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Right Main Bronchus Disruption Discovered after One Year of Blunt Chest Trauma
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作者 Mohamed Alhaj Moustafa 《Open Journal of Thoracic Surgery》 2022年第4期51-59,共9页
Central airway injury is a very rare entity during blunt chest trauma. It is serious and may be fatal. Usually, it has fundamental manifestations but in some cases, it is insidious and has been discovered lately. It’... Central airway injury is a very rare entity during blunt chest trauma. It is serious and may be fatal. Usually, it has fundamental manifestations but in some cases, it is insidious and has been discovered lately. It’s suspected when major air leaks from the chest tube and the lung fail to expand despite adequate chest drainage. Right main bronchus injuries are the most frequent. Diagnosis can be suspected clinically and confirmed by Ct scan and bronchoscopy. Conservative management can be applied in special cases but the majority of cases need surgical intervention which depends on primary reconstruction. An early diagnosis and treatment can avoid dramatic complications and provide complete recovery. Associated other organ injury is common and is an important mortality factor. Close cooperation with the emergency team and anesthesiologists is necessary. Here I presented a case of right main bronchus disruption discovered after one year of blunt chest trauma with complete lung atelectasis, managed successfully by resection of the fibrotic injured bronchus and primary reconstruction saving the lung. 展开更多
关键词 blunt chest trauma Tracheobronchial Injuries Bronchial Reconstruction
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Management of computed tomography scan detected hemothorax in blunt chest trauma:What computed tomography scan measurements say? 被引量:2
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作者 Mahdi Malekpour Kenneth Widom +4 位作者 James Dove Joseph Blansfield Mohsen Shabahang Denise Torres Jeffrey L Wild 《World Journal of Radiology》 CAS 2018年第12期184-189,共6页
AIM To investigate the hemothorax size for which tube thoracostomy is necessary.METHODS Over a 5-year period, we included all patients who were admitted with blunt chest trauma to our level 1 trauma center. Focus was ... AIM To investigate the hemothorax size for which tube thoracostomy is necessary.METHODS Over a 5-year period, we included all patients who were admitted with blunt chest trauma to our level 1 trauma center. Focus was placed on identifying the hemothorax size requiring tube thoracostomy.RESULTS A total number of 274 hemothoraces were studied. All patients with hemothoraces measuring above 3 cm received a chest tube. The 50% predicted probability of tube thoracostomy was 2 cm. Pneumothorax was associated with odds of receiving tube thoracostomy for hemothoraces below 2 cm(Odds Ratio:4.967, 95%CI: 2.225-11.097, P < 0.0001).CONCLUSION All patients with a hemothorax size greater than 3% underwent tube thoracostomy. Prospective studies are warranted to elucidate the clinical outcome of patients with smaller hemothoraces. 展开更多
关键词 chest trauma blunt HEMOTHORAX chest tube OCCULT Computed tomography scan
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Clinical Approach for the Pneumomediastinum after Blunt Chest Trauma 被引量:1
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作者 Onder Kavurmaci Tevfik Ilker Akcam +4 位作者 Ali Ozdil Ayse Gul Ergonul Kutsal Turhan Alpaslan Cakan Ufuk Cagirici 《Open Journal of Thoracic Surgery》 2017年第1期8-13,共6页
Objective: Pneumomediastinum (PM) can be observed after blunt and penetrating chest trauma. Most of the patients with PM due to trauma can be managed conservatively. This study aimed to evaluate the cases with PM on t... Objective: Pneumomediastinum (PM) can be observed after blunt and penetrating chest trauma. Most of the patients with PM due to trauma can be managed conservatively. This study aimed to evaluate the cases with PM on thorax computed tomography (CT) after blunt chest trauma (BCT). Methods: Medical records of patients with PM due to BCT between January 2000 and December 2014 were reviewed retrospectively. Thorax CT was used to verify pneumomediastinum in all patients. Twenty-four patients which had different causes of PM (penetrating trauma, iatrogenic, spontaneous) were excluded from the study. Data of sixty-nine patients with the diagnosis of PM secondary to BCT and who were observed without any further procedure for the cause of PM, were evaluated retrospectively. Results: There were 59 male and 10 female patients with the mean age of 47.60 ± 17.47 years (range, 16 to 80 years). The most common cause of PM etiology was traffic accident with a rate of 38 (55.06%) patients, followed by fall from height in 25 (36.24%), compression in 3 (4.35%) and drubbing