Treatment of Peripheral Neuropathy: Combination Therapy Using LED Light, Extracorporeal Shockwave Therapy, Platelet Rich Plasma, and an Oral Dietary Supplement

Objectives: Peripheral neuropathy (PN) is a significant contributor to disability in the elderly. It is also one of the most prevalent complications of type 2 diabetes, prediabetes and metabolic syndrome. PN is commonly associated with pain, numbness, tingling, burning, and cramping in the feet and legs. Current treatment options are limited to controlling pain, seizures and use of antidepressant medications. These treatments have undesirable side effects and don’t stop PN progression. Here we utilized a combination of individual-specific modalities to improve local circulation and relieve PN symptoms. Methods: We conducted an open-label, multicenter pilot trial with 34 subjects (19 males and 15 females ranging from 40 - 85 years of age). All of the participants were diagnosed with peripheral neuropathy and had bilateral symptoms in their feet, and many reported the same symptoms (pain, numbness, tingling, burning, and cramping) in their lower legs. The duration of symptoms ranged from four months to over six years. On Day 0, subjects were given a 90-day supply of the oral supplement with dosing instructions and a LED light therapy device. They also received three platelet-rich plasma (PRP) injections in their lower extremities. Subjects also received an extracorporeal shockwave therapy (ESWT) treatment for each foot and subsequently twice per week for the first six weeks, then once weekly for the duration of the study. Subjects filled out the Brief Pain Index (BPI) at weekly intervals. On Day 90, subjects completed the Patient Global Impression of Change (PGIC) survey. Results: There were significant responses to pain, as evidenced by BPI scores at weeks 8, 9, 10 and 11 (p = 0.02, 0.01, 0.02, and 0.003, respectively). Analysis of the final day PGIC survey showed a favorable outcome for 73% of participants (p = 0.003), with the majority reporting Very Much Improved. Conclusions: By utilizing a multi-modality treatment protocol that includes PRP, LED light therapy, ESWT and an oral dietary supplement, we observed significant reductions in BPI scores. Quality of life and their overall impression of change (PGIC) were significantly improved, and there were no significant side effects.

Potential of photodynamic therapy in the management of infectious oral diseases

Photodynamic therapy(PDT)can take place in the presence of three elements:Light with an appropriate wavelength;a photosensitizer;and the presence of oxygen.This type of treatment is very effective overall against bacterial,viral and mycotic cells.In the last 10 years many papers have been published on PDT with different types of photosensitizers(e.g.,methylene blue,toluidine blue,indocyanine green,curcumin-based photosensitizers),different wavelengths(e.g.,460 nm,630 nm,660 nm,810 nm)and various parameters(e.g.,power of the light,time of illumination,number of sessions).In the scientific literature all types of PDT seem very effective,even if it is difficult to find a standard protocol for each oral pathology.PDT could be an interesting way to treat some dangerous oral infections refractory to common pharmacological therapies,such as candidiasis from multidrug-resistant Candida spp.

Novel intense pulsed light-photodynamic therapy strategy in the treatment of facial actinic keratoses concomitant with rosacea

Rosacea presents as transient or persistent erythema,papules,pustules,fAushing,and telangi-ectasia on the middle of the face,which has some clinical similarity with act inic keratosis(AK).These two conditions can coexist in the same patient.Dermoscopy and reflect ance confocal microscopy(RCM)could be useful methods for diagnosis and monitoring treatment efficacy.Novel intense pulsed light-photodynamic therapy(IPL-PDT)may have better tolerance and curative effect than traditional red-light 5-aminolevulinic acid photodynamic therapy(ALA-PDT).Herein,we present a case of facial AKs concomitant with rosacea where combination therapy of novel IPL-PDT and oral minocycline was effective in that AK lesions were eliminated and the patient's facial erythema and telangiectasia were significantly improved.

Multi-watt near-infrared light therapy as a neuroregenerative treatment for traumatic brain injury

Infrared light represents a broad spectrum of light with wavelengths from 700 nm to 1 million nm（1,000 microns）.At its shortest wavelengths（referred to as near-infrared）,it merges with the red spectrum of visible light.At the longest end（referred to as far-infrared）,it blends into the range of microwaves.

