Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese women

Growth differentiation factor 11 （GDF11） is an important circulating factor that regulates aging. However, the role of GDF11 in bone metabolism remains unclear. The present study was undertaken to investigate the relationship between serum GDF11 level, bone mass, and bone turnover markers in postmenopausal Chinese women. Serum GDF11 level, bone turnover biochemical markers, and bone mineral density （BMD） were determined in 169 postmenopausal Chinese women （47-78 years old）. GDF11 serum levels increased with aging. There were negative correlations between GDF11 and BMD at the various skeletal sites. After adjusting for age and body mass index （BMI）, the correlations remained statistically significant. In the multiple linear stepwise regression analysis, age or years since menopause, BMI, GDF11, and estradiol were independent predictors of BMD. A significant negative correlation between GDF11 and bone alkaline phosphatase （BAP） was identified and remained significant after adjusting for age and BMI. No significant correlation was noted between cross-linked N-telopeptides of type I collagen （NTX） and GDF11. In conclusion, GDF11 is an independent negative predictor of BMD and correlates with a biomarker of bone formation, BAP, in postmenopausal Chinese women. GDF11 potentially exerts a negative effect on bone mass by regulating bone formation.

Low-level laser therapy enhances the number of osteocytes in calvaria bone defects of ovariectomized rats

Background : Osteoporosis can make bone repair difficult. Low-level laser therapy( LLLT) has been shown to be a promising tool for bone neoformation. This study aimed to analyze the effect of LLLT on calvaria bone defects of ovariectomized rats using stereology. Methods : Fifty-four Wistar rats were subjected to bilateral ovariectomy, and bone defects were created in calvaria after 150 days. The animals were divided into nine groups(n = ?6 per group), and 24 hours after the bone defects were created they received three, six or 12 sessions of LLLT at 0, 20 or 30 J/cm 2, using a 780-nm low-intensity GaAlAs laser. One-way ANOVA followed by Tukey ' s post hoc test was used for data processing. A difference of P < 0.05 was considered statistically significant. The parameters evaluated were osteocyte density( Nv_(ost)), total osteocyte number( Nto ost), trabecular surface density( Sv_t), and trabecular surface area( Sa_t). Results : Data obtained showed that Nto ost, Sv t, and Sa t in group G2 rats were significantly different from G1(0 J/cm^2)( P < 0.05). Compared to group G4, G5 presented higher values for the parameters Sv t and Sa t, and G6 presented significantly higher values for almost all the analyzed parameters( Nv _(ost), Nto_(ost), Sv_t, and Sa t)( P < 0.05). Compared to group G7, G8 showed a higher value only for the parameter Sa t, and G9 showed significantly higher values for parameters Nv ost, Nto ost, Sv_t, and Sa_t. Conclusion : We conclude that LLLT stimulated bone neoformation and contributed to an increase in the total number of osteocytes, especially with a laser energy density of 30 J/cm^2 given for six and 12 sessions.

Association of Bone Turnover Levels with MTHFR Gene Polymorphisms among Pregnant Women in Wuhan, China

