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Plackett-Burman和Central Composite Design试验设计法优化石榴皮中熊果酸的SFE-CO_2萃取工艺 被引量:7
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作者 王占一 金美花 +3 位作者 王玉海 张立华 毕海丹 李卓瓦 《中药材》 CAS CSCD 北大核心 2015年第3期610-614,共5页
目的:探讨应用SFE-CO2萃取石榴皮中熊果酸的最佳工艺。方法:以熊果酸得率为考察指标,通过Plackett-Burman(PB)试验设计筛选影响熊果酸得率的显著性因素,最陡爬坡试验逼近熊果酸得率最大区域,Central Composite Design(CCD)试验设计对显... 目的:探讨应用SFE-CO2萃取石榴皮中熊果酸的最佳工艺。方法:以熊果酸得率为考察指标,通过Plackett-Burman(PB)试验设计筛选影响熊果酸得率的显著性因素,最陡爬坡试验逼近熊果酸得率最大区域,Central Composite Design(CCD)试验设计对显著性因素进行响应面优化得到影响熊果酸得率的二阶数学模型,进而得出最佳工艺条件。结果:SFE-CO2萃取石榴皮中熊果酸的最佳工艺条件为:萃取温度46.29℃,萃取时间91.6 min,萃取压力34.49 MPa,在此条件下,验证试验测得熊果酸得率为12.508 mg/g,与模型预测值12.645 mg/g接近。结论:将PB试验和CCD试验设计联合应用于优化石榴皮中熊果酸SFE-CO2萃取工艺,筛选结果具有统计学意义,工艺操作具有可行性。 展开更多
关键词 石榴皮 SFE-CO2萃取 熊果酸 PLACKETT-BURMAN central composite design
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Analysis of Heat Transfer Performance of Oscillating Heat Pipes Based on a Central Composite Design 被引量:12
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作者 马永锡 张红 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2006年第2期223-228,共6页
Oscillating heat pipes (OHPs) are very promising cooling devices. Their heat transfer performance is af- fected by many factors, and the form of the relationship between the performance and the factors is complex and ... Oscillating heat pipes (OHPs) are very promising cooling devices. Their heat transfer performance is af- fected by many factors, and the form of the relationship between the performance and the factors is complex and non-linear. In this paper, the effects of charging ratio, inclination angle, and heat input and their interaction effects on heat transfer performance of a looped copper-water OHP are analyzed. First, suppose that the relationship between the response and the variables approximates a second-order model. And use the central composite design to arrange the ex- periment. Then, the method of least squares is used to estimate the parameters in the second-order model. Finally, multi- variate variance analysis is used to analyze the model. The results show that the assumption is right, that is to say, the re- lationship is well modeled by a second-order function. Among the three main effect variables, the effect of inclination angle is the most significant, but their interaction effects are not significant. In the range of the considered factors, both the optimum charging ratio and the optimum inclination angle increase as the heating water flow rate increases. 展开更多
关键词 oscillating heat pipe heat transfer central composite experimental design variance analysis
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Application of response surface methodology and central composite rotatable design for modeling the influence of some operating variables of the lab scale thickener performance 被引量:2
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作者 Aghajani Shahrivar Alireza Soltani Goharrizi Ataallah +3 位作者 Ebrahimzadeh Gheshlaghi Majid Sarafi Amir Razmirad Mohammad Abdollahi Hadi 《International Journal of Mining Science and Technology》 SCIE EI 2013年第5期717-724,共8页
This study discussed the application of response surface methodology(RSM)and central composite rotatable design(CCRD)for modeling and optimization of the influence of some operating variables on the performance of a l... This study discussed the application of response surface methodology(RSM)and central composite rotatable design(CCRD)for modeling and optimization of the influence of some operating variables on the performance of a lab scale thickener for dewatering of tailing in the flotation circuit.Four thickener operating variables,namely feed flowrate,solid percent,flocculant dosage and feedwell height were changed during the tests based on CCRD.The ranges of values of the thickener variables used in the design were a feed flowrate of 9–21 L/min,solid percent of 8%–20%,flocculant dosage of 1.25–4.25 g/t and feedwell height of 16–26 cm.A total of 30 thickening tests were conducted using lab scale thickener on flotation tailing obtained from the Sarcheshmeh copper mine,Iran.The underflow solid percent and bed height were expressed as functions of four operating parameters of thickener.Predicted values were found to be in good agreement with experimental values(R2values of 0.992 and 0.997 for underflow solid percent and bed height,respectively).This study has shown that the RSM and CCRD could effciently be applied for the modeling of thickener for dewatering of flotation tailing. 展开更多