Why and how does light therapy offer neuroprotection in Parkinson＇s disease？

Red and infrared light （X = 600-1,070 nm） therapy, known also as photobiomodulation, has been reported to offer neu-roprotection and to improve locomotor behaviour in animal models of Parkinson＇s disease, from rodents to non-human primates （Rojas and Gonzalez-Lima, 2011; Hamblin, 2016; Johnstone et al., 2016）. The neuroprotective aspect of this therapy is particularly relevant; the saving of neurons that would normally die as a result of the parkinsonian degeneration, is without doubt,

Treatment of Recalcitrant Viral Warts with Photodynamic Therapy with Mal and Red Light

Background: Photodynamic therapy (PDT) is a treatment for non-melanoma skin cancer. In recent years, its use has expanded to new indications. Viral warts (VW) are some of the most promising. Methods: A retrospective, descriptive, observational study was carried out. Patients who did not respond to cryotherapy were selected and were occluded with methyl aminolevulinate (MAL) for three hours and they were illuminated with red light. Tolerance to treatment was evaluated using a visual analog scale for pain (from 0 to 10). Results: A total of 15 patients with 134 VW were treated. A complete response was obtained in 13 of 15 patients (87%) and in 127 of 134 lesions (95%). The mean number of sessions was 3.1 (range 1 to 6) and the average pain score was 3.1 (range 0 to 8). Conclusions: PDT is a treatment that offers good results in the treatment of VW that are resistant to routine treatment. The treatment was well tolerated in our patient group.

The Successful Treatment of Dysarthria Using Strannik Light Therapy (Biofeedback): A Case Study

This article reports a case of dysarthria which was successfully treated by Strannik Light Therapy (SLT). It briefly discusses the known etiology for the condition and illustrates that dysarthria must be a problem of autonomic dysfunction in which pathological changes can influence the structure and/or subsequent function of the dynamic interplay between the brain and the organs involving the autonomic nervous system and physiological systems. The author reports a particular case in which a patient undertaking SLT fully recovered the ability to speak within 6 days.

Experimental study of red light therapy instrument combined with insulin on type 2 diabetic foot model rats

Objective: To investigate the therapeutic effect and clinical value of red light therapy combined with insulin therapy on wound in type 2 diabetic foot (DF) rats. Methords: Wistar rats were injected intraperitoneally with medium-dose high-fat and high-fat streptozotocin and carefully controlled at room temperature. The type 2 diabetes mellitus Wistar rats were reproved with high glucose and high fat streptozotocin (STZ) Foot involvement in the establishment of type 2 diabetic foot rat model. The rats were randomly divided into three groups: metformin 0.140 g/kg group, red light therapy group combined with insulin treatment group, model group, blank control group (30 d after intragastric administration of rats), further observation of each group of rat wounds Healing rate, insulin, blood glucose and blood lipid and vascular endothelial activity factors such as laboratory changes. Results: The observation of red light therapy combined with insulin treatment group was the most obvious, the difference was statistically significant, significantly promoted wound healing in DF rats, increased healing rate, increased insulin sensitivity (NO) and nitric oxide synthase (NOS) were increased in the serum of rats. The insulin resistance and platelet aggregation rate of the DF model rats were significantly higher than those of the control group, and the insulin sensitivity index (ISI) , Blood glucose, blood lipid, blood viscosity and endothelin (ET) and other active factors were significantly reduced. Conclusion: (1) treatment of red light therapy can improve blood rheology, improve glucose and lipid metabolism, improve insulin sensitivity, Vascular endothelial cell activation and so on to improve the wound healing rate of DF wound in rats. (2) The treatment of red light therapy is effective, safe and high in clinical application.