in 3 (4.35%) patients. There was a 12.46 ± 6.42 days (range, 6 to 28 days) mean duration of chest tube drainage which was performed for accompanying pathologies like pneumothorax and hemothorax. No complication was determined for short and long term follow-up of patients when all hospital records were analyzed in terms of complication. Conclusions: PM after BCT may be a marker of esophageal and tracheobronchial injury and invasive procedures like bronchoscopy and endoscopy can be needed for differential diagnosis. We evaluated 69 patients in good general status and no need for intensive care management with PM in this study and observed them without any further procedure. As a result of these findings we concluded that for the PM patients after BCT with uneventful clinical course, conservative treatment without any further procedure is a safe and sufficient method. 展开更多
关键词 PNEUMOMEDIASTINUM blunt chest trauma
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CT as a first-line modality in elderly patients with stable blunt chest trauma 被引量:1
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作者 Alexander Becker Tamar Dola +1 位作者 Yuri Berlin Dan Hershko 《Chinese Journal of Traumatology》 CAS CSCD 2021年第5期255-260,共6页
Blunt thoracic injuries are common among elderly patients and may be a common cause of morbidity and death from blunt trauma injuries.We aimed to examine the impact of chest CT on the diagnosis and change of managemen... Blunt thoracic injuries are common among elderly patients and may be a common cause of morbidity and death from blunt trauma injuries.We aimed to examine the impact of chest CT on the diagnosis and change of management plan in elderly patients with stable blunt chest trauma.We hypothesized that chest CT may play an important role in providing optimal management to this subgroup of trauma patients.;A retrospective analysis was performed on all the admitted adult blunt trauma patients between January 2014 and December 2018.Stable blunt chest trauma patients with abbreviated injury severity(AIS)<3 for extra-thoracic injuries confirmed with chest X-ray(CXR)and chest CT on admission or during hospitalization were included in the study.The AIS is an international scale for grading the severity of anatomic injury following blunt trauma.Primary outcome variables were occult injuries,change in management,need for surgical procedures,missed injuries,readmission rate,intensive care unit(ICU)and length of hospital stay.;There are 473 patients with blunt chest trauma included in the study.The study patients were divided into two groups according to the age range:group 1:289 patients were included and aged 18-64 years;group 2:184 patients were included and aged 65-99 years.Elderly patients in group 2 more often required ICU admission(11.4%vs.5.2%),had a longer length of ICU stay(days)(median 11 vs.6,p=0.01),and the length of hospital stay(days)(median 14 vs.6,p=0.04).Injuries identified on chest CT has led to a change of management in 4.4%of young patients in group 1 and in 10.9%of elderly patients in group 2 with initially normal CXR.Chest CT resulted in a change of management in 12.8%of young patients in group 1 and in 25.7%of elderly patients in group 2 with initially abnormal CXR.;Chest CT led to a change of management in a substantial proportion of elderly patients.Therefore,we recommend chest CT as a first-line imaging modality in patients aged over 65 years with isolated blunt chest trauma. 展开更多
关键词 blunt chest trauma ELDERLY chest computed tomography
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Assessment of internal mammary artery injury after blunt chest trauma: a literature review
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作者 Jin-ming CHEN Jin LV +1 位作者 Kai MA Jing YAN 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2014年第10期864-869,共6页
The occurrence, bleeding, and treatment of internal mammary artery(IMA) injury after blunt chest trauma have not been well described in the literature. We reviewed articles published from July 1977 to February 2014 ... The occurrence, bleeding, and treatment of internal mammary artery(IMA) injury after blunt chest trauma have not been well described in the literature. We reviewed articles published from July 1977 to February 2014 describing IMA injury after blunt chest trauma in 49 patients. There was a predominant incidence in males and on the left side. Blunt trauma to the IMA can cause anterior mediastinal hematoma, hemothorax, pseudoaneurysm, arteriovenous fistula, and extra-pleural hematoma. Of the 49 patients studied, 20 underwent embolization, 22 underwent surgical operation, 4 were managed by clinical observation, and 3 had undescribed treatment. Different parts and extents of IMA injury, adjacent vein injury, as well as the integrity of the pleura determined differences in bleeding modality. Prompt diagnosis, complete hemostasis, aggressive resuscitation, and multidisciplinary teams are recommended for patients with IMA injury. 展开更多
