肾病(DN)的相关性,从而找出准确诊断DN的相关因素。方法选取259名糖尿病(DM)患者,收集Cys-C、β2-MG、UA等相关项目指标,运用相应的统计学方法分析相关项目与尿白蛋白/肌酐比值(UACR)的关系。结果UACR≥30 mg/g作为DN的诊断临界点时,显示Cys-C、β2-MG、UA、收缩压(SBP)、餐后2 h血糖(2 h PG)、病程等6个项目是UACR的独立危险因素,当某一DM患者Cys-C≥1.435 mg/L、β2-MG≥2.055 mg/L、UA≥320μmol/L、SBP≥145 mmHg、2 h PG≥8.5 mmol/L、病程≥4.5年时,患者发展成早期DN的风险较大,相对应的临界值患病概率为81.5%。结论联合检测Cys-C、β2-MG、UA、SBP、2 h PG、病程等6个项目可以较好预测DN的发生。
