To investigate the effects of drinking the soaking of Malus domeri(Bois)Chev.leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city,Guangxi,China.It has been reported that longevity...To investigate the effects of drinking the soaking of Malus domeri(Bois)Chev.leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city,Guangxi,China.It has been reported that longevity is closely related to metabolism and the gut microbiota.The 16S rRNA sequencing and liquid chromatography-mass spectrometry(LC-MS)were used to analysis fecal samples and explore the factors affecting longevity in the region.Interestingly,we discovered,that elderly individuals who had been drinking the soaking of M.domeri(Bois)Chev.leaves for a long time exhibited higher diversity of the gut microbiota than without drinking the soaking,notably.The proportions of Ruminococcaceae and Prevotella were decreased in those who did not drink this soaking.In addition,a total of 106 metabolites were characterized,and the people of long-lived people(>90 years old)and elderly people(<90 years old)who drinking soaking of M.domeri(Bois)Chev.leaves significantly altered the gut microbiota and upregulated levels of haplopine,farnesol,genipic acid,momordicinin,2-hydroxyestrone,hydroxyphenyllactic acid,caffeic acid,sophoraflavanone B,and soyasaponin I.We preliminarily determined that M.domeri(Bois)Chev.leaves consumption may be an important factor affecting longevity in this area.展开更多
城市河道水质黑臭直接影响人们生存环境和生活质量,准确识别城市黑臭水体对城市生态文明建设具有重大意义。基于GF-2 PMS数据,利用TSUWI(Two-Step Urban Water Index)指数提取研究区水体分布,在此基础上,分别计算影像的黑臭水体归一化...城市河道水质黑臭直接影响人们生存环境和生活质量,准确识别城市黑臭水体对城市生态文明建设具有重大意义。基于GF-2 PMS数据,利用TSUWI(Two-Step Urban Water Index)指数提取研究区水体分布,在此基础上,分别计算影像的黑臭水体归一化比值指数BOI和NDBWI值,采用面向对象的最优特征选择搜索算法SEaTH(Seperability and Thresholds),确定黑臭水体与一般水体的4个分离特征,构成特征空间,利用K-mean算法进行多特征聚类分析,进行黑臭水体的识别与分类。结果表明,南京市研究区范围内共有6条河道15段存在不同程度的黑臭情况,面积约为0.38km^(2),占城区水域(剔除长江南京段面积)面积的1.98%,经实地调查验证,黑臭水体的识别精度为81%。研究表明该方法可以实现对城市河道黑臭水体的监测与评价,为城市水环境治理提供技术支撑。展开更多
This work,using a structurationist approach,phenomenological structuralism,argues that the Haitian Revolution and Jean-Jacques Dessalines represented the first embodiment of Alexandre Kojève’s“End of History”t...This work,using a structurationist approach,phenomenological structuralism,argues that the Haitian Revolution and Jean-Jacques Dessalines represented the first embodiment of Alexandre Kojève’s“End of History”thesis.Following the Haitian Revolution,which is a revolt against slavery and mercantilist capitalism,the founder of the country,Jean-Jacques Dessalines,attempted to synthesize three forms of system and social integration on the island in order to constitute the nation of Haiti:the mercantilist and liberal capitalism of the Affranchis,petit-bourgeois blacks and mulatto elites,respectively;and the Lakouism,communism,of the African majority on the island.In this sense,Dessalines represented the first embodiment of Kojève’s end of history Hegelian thesis.Using a structurationist,structural Marxist,understanding of practical consciousness constitution,the work explores the origins and basis for Dessalines’s social,political,and economic policies to that end.The death of Dessalines,I conclude,would undermine this revolutionary impetus of the Haitian Revolution,rendering it insignificant,and converted Haiti into the so-called poorest country in the Western Hemisphere under American neoliberal capitalist hegemony.展开更多
Both Booker T.Washington and W.E.B.Du Bois are the prominent thinkers who provide inspirations for African Americans on their way to strive for political,economic and social emancipations.Their ideas arise from the sp...Both Booker T.Washington and W.E.B.Du Bois are the prominent thinkers who provide inspirations for African Americans on their way to strive for political,economic and social emancipations.Their ideas arise from the specific determinants of the historical period where they respectively live.People are often more aware of and interested in the differences and even conflicts of their propositions.In essence,thinking of the latter is a logic continuity of that of the former.Their ideas share a logic commonality,which is that they are conservative in the base,and reformist in the implementing steps.展开更多