关键词 Internal mammary artery injury blunt chest trauma BLEEDING TREATMENT
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Delayed diagnosis for tricuspid regurgitation after blunt chest trauma
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作者 Zhao Haige Robert A. McCready +4 位作者 Fan Jingya Hu Peng Ni Yiming Dominige Calcaterra Ma Liang 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第9期1794-1795,共2页
Tricuspid valve regurgitation is a rare complication of blunt chest trauma.Approximately 150 cases have been reported since first being described by Todd et al in 1848.1 During the past few decades traumatic tricuspid... Tricuspid valve regurgitation is a rare complication of blunt chest trauma.Approximately 150 cases have been reported since first being described by Todd et al in 1848.1 During the past few decades traumatic tricuspid regurgitation has been reported with increasing frequency,which may in part be attributed to more patients surviving blunt chest trauma as well as improved diagnostic imaging studies,such as echocardiography.The incidence of traumatic tricuspid regurgitation is likely underestimated since chronic,isolated tricuspid insufficiency may be well tolerated in some patients who experience few or no symptoms after the traumatic event.2 Furthermore,some patients may not recall antecedent chest trauma unless specifically questioned.Most cases of traumatic tricuspid regurgitation are secondary to blunt chest trauma.1 展开更多
关键词 tricuspid valve regurgitation blunt chest trauma delayed diagnosis
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Coronary artery dissection and acute myocardial infarction after blunt chest trauma
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作者 刘龙斌 郭航远 邢杨波 《South China Journal of Cardiology》 CAS 2012年第3期197-200,205,共5页
Coronary artery dissection and acute myocar-dial infarction(AMI) after blunt chest trauma (BCT) has rarely been reported1'2. This report describes two cases of the left anterior de-scending(LAD) artery dissecti... Coronary artery dissection and acute myocar-dial infarction(AMI) after blunt chest trauma (BCT) has rarely been reported1'2. This report describes two cases of the left anterior de-scending(LAD) artery dissection and AMI after BCT, successfully treated with percutaneous coronary intervention (PCI) and they dis-charged without complications. 展开更多
关键词 FIGURE ECG LAD Coronary artery dissection and acute myocardial infarction after blunt chest trauma BCT AMI PCI
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Chest X-rays in detecting injuries caused by blunt trauma
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作者 Kadir Agladioglu Mustafa Serinken +3 位作者 Onur Dal Halil Beydilli Cenker Eken Ozgur Karcioglu 《World Journal of Emergency Medicine》 CAS 2016年第1期55-58,共4页
BACKGROUND:The appropriate sequence of different imagings and indications of thoracic computed tomography(TCT)in evaluating chest trauma have not yet been clarified at present.The current study was undertaken to deter... BACKGROUND:The appropriate sequence of different imagings and indications of thoracic computed tomography(TCT)in evaluating chest trauma have not yet been clarified at present.The current study was undertaken to determine the value of chest X-ray(CXR)in detecting chest injuries in patients with blunt trauma.METHODS:A total of 447 patients with blunt thoracic trauma who had been admitted to the emergency department(ED)in the period of 2009–2013 were retrospectively reviewed.The patients met inclusion criteria(age>8 years,blunt injury to the chest,hemodynamically stable,and neurologically intact)and underwent both TCT and upright CXR in the ED.Radiological imagings were re-interpreted after they were collected from the hospital database by two skilled radiologists.RESULTS:Of the 447 patients,309(69.1%)were male.The mean age of the 447 patients was 39.5±19.2(range 9 and 87 years).158(35.3%)patients were injured in motor vehicle accidents(MVA).CXR showed the highest sensitivity in detecting clavicle fractures[95%CI 78.3(63.6–89)]but the lowest in pneuomediastinum[95%CI 11.8(1.5–36.4)].The specificity of CXR was close to 100%in detecting a wide array of entities.CONCLUSION:CXR remains to be the first choice in hemodynamically unstable patients with blunt chest trauma.Moreover,stable patients with normal CXR are candidates who should undergo TCT if significant injury has not been ruled out. 展开更多
关键词 chest blunt trauma X-Rays Computed tomography Emergency department
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Blunt Traumatic Pericardial Rupture with Traumatic Amaurosis Fugax Presenting as Massive Haemothorax: A Conundrum?