Highly Selective Photodynamic Therapy with a Short Drug-Light Interval Using a Cytotoxic Photosensitizer Porphyrus Envelope for Drug-Resistant Prostate Cancer Cells

Background: Photodynamic therapy (PDT) is a less invasive cancer treatment using photochemical reactions induced by light irradiation to a photosensitizer (PS). Highly selective PDT with fast accumulation of the PS in target site might be a promising treatment option for drug-resistant prostate cancer facing high incidence rate of elderly men who have no effective treatment options and require a minimally invasive treatment. Hemagglutinating virus of Japan envelope (HVJ-E) allows selective and fast drug delivery to the drug-resistant prostate cancer cells via rapid cell membrane fusion. PS named porphyrus envelope (PE) has been developed by insertion of lipidated protoporphyrin IX (PpIX lipid) into HVJ-E. In this study, we investigated the optimal conditions for PE preparation and laser irradiation for highly selective PDT using PE with a short drug-light interval. Materials and Methods: Human hormon refractory prostate cancer cell line PC-3 and human normal prostate epithelial cell line PNT2 were cultured. PpIX lipid uptake and cytotoxicity of PDT in the cells incubated with PE for 10 min were evaluated by measuring fluorescence intensity and by using a cell counting reagent 24 h after PDT, respectively. Results: PpIX lipid uptake and cytotoxicity of PDT were increased with PpIX lipid concentration. Cytotoxicity of PDT using PE was more than 9 times as strong as that with PpIX lipid and PpIX induced by 5-aminolevulinic acid. Much stronger cytotoxicity was induced in PC-3 cells than PNT2 cells with the ratio of cell death rate for cancer to normal cells up to 4.64 ± 0.09. Conclusions: Fast PS delivery with HVJ-E allows highly selective PDT with a short drug-light interval. Therefore, PDT using PE has a potential to shorten treatment period and reduce side effects of PDT.

红光治疗仪联合藻酸盐敷料对下肢骨折术后创面愈合的疗效

目的:探讨红光治疗仪联合藻酸盐敷料对下肢骨折术后创面愈合效果。方法:选取80例下肢骨折患者,分为观察组与对照组,比较两组治疗前后FN与EGF水平差异。结果:观察组在术后14d、21d、28d的骨痂密度评分均高于对照组(P<0.05)。观察组术后2d、4d、6d疼痛评分均低于对照组(P<0.05)。治疗后,两组血清FN和EGF水平均高于治疗前,且观察组血清FN和EGF水平高于对照组(P<0.05)。结论:红光治疗仪联合藻酸盐敷料用于下肢骨折术后创面愈合,安全有效,能够促进骨痂生长,减轻患者疼痛程度,改善血清FN与EGF水平。

茵栀黄口服液联合间断蓝光照射治疗新生儿高胆红素血症的临床效果分析

目的探讨茵栀黄联合间断蓝光治疗新生儿高胆红素血症的临床疗效。方法简单随机选取2021年1月—2022年12月丰县人民医院收治的新生儿病理性黄疸100例为研究对象,根据随机数表法分成两组,各50例,对照组采取蓝光治疗,观察组采取蓝光联合茵栀黄治疗,比较两组临床疗效、中医症候评分、血清胆红素水平及不良反应发生率。结果观察组疗效为96.00%,高于对照组的80.00%,差异有统计学意义(χ^(2)=4.640,P=0.031);治疗后,观察组的血清的中医症候评分低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的血清胆红素水平低于对照组,差异有统计学意义(P<0.05);治疗期间两组的不良反应的发生率比较,差异无统计学意义(P>0.05)。结论茵栀黄口服液联合间断蓝光照射治疗新生儿高胆红素血症可提高治疗效果,促进胆红素排泄,改善临床症状,且安全性高。

光照治疗在双相障碍抑郁发作患者中应用研究进展

现有抗抑郁治疗方法对双相障碍(bipolar disorder,BD)抑郁发作期患者的疗效不甚理想。多项研究探索了光照治疗BD抑郁发作期患者的疗效,并对光疗的参数、设备和安全性等进行研究。较多meta分析和随机对照研究表明光疗能明显改善BD患者的抑郁症状,无论是低光强还是高光强的白光均有这种效果,蓝光抗抑郁疗效尚不明确。光疗起效快,最好在清晨进行,每次持续30~60 min不等,对患者最有益的光照疗程尚无定论。目前最常用的光疗设备是灯箱,光疗眼镜的安全性有待探索。如选择符合安全标准的光疗灯,BD患者光疗整体安全性较高,转躁狂或轻躁狂风险低。总之,光照治疗BD抑郁发作期患者具有较好前景,未来可开展更多的BD患者光疗研究,以期形成BD患者的光疗处方。

