The traditional way of breeding pastured animals is year-round pasture keeping without any additional fertilizing. Recently, among adult animals and the resulting offspring, a large number of individuals with low leve...The traditional way of breeding pastured animals is year-round pasture keeping without any additional fertilizing. Recently, among adult animals and the resulting offspring, a large number of individuals with low levels of natural resistance have begun to appear, which negatively affects the productivity of adults, and growth and development, as well as the safety of the resulting offspring. In this regard, the aim of the study was to study the effects of full-fledged feeding of females during pregnancy on the level of natural resistance of the received goats. To achieve this goal, a number of modern physiological and biochemical research methods were used. According to the results obtained, it was established that with the organization of full-fledged feeding, the period of suckling of the goat develops normally and the resulting baby goats are born with increased levels of natural resistance and more massive. In the goats of the experimental group, these advantages persist steadily until the age of one year, and to a certain extent ensure the normal preservation of the received goats and their growth and development. This makes it possible for farmers to fatten goats unused in breeding from 8 - 9 months of age and donate them for meat as an additional economic supplement to production.展开更多
Stab resistance body armor(SRBA)is essential in protecting people from knife injuries.The protective parts of traditional SRBA are made of multi-layered ultra-high molecular weight polyethylene(UHMWPE),which cause...Stab resistance body armor(SRBA)is essential in protecting people from knife injuries.The protective parts of traditional SRBA are made of multi-layered ultra-high molecular weight polyethylene(UHMWPE),which causes heavy heat stress for people wearing it.The protective parts of SRBA manufactured using laser sintering(LS)3D printing technology provide high manufacturing flexibility and low weight.Two different structures,plain plate and pyramid-structured plate,were investigated.The pyramid structure showed much higher stab resistance property then the plain plate,because of the angle and thickness effects.This is the first effort applying the LS technology and polyamide(PA)material(PA3200)on SRBA.By applying the pyramid structure on the protective layer of the SRBA,the total weight could reduce 30%-40%.展开更多
In CSEM exploration, the receivers are generally located about three to five times the skin depth from the transmitter. In this paper, we study the effect of a conductor between the transmitter and the survey area on ...In CSEM exploration, the receivers are generally located about three to five times the skin depth from the transmitter. In this paper, we study the effect of a conductor between the transmitter and the survey area on the target conductor response using forward modeling and inversion. The 2D forward finite element calculations show that the conductor mainly affects the response at middle and low frequencies. The lower the resistivity and the larger the conductor, the larger the effect and the effect increases with decreasing frequency. The inversion results indicate that the calculated position of the target body can move towards the source, leading to an incorrect interpretation without considering the conductor. In order to reduce the effect of a conductor between the source and the survey area, CSEM acquisition should be conducted in three dimensions using multiple sources and 3D inversion should be used during interpretation.展开更多
Objective:To explore whether or not the changes in body surface resistance at yuan-source points of three yin meridians of foot can specifically responds the onset of primary dysmenorrhea(PD) in females of menstrual p...Objective:To explore whether or not the changes in body surface resistance at yuan-source points of three yin meridians of foot can specifically responds the onset of primary dysmenorrhea(PD) in females of menstrual period and the before and after,so as to provide the evidence for acupoint selection in clinic.Methods:A total of 90 cases of PD were recruited in a PD group and 90 healthy female undergraduates were recruited in a normal group.The yuan-source of points of three yin meridians of foot were selected,i.e.Taibai(太白SP3),Taichong(太冲LR3) and Taixi(太溪KI3).The acupoints for control were Xuehai(血海SP10),the non-special acupoint,Xuanzhong(悬钟GB39),the acupoint not on the relevant meridian,as well as a non-meridian point.Successively,before menstruation,on Day 1 during menstruation and on Day 3 after menstruation,the body surface