The identity of paramedic professions is bound to develop in order to adapt to the changes of the world of health. Careproviders＇ identity is based on the interpersonal dimension, yet French massage-physiotherapy bas...The identity of paramedic professions is bound to develop in order to adapt to the changes of the world of health. Careproviders＇ identity is based on the interpersonal dimension, yet French massage-physiotherapy bases this interpersonal competence on touch. This is why many practitioners try to develop this aspect of their practice through continuing professional education. Danis Bois Method （MOthode Danis Bois： MDB） of fasciatherapy, characterized by its relational and sensitive approach to care and touch, stands in this field. This paper will present the impacts of this manual therapy on the professional identity of 446 masseurs-physiotherapists who took part in a self-assessment survey. The results show that, in spite of the few difficulties they meet within their duties, practicing fasciatherapy integrates perfectly well into the framework of massage-physiotherapy. It largely reinforces the feeling of therapeutical efficacy and the capacity to meet the evolution in health needs （chronic diseases, mental suffering, and patients＇ quality of life）. It also restores meaning and value to the profession and boosts motivation as well as it fosters the congruence of both considered as an added value to masso-physiotherapy, a means to accom professional identity pets plish onal and professional identities. It is thus oneself and an essential component of展开更多
Glacial cirques are typical landscape features of mid-latitude mountain environments like the Central Pyrenees. Their morphology as well as their spatial distribution provides insights about past glaciers and climates...Glacial cirques are typical landscape features of mid-latitude mountain environments like the Central Pyrenees. Their morphology as well as their spatial distribution provides insights about past glaciers and climates. In this study, we examine the distribution, morphometrical and topographical characteristics of glacial cirques in two U-shaped glacial valleys located in the Central Pyrenees – the Aran and the Boí valleys. They are located in different aspects of this mountain range(north vs south) under different climatic influences that promoted distinct glaciation patterns during the late Pleistocene. The spatial mapping of these landforms was carried out using high-resolution imagery and field observations. We analysed the data of the morphometrical and topographical variables of the glacial cirques by using different statistical and geospatial methods in order tounveil the factors controlling their formation and development. A total of 186 glacial cirques were mapped in the study area, including 119 in the Aran and 67 in the Boí valleys. The local topography and microclimate conditions lead to substantial differences in both areas in terms of the morphology and dimensions of the cirques. Glacial cirques in Boí are distributed at slightly higher elevations than in Aran and they are also larger, though their dimensions decrease with elevation in both valleys. Aran cirques are mostly oriented NE, while Boí landforms do not show any prevailing aspect. Even though lithology does not control the distribution of the glacial cirques, some specific lithological settings may favour the development of larger cirques. In general, glacial cirques in the Aran and the Boí valleys show morphometrical properties similar to those reported in other mid-latitude mountain ranges.展开更多