Pregnancy is a critical stimulator of bone mineral resorption. We used to find the MTHFR gene polymorphisms are related with blood lead levels among pregnant women. Pregnancy-stimulated bone turnover may be associated with MTHFR gene polymorphisms too. In this article, we aimed to determine the relationship between MTHFR gene polymorphisms and bone turnover rates among the pregnant women. The participants including pregnant and non-pregnant women were selected and recruited during their routine prenatal or physical examination from July to October in 2012. A total of 1000 participants, including 250 pregnant women in the first, second, and third trimesters and 250 non-pregnant women, were enrolled in the study. Finally, after excluding 27 participants unable to provide blood samples, 973 eligible participants （i.e., 234, 249, and 248 pregnant women in the first, second, and third trimesters, respectively, and 242 non-pregnant women） were included in the research. The MTHFR gene 1298CC homozygote carriers were more susceptible to yield higher plasma homocysteine levels than the 1298AA/AC carriers, with standardized coefficients of 0.086 （P〈0.05） and 0.104 （P〈0.01） of all the participants and the pregnant women, respectively. The MTHFR gene 1793AA homozygote carriers more likely showed higher plasma osteocalcin levels （standardized β=0.091, P〈0.01） than the 1793GG/GA carriers among all the subjects. Plasma homocysteine levels were positively correlated with blood lead levels among the participants and the pregnant women with standardized coefficients of 0.320 （P〈0.01） and 0.179 （P〈0.01）, respectively. Plasma osteocalcin levels were positively associated with blood lead levels among pregnant and non-pregnant women with standardized coefficients of 0.084 （P〈0.05） and 0.125 （P〈0.01）, respectively. In conclusion, homocysteine and osteocalcin contents in plasma are associated with the MTHFR gene A1298C polymorphism and blood lead levels among pregnant women. The MTHFR gene A1298C polymorphism-related homocysteine is a possible risk factor for increased blood lead levels among Chinese women.

Natural radioactivity level of associated bone-coal mining area in Zhejiang Province

The geographic distribution, γ-radiation level and specific activity of radionuclides of the bone-coal mines in Zhejiang Province were reported. The weighted average of γ-radiation dose rate of the bone-coal mines is 566 nGy/h for 107 main bone-coal mines. The weighted mean activity of 238U, 226Ra, 232Th and 40K in the samples are 949, 918, 34 and 554 Bq/kg for 171 samples of bone-coal, respectively.

Investigation of environmental activity levels of bone-coal min-ing area in five provinces

During 1991-1993,the activity levels of the bone-coal mines were investigated in Zhejiang,Hubei,Hunan,Jiangxi and Anhui Province,respectively,where the reserve of bone-coal is about 90% of our country’s total reserve.The average of γ radiation doserate level measured for bone-coal,bone-coal cinder(BCC) and bone-coal cinder brick(BCCB) in these provinces is about 500 nGy/h,400 nGy/h and 700 nGy/h respectively,while that for fields,roads and houses made of BCCB in corresponding regions of these provinces is about 200 nGy/h,260 nGy/h and 300 nGy/h respectively.It is shown that the environmental activity level of bone-coal mining area is about 3 times higher than the reference spots.

Radioactivity level of the ambient environment of Anren bone-coal power station

The radioactivity level of the ambient environment of Anren Bone-coal Power Station (BCPS) was investigated systematically. The γ radiation dose rate level in the environment, the content of 238U and 226Ra in the ambient soil and the farmland in the direction of downwind, the concentrations of 238U. 232Th. 226Ra 40K and 222Rn as well as α potential energy in air, and the concentrations of natural U and Th in effluent are all higher than the corresponding values of the reference site. The additional annual effective dose equivalent to the residents living in the houses made of bone-coal cinder brick is 2.7 mSv.

利拉鲁肽联合胰岛素对2型糖尿病合并骨质疏松患者的疗效

目的探究利拉鲁肽联合胰岛素对2型糖尿病(type 2 diabetic mellitus,T2DM)合并骨质疏松(osteporsis,OP)患者血清爱帕琳肽(Apelin)水平、骨密度及骨代谢水平的影响。方法选取收治的80例T2DM合并OP患者,随机分为试验组和对照组,各40例。对照组给予胰岛素治疗,试验组在此基础上联合利拉鲁肽治疗,观察2组治疗后的疗效,治疗前后糖代谢、血清Apelin和脂联素(adiponectin,ADPN)水平、各部位骨密度(bone mineral density,BMD)、骨代谢指标[骨特异性碱性磷酸酶(bone-specific alkaline phosphatases,BAP)、骨钙素(bone gla protein,BGP)和Ⅰ型胶原N端肽(typeⅠcollagen N-terminal peptide,NTX)]和不良反应发生情况。结果试验组的总有效率明显高于对照组(P<0.05);治疗后,试验组的空腹、餐后2 h血糖和糖化血红蛋白(hemoglobin A1c,HbA1c)水平明显低于对照组(P<0.05),血清Apelin和ADPN水平显著高于对照组(P<0.05),腰椎L2~L4和股骨颈的BMD明显高于对照组(P<0.05),BAP和BGP水平高于对照组,NTX水平低于对照组(P<0.05);治疗期间2组不良反应发生率比较差异无统计学意义。结论采用利拉鲁肽和胰岛素联合治疗T2DM合并OP患者的疗效良好,能改善患者糖代谢水平,提高血清Apelin和ADPN水平,增加各部位BMD,改善骨代谢,且未增加不良反应发生率。