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作者 Isaac Okyere Samuel Gyasi Brenu Perditer Okyere 《Open Journal of Thoracic Surgery》 2019年第2期9-16,共8页
Introduction: Blunt traumatic pericardial rupture (BTPR) or traumatic pericardiotomy is a rare typical trauma. It is usually discovered at autopsy. Surgical repair is mandatory especially if prompt diagnosis is made b... Introduction: Blunt traumatic pericardial rupture (BTPR) or traumatic pericardiotomy is a rare typical trauma. It is usually discovered at autopsy. Surgical repair is mandatory especially if prompt diagnosis is made because of the associated high mortality. Clinical Case: We report the successful management and survival of BTPR patient after chest trauma presenting with massive haemothorax and transient loss of vision, necessitating urgent surgical treatment. The patient was involved in a road traffic accident having a head-on collision with the rear of the vehicle ahead whiles trying to overtake it. Discussion: It is usually discovered at autopsy or during emergent surgical exploration through either sternotomy or thoracotomy [1] due to its delayed diagnosis, unusual presentation, association with other major cardiopulmonary injuries and complications such as cardiac herniation, fatal arrhythmias, cardiogenic shock and cardiac arrest. Conclusion: Blunt traumatic pericardial rupture should be suspected in any patient in whom hemodynamic instability occurs rapidly after trauma without evidence of major bleeding. Prompt surgical exploration may yield excellent results. 展开更多
关键词 blunt chest trauma PERICARDIAL RUPTURE HAEMOTHORAX THORACOTOMY AMAUROSIS Fugax
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Ventricular Septal Defect after Blunt Trauma in a Case of Preexisting Prosthetic Mitral Valve
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作者 Bhargava Nishith Mangukia Chirantan +2 位作者 Virmani Sanjula Singh Harpreet Satsangi K. Deepak 《World Journal of Cardiovascular Surgery》 2014年第12期227-231,共5页
We present a case of an isolated large ventricular septal defect (VSD) following blunt chest trauma in a motor vehicle accident in the patient with preexisting mechanical mitral valve. Transthoracic echocardiography r... We present a case of an isolated large ventricular septal defect (VSD) following blunt chest trauma in a motor vehicle accident in the patient with preexisting mechanical mitral valve. Transthoracic echocardiography revealed a large muscular VSD with significant left to right shunt along with septal edema. Surgical repair was performed in view of Qp:Qs of 2.5 with significant hemodynamic instability despite intra-aortic balloon pump. The ventricular septal defect was found in apical muscular portion of the interventricular septum, which was closed through left ventriculotomy. We here discuss the possible mechanisms of damage and importance of timely surgery. To conclude, minor looking external injury might contain devastating damage inside, especially with patients on anti-coagulant therapy. 展开更多