resistance at the above-mentioned test sites was detected in the participants of two groups each day.The resistance imbalance degree(RID) of the bilateral acupoints was taken as the outcome indicator.The observation lasted one menstrual cycle.Results:(1) Intra-group comparison:at LR3,the RID was lower on Day 1 during menstruation than that before menstruation significantly in the normal group(P ≤0.05).There was no significant change in RID at the same time points,but RID on Day 3 after menstruation was lower significantly than that before menstruation in the PD group(P ≤0.05).At SP3,KI3,SP10,GB39 and sham acupoint,there were no significant differences in RID among different time points within the same group(all P> 0.05).(2) Intergroup comparison:there were no significant differences in RID among different time points at the same point.(all P> 0.05).Conclusion:RID at yuan-source points of three yin meridians of foot cannot specifically respond to PD.However,at LR3,before and after menstruation,RID changes are different between PD patients and healthy female undergraduates,which needs a further study in the future.展开更多
AIM: To investigate the effect of intensive vs conventional insulin therapy on perioperative nutritional substrates metabolism in patients undergoing radical distal gastrectomy. METHODS: Within 24 h of intensive care ...AIM: To investigate the effect of intensive vs conventional insulin therapy on perioperative nutritional substrates metabolism in patients undergoing radical distal gastrectomy. METHODS: Within 24 h of intensive care unit management, patients with gastric cancer were enrolled after written informed consent and randomized to the intensive insulin therapy (IIT) group to keep glucose levels from 4.4 to 6.1 mmol/L or the conventional insulin therapy (CIT) group to keep levels less than 10 mmol/L. Resting energy expenditure (REE), respiratory quotient (RQ), resting energy expenditure per kilogram (REE/kg), and the lipid oxidation rate were monitored by the indirect calorimeter of calcium citrate malate nutrition metabolism investigation system. The changes in body composition were analyzed by multi-frequency bioimpedance analysis. Blood fasting glucose and insulin concentration were measured for assessment of Homeostasis model assessment of insulin resistance. RESULTS: Sixty patients were enrolled. Compared with preoperative baseline, postoperative REE increased by over 22.15% and 11.07%; REE/kg rose up to 27.22 ± 1.33 kcal/kg and 24.72 ± 1.43 kcal/kg; RQ decreased to 0.759 ± 0.034 and 0.791 ± 0.037; the lipid oxidation ratio was up to 78.25% ± 17.74% and 67.13% ± 12.76% supported by parenteral nutrition solutions from 37.56% ± 11.64% at the baseline; the level of Ln-HOMA-IR went up dramatically (P < 0.05, respectively) on postoperative days 1 and 3 in the IIT group. Meanwhile the concentration of total protein, albumin and triglyceride declined significantly on postoperative days 1 and 3 compared with pre-operative levels (P < 0.05, respectively). Compared with the CIT group, IIT reduced the REE/kg level (27.22 ± 1.33 kcal/kg vs 29.97 ± 1.47 kcal/kg, P = 0.008; 24.72 ± 1.43 kcal/kg vs 25.66 ± 1.63 kcal/kg, P = 0.013); and decreased the Ln-HOMA-IR score (P = 0.019, 0.028) on postoperative days 1 and 3; IIT decreased the level of CRP on postoperative days 1 and 3 (P = 0.017, 0.006); the total protein and albumin concentrations in the IIT group were greater than those in the CIT group (P = 0.023, 0.009). Postoperative values of internal cell fluid (ICF), fat mass, protein mass (PM), muscle mass, free fat mass and body weight decreased obviously on postoperative 7th day compared with the preoperative baseline in the CIT group (P < 0.05, respectively). IIT reduced markedly consumption of fat mass, PM and ICF compared with CIT (P = 0.009 to 0.026). CONCLUSION: There were some benefits of IIT in decreasing the perioperative insulin resistance state, reducing energy expenditure and consumption of proteins and lipids tissue in patients undergoing gastrectomy.展开更多
From the magnetotelluric detection in the epicentral region and the adjacent areas of the 1605 M7.5 Qiongzhou earthquake, we have discovered there is a low resistive body in the deep crust of the epicentral region. Th...From the magnetotelluric detection in the epicentral region and the adjacent areas of the 1605 M7.5 Qiongzhou earthquake, we have discovered there is a low resistive body in the deep crust of the epicentral region. The low resistive body extends straightly from the depth of about 13 km to the upper mantle, which is supposed as an uprising mantle pole. We therefore consider it is just the existing mantle pole and its upwelling thermal material that result in the faulting and stick-slipping activities of the upper crust, which is an important factor for the M7.5 Qiongzhou great earthquake occurrence. The postseismic faulting activity is characterized by creep, which shows that the risk is greatly decreased for the occurrence of a great earthquake with similar intensity in the future.展开更多