正畸联合骨水平种植体修复在牙列缺损中的应用效果评价

目的:评价正畸联合骨水平种植体修复在牙列缺损中的应用效果。方法 :回顾分析2020年1月—2022年1月因牙列缺损就诊的88例下颌后牙区单牙种植患者的资料,其中,骨水平种植体修复44例(对照组),正畸联合骨水平种植体修复44例(试验组)。比较2组种植体植入成功率、种植体牙周健康情况、咀嚼功能、种植体稳定情况、术后并发症及患者满意度。采用SPSS 18.0软件包对数据进行统计学分析。结果:2组植入3个月、6个月的成功率相比,差异无统计学意义(P>0.05),试验组植入12个月的成功率显著高于对照组(P<0.05)。试验组植入12个月的龈沟出血指数(gingival sulci bleeding index,SBI)、探诊深度(probing depth,PD)显著低于对照组(P<0.05),2组植入12个月的骨吸收量相比,差异无统计学意义(P>0.05)。2组治疗后最大力咬合时咬肌、颞肌肌电活动显著高于治疗前(P<0.05),试验组治疗后最大力咬合时咬肌、颞肌肌电活动显著高于对照组(P<0.05)。2组6个月、12个月时的种植体稳定系数显著高于3个月(P<0.05),2组12个月时的种植体稳定系数显著高于6个月(P<0.05),试验组6个月、12个月时的种植体稳定系数显著高于对照组(P<0.05)。2组总并发症发生率相比,差异无统计学意义(P>0.05)。试验组患者满意度显著高于对照组(P<0.05)。结论:正畸联合骨水平种植体修复牙列缺损可提高种植成功率及咀嚼效能,改善种植体牙周健康情况,提升患者满意度。

短种植体的临床应用研究进展

种植修复时常面临可用骨高度不足的问题,使用短种植体可解决骨增量手术之需。短种植体作为骨增量手术的替代治疗方案,在临床上已取得较好的短期效果,但短种植体的远期存留率还偏低,仍需临床进一步验证。本文就短种植体的定义、结构特点、临床应用、临床效果及展望等相关进行综述。

物理因子促进干细胞的成骨分化

背景:针对骨缺损传统修复方法的局限性,干细胞广泛应用于再生医学的研究。化学性因子是当前的研究热点,但是近年来的研究证实,国内外应用物理因素调控干细胞分化的研究不断深入,物理因子联合生物支架在骨组织工程中为解决骨缺损修复难题提供了一种新的思路和方法,具有良好的发展前景。目的:就物理因子如电磁场、超声等对干细胞成骨分化的分子机制以及信号通路的调控、在骨组织工程中应用的可行性等方面做一总结。方法:应用计算机检索中国知网和PubMed数据库中近20年的相关文献,在标题和摘要中以“干细胞,骨缺损,成骨分化,电磁场,超声,冲击波,低强度激光,机械力,骨组织工程”或“stem cell,osteoporosis,osteogenic differentiation,Electromagnetic Fields,Ultrasound,Bone Tissue Engineering”为检索词进行检索,对相关文章94篇进行综述分析。结果与结论:(1)物理因子作为一种无创、非接触的辅助疗法对骨组织工程有着显著影响,在调控干细胞的成骨分化、促进细胞的增殖以及在骨工程支架内的生存能力方面有着积极作用。(2)除了激活信号通路和成骨基因转录外,物理因子还可以改善血管化、增加支架中形成的骨的体积、面积和厚度,可以促进骨整合,提高骨支架再生健康骨组织的成功率。(3)然而,将物理因子用于骨组织工程的研究均采用不同的实验条件,如支架类型、细胞类型及干预条件等,无法直接进行比较以确定最佳参数设置,在临床应用中,这些不同干预对促进骨折愈合的有效性研究结果也缺乏一致性,因此未来还需要进一步确定物理因子用于骨组织工程的最佳参数。(4)总体而言,物理因子作为一种理想的辅助疗法,在与各种生物材料结合并应用于骨组织工程方面具有巨大的潜力。