新生儿病理性黄疸血清总胆红素、AST、ALT、ALB水平与蓝光治疗效果的关系

目的 研究新生儿病理性黄疸血清总胆红素、谷草转氨酶(AST)、谷丙转氨酶(ALT)、白蛋白(ALB)水平与蓝光治疗效果的关系。方法 收集2020年6月至2022年12月期间于南阳市中心医院新生儿重症监护病区诊治的97例新生儿病理性黄疸的病历资料,根据患儿蓝光照射治疗效果评估结果分为有效组和无效组,其中有效组共57例,无效组共40例。两组患儿均接受蓝光照射治疗,并进行血清总胆红素、AST、ALT、ALB检测。比较两组治疗前黄疸指数、血清总胆红素、AST、ALT、ALB水平,并分析患儿治疗前血清总胆红素、AST、ALT、ALB水平与蓝光治疗效果相关性。结果 治疗前,有效组黄疸指数低于无效组,差异有统计学意义(t=3.346,P<0.05);有效组血清总胆红素、AST、ALT水平低于无效组,血清ALB水平高于无效组,差异有统计学意义(t=3.635、2.273、2.167、8.689,P<0.05);经Logistic多因素分析,总胆红素、AST、ALT水平变化均为影响新生儿病理性黄疸病情严重程度的独立危险因素,ALB水平变化为影响新生儿病理性黄疸病情严重程度的独立保护因素(P<0.05);经Spearman相关性分析显示,患儿治疗前血清总胆红素、AST、ALT与病情严重程度成正比,ALB水平与病情严重程度成反比(P<0.05)。结论 治疗前新生儿病理性黄疸血清总胆红素、AST、ALT水平越低,ALB越高,可提示患儿病情程度越轻,从而越有利于蓝光治疗效果。

光照治疗对双相抑郁的疗效与安全性的回顾与新进展

双相情感障碍(Bipolar Disorder,BD)是慢性和复发性的疾病,其中针对双相抑郁的治疗手段有限。研究发现对季节性抑郁障碍(Seasonal Affective Disorder,SAD)治疗有效的光照治疗(Light Therapy,LT)也可用于治疗双相抑郁。LT通过改善BD昼夜节律紊乱以及调节单胺类神经递质发挥抗抑郁作用。LT作为双相抑郁药物治疗的辅助手段,相对安全而有效。目前需要研究设置更规范、样本量更大、干预及随访周期更长的随机对照研究为LT治疗双相抑郁提供有力证据。

LIGHT-Fc基因转染对食管癌细胞株Eca109抑制作用的初步研究

目的 探讨LIGHT对人食管癌细胞的体外抑制效应。方法 以DOTAP脂质体介导LIGHT Fc基因转染人食管癌细胞株Eca10 9,通过绘制细胞生长曲线及MTT比色法观察LIGHT Fc转染对Eca10 9细胞生长的影响 ,用RT PCR法检测LIGHT受体在Eca10 9细胞上的表达。结果 LIGHT Fc基因的表达可以抑制Eca10 9细胞的生长。在低血清培养时 ,Eca10 9 LIGHT细胞的生长曲线较对照组明显降低 ;MTT比色显示Eca10 9 LIGHT的细胞活力与对照组相比有显著性差异 (P<0 .0 5 )。结论 LIGHT Fc基因转染对人食管癌Eca10 9细胞具有体外抑制作用 。

近视前期的研究现状

近视导致的视觉损伤以及致盲已成为全球性负担,世界卫生组织已将近视的防控列入全球防盲计划中。我国近视发展呈现高发、低龄化、高度数化趋势,防控端口前移成为解决窘迫现状的重要策略。近视前期(premyopia)是指儿童的屈光度数≤+0.75 D和>-0.50 D的阶段,该阶段存在多种可能发展为近视的危险因素。目前近视前期的发生率和其转变为近视的概率居高,主要防控措施包括构建预测近视前期转变为近视的模型、强调减少危险因素暴露、使用低浓度阿托品滴眼液、红光治疗、光学离焦干预等。文章就近视前期的发生率及其转变为近视的概率现状以及现有防控措施的研究进展进行综述,以期为近视前期阶段防控近视提供参考。

