Botulinum toxin type-A (BTX-A), a subtype from known seven types of botulinum neurotoxin (serotype A-G), is produced by a gram-positive bacterium, <i>Clostridium botulinum</i>. The toxin is now widely and ...Botulinum toxin type-A (BTX-A), a subtype from known seven types of botulinum neurotoxin (serotype A-G), is produced by a gram-positive bacterium, <i>Clostridium botulinum</i>. The toxin is now widely and efficiently used in treating a plethora of diverse symptoms and conditions. Recent evidence in the literature also shows that BTX-A exhibits a wide range of effects on non-neuronal cells. Its potential has markedly expanded to clinical applications other than the treatment of neurological and muscular conditions that are characterized by neuronal hyperactivity. A number of studies have shown BTX-A to improve the quality of scar outcome and prevent the formation of keloids and HTS. Although the mechanism of action of BTX-A on wound healing is still not clearly understood, lately there has been extensive research to grasp the underlying mechanisms of this multifunctional toxin. BTX-A seems to affect wound healing by a number of mechanisms that include action on tensile forces, inhibition of fibroblasts differentiation, downregulation of TGF-<i><span style="white-space:nowrap;">β</span></i>1 and collagen expression. This review will explore the responses of Botulinum toxin type-A on wound healing and preventing pathological scars like HTS and keloids, and comprehend the overall effect BTX-A has on wound healing.展开更多
目的探索A型肉毒毒素（botulinurn toxin type A，BTXA）对早期增生性瘢痕（hypertrophic scar，HTS）的临床预防及治疗效果。方法早期HTS周围及组织内注射BTXA，观察瘢痕注射药物后形态学变化、组织学变化及临床症状表现；手术切口缝...目的探索A型肉毒毒素（botulinurn toxin type A，BTXA）对早期增生性瘢痕（hypertrophic scar，HTS）的临床预防及治疗效果。方法早期HTS周围及组织内注射BTXA，观察瘢痕注射药物后形态学变化、组织学变化及临床症状表现；手术切口缝合后即刻向周围肌肉浅层注射BTXA，观察远期瘢痕愈合情况。结果局部注射BTXA可以明显减轻早期FITS疼痛和瘙痒症状，促使瘢痕组织萎缩、软化；组织切片HE染色显示HTS组织内结构有所变化。同时，手术切口周围肌肉浅层注射BTXA可以降低术后切口HTS的发生、发展概率。结论BTXA对早期HTS具有一定程度的治疗和预防作用，其疗效可能是通过降低瘢痕两侧张力及活动，干扰瘢痕内小神经传导，以及影响成纤维细胞增殖分化，促进凋亡进而减少胶原合成而起作用。展开更多
文摘Botulinum toxin type-A (BTX-A), a subtype from known seven types of botulinum neurotoxin (serotype A-G), is produced by a gram-positive bacterium, <i>Clostridium botulinum</i>. The toxin is now widely and efficiently used in treating a plethora of diverse symptoms and conditions. Recent evidence in the literature also shows that BTX-A exhibits a wide range of effects on non-neuronal cells. Its potential has markedly expanded to clinical applications other than the treatment of neurological and muscular conditions that are characterized by neuronal hyperactivity. A number of studies have shown BTX-A to improve the quality of scar outcome and prevent the formation of keloids and HTS. Although the mechanism of action of BTX-A on wound healing is still not clearly understood, lately there has been extensive research to grasp the underlying mechanisms of this multifunctional toxin. BTX-A seems to affect wound healing by a number of mechanisms that include action on tensile forces, inhibition of fibroblasts differentiation, downregulation of TGF-<i><span style="white-space:nowrap;">β</span></i>1 and collagen expression. This review will explore the responses of Botulinum toxin type-A on wound healing and preventing pathological scars like HTS and keloids, and comprehend the overall effect BTX-A has on wound healing.
文摘目的探索A型肉毒毒素（botulinurn toxin type A，BTXA）对早期增生性瘢痕（hypertrophic scar，HTS）的临床预防及治疗效果。方法早期HTS周围及组织内注射BTXA，观察瘢痕注射药物后形态学变化、组织学变化及临床症状表现；手术切口缝合后即刻向周围肌肉浅层注射BTXA，观察远期瘢痕愈合情况。结果局部注射BTXA可以明显减轻早期FITS疼痛和瘙痒症状，促使瘢痕组织萎缩、软化；组织切片HE染色显示HTS组织内结构有所变化。同时，手术切口周围肌肉浅层注射BTXA可以降低术后切口HTS的发生、发展概率。结论BTXA对早期HTS具有一定程度的治疗和预防作用，其疗效可能是通过降低瘢痕两侧张力及活动，干扰瘢痕内小神经传导，以及影响成纤维细胞增殖分化，促进凋亡进而减少胶原合成而起作用。