关键词 blunt trauma chest VENTRICULAR SEPTAL Defect PROSTHETIC MITRAL Valve
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Thoracoscopic diagnosis of traumatic pericardial rupture with cardiac hernia:A case report 被引量:1
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作者 Yong-Yong Wu Zhong-Liang He Zi-Ying Lu 《World Journal of Clinical Cases》 SCIE 2021年第16期4001-4006,共6页
BACKGROUND Pericardial rupture caused by blunt chest trauma is rare in clinical practice.Because of its atypical clinical symptoms,and because surgeons are often unfamiliar with the clinical and radiological manifesta... BACKGROUND Pericardial rupture caused by blunt chest trauma is rare in clinical practice.Because of its atypical clinical symptoms,and because surgeons are often unfamiliar with the clinical and radiological manifestations of the injury,preoperative diagnosis is difficult;it is easily misdiagnosed and causes serious consequences.CASE SUMMARY A 60-year-old man,previously healthy,was transported to the emergency room after falling from a great height.Upon arrival,his vital signs were stable.Electrocardiography and echocardiography were performed,and there was no sign of cardiac injury or ischemia.Chest and abdomen computerized tomography revealed pneumopericardium,hemopneumothorax,lung contusion,multiple rib fractures on the right side(Figure 1),and right scapula and clavicle fractures.He was admitted to the inpatient department for further observation after tube thoracostomy.The next day,the patient suddenly experienced rapid arrhythmia(the ventricular rate reached 150-180 beats/min)when turning onto his right side,accompanied by a blood pressure drop to 70/45 mm Hg and a chief complaint of palpitation.Thoracoscopy was performed urgently,and a large vertical tear(8 cm×6 cm)was found in the pericardium.The defect was successfully repaired using a heart Dacron patch.His postoperative condition was uneventful without any fluctuations in vital signs,and he was transferred to the orthopedics department for further surgery on postoperative day 8.CONCLUSION Although the possibility of pericardial rupture combined with cardiac hernia is extremely low,it is one of the causes of cardiogenic shock following blunt trauma.Therefore,clinicians need to be more familiar with its characteristic manifestations and maintain a high degree of vigilance against such injuries to avoid disastrous consequences. 展开更多
关键词 Pericardial rupture Cardiac hernia blunt chest trauma Thoracoscope Case report
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Ventricular Fibrillation Caused by Traumatic Coronary Artery Dissection
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作者 Jun-ya Ishikawa Naoto Morimura +3 位作者 Eri Nagai Kyota Nakamura Makoto Shimizu Keiji Uchida 《Case Reports in Clinical Medicine》 2015年第4期119-123,共5页