Integrin expression forms focal adhesions, but how this process is physiologically regulated is unclear. Ihog proteins are evolutionarily conserved, playing roles in Hedgehog signaling and serving as trans-homophilic ...Integrin expression forms focal adhesions, but how this process is physiologically regulated is unclear. Ihog proteins are evolutionarily conserved, playing roles in Hedgehog signaling and serving as trans-homophilic adhesion molecules to mediate cell-cell interactions. Whether these proteins are also engaged in other cell adhesion processes remains unknown. Here, we report that Drosophila Ihog proteins function in the integrin-mediated adhesions. Removal of Ihog proteins causes blister and spheroidal muscle in wings and embryos, respectively. We demonstrate that Ihog proteins interact with integrin via the extracellular portion and that their removal perturbs integrin distribution. Finally, we show that Boc, a mammalian Ihog protein,rescues the embryonic defects caused by removing its Drosophila homologs. We thus propose that Ihog proteins contribute to integrin-mediated focal adhesions.展开更多
基金supported by the National Natural Science Foundation of China (32072193)the Natural Science Foundation of Guangxi,China (2020GXNSFBA297083)。
文摘To investigate the effects of drinking the soaking of Malus domeri(Bois)Chev.leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city,Guangxi,China.It has been reported that longevity is closely related to metabolism and the gut microbiota.The 16S rRNA sequencing and liquid chromatography-mass spectrometry(LC-MS)were used to analysis fecal samples and explore the factors affecting longevity in the region.Interestingly,we discovered,that elderly individuals who had been drinking the soaking of M.domeri(Bois)Chev.leaves for a long time exhibited higher diversity of the gut microbiota than without drinking the soaking,notably.The proportions of Ruminococcaceae and Prevotella were decreased in those who did not drink this soaking.In addition,a total of 106 metabolites were characterized,and the people of long-lived people(>90 years old)and elderly people(<90 years old)who drinking soaking of M.domeri(Bois)Chev.leaves significantly altered the gut microbiota and upregulated levels of haplopine,farnesol,genipic acid,momordicinin,2-hydroxyestrone,hydroxyphenyllactic acid,caffeic acid,sophoraflavanone B,and soyasaponin I.We preliminarily determined that M.domeri(Bois)Chev.leaves consumption may be an important factor affecting longevity in this area.
文摘城市河道水质黑臭直接影响人们生存环境和生活质量,准确识别城市黑臭水体对城市生态文明建设具有重大意义。基于GF-2 PMS数据,利用TSUWI(Two-Step Urban Water Index)指数提取研究区水体分布,在此基础上,分别计算影像的黑臭水体归一化比值指数BOI和NDBWI值,采用面向对象的最优特征选择搜索算法SEaTH(Seperability and Thresholds),确定黑臭水体与一般水体的4个分离特征,构成特征空间,利用K-mean算法进行多特征聚类分析,进行黑臭水体的识别与分类。结果表明,南京市研究区范围内共有6条河道15段存在不同程度的黑臭情况,面积约为0.38km^(2),占城区水域(剔除长江南京段面积)面积的1.98%,经实地调查验证,黑臭水体的识别精度为81%。研究表明该方法可以实现对城市河道黑臭水体的监测与评价,为城市水环境治理提供技术支撑。
文摘This work,using a structurationist approach,phenomenological structuralism,argues that the Haitian Revolution and Jean-Jacques Dessalines represented the first embodiment of Alexandre Kojève’s“End of History”thesis.Following the Haitian Revolution,which is a revolt against slavery and mercantilist capitalism,the founder of the country,Jean-Jacques Dessalines,attempted to synthesize three forms of system and social integration on the island in order to constitute the nation of Haiti:the mercantilist and liberal capitalism of the Affranchis,petit-bourgeois blacks and mulatto elites,respectively;and the Lakouism,communism,of the African majority on the island.In this sense,Dessalines represented the first embodiment of Kojève’s end of history Hegelian thesis.Using a structurationist,structural Marxist,understanding of practical consciousness constitution,the work explores the origins and basis for Dessalines’s social,political,and economic policies to that end.The death of Dessalines,I conclude,would undermine this revolutionary impetus of the Haitian Revolution,rendering it insignificant,and converted Haiti into the so-called poorest country in the Western Hemisphere under American neoliberal capitalist hegemony.
文摘Both Booker T.Washington and W.E.B.Du Bois are the prominent thinkers who provide inspirations for African Americans on their way to strive for political,economic and social emancipations.Their ideas arise from the specific determinants of the historical period where they respectively live.People are often more aware of and interested in the differences and even conflicts of their propositions.In essence,thinking of the latter is a logic continuity of that of the former.Their ideas share a logic commonality,which is that they are conservative in the base,and reformist in the implementing steps.
