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The effectiveness of the mononuclear fraction of autologous bone marrow in the treatment of experimental chronic limb ischemia
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作者 Anzhelika Yu.Orlova Elena B.Artyushkova +2 位作者 CUI Wei Boris S.Sukovatyh CUI Jing-zhen 《哈尔滨医科大学学报》 CAS 2017年第6期580-584,共5页
Objective To study of the effectiveness of using autologous mononuclear fraction of bone marrow for the treatment of chronic limb ischemia. Methods Results of autologous mononuclear fraction of bone marrow in 90 labor... Objective To study of the effectiveness of using autologous mononuclear fraction of bone marrow for the treatment of chronic limb ischemia. Methods Results of autologous mononuclear fraction of bone marrow in 90 laboratory Wistar rats on a background of creating chronic limb ischemia was presented. Sampling was carried out from the bone marrow of the femur of the animal. The mononuclear fraction of bone marrow autologous 4 × 106 cells in a volume of 200 microliter were injected into the ischemic limb of the two points,in each of which 100 microliter:(1)Paravessel directly below the inguinal ligament at the level of the sacroiliac joint in the area of the anatomical location of collaterals in the projection of the internal iliac artery and its branches;(2)Intramuscularly in gastrocnemius muscle anterior-lateral surface of the middle third of the leg. Results In the experimental group of rats treated with autologous mononuclear fraction of bone marrow,the level of microcirculation compared with the intact group of animals on day 21 was higher than 6. 1% by day 28% ~ 31. 2%; compared with the control group-day 10 increased by 111% at day 21,85. 7% on day 28% ~ 97%. Conclusion Proposed method of treating pathogenically justified and can be recommended for use in clinical practice in the treatment of patients with chronic obliterating diseases of lower limb arteries. 展开更多
关键词 chronic limb ischemia transplantation of autologous mononuclear fraction of bone marrow cell therapy angiogenesis chronic obliterating diseases of lower limb arteries
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TREATMENT OF APLASTIC ANEMIA: ALLOGENEIC BONE MARROW TRANSPLANTATION VERSUS IMMUNOMODULATION THERAPY WITH ANTILYMPHOCYTE GLOBULIN
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作者 CCKim JYJin DjKim 《Chinese Medical Journal》 SCIE CAS CSCD 1994年第10期17-18,共2页
There are two arms in the management of aplastic anemia,one allogeneic bone marrow transplantation(BMT) and the other immunomodulation therapy with antilymphocyte globulin(ALG).
关键词 OVER TREATMENT OF APLASTIC ANEMIA CR ALLOGENEIC bone marrow transplantation VERSUS IMMUNOMODULATION therapy WITH ANTILYMPHOCYTE GLOBULIN
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