关键词 Response surface methodology central composite rotatable design MODELING THICKENER
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Modeling and Optimization of Catalytic Dehydration of Ethanol to Ethylene Using Central Composite Design 被引量:1
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作者 孔海宁 齐二石 +2 位作者 李钢 何曙光 张宪 《Transactions of Tianjin University》 EI CAS 2009年第5期366-370,共5页
The central composite design in the modeling and optimization of catalytic dehydration of ethanol to ethylene was performed to improve the ethylene yield.A total of 20 experiments at random were conducted to investiga... The central composite design in the modeling and optimization of catalytic dehydration of ethanol to ethylene was performed to improve the ethylene yield.A total of 20 experiments at random were conducted to investigate the effect of reaction temperature,Si/Al ratios of H-ZSM-5 catalyst and liquid hourly space velocity(LHSV) on the ethylene yield.The results show that the relationship between ethylene yield and the three significant independent variables can be approximated by a nonlinear polynomial model,with R-squared of 99.9%and adjusted R-squared of 99.8%.The maximal response for ethylene yield is 93.4%under the optimal condition of 328 ℃,Si/Al ratio 85,and LHSV 3.8 h-1. 展开更多
关键词 central composite design catalytic dehydration of ethanol ethylene yield MODELING OPTIMIZATION
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Calibration of Discrete Element Heat Transfer Parameters by Central Composite Design 被引量:1
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作者 Zongquan DENG Jinsheng CUI +1 位作者 Xuyan HOU Shengyuan JIANG 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2017年第2期419-427,共9页
The efficiency and precision of parameter calibration in discrete element method (DEM) are not satisfactory, and parameter calibration for granular heat transfer is rarely involved. Accordingly, parameter calibratio... The efficiency and precision of parameter calibration in discrete element method (DEM) are not satisfactory, and parameter calibration for granular heat transfer is rarely involved. Accordingly, parameter calibration for granular heat transfer with the DEM is studied. The heat transfer in granular assemblies is simulated with DEM, and the effective thermal conductivity (ETC) of these granular assemblies is measured with the transient method in simulations. The measurement testbed is designed to test the ETC of the granular assemblies under normal pressure and a vacuum based on the steady method. Central composite design (CCD) is used to simulate the impact of the DEM parameters on the ETC of granular assemblies, and the heat transfer parameters are calibrated and compared with experimental data. The results show that, within the scope of the considered parameters, the ETC of the granular assemblies increases with an increasing particle thermal conductivity and decreases with an increasing particle shear modulus and particle diameter. The particle thermal conductivity has the greatest impact on the ETC of granular assemblies followed by the particle shear modulus and then the particle diameter. The calibration results show good agreement with the experimental results. The error is less than 4%, which is within a reasonable range for the scope of the CCD parameters. The proposed research provides high efficiency and high accuracy parameter calibration for granular heat transfer in DEM. 展开更多
关键词 Granular assembly · Parameter calibration · Effective thermal conductivity (ETC) · Discrete element method (DEM) · central composite design (CCD) · Vacuum
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Extraction Process Optimization of Total Flavonoids from Mallotus apelta Stems by Central Composite Design/Response Surface Method 被引量:2