益肾补骨汤联合康复训练治疗肝肾阴虚型股骨粗隆间骨折的临床观察

目的:观察益肾补骨汤联合康复训练治疗肝肾阴虚型骨质疏松性股骨粗隆间骨折患者的临床效果。方法:选择2019年3月—2023年3月在三明市中西医结合医院骨科诊治的肝肾阴虚型骨质疏松性股骨粗隆间骨折患者72例,采用随机数表法分成两组,各36例。对照组采用碳酸钙D3片和骨化三醇胶丸治疗,研究组在对照组基础上应用益肾补骨汤联合康复训练治疗。观察两组临床疗效,比较两组治疗前后视觉模拟评分法(VAS)评分、Harris髋关节功能评分、骨密度及骨代谢指标水平。结果:治疗后,研究组总有效率为97.22%,高于对照组的77.78%,差异有统计学意义(P<0.05)。两组VAS评分、骨碱性磷酸酶低于治疗前,Harris髋关节功能评分、骨钙素、骨密度均高于治疗前,且研究组VAS评分、骨碱性磷酸酶低于对照组,Harris评分、骨钙素、骨密度均高于对照组,差异有统计学意义(P<0.05)。结论:采用益肾补骨汤联合康复训练治疗肝肾阴虚型骨质疏松性股骨粗隆间骨折患者效果显著,能够有效减轻疼痛,促进髋关节功能的恢复,增强骨代谢水平。

探讨切开复位内固定术对三踝骨折治疗的临床效果及踝关节功能的影响

目的探讨切开复位内固定术对三踝骨折治疗的临床效果及踝关节功能的影响。方法选取2021年1月—2023年12月山东省青岛市城阳区第二人民医院收治的70例三踝骨折患者为研究对象,以随机数表法分为两组,每组35例。传统组采用手法复位石膏外固定治疗,观察组采用切开复位内固定术治疗。对比两组骨代谢水平、踝关节功能、手术相关指标及治疗有效率。结果治疗后,观察组骨代谢相关指标、手术相关指标及踝关节功能均优于传统组,差异有统计学意义(P均<0.05)。观察组治疗有效率为97.14%,高于传统组的74.28%,差异有统计学意义(χ^(2)=7.467,P<0.05)。结论切开复位内固定术治疗三踝骨折的效果显著,可有效提高患者的骨代谢水平,改善手术相关指标和踝关节功能,提高治疗效果。