红光疗法结合艾灸治疗中风偏瘫的效果及安全性

目的分析红光疗法结合艾灸治疗中风偏瘫的效果及安全性。方法回顾性选取2022年1月—2023年1月金乡县人民医院收治的128例中风偏瘫患者的临床资料,按照治疗方式的不同分为研究组(64例,红光疗法结合艾灸治疗)和参考组(64例,传统康复治疗)。比较两组患者的中医证候积分、自理能力、肢体功能、美国国立卫生院卒中量表(National Institute Health Stroke Scale,NIHSS)评分、并发症发生情况。结果治疗前,两组患者的中医证候积分、自理能力、肢体功能、NIHSS评分比较,差异无统计学意义(P均>0.05);治疗1个月、3个月后,研究组的中医证候积分、自理能力、肢体功能、NIHSS评分优于参考组,差异有统计学意义(P均<0.05)。研究组的并发症发生率为0,低于参考组的9.38%,差异有统计学意义(χ^(2)=4.372,P<0.05)。结论中风偏瘫患者通过红光疗法结合艾灸治疗,能够改善症状评分、自理能力、肢体功能、神经功能,有效降低并发症发生率。

面向阿尔茨海默病的非侵入性光生物调节治疗

据我国阿尔茨海默病协会官方网站显示,在我国60岁及以上老年人中约有1500万痴呆患者,其中1000万是阿尔茨海默病患者。随着我国人口结构老龄化,这一数据还将不断攀升。目前,按照现代医学寻找治疗靶点的逻辑思路,尚无有效治疗阿尔茨海默病的因应对策,药物治疗有许多限制,外科手术也无能为力。对此,我们不得不重新思考传统的系统化、整体化和功能化观点,并针对产生阿尔茨海默病背后的先导因素采取相应的治疗策略。近年来,关于光生物调节(PBM)治疗神经退行性疾病的研究逐渐增多,越来越多的学者尝试采用非侵入性PBM方式延缓、抑制,甚至逆转神经元退行性病变。在神经疾病治疗方面,PBM作为一种新的治疗方式,具有无创伤、无副作用、可以调节氧自由基浓度、激活干细胞调节细胞转录、刺激神经递质分泌、激发突触与神经元生长等显著优点。这些优点是其他治疗方式无与伦比的。本文综述了现代医学关于阿尔茨海默病治疗的靶点,阐释了PBM治疗阿尔茨海默病的机制,从动物模型、临床试验、病理与细胞模型方面系统总结了PBM治疗阿尔茨海默病的进展,并对未来发展做出展望,旨在为探索阿尔茨海默病临床干预新措施以及发展先进治疗方法和医疗器械提供参考。

颈椎光疗仪改善慢性颈痛患者颈部疼痛及相关功能的作用

背景:红光治疗具有无创、性价比高等特点,在临床上被广泛应用于治疗各种急慢性疼痛,但目前临床上使用的光疗设备成本昂贵、具有一定的场地限制,因此有必要探索更加便捷经济的光疗应用途径。目的:观察居家型颈椎光疗仪对于慢性颈痛的临床疗效。方法:于2022年11月至2023年2月在上海交通大学医学院附属第九人民医院康复医学科招募慢性颈痛患者24例,其中女18例,男6例;年龄(29.67±6.40)岁;体质量指数为(21.39±3.52)kg/m^(2)。每日使用颈椎光疗仪2次,每次20 min,持续4周。观察治疗前、治疗2周及治疗4周后的疼痛目测类比评分、肌肉压痛阈值、颈部主动活动度、颈部功能障碍指数及匹兹堡睡眠质量指数变化情况。结果与结论:①与治疗前相比,治疗4周后目测类比评分、压痛阈值、颈部功能障碍指数及匹兹堡睡眠质量指数均有显著改善(P<0.05),同时部分颈椎部分活动度(后伸及左右旋转)出现改善(P<0.05);②其中双侧目测类比评分、左斜方肌压痛阈值、C_(5)C_(6)压痛阈值及颈部功能障碍指数在治疗2周后即出现改善(P<0.05);③提示该颈椎光疗仪的应用在短期内可以改善慢性颈痛患者的疼痛评分、肌肉压痛、睡眠质量、功能水平及部分主动活动度,是一项便捷有效安全的治疗方法。