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作者 Xiao HUANG Dengfeng ZOU +3 位作者 Ruifen FAN Shuoying GUO Hua ZHU Aize XIE 《Medicinal Plant》 2017年第5期54-57,共4页
[Objectives] To optimize the extraction process of total flavonoids in stems of Mallotus apelta. [Methods]On the basis of singlefactor test,with volume fraction of ethanol,extraction time and ratio of solvent as indep... [Objectives] To optimize the extraction process of total flavonoids in stems of Mallotus apelta. [Methods]On the basis of singlefactor test,with volume fraction of ethanol,extraction time and ratio of solvent as independent variables,the content of total flavonoids as dependent variables,the completely secondary response surface regression fitting was conducted on the independent and dependent variables,and the Response Surface Method was used to optimize the optimum extraction process of total flavonoids in Mallotus apelta stems and predict the optimum process. [Results] The optimum extraction process of total flavonoids in Mallotus apelta was determined as follows: ethanol concentration of 71. 5%; extraction time of 154. 6 min; solid-liquid ratio of 1∶19. 2; total flavonoids content of 7. 060 mg/g; fitted binomial squared correlation coefficient R^2= 0. 8751.[Conclusions]Composite Design/Response Surface Method could be used in the extraction process optimization of total flavonoids in Mallotus apelta stems,the mathematical model established had high prediction accuracy,the method was simple and operability was good. 展开更多
关键词 central composite design/Response Surface Method Mallotus apelta TOTAL FLAVONOIDS
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Optimization of Extraction Process of Clerodendrum philippinum Schauer var. simplex Mlodenke Total Flavonoids(CPTF) by Central Composite Design-Response Surface Methodology 被引量:3
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作者 Bo LI Simao HUANG +3 位作者 Xiaohua PANG Boting XI Houkang CAO Kefeng ZHANG 《Medicinal Plant》 CAS 2018年第3期17-20,共4页
[Objectives] The research aimed to optimize extraction process of Clerodendrum philippinum Schauer var. simplex Mlodenke total flavonoids( CPTF),and provide reference for its development and utilization. [Methods] Bas... [Objectives] The research aimed to optimize extraction process of Clerodendrum philippinum Schauer var. simplex Mlodenke total flavonoids( CPTF),and provide reference for its development and utilization. [Methods] Based on single-factor test,ethanol concentration,extraction temperature and extraction time were taken as independent variables,and total flavonoids yield was taken as dependent variable. The test was conducted according to central composite design principle. Multivariate linear regression and binomial equation fitting of the result were conducted,and extraction process of CPTF was optimized by using response surface methodology. [Results]The optimal extraction process of CPTF was as below: ethanol concentration 54. 76%,extraction temperature 83. 92℃,extraction time 102. 64 min,solid-liquid ratio 1:20,extraction for twice. [Conclusions] The extraction process of CPTF by central composite design-response surface methodology was simple and feasible,with reliable prediction result,which was suitable for industrial production. 展开更多
关键词 central composite design-response surface methodology Guoqiangfeng Total flavonoids Extraction process
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Modeling of biodiesel production: Performance comparison of Box–Behnken, face central composite and full factorial design
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作者 Vlada B.Veljkovic Ana V. Velickovic +1 位作者 Jelena M. Avramovic Olivera S. Stamenkovic 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2019年第7期1690-1698,共9页