全程化疼痛管理在晚期肺癌骨转移疼痛患者中的应用效果

目的探讨全程化疼痛管理在晚期肺癌骨转移疼痛患者中的应用效果。方法选取126例肺癌骨转移疼痛患者,将2020年1月至2021年6月接受常规疼痛管理的68例患者作为对照组,将2021年7月至2022年12月接受全程化疼痛管理的58例患者作为观察组。比较两组患者的数字分级评分法(NRS)评分、爆发性疼痛发生情况、癌痛状况[美国疼痛学会病人结局问卷修订量表(APS-POQ-Medified)]、心理状态[抑郁自评量表(SDS)、焦虑自评量表(SAS)]、生活质量[欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30)]及护理满意度。结果干预后,两组患者NRS评分均低于本组干预前,观察组患者NRS评分低于对照组,对照组患者爆发性疼痛发生率为42.65%,高于观察组患者的13.79%,差异均有统计学意义(P﹤0.05)。干预后,两组患者疼痛控制满意度评分均高于本组干预前,疼痛程度、疼痛影响、疼痛信念评分均低于本组干预前,观察组患者疼痛控制满意度评分高于对照组,疼痛程度、疼痛影响、疼痛信念评分均低于对照组,差异均有统计学意义(P﹤0.05)。干预后,两组患者SDS、SAS评分均低于本组干预前,观察组患者SDS、SAS评分均低于对照组,差异均有统计学意义(P﹤0.05)。干预后,两组患者EORTC QLQ-C30量表各维度评分均高于本组干预前,观察组患者EORTC QLQ-C30量表各维度评分均高于对照组,差异均有统计学意义(P﹤0.05)。观察组患者的护理满意度为98.28%,明显高于对照组患者的80.88%,差异有统计学意义(P﹤0.01)。结论全程化疼痛管理应用于晚期肺癌骨转移疼痛患者中,能够明显改善疼痛程度和负性情绪,提高生活质量和护理满意度。

PGE2、COX-2表达与牙槽骨成骨活性、内氧水平的关系

目的:探讨前列腺素E2(prostaglandin E2,PGE2)、环氧合酶2(cyclooxygenase-2,COX-2)表达与牙槽骨成骨活性、内氧水平的关系。方法:选择2021年3月—2023年3月收治的56例慢性牙周炎且牙槽骨感染的患者为试验(牙周炎)组,同一时段53例健康牙槽骨为对照组。采用组织块培养法进行成骨细胞培养,采用改良Kaplow碱性磷酸酶(alkaline phosphatase,ALP)染色鉴定细胞,利用ELISA试剂盒检测COX-2、PGE2、破骨细胞抑制因子(osteoclastogenesis inhibitory factor,OPG)和核因子κB受体活化因子配体(receptor activator of nuclear factor-κb ligand,RANKL)等的表达,比较2组患者PGE2、COX-2、OPG、内氧水平、ALP和RANKL的表达水平,并分析其相关性。采用SPSS 27.0软件包对数据进行统计学分析。结果:牙周炎组的PGE2、COX-2、RANKL显著高于对照组,而OPG、内氧水平、ALP显著低于对照组(P<0.05)。PGE2、COX2呈高度正相关,与OPG、内氧水平和ALP呈高度负相关,但与RANKL呈高度正相关(P<0.05)。结论:PGE2、COX-2表达与ALP、内氧水平呈高度负相关,可考虑通过增加内氧水平,加大氧分压,并通过药物调节ALP水平,改变牙周炎或其他类似疾病的炎症状况。

不同跑步速度对大鼠股骨皮质骨组织失效应变的影响

目的 预测皮质骨组织失效应变,探究不同跑步速度对大鼠股骨皮质骨力学性能的影响。方法 设定皮质骨材料失效应变阈值,针对大鼠股骨有限元模型进行三点弯曲下的断裂模拟,将每次预测所得载荷-位移曲线与同一样本实验曲线进行比较拟合,以此反演预测组织失效应变。结果 皮质骨组织失效应变在不同跑步速度下存在显著差异,说明不同跑步速度对皮质骨结构微观力学性能产生一定影响。其中组织失效应变在以12 m/min速度跑步中最大,在以20 m/min速度跑步中最小。结论 通过观测组织失效应变变化趋势,并结合皮质骨结构的宏观断裂载荷与纳观组织弹性模量变化趋势,探讨不同跑步速度对皮质骨结构力学性能的综合影响,并找到有利于提升皮质骨力学性能的跑步速度,为通过跑步锻炼提高骨强度提供理论依据。