Coronary artery dissection due to blunt chest trauma (traumatic coronary artery dissection [TCAD]) may heal spontaneously, and some surgeons believe that conservative or elective treat-ments are sufficient, provided t... Coronary artery dissection due to blunt chest trauma (traumatic coronary artery dissection [TCAD]) may heal spontaneously, and some surgeons believe that conservative or elective treat-ments are sufficient, provided that there are no progressing ischemic symptoms. However, we report a patient who experienced sudden ventricular fibrillation (VF) during initial medical care for trauma injuries. The 32-year-old woman was riding in a passenger car when an accident occurred, and was subsequently transported to our emergency department. Twelve-lead electrocardiography revealed ST segment elevation in leads II, III, and aVF, although her vital signs remained stable. Therefore, we prioritized assessing the trauma at other sites, and VF suddenly occurred. Coronary angiography was performed with repeated defibrillation and chest compressions, which resulted in recovery of spontaneous circulation. Occlusion was observed in the right coronary artery, which we treated with balloon angioplasty. However, intravascular ultrasonography (IVUS) subsequently revealed coronary artery dissection, a stent was placed, and the patient successfully recovered. Therefore, IVUS may be useful for diagnosing TCAD, and swift intervention is needed if TCAD is detected. 展开更多
关键词 Coronary Artery Dissection blunt chest trauma Ventricular FIBRILLATION Acute Myocardial INFARCTION INTRAVASCULAR Ultrasonography
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Blunt trauma related chest wall and pulmonary injuries: An overview 被引量:25
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作者 Bekir Nihat Dogrul Ibrahim Kiliccalan +1 位作者 Ekrem Samet Asci Selim Can Peker 《Chinese Journal of Traumatology》 CAS CSCD 2020年第3期125-138,共14页
Physical traumas are tragic and multifaceted injuries that suddenly threaten life.Although it is the third most common cause of death in all age groups,one out of four trauma patients die due to thoracic injury or its... Physical traumas are tragic and multifaceted injuries that suddenly threaten life.Although it is the third most common cause of death in all age groups,one out of four trauma patients die due to thoracic injury or its complications.Blunt injuries constitute the majority of chest trauma.This indicates the im porta nee of chest trauma among all traumas.Blunt chest trauma is usually caused by motor vehicle accident,falling from height,blunt instrument injury and physical assault.As a result of chest trauma,many injuries may occur,such as pulm onary injuries,and these require urge nt in terve ntion.Chest wall and pulmonary injuries range from rib fractures to flail chest,pneumothorax to hemothorax and pulmonary contusion to tracheobronchial injuries.Following these injuries,patients may present with a simple dyspnea or even respiratory arrest.For such patie nt,it is imports nt to understa nd the treatme nt logic and to take a multidisciplinary approach to treat the pulmonary and chest wall injuries.This is because only 10%of thoracic trauma patients require surgical operation and the remaining 90%can be treated with simple methods such as appropriate airway,oxygen support,maneuvers,volume support and tube thoracostomy.Adequate pain control in chest trauma is sometimes the most basic and best treatment.With definite diagnosis,the morbidity and mortality can be significantly reduced by simple treatment methods. 展开更多