The performances of the response surface methodology(RSM)in connection with the Box–Behnken,face central composite or full factorial design(BBD,FCCD or FFD,respectively)were compared for the use in modeling of the Na... The performances of the response surface methodology(RSM)in connection with the Box–Behnken,face central composite or full factorial design(BBD,FCCD or FFD,respectively)were compared for the use in modeling of the NaOH-catalyzed sunflower oil ethanolysis.The influence of temperature,catalyst loading,and ethanol-to-oil molar ratio(EOMR)on fatty acid ethyl esters(FAEE)content was evaluated.All three multivariate strategies were efficient in the statistical modeling and optimization of the influential process variables but BBD and FCCD realization involved less number of experiments,generating smaller costs,requiring less work and consuming shorter time than the corresponding FFD.All three designs resulted in the same optimal catalyst loading(1.25%of oil)and EOMR(12:1).The reduced two-factorinteraction(2 FI)models based on the BBD and FCCD defined a range of optimal reaction temperature(25℃–75℃)and 25℃,respectively while the same model based on the 33 FFD appointed 75℃.The predicted FAEE content of about 97%–98.0%was close to the experimentally obtained FAEE content of about 97.0%–97.6%under the optimal reaction conditions.Therefore,the simpler BBD or FCCD might successfully be applied for statistical modeling of biodiesel production processes instead of the more extensive,more laborious and more expensive FFD. 展开更多
关键词 BIODIESEL box-behnken design Model reduction Face central composite design Full factorial design OPTIMIZATION
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Optimization of extraction technology of safflower polysaccharide based on central composite design-response surface methodology
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作者 Rui Wang Ya-Lan Li +1 位作者 Hao-Tian Bai Jing Yang 《Journal of Hainan Medical University》 2022年第5期11-17,共7页
Objective:To explore the best extraction technology of safflower polysaccharide by central composite design response surface methodology and evaluate its quality.Methods:Taking the extraction rate of Carthamus tinctor... Objective:To explore the best extraction technology of safflower polysaccharide by central composite design response surface methodology and evaluate its quality.Methods:Taking the extraction rate of Carthamus tinctorius polysaccharide as the index,taking the ratio of solid to liquid,extraction time,extraction temperature and extraction times as the investigation factors,based on the single factor experiment,the central composite design-response surface methodology was used to optimize the optimum extraction process of Carthamus tinctorius polysaccharide and verify it.Results:The response surface model was established with the extraction rate of Carthamus tinctorius polysaccharide as dependent variable Y,the ratio of solid to liquid,extraction time and extraction temperature as independent variables X,P<0.0001.The optimum extraction process was as follows:the ratio of solid to liquid was 1:16.69,the extraction temperature was 91.39℃,and the extraction working time was 89.78min.Under these conditions,the extraction rate of safflower polysaccharide can reach 7.45%,The experimental results show that RSD is 1.05%,and the model can well predict the experimental results.Conclusion:Central Composite Design-Response Surface Methodology has the advantages of high extraction rate,simple,effective and reasonable process operation,high stability and high precision,which can be fully applied to the resource management and utilization of safflower polysaccharide. 展开更多
关键词 Safflower polysaccharide central composite design Extraction process Extraction percentage
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Central Composite Design Method for the Preparation, Stability and Properties of Water-in-Diesel Nano Emulsions
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作者 Ali Ghufran Khidhir Adel Sharif Hamadi 《Advances in Chemical Engineering and Science》 2018年第3期176-189,共14页