In order to stody the effect of a traditional Chinese medical treating method (StrengtheningBody Resistance Method) on asthma attack, asthmatic patients of either Cold type or Heat type were dividedinto two groups and...In order to stody the effect of a traditional Chinese medical treating method (StrengtheningBody Resistance Method) on asthma attack, asthmatic patients of either Cold type or Heat type were dividedinto two groups and treated with tlie Chinese methods ' Zhibiao' I symptomatic treatments, as the controlgroup) and 'Biaoben Jianzhi' (treating both the secondary and principal aspects of a disease, as the testgroup) respectively. The results showed tliat the markedly effective rates were higher in ttie two ' BiaobenJianzhi' groups than that in the two 'Zhibiao' groups. After treatment, the changeS of one second forced ex-piratory volume (FEV1) and the peak expiratory flow of patients of the former were also greater than those otthe latter; the proportion of cells carrying human leukocyte antigen class II(HLA-DR+ cell) , the baSOphiliccoll releasing capacity I HBR) and the T coll hyperplasia resporise to specific allergens of patients of the'Biaoben Jianzhi' groiJps were all redced while those of the 'Zhibiao' groiJps chafiged little. These resultssuggested that the 'Strengthening Body Resistaiice method' played an important role in regulating immunityfor relieving asthma attack.展开更多
OBJECTIVE: To explore the short and long-term efficacy of combining Fuzhengliqi mixture (FLM) with acupuncture in treating functional constipation (FC). METHODS: The 560 patients with confirmed diagnosis of FC were ra...OBJECTIVE: To explore the short and long-term efficacy of combining Fuzhengliqi mixture (FLM) with acupuncture in treating functional constipation (FC). METHODS: The 560 patients with confirmed diagnosis of FC were randomly assigned to four groups: FLM group, acupuncture group, combined therapy group, and control group. There were 140 cases in each group. The FLM group was administered FLM 60 mL twice a day, while the acupuncture group was treated with acupuncture at acupoints Tianshu (ST 25), Shangjuxu (ST 37), Zusanli (ST 36), Dachangshu (BL 25), and Zhigou (TE 6) twice a day, the combined therapy group with FLM and acupuncture, and the control group was administered mosapride (5 mg thrice a day) and Macrogol 4000 (10 g twice a day). The treatment lasted 6 weeks. The defecation interval, stool property, constipation symptoms, and accompanying symptomswere recorded, graded, and scored.The gastrointestinal transit time (GITT) and motilin (MTL) level in serum and life quality score were detected at three time points (pre-treatment, at the end of treatment, and 60 weeks post-treatment). Moreover, the adverse reactions were also observed. RESULTS: In the FLM group 2 cases were eliminated for not taking medication strictly according to the research plan and 1 case was lost to follow-up, while 2 cases in the acupuncture group and 2 cases in the combined therapy group were lost to follow-up. Compared with those detected pre-treat- ment, the defecation interval, stool property, consti- pation symptom grade, accompanying symptom grade, and GITT were all decreased markedly at the end of treatment in every group, while the MTL levels in serum and life quality score were increased markedly (P<0.01), the above-mentioned detecting indices were better in the combined therapy group than those in other groups (P<0.05). Compared with the end of treatment, above-mentioned detecting indices all recurred significantly in the FLM group and control group 60 weeks post-treatment (P>0.05), but these indices recurred insignificantly in the acupuncture and combined therapy groups (P>0.05). The short and long-term total effective rates in the combined therapy group were significantly different from those in other groups (P<0.05 or P<0.01). No serious adverse reactions were found in four groups. CONCLUSION: Both FLM and acupuncture can significantly shorten the defecation interval and GITT, increase MTL levels in serum, decrease the scores of stool property, constipation symptoms, and accompanying symptoms in patients with FC to increase their life quality. The combined therapy is much better in long-term efficacy and the safety is also good, worth spreading in clinical practice.展开更多
