Three non-isoprenoid botryane sesquiterpenoids,named boledulins A-C(1-3),have been isolated from the cultures of basidiomycete Boletus edulis Bull.The structures were established by means of spectroscopic methods.Bole...Three non-isoprenoid botryane sesquiterpenoids,named boledulins A-C(1-3),have been isolated from the cultures of basidiomycete Boletus edulis Bull.The structures were established by means of spectroscopic methods.Boledulin A(1)exhibited moderate inhibitory activity against five human cancer cell lines.展开更多
Arthrinins E-G(1-3),three new sesquiterpenoids possessing non-isoprenoid botryane skeleton,were isolated from the fermentation of an endophytic fungus named Arthrinium sp.HS66 which colonized in the stems of Isodon xe...Arthrinins E-G(1-3),three new sesquiterpenoids possessing non-isoprenoid botryane skeleton,were isolated from the fermentation of an endophytic fungus named Arthrinium sp.HS66 which colonized in the stems of Isodon xerophilus.Their structures were determined by extensive spectroscopic methods.Furthermore,the structure of 1 was unambiguously confirmed by X-ray diffraction,while those of 2 and 3 were verified through quantum chemical calculation of NMR data and ECD spectra.展开更多
In this paper,we report the concise total syntheses of three botryane sesquiterpenoids:dehydrobotrydienal,dehydrobotrydienol,and 10-oxodehydrodihydrobotrydial.The key transformations include tandem Co-tetramethylthiou...In this paper,we report the concise total syntheses of three botryane sesquiterpenoids:dehydrobotrydienal,dehydrobotrydienol,and 10-oxodehydrodihydrobotrydial.The key transformations include tandem Co-tetramethylthiourea-catalyzed Pauson–Khand and 6π-electrocyclization reactions to forge the tricyclic core structure of the botryanes,and further oxidative aromatization and oxidation to complete the total syntheses.展开更多
基金This work was supported in part by the National Natural Sci This project was supported by the National Basic Research Program of China(973 Program,2009CB522300)the National Natural Sciences Foundation of China(30830113)MOST(2009ZX09501-029).
文摘Three non-isoprenoid botryane sesquiterpenoids,named boledulins A-C(1-3),have been isolated from the cultures of basidiomycete Boletus edulis Bull.The structures were established by means of spectroscopic methods.Boledulin A(1)exhibited moderate inhibitory activity against five human cancer cell lines.
基金supported financially by the National Natural Science Foundation of China(No.81874298)the CAS“Light of West China”program(Pema-Tenzin Puno)the Yunnan Science Fund for Distinguished Young Scholars(2019FJ002).
文摘Arthrinins E-G(1-3),three new sesquiterpenoids possessing non-isoprenoid botryane skeleton,were isolated from the fermentation of an endophytic fungus named Arthrinium sp.HS66 which colonized in the stems of Isodon xerophilus.Their structures were determined by extensive spectroscopic methods.Furthermore,the structure of 1 was unambiguously confirmed by X-ray diffraction,while those of 2 and 3 were verified through quantum chemical calculation of NMR data and ECD spectra.
基金supported by the National Natural Science Foundation of China (Nos. 21772008, 21632002 and U1606403)Natural Science Foundation of Guangdong Province (No. 2016A030306011)+1 种基金Shenzhen Basic Research Program (Nos. JCYJ20170818090044432 and JCYJ20160226105337556)Qingdao National Laboratory for Marine Science and Technology (No. LMDBKF201703)
文摘In this paper,we report the concise total syntheses of three botryane sesquiterpenoids:dehydrobotrydienal,dehydrobotrydienol,and 10-oxodehydrodihydrobotrydial.The key transformations include tandem Co-tetramethylthiourea-catalyzed Pauson–Khand and 6π-electrocyclization reactions to forge the tricyclic core structure of the botryanes,and further oxidative aromatization and oxidation to complete the total syntheses.