文摘The identity of paramedic professions is bound to develop in order to adapt to the changes of the world of health. Careproviders＇ identity is based on the interpersonal dimension, yet French massage-physiotherapy bases this interpersonal competence on touch. This is why many practitioners try to develop this aspect of their practice through continuing professional education. Danis Bois Method （MOthode Danis Bois： MDB） of fasciatherapy, characterized by its relational and sensitive approach to care and touch, stands in this field. This paper will present the impacts of this manual therapy on the professional identity of 446 masseurs-physiotherapists who took part in a self-assessment survey. The results show that, in spite of the few difficulties they meet within their duties, practicing fasciatherapy integrates perfectly well into the framework of massage-physiotherapy. It largely reinforces the feeling of therapeutical efficacy and the capacity to meet the evolution in health needs （chronic diseases, mental suffering, and patients＇ quality of life）. It also restores meaning and value to the profession and boosts motivation as well as it fosters the congruence of both considered as an added value to masso-physiotherapy, a means to accom professional identity pets plish onal and professional identities. It is thus oneself and an essential component of
基金supported by the Research Group Climate Change and Environmental Systems(ZEPHYRUS)of the Institute of GeographySpatial Planning of the University of Lisbon+4 种基金a grant from the Erasmus+LLP Programme Grant funding the research stay of Luis Lopes at the University of Barcelonasupported by the Ramón y Cajal Program of the Spanish Ministry of Economy and Competitiveness(RYC-2015-17597)Financial support was also provided by the research group ANTALP(Antarctic,Arctic and Alpine environments,2017-SGR-1102)the PALEOGREEN(CTM2017-87976-P)CRONOANTAR(CTM2016-77878-P)projects of the Spanish Ministry of Economy and Competitiveness
文摘Glacial cirques are typical landscape features of mid-latitude mountain environments like the Central Pyrenees. Their morphology as well as their spatial distribution provides insights about past glaciers and climates. In this study, we examine the distribution, morphometrical and topographical characteristics of glacial cirques in two U-shaped glacial valleys located in the Central Pyrenees – the Aran and the Boí valleys. They are located in different aspects of this mountain range(north vs south) under different climatic influences that promoted distinct glaciation patterns during the late Pleistocene. The spatial mapping of these landforms was carried out using high-resolution imagery and field observations. We analysed the data of the morphometrical and topographical variables of the glacial cirques by using different statistical and geospatial methods in order tounveil the factors controlling their formation and development. A total of 186 glacial cirques were mapped in the study area, including 119 in the Aran and 67 in the Boí valleys. The local topography and microclimate conditions lead to substantial differences in both areas in terms of the morphology and dimensions of the cirques. Glacial cirques in Boí are distributed at slightly higher elevations than in Aran and they are also larger, though their dimensions decrease with elevation in both valleys. Aran cirques are mostly oriented NE, while Boí landforms do not show any prevailing aspect. Even though lithology does not control the distribution of the glacial cirques, some specific lithological settings may favour the development of larger cirques. In general, glacial cirques in the Aran and the Boí valleys show morphometrical properties similar to those reported in other mid-latitude mountain ranges.
基金supported by National Natural Science Foundation of China (91754109, 31771544, 31730044)。
文摘Integrin expression forms focal adhesions, but how this process is physiologically regulated is unclear. Ihog proteins are evolutionarily conserved, playing roles in Hedgehog signaling and serving as trans-homophilic adhesion molecules to mediate cell-cell interactions. Whether these proteins are also engaged in other cell adhesion processes remains unknown. Here, we report that Drosophila Ihog proteins function in the integrin-mediated adhesions. Removal of Ihog proteins causes blister and spheroidal muscle in wings and embryos, respectively. We demonstrate that Ihog proteins interact with integrin via the extracellular portion and that their removal perturbs integrin distribution. Finally, we show that Boc, a mammalian Ihog protein,rescues the embryonic defects caused by removing its Drosophila homologs. We thus propose that Ihog proteins contribute to integrin-mediated focal adhesions.