The performance of a partially depleted silicon-on-insulator (PDSO1) dynamic threshold MOSFET (DT- MOS) is degraded by the large body capacitance and body resistance. Increasing silicon film thickness can reduce t...The performance of a partially depleted silicon-on-insulator (PDSO1) dynamic threshold MOSFET (DT- MOS) is degraded by the large body capacitance and body resistance. Increasing silicon film thickness can reduce the body resistance greatly, but the body capacitance also increases significantly at the same time. To solve this problem, a novel SOl DTMOSFET structure (drain/source-on-local-insulator structure) is proposed. From ISE simulation, the improvement in delay, obtained by optimizing p-n junction depth and silicon film thickness, is very significant. At the same time, we find that the drive current increases significantly as the thickness of the silicon film increases. Furthermore, only one additional mask is needed to form the local SIMOX, and other fabrication processes are fully compatible with conventional CMOS/SOI technology.展开更多
Objective: To study the effects of 24 Chinese medicinal herbs on nucleic acid, protein and cellcycle of human lung adenocarcinoma cells. Methods: Using flow cytometry the authors analysed the effects of 24Chinese medi...Objective: To study the effects of 24 Chinese medicinal herbs on nucleic acid, protein and cellcycle of human lung adenocarcinoma cells. Methods: Using flow cytometry the authors analysed the effects of 24Chinese medicinal herbs (CMH) in compound recipe on proliferation index (PI), DNA index, protein index andratio of various phases in cell cycle of human lung adenocarcinoma cells (SPC-A-1). Results: The PI was morethan 20%, in 4 CMH, while 3 CMH, Gynostemma Pentaphylla, Radix Glehnia, and Radix Ginseng couldstrengthen the body resistance. That suggested using CMH of strengthening body resistance could not only serveas conventional ionic but also as tumor cell inhibitor. Meanwhile the action points of 24 CMH on cell cycle weredifferent from one another. Conclusions: According to these results, Chinese recipes were more effective in clinical practice.展开更多
In the fabrication of a 48 mm×48 mm silicon micro-strip nuclear radiation detector with 96 strips on each side, a perfect P-N junction cannot be formed consistently by the one-step implantation process, and thus ...In the fabrication of a 48 mm×48 mm silicon micro-strip nuclear radiation detector with 96 strips on each side, a perfect P-N junction cannot be formed consistently by the one-step implantation process, and thus over 50% of strips produced do not meet application requirements. However, the method of stratified implantation not only avoids the P region between the surface of wafers and the P+ region, but also overcomes the shadow effect. With the help of the stratified implantation process, a perfect functional P-N junction can be formed, and over 95% of strips meet application requirements.展开更多
The annealing process for boron implantation is a crucial step during large size nuclear radiation detector fabrication. It can reduce the lattice defects and the projection straggling. A two-step annealing process fo...The annealing process for boron implantation is a crucial step during large size nuclear radiation detector fabrication. It can reduce the lattice defects and the projection straggling. A two-step annealing process for boron implantation was developed instead of a one-step annealing process, and the reverse body resistance of a silicon micro-strip detector was significantly increased, which means that the performance of the detector was improved.展开更多
文摘The traditional way of breeding pastured animals is year-round pasture keeping without any additional fertilizing. Recently, among adult animals and the resulting offspring, a large number of individuals with low levels of natural resistance have begun to appear, which negatively affects the productivity of adults, and growth and development, as well as the safety of the resulting offspring. In this regard, the aim of the study was to study the effects of full-fledged feeding of females during pregnancy on the level of natural resistance of the received goats. To achieve this goal, a number of modern physiological and biochemical research methods were used. According to the results obtained, it was established that with the organization of full-fledged feeding, the period of suckling of the goat develops normally and the resulting baby goats are born with increased levels of natural resistance and more massive. In the goats of the experimental group, these advantages persist steadily until the age of one year, and to a certain extent ensure the normal preservation of the received goats and their growth and development. This makes it possible for farmers to fatten goats unused in breeding from 8 - 9 months of age and donate them for meat as an additional economic supplement to production.