Tissue level microstructure and mechanical properties of the femoral head in the proximal femur of fracture patients

This study aims to investigate the regional variations of trabecular morphological parameters and mechanical parameters of the femoral head,as well as to determine the relationship between trabecular morphological and mechanical parameters.Seven femoral heads from patients with fractured proximal femur were scanned using a micro-CT system.Each femoral head was divided into 12 sub-regions according to the trabecular orientation.One 125 mm^3 trabecular cubic model was reconstructed from each sub-region.A total of 81 trabecular models were reconstructed,except three destroyed sub-regions from two femoral heads during the surgery.Trabecular morphological parameters,i.e.trabecular separation（Tb.Sp）,trabecular thickness（Tb.Th）,specific bone surface（BS/B V）,bone volume fraction（BV/TV）,structural model index（SMI）,and degree of anisotropy（DA） were measured.Micro-finite element analyses were performed for each cube to obtain the apparent Young＇s modulus and tissue level von Mises stress distribution under 1%compressive strain along three orthogonal directions,respectively.Results revealed significant regional variations in the morphological parameters（P〈0.05）.Young＇s moduli along the trabecular orientation were significantly higher than those along the other two directions.In general,trabecular mechanical properties in the medial region were lower than those in the lateral region.Trabecular mechanical parameters along the trabecular orientation were significantly correlated with BS/BV,BV/TV,Tb.Th,and DA.In this study,regional variations of microstructural features and mechanical properties in the femoral head of patients with proximal femur fracture were thoroughly investigated at the tissue level.The results of this study will help to elucidate the mechanism of femoral head fracture for reducing fracture risk and developing treatment strategies for the elderly.

滋阴泻火方治疗青春期男性乳房发育的临床效果

目的探讨滋阴泻火方治疗青春期男性乳房发育的临床效果。方法选取2019年4月至2021年5月江西省儿童医院收治的61例青春期乳房发育男性患者作为研究对象,按照随机数字表法分为对照组(31例)与中药组(30例)。对照组采用常规健康指导干预,中药组在对照组基础上采用滋阴泻火方治疗。比较两组患者治疗3个月的临床指标、临床疗效和中医证候积分,性激素指标[促黄体生成素(LH)、促卵泡激素(FSH)和雌二醇(E2)],X线检查骨龄[△骨龄(BA)/△实际年龄(CA)]。结果中药组患者治疗后乳腺肿块结节直径小于对照组,视觉模拟评分法(VAS)评分低于对照组,差异有统计学意义(P<0.05);中药组患者治疗后中医证候积分均低于本组治疗前,且各证候积分均低于对照组,差异有统计学意义(P<0.05);中药组的临床疗效率为96.67%,高于对照组的58.06%,差异有统计学意义(P<0.05);两组患者治疗前后的LH和FSH比较,差异无统计学意义(P>0.05),中药组治疗后的E2和△BA/△CA均低于对照组,差异有统计学意义(P<0.05)。结论滋阴泻火方治疗青春期男性乳房发育的疗效明显,可改善患儿性激素水平并缓解乳房进一步发育,且安全性高。

Relatively High Bone Mineral Density in Chinese Adolescent Dancers Despite Lower Energy Intake and Menstrual Disorder

