(+) Camphor derived N crotonoylsultam 2, readily available from chiral auxiliary bornane 10,2 sultam and crotonoyl chloride, reacted with selected Grignard reagent 3(R= n butyl, n pentyl , n ...(+) Camphor derived N crotonoylsultam 2, readily available from chiral auxiliary bornane 10,2 sultam and crotonoyl chloride, reacted with selected Grignard reagent 3(R= n butyl, n pentyl , n hexyl, n heptyl) under the control of CuI or not being at low temperatures, giving diasteroisomers 4, 5 respectively. After nondestructive cleavage both enantiomers of the acid and alcohol were obtained in high e.e .%. The d.e .% of 4,5 was determined by HPLC, and the assignment of these values was discussed by analyzing 1H NMR(500 MHz).展开更多
文摘(+) Camphor derived N crotonoylsultam 2, readily available from chiral auxiliary bornane 10,2 sultam and crotonoyl chloride, reacted with selected Grignard reagent 3(R= n butyl, n pentyl , n hexyl, n heptyl) under the control of CuI or not being at low temperatures, giving diasteroisomers 4, 5 respectively. After nondestructive cleavage both enantiomers of the acid and alcohol were obtained in high e.e .%. The d.e .% of 4,5 was determined by HPLC, and the assignment of these values was discussed by analyzing 1H NMR(500 MHz).