基金Supported by the Independent Research Project of State Key Laboratory of Explosion Science and Technology(YBKT16-13)Beijing Institute of Technology Research Fund Program for Young Scholars(2-205205-2014)National Key Rsearch Program(2016YFC0802801-4)
文摘Stab resistance body armor(SRBA)is essential in protecting people from knife injuries.The protective parts of traditional SRBA are made of multi-layered ultra-high molecular weight polyethylene(UHMWPE),which causes heavy heat stress for people wearing it.The protective parts of SRBA manufactured using laser sintering(LS)3D printing technology provide high manufacturing flexibility and low weight.Two different structures,plain plate and pyramid-structured plate,were investigated.The pyramid structure showed much higher stab resistance property then the plain plate,because of the angle and thickness effects.This is the first effort applying the LS technology and polyamide(PA)material(PA3200)on SRBA.By applying the pyramid structure on the protective layer of the SRBA,the total weight could reduce 30%-40%.
基金supported by the Project kzcx2-yw-113,kzcx2-yw-121 and kzcx1-yw-15-4,CAS
文摘In CSEM exploration, the receivers are generally located about three to five times the skin depth from the transmitter. In this paper, we study the effect of a conductor between the transmitter and the survey area on the target conductor response using forward modeling and inversion. The 2D forward finite element calculations show that the conductor mainly affects the response at middle and low frequencies. The lower the resistivity and the larger the conductor, the larger the effect and the effect increases with decreasing frequency. The inversion results indicate that the calculated position of the target body can move towards the source, leading to an incorrect interpretation without considering the conductor. In order to reduce the effect of a conductor between the source and the survey area, CSEM acquisition should be conducted in three dimensions using multiple sources and 3D inversion should be used during interpretation.
基金Supported by National Natural Science Foundation of China:81573884,81973755,81603542Excellent Innovation Team Construction Project of Hebei University of Chinese Medicine:JTZ2020008。
文摘Objective:To explore whether or not the changes in body surface resistance at yuan-source points of three yin meridians of foot can specifically responds the onset of primary dysmenorrhea(PD) in females of menstrual period and the before and after,so as to provide the evidence for acupoint selection in clinic.Methods:A total of 90 cases of PD were recruited in a PD group and 90 healthy female undergraduates were recruited in a normal group.The yuan-source of points of three yin meridians of foot were selected,i.e.Taibai(太白SP3),Taichong(太冲LR3) and Taixi(太溪KI3).The acupoints for control were Xuehai(血海SP10),the non-special acupoint,Xuanzhong(悬钟GB39),the acupoint not on the relevant meridian,as well as a non-meridian point.Successively,before menstruation,on Day 1 during menstruation and on Day 3 after menstruation,the body surface resistance at the above-mentioned test sites was detected in the participants of two groups each day.The resistance imbalance degree(RID) of the bilateral acupoints was taken as the outcome indicator.The observation lasted one menstrual cycle.Results:(1) Intra-group comparison:at LR3,the RID was lower on Day 1 during menstruation than that before menstruation significantly in the normal group(P ≤0.05).There was no significant change in RID at the same time points,but RID on Day 3 after menstruation was lower significantly than that before menstruation in the PD group(P ≤0.05).At SP3,KI3,SP10,GB39 and sham acupoint,there were no significant differences in RID among different time points within the same group(all P> 0.05).(2) Intergroup comparison:there were no significant differences in RID among different time points at the same point.(all P> 0.05).Conclusion:RID at yuan-source points of three yin meridians of foot cannot specifically respond to PD.However,at LR3,before and after menstruation,RID changes are different between PD patients and healthy female undergraduates,which needs a further study in the future.