关键词 blunt chest trauma Rib fractures PNEUMOTHORAX HEMOTHORAX Pulmonary contusion Pain management
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不同致伤条件撞击对兔钝性胸部创伤伤情影响的实验研究 被引量:23
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作者 闵家新 朱佩芳 +3 位作者 王正国 刘宝松 周继红 翁格文 《第三军医大学学报》 CAS CSCD 北大核心 2000年第6期509-511,共3页
目的 探讨不同致伤参数对兔钝性胸部创伤后胸部各器官伤情的影响。方法 采用兔钝性胸部创伤模型 ,设置不同的致伤参数 ,观察其对胸部各器官的伤情影响及其对死亡率的影响。结果 驱动压力越大 ,胸部各器官伤情越重 ;撞击面积越大 ,对... 目的 探讨不同致伤参数对兔钝性胸部创伤后胸部各器官伤情的影响。方法 采用兔钝性胸部创伤模型 ,设置不同的致伤参数 ,观察其对胸部各器官的伤情影响及其对死亡率的影响。结果 驱动压力越大 ,胸部各器官伤情越重 ;撞击面积越大 ,对胸壁和肺的损伤较重 ,但心脏伤情并不随之加重 ;收缩末期撞击对心脏的损伤较重 ,舒张末期撞击对大血管系统的影响较大 ;死亡率与驱动压力、撞击面积成正比 ;舒张末期撞击死亡率上升。结论 致伤参数不同 。 展开更多
关键词 钝性胸部创伤 致伤参数 影响
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右美托咪定对撞击性肺损伤大鼠的肺保护作用 被引量:7
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作者 李鹏 陈丹丹 +5 位作者 陈彰强 程江霞 秦汉 李霞 杨文超 彭晓红 《临床麻醉学杂志》 CAS CSCD 北大核心 2016年第11期1108-1111,共4页
目的探讨右美托咪定对撞击性肺损伤大鼠肺部的保护机制。方法清洁级成年雄性SD大鼠40只,随机均分为五组:正常对照组(C组)、右美托咪定组(D组)、胸部创伤模型组(T组)、胸部创伤模型^+右美托咪定处理组(TD组)和胸部创伤模型^+右美托咪定^... 目的探讨右美托咪定对撞击性肺损伤大鼠肺部的保护机制。方法清洁级成年雄性SD大鼠40只,随机均分为五组:正常对照组(C组)、右美托咪定组(D组)、胸部创伤模型组(T组)、胸部创伤模型^+右美托咪定处理组(TD组)和胸部创伤模型^+右美托咪定^+育亨宾(α2肾上腺素能受体阻断剂)组(TDY组)。C和D组只麻醉不创伤,T、TD、TDY组复制大鼠胸部撞击模型。持续监测五组大鼠创伤后0.5、1、2、4和6h的有创平均动脉血压(MIAP),处死前抽取动脉血0.5ml行动脉血气分析;采用免疫组织法检测肺组织NF-κBp65的表达;酶联免疫吸附实验(ELISA)检测血清中TNF-α和IL^(-1)β浓度;检测支气管肺泡灌洗液(BALF)中中性粒细胞占白细胞百分比(PMN),计算肺湿/干比(W/D);HE染色光镜下观察肺组织病理改变。结果创伤后0.5、1、2h时D组MIAP明显高于T组,创伤后4和6h时D组MIAP明显低于C和T组(P<0.05);创伤后1hTDY组MIAP明显高于,创伤后4和6hTDY组MIAP明显低于C和TD组(P<0.05)。T、TD和TDY组PaO_2、PaCO_2明显低于,pH、TNF-α和IL^(-1)β浓度明显高于C组(P<0.01)。D、TD和TDY组PaO_2、PaCO_2明显高于,血清TNF-α和IL^(-1)β浓度明显低于T组(P<0.01),T组pH明显高于D组,但明显低于TD、TDY组(P<0.01)。D组肺组织NF-κBp65,T、TD和TDY组肺组织NF-κBp65、W/D和PMN明显高于C组(P<0.05);D、TD、TDY组肺组织NF-κBp65、M/D和PMN明显低于T组(P<0.01);TDY组肺组织NF-κBp65、M/D和PMN明显高于TD组(P<0.01)。结论盐酸右美托咪定可通过抑制肺组织和血清中炎症因子的表达减轻创伤性肺损伤的程度。 展开更多
关键词 右美托咪定 胸部撞击伤 急性肺损伤 炎症因子
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钝性胸部创伤后心功能障碍与心肌细胞内ATPase变化的关系 被引量:3
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作者 闵家新 朱佩芳 +2 位作者 王正国 吴秋平 彭祖胜 《中国胸心血管外科临床杂志》 CAS 2009年第2期123-126,共4页
目的探讨心肌细胞内三磷酸腺苷酶(ATPase)的变化在钝性胸部创伤(BCT)后心功能障碍发生机制中的意义。方法采用随机数字表法将36只兔分为6组:正常对照组(创伤前),伤后2h、4h、8h、12h和24h组,每组6只。用BIM-Ⅱ型生物撞击机建立BCT模型,... 目的探讨心肌细胞内三磷酸腺苷酶(ATPase)的变化在钝性胸部创伤(BCT)后心功能障碍发生机制中的意义。方法采用随机数字表法将36只兔分为6组:正常对照组(创伤前),伤后2h、4h、8h、12h和24h组,每组6只。用BIM-Ⅱ型生物撞击机建立BCT模型,经右颈总动脉插管至左心室测左室压力,在创伤后2h、4h、8h、12h和24h各时间点测定血流动力学指标和心肌匀浆组织、线粒体及胞浆内ATPase活性。结果与对照组比较,创伤后2h时2h组左心室收缩期末压(LVESP)、左心室内压最大上升速率(+dp/dtmax)、等容收缩压(IP)、实测心肌最大收缩速度(Vpm)明显下降(P<0.05),在伤后4~12h时4h组、8h组、12h组恢复至创伤前水平(P>0.05);等容舒张期左室内压下降时间常数(T)、左心室舒张期末压(LVEDP)、左室内压最大下降速率(-dp/dtmax)在伤后24h组与对照组比较差异有统计学意义(P<0.05,0.01)。伤后2h组、4h组心肌匀浆组织、线粒体及胞浆ATPase活性下降(P<0.05,0.01),分别至伤后8~12h时分别恢复至创伤前水平(P>0.05)。相关分析表明:LVEDP和-dp/dtmax与心肌匀浆组织Na+-K+-ATPase活性改变呈明显负相关(r=-0.674,-0.691,P<0.05),与Ca2+-ATPase活性改变呈明显负相关(r=-0.613,-0.642,P<0.05);与心肌细胞线粒体Na+-K+-ATPase活性改变呈明显负相关(r=-0.622,-0.616,P<0.05);与心肌细胞胞浆Ca2+-ATPase活性改变呈明显负相关(r=-0.672,-0.658,P<0.05),与心肌细胞胞浆Na+-K+-ATPase活性改变呈明显负相关(r=-0.627,-0.632,P<0.05),与心肌细胞胞浆Mg2+-ATPase活性改变呈明显负相关(r=-0.677,-0.661,P<0.05)。结论BCT后左心室收缩/舒张功能受到损害,尤以舒张功能障碍为主,心肌细胞中ATPase活性下降可能是其原因之一。 展开更多