Objective The effect of dietary restriction, intense exercise and menstrual dysfunction on bone mineral density remains controversial. The aim of this study was to assess the skeletal health status and relationship between bone mineral density and nutrient intake, menstrual status, estrogen level and other factos in Chinese adolescent dancers. Methods Sixty dancers and 77 healthy controls underwent measurements of bone density, body composition, and estrogen level. Nutrient intake, menstrual status and physical activity were assessed with questionnaires. The correlation between these factors were analyzed. Results The dancers under study had a significantly lean body mass index （18.3±1.4 kg/m^2 vs. 21.7±3.1 kg/m^2）, lower percentage of body fat （0.25±0.05 vs. 0.34±0.04） and later age at menarche （14.0±0.9 y vs. 13.0±1.3 y）, and the estrogen level, daily calorie and fat intake in them were also lower than in the controls. All the dancers undertook intensive physical activity every day and up to 69% of them suffered from irregular menarche. Yet they had relatively high BMD and BMC of the total body and legs than the controls after adjusting for BM1 and age. Site-specific BMD was positively correlated to BMI, body composition and training hours per week and negatively correlated to the age at menarche and menstrual frequency. Conclusions The relatively high BMD and BMC of the dancers at the total body and legs were probably caused by high levels of weight-bearing physical activity. To ameliorate disordered eating, especially low energy intake might be helpful to prevent the Triad and to improve the bone health in adolescent dancers.

补肾健骨汤对绝经后骨质疏松症患者骨代谢指标及性激素水平影响研究

目的:探讨补肾健骨汤对绝经后骨质疏松症(PMOP)患者骨代谢指标及性激素水平的影响。方法:选取100例PMOP患者为研究对象,随机分为观察组和对照组,两组均为50例。对照组给予常规治疗,观察组在对照组基础上加用自拟补肾健骨汤治疗。比较两组患者治疗前后骨代谢指标[骨钙素(OC)、碱性磷酸酶(BAP)、骨保护素(OPG)]、不同部位骨密度(腰椎、全髋、股骨颈)、性激素[雌二醇(E2)、促卵泡激素(FSH)、黄体生成素(LH)]水平、细胞因子[白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、胰岛素样生长因子(IGF-1)]以及数字疼痛评分(NRS)、Oswestry功能障碍指数(ODI)。结果:治疗后两组OC、BAP、OPG水平均高于治疗前(P<0.05),且观察组OC、BAP、OPG水平高于对照组(P<0.05);治疗后两组腰椎、全髋、股骨颈部位骨密度均高于治疗前(P<0.05),且观察组腰椎、全髋、股骨颈部位骨密度高于对照组(P<0.05);治疗后两组E2水平高于治疗前,LH、FSH水平低于治疗前(P<0.05),且观察组E2水平高于对照组,LH、FSH水平低于对照组(P<0.05);治疗后两组IL-6、TNF-α低于治疗前,IGF-1高于治疗前(P<0.05),且观察组IL-6、TNT-α低于对照组,IGF-1高于对照组(P<0.05);治疗后两组NRS评分、ODI均低于治疗前(P<0.05),且观察组NRS评分以及ODI低于对照组(P<0.05)。结论:补肾健骨汤可有效调节骨代谢指标、性激素水平与细胞因子水平,增强骨密度,改善骨质疏松症状。

利拉鲁肽对2型糖尿病患者骨代谢、骨密度的影响分析

目的 研究对于2型糖尿病(type 2 diabetes mellitus,T2DM)患者应用利拉鲁肽治疗对其骨密度、骨代谢的影响。方法 选取2021年1—12月年福州市第一医院收治的78例T2DM患者作为研究对象,依据不同用药方案分为两组,各39例。对照组应用二甲双胍治疗,观察组应用利拉鲁肽治疗,对比两组治疗效果。结果观察组ALP(98.64±5.39)U/L,Ca(2.41±0.04)mmol/L,显著优于对照组的(104.93±5.58)U/L,(2.15±0.04)mmol/L。差异有统计学意义(P<0.05)。观察组FPG、2 hPG、HbAlc和对照组对比,差异无统计学意义(P>0.05)。观察组腰L1~L4骨密度、股骨骨密度和对照组相比,差异无统计学意义(P>0.05)。观察组总不良反应发生率5.13%,与对照组5.13%对比,差异无统计学意义(P>0.05)。结论 对于T2DM患者给予利拉鲁肽治疗更有利于改善患者骨代谢水平,同时具有良好的降糖效果,且不良反应少,用药安全性高,对于远期预后有积极影响。