基金Supported by The Health Science and Technology Development Project of Shandong, No. 2005HZ024
文摘AIM: To investigate the effect of intensive vs conventional insulin therapy on perioperative nutritional substrates metabolism in patients undergoing radical distal gastrectomy. METHODS: Within 24 h of intensive care unit management, patients with gastric cancer were enrolled after written informed consent and randomized to the intensive insulin therapy (IIT) group to keep glucose levels from 4.4 to 6.1 mmol/L or the conventional insulin therapy (CIT) group to keep levels less than 10 mmol/L. Resting energy expenditure (REE), respiratory quotient (RQ), resting energy expenditure per kilogram (REE/kg), and the lipid oxidation rate were monitored by the indirect calorimeter of calcium citrate malate nutrition metabolism investigation system. The changes in body composition were analyzed by multi-frequency bioimpedance analysis. Blood fasting glucose and insulin concentration were measured for assessment of Homeostasis model assessment of insulin resistance. RESULTS: Sixty patients were enrolled. Compared with preoperative baseline, postoperative REE increased by over 22.15% and 11.07%; REE/kg rose up to 27.22 ± 1.33 kcal/kg and 24.72 ± 1.43 kcal/kg; RQ decreased to 0.759 ± 0.034 and 0.791 ± 0.037; the lipid oxidation ratio was up to 78.25% ± 17.74% and 67.13% ± 12.76% supported by parenteral nutrition solutions from 37.56% ± 11.64% at the baseline; the level of Ln-HOMA-IR went up dramatically (P < 0.05, respectively) on postoperative days 1 and 3 in the IIT group. Meanwhile the concentration of total protein, albumin and triglyceride declined significantly on postoperative days 1 and 3 compared with pre-operative levels (P < 0.05, respectively). Compared with the CIT group, IIT reduced the REE/kg level (27.22 ± 1.33 kcal/kg vs 29.97 ± 1.47 kcal/kg, P = 0.008; 24.72 ± 1.43 kcal/kg vs 25.66 ± 1.63 kcal/kg, P = 0.013); and decreased the Ln-HOMA-IR score (P = 0.019, 0.028) on postoperative days 1 and 3; IIT decreased the level of CRP on postoperative days 1 and 3 (P = 0.017, 0.006); the total protein and albumin concentrations in the IIT group were greater than those in the CIT group (P = 0.023, 0.009). Postoperative values of internal cell fluid (ICF), fat mass, protein mass (PM), muscle mass, free fat mass and body weight decreased obviously on postoperative 7th day compared with the preoperative baseline in the CIT group (P < 0.05, respectively). IIT reduced markedly consumption of fat mass, PM and ICF compared with CIT (P = 0.009 to 0.026). CONCLUSION: There were some benefits of IIT in decreasing the perioperative insulin resistance state, reducing energy expenditure and consumption of proteins and lipids tissue in patients undergoing gastrectomy.
基金Joint Seismological Science Foundation of China (104123).
文摘From the magnetotelluric detection in the epicentral region and the adjacent areas of the 1605 M7.5 Qiongzhou earthquake, we have discovered there is a low resistive body in the deep crust of the epicentral region. The low resistive body extends straightly from the depth of about 13 km to the upper mantle, which is supposed as an uprising mantle pole. We therefore consider it is just the existing mantle pole and its upwelling thermal material that result in the faulting and stick-slipping activities of the upper crust, which is an important factor for the M7.5 Qiongzhou great earthquake occurrence. The postseismic faulting activity is characterized by creep, which shows that the risk is greatly decreased for the occurrence of a great earthquake with similar intensity in the future.
文摘In order to stody the effect of a traditional Chinese medical treating method (StrengtheningBody Resistance Method) on asthma attack, asthmatic patients of either Cold type or Heat type were dividedinto two groups and treated with tlie Chinese methods ' Zhibiao' I symptomatic treatments, as the controlgroup) and 'Biaoben Jianzhi' (treating both the secondary and principal aspects of a disease, as the testgroup) respectively. The results showed tliat the markedly effective rates were higher in ttie two ' BiaobenJianzhi' groups than that in the two 'Zhibiao' groups. After treatment, the changeS of one second forced ex-piratory volume (FEV1) and the peak expiratory flow of patients of the former were also greater than those otthe latter; the proportion of cells carrying human leukocyte antigen class II(HLA-DR+ cell) , the baSOphiliccoll releasing capacity I HBR) and the T coll hyperplasia resporise to specific allergens of patients of the'Biaoben Jianzhi' groiJps were all redced while those of the 'Zhibiao' groiJps chafiged little. These resultssuggested that the 'Strengthening Body Resistaiice method' played an important role in regulating immunityfor relieving asthma attack.
