From the first application of the Boolean model to the cell cycle regulation network of budding yeast,new regulative pathways have been discovered,par-ticularly in the G1/S transition circuit.This discovery called for...From the first application of the Boolean model to the cell cycle regulation network of budding yeast,new regulative pathways have been discovered,par-ticularly in the G1/S transition circuit.This discovery called for finer modeling to study the essential biology,and the resulting outcomes are first introduced in the ar-ticle.A traditional Boolean network model set up for the new G1/S transition circuit shows that it cannot correctly simulate real biology unless the model parameters are fine tuned.The deficiency is caused by an overly coarse-grained description of the inhibitor binding process,which shall be overcome by a two-vector model proposed whose robustness is surveyed using random perturba-tions.Simulations show that the proposed two-vector model is much more robust in describing inhibitor binding processes within the Boolean framework.展开更多
基金supported by the Chinese Ministry of Science and Technology(2003CB715900)the National Natural Science Foundation of China(Grant No.20640120446).
文摘From the first application of the Boolean model to the cell cycle regulation network of budding yeast,new regulative pathways have been discovered,par-ticularly in the G1/S transition circuit.This discovery called for finer modeling to study the essential biology,and the resulting outcomes are first introduced in the ar-ticle.A traditional Boolean network model set up for the new G1/S transition circuit shows that it cannot correctly simulate real biology unless the model parameters are fine tuned.The deficiency is caused by an overly coarse-grained description of the inhibitor binding process,which shall be overcome by a two-vector model proposed whose robustness is surveyed using random perturba-tions.Simulations show that the proposed two-vector model is much more robust in describing inhibitor binding processes within the Boolean framework.