关键词 创伤 钝性胸部创伤 心脏功能 三磷酸腺苷酶
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钝性胸部创伤后血流动力学变化及意义 被引量:1
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作者 闵家新 朱佩芳 王正国 《第三军医大学学报》 CAS CSCD 北大核心 2002年第8期947-948,共2页
目的 探讨钝性胸部创伤 (BCT)后血流动力学变化及意义。方法 选取兔 2 0只 ,经右颈总动脉插管至左心室测左室压力 ,左股动脉插管测平均动脉压 (MAP)。采用BIM Ⅱ型生物撞击机致成BCT模型 ,分别在伤前、伤后 1、2、4、6、8、12、2 4h... 目的 探讨钝性胸部创伤 (BCT)后血流动力学变化及意义。方法 选取兔 2 0只 ,经右颈总动脉插管至左心室测左室压力 ,左股动脉插管测平均动脉压 (MAP)。采用BIM Ⅱ型生物撞击机致成BCT模型 ,分别在伤前、伤后 1、2、4、6、8、12、2 4h监测血流动力学变化。结果 BCT后心脏功能受到损害 ,左心室收缩功能在伤后 4h~ 6h恢复至伤前水平 ,而舒张功能在伤后 2 4h不能恢复至伤前水平。结论 BCT后血流动力学发生明显改变 ,左心室以舒张功能障碍为主 。 展开更多
关键词 创伤 钝性胸部创伤 心脏功能 血流动力学 BCT
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心肌挫伤后心肌酶谱和心脏肌钙蛋白-T的含量变化 被引量:1
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作者 闵家新 朱佩芳 +2 位作者 王正国 刘宝松 翁格文 《第三军医大学学报》 CAS CSCD 北大核心 2000年第2期139-141,共3页
目的 :观察心脏肌钙蛋白 T(cTn T)和心肌酶谱(ME)在心肌挫伤(CC)后含量变化及其对CC的诊断价值。方法 :采用兔钝性胸部创伤(BCT)模型 ,致成中度至重度CC ,分别在伤前、伤后4、8和24h抽血测定血清cTn T和ME含量。结果 :伤后4h ,血清cTn ... 目的 :观察心脏肌钙蛋白 T(cTn T)和心肌酶谱(ME)在心肌挫伤(CC)后含量变化及其对CC的诊断价值。方法 :采用兔钝性胸部创伤(BCT)模型 ,致成中度至重度CC ,分别在伤前、伤后4、8和24h抽血测定血清cTn T和ME含量。结果 :伤后4h ,血清cTn T和ME含量明显升高(P<0.01) ,持续至伤后24h。其中cTn T在伤后24h升高最为明显 ,ME有所下降 ,但仍然明显高于伤前(P<0.01)。结论 :cTn T和ME对CC的早期诊断均有意义 ,但cTn T的敏感性更高。 展开更多
关键词 心肌挫伤 心脏肌钙蛋白-T 心肌酶谱
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心脏肌钙蛋白-T和心肌酶谱对心肌挫伤诊断价值的比较 被引量:1
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作者 闵家新 朱佩芳 +2 位作者 王正国 刘宝松 翁格文 《创伤外科杂志》 1999年第4期211-213,共3页
目的比较心脏肌钙蛋白-T(cTn-T)和心肌酶谱(ME)在心肌挫伤(CC)中的诊断价值。方法采用兔钝性胸部创伤模型,造成中度至重度CC,分别在伤前、伤后4小时、8小时和24小时抽血测定血清cTn-T和ME含量。结果伤后4小时,血清cTn-T和ME... 目的比较心脏肌钙蛋白-T(cTn-T)和心肌酶谱(ME)在心肌挫伤(CC)中的诊断价值。方法采用兔钝性胸部创伤模型,造成中度至重度CC,分别在伤前、伤后4小时、8小时和24小时抽血测定血清cTn-T和ME含量。结果伤后4小时,血清cTn-T和ME含量明显升高(P<0.01),持续至伤后24小时。其中cTn-T在伤后24小时升高最为明显,ME有所下降,但仍然明显高于伤前(P<0.01)。结论cTn-T和ME对CC的早期诊断均有意义,但CTn—T的敏感性更高,持续时间更长。 展开更多
关键词 心脏肌钙蛋白-T 心肌酶谱 心肌挫伤 诊断
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兔钝性胸部创伤后心脏功能的改变 被引量:1
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作者 闵家新 朱佩芳 王正国 《中国胸心血管外科临床杂志》 CAS 2008年第5期369-373,共5页
目的探讨兔钝性胸部创伤(BCT)后心脏功能的变化规律,为临床诊断和治疗BCT提供理论依据。方法家兔20只,采用BIM-Ⅱ型生物撞击机撞击兔胸部,制作中度至重度BCT模型。分别于伤前、伤后1h、2h、4h、6h、8h、12h和24h采用超声心动图、心导管... 目的探讨兔钝性胸部创伤(BCT)后心脏功能的变化规律,为临床诊断和治疗BCT提供理论依据。方法家兔20只,采用BIM-Ⅱ型生物撞击机撞击兔胸部,制作中度至重度BCT模型。分别于伤前、伤后1h、2h、4h、6h、8h、12h和24h采用超声心动图、心导管和单光子发射型计算机断层摄影术(SPECT)检测兔BCT后心脏功能的改变。结果中心静脉压(CVP)、左心室舒张期末压(LVEDP)、等容舒张期左心室内压下降时间常数(T)于伤后24h仍高于伤前(P<0.05,0.01),左心室内压最大下降速率(-dp/dtmax)于伤后24h仍低于伤前(P<0.05);右心室射血分数(EF)、1/3射血分数(1/3EF)、1/3射血率(1/3ER)和1/3充盈率(1/3FR)∶1/3ER在伤后24h仍明显低于伤前(P<0.05);左心室高峰充盈率(PFR)、1/3充盈分数(1/3FF)、1/3FR、PFR/PER和1/3FR∶1/3ER在伤后24h仍明显低于伤前(P<0.05,0.01)。结论BCT后心脏功能发生明显的改变,但左、右心室表现不一致,右心室主要表现为收缩功能障碍,左心室主要表现为舒张功能障碍。心导管、SPECT和超声心动图均能检测BCT后心脏功能的改变,但SPECT更精确,超声心动图更方便。 展开更多
关键词 钝性胸部创伤 心脏功能 诊断
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