文摘OBJECTIVE: To explore the short and long-term efficacy of combining Fuzhengliqi mixture (FLM) with acupuncture in treating functional constipation (FC). METHODS: The 560 patients with confirmed diagnosis of FC were randomly assigned to four groups: FLM group, acupuncture group, combined therapy group, and control group. There were 140 cases in each group. The FLM group was administered FLM 60 mL twice a day, while the acupuncture group was treated with acupuncture at acupoints Tianshu (ST 25), Shangjuxu (ST 37), Zusanli (ST 36), Dachangshu (BL 25), and Zhigou (TE 6) twice a day, the combined therapy group with FLM and acupuncture, and the control group was administered mosapride (5 mg thrice a day) and Macrogol 4000 (10 g twice a day). The treatment lasted 6 weeks. The defecation interval, stool property, constipation symptoms, and accompanying symptomswere recorded, graded, and scored.The gastrointestinal transit time (GITT) and motilin (MTL) level in serum and life quality score were detected at three time points (pre-treatment, at the end of treatment, and 60 weeks post-treatment). Moreover, the adverse reactions were also observed. RESULTS: In the FLM group 2 cases were eliminated for not taking medication strictly according to the research plan and 1 case was lost to follow-up, while 2 cases in the acupuncture group and 2 cases in the combined therapy group were lost to follow-up. Compared with those detected pre-treat- ment, the defecation interval, stool property, consti- pation symptom grade, accompanying symptom grade, and GITT were all decreased markedly at the end of treatment in every group, while the MTL levels in serum and life quality score were increased markedly (P<0.01), the above-mentioned detecting indices were better in the combined therapy group than those in other groups (P<0.05). Compared with the end of treatment, above-mentioned detecting indices all recurred significantly in the FLM group and control group 60 weeks post-treatment (P>0.05), but these indices recurred insignificantly in the acupuncture and combined therapy groups (P>0.05). The short and long-term total effective rates in the combined therapy group were significantly different from those in other groups (P<0.05 or P<0.01). No serious adverse reactions were found in four groups. CONCLUSION: Both FLM and acupuncture can significantly shorten the defecation interval and GITT, increase MTL levels in serum, decrease the scores of stool property, constipation symptoms, and accompanying symptoms in patients with FC to increase their life quality. The combined therapy is much better in long-term efficacy and the safety is also good, worth spreading in clinical practice.
文摘The performance of a partially depleted silicon-on-insulator (PDSO1) dynamic threshold MOSFET (DT- MOS) is degraded by the large body capacitance and body resistance. Increasing silicon film thickness can reduce the body resistance greatly, but the body capacitance also increases significantly at the same time. To solve this problem, a novel SOl DTMOSFET structure (drain/source-on-local-insulator structure) is proposed. From ISE simulation, the improvement in delay, obtained by optimizing p-n junction depth and silicon film thickness, is very significant. At the same time, we find that the drive current increases significantly as the thickness of the silicon film increases. Furthermore, only one additional mask is needed to form the local SIMOX, and other fabrication processes are fully compatible with conventional CMOS/SOI technology.
文摘Objective: To study the effects of 24 Chinese medicinal herbs on nucleic acid, protein and cellcycle of human lung adenocarcinoma cells. Methods: Using flow cytometry the authors analysed the effects of 24Chinese medicinal herbs (CMH) in compound recipe on proliferation index (PI), DNA index, protein index andratio of various phases in cell cycle of human lung adenocarcinoma cells (SPC-A-1). Results: The PI was morethan 20%, in 4 CMH, while 3 CMH, Gynostemma Pentaphylla, Radix Glehnia, and Radix Ginseng couldstrengthen the body resistance. That suggested using CMH of strengthening body resistance could not only serveas conventional ionic but also as tumor cell inhibitor. Meanwhile the action points of 24 CMH on cell cycle weredifferent from one another. Conclusions: According to these results, Chinese recipes were more effective in clinical practice.
基金Supported by National Natural Science Foundation of China(11175223,11305231,11205220)
文摘In the fabrication of a 48 mm×48 mm silicon micro-strip nuclear radiation detector with 96 strips on each side, a perfect P-N junction cannot be formed consistently by the one-step implantation process, and thus over 50% of strips produced do not meet application requirements. However, the method of stratified implantation not only avoids the P region between the surface of wafers and the P+ region, but also overcomes the shadow effect. With the help of the stratified implantation process, a perfect functional P-N junction can be formed, and over 95% of strips meet application requirements.
文摘The annealing process for boron implantation is a crucial step during large size nuclear radiation detector fabrication. It can reduce the lattice defects and the projection straggling. A two-step annealing process for boron implantation was developed instead of a one-step annealing process, and the reverse body resistance of a silicon micro-strip detector was significantly increased, which means that the performance of the detector was improved.