Water in diesel nano-emulsion (WiDNE) due to their nano size, kinetically stable gives its beneficial in commercial and environmental aspects. However, the capability of this fuel strongly depends on the method of pre... Water in diesel nano-emulsion (WiDNE) due to their nano size, kinetically stable gives its beneficial in commercial and environmental aspects. However, the capability of this fuel strongly depends on the method of preparation, stability and their physic-chemical properties. Central composite design (CCD) method was used to optimize variable interactions in order to obtain maximum stability. Methodology RSM method with six independent variables was selected in order to understand the impacts on droplet size. The response surface and 3D plots of the quadratic polynomial model were created for studying the combination effect on response. Dynamic light scattering DLS technique was used for measuring of droplet sizes. The analysis result by ANOVA was with 95% confidence displaying F value model was 52.82. The results displayed model was fulfilled with the assumptions of ANOVA. This study has relied on Design Expert software to locate the optimum droplet size situations. The measured diameter is 26 nm, with 0.0297 errors between actual conditions and measured value. The optimum blend properties of prepared WiDNE fuel were compared with conventional diesel. Improvements in physical properties were observed in presence of water in WiDNE. 展开更多
关键词 WATER in DIESEL Optimization central composite design STABILITY
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Optimization of Extraction Process of Total Flavonoids from Akebia trifoliata (Thunb.) Koidz. by Central Composite Design-Response Surface Methodology 被引量:4
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作者 Houkang CAO Boting XI +2 位作者 Simao HUANG Xiaohua PANG Kefeng ZHANG 《Medicinal Plant》 2017年第2期15-18,共4页
[Objectives]To optimize extraction process of total flavonoids from Akebia trifoliata( Thunb.) Koidz.,so as to provide references for development and use of Akebia trifoliata( Thunb.) Koidz. [Methods]The extraction ra... [Objectives]To optimize extraction process of total flavonoids from Akebia trifoliata( Thunb.) Koidz.,so as to provide references for development and use of Akebia trifoliata( Thunb.) Koidz. [Methods]The extraction rate of total flavonoids of Akebia trifoliata( Thunb.)Koidz. was taken as observation indicator. On the basis of single factor experiment,central composite design( CCD) was used to evaluate the effects of the extraction temperature,extraction time,and ethanol concentration on the extraction process. Multiple linear regression and binomial fitting were used,and response surface methodology( RSM) was used to select the optimum extraction process. [Results] The optimum extraction process conditions for total flavonoids of Akebia trifoliata( Thunb.) Koidz. was extraction temperature: 83. 92 ℃; extraction time:96. 47 min; ethanol concentration: 63. 92%; extraction times: two times; solid to liquid ratio: 1 ∶ 20; extraction rate of total flavonoids:4. 55%. [Conclusions] The central composite design-response surface methodology( CCD-RSM) is simple,convenient,and feasible for extraction of total flavonoids from Akebia trifoliata( Thunb.) Koidz.,and the prediction results are reliable. 展开更多
关键词 central composite design-response surface methodology(CCD-RSM) Akebia trifoliata(Thunb.) Koidz. TOTAL FLAVONOIDS Extraction PROCESS
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Central-Composite Design响应面实验设计用于金盏菊提取工艺的研究
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作者 时宇 成永燕 +3 位作者 刘芷萱 刘睿姿 孙政 迟梦辰 《食品安全导刊》 2022年第12期117-120,共4页
目的:确定金盏菊最佳提取工艺条件。方法:以金盏菊中总黄酮含量及浸膏得率为考察指标,应用中心组合(Central composite design,CCD)响应面实验设计,考察药材与提取溶剂的比例(料液比)、乙醇浓度、提取时间对金盏花提取效率的影响。结果... 目的:确定金盏菊最佳提取工艺条件。方法:以金盏菊中总黄酮含量及浸膏得率为考察指标,应用中心组合(Central composite design,CCD)响应面实验设计,考察药材与提取溶剂的比例(料液比)、乙醇浓度、提取时间对金盏花提取效率的影响。结果:根据二项式拟合方程,确定金盏花最佳提取工艺条件为药材与溶剂的比例为1∶12,乙醇浓度为68%,提取时间为1.8 h,提取两次。结论:中心组合响应面实验设计能够对金盏菊的提取工艺进行优化筛选。 展开更多
关键词 金盏菊 中心组合设计 总黄酮 提取工艺
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Central Composite Design响应面法优化厚裂凤仙花总黄酮提取工艺研究
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作者 文琴琴 徐梅 +3 位作者 严福林 张浪 周雅雪 魏升华 《广东化工》 CAS 2022年第3期72-75,78,共5页
为厚裂凤仙花中总黄酮资源的开发利用,本文采用单因素与星点-效应面法相结合的方式,考察提取溶剂浓度、料液比、提取时间、提取次数对厚裂凤仙花中总黄酮提取率的影响。优选出厚裂凤仙花总黄酮最佳提取方法为:甲醇体积分数80%,料液比为1... 为厚裂凤仙花中总黄酮资源的开发利用,本文采用单因素与星点-效应面法相结合的方式,考察提取溶剂浓度、料液比、提取时间、提取次数对厚裂凤仙花中总黄酮提取率的影响。优选出厚裂凤仙花总黄酮最佳提取方法为:甲醇体积分数80%,料液比为1︰64,提取时间为50 min;提次数为3次;验证实验结果表明,总黄酮平均提取率为5.51 mg/g,与实验模型RSD值为0.79%。建立的模型与实际方案有较高拟合度,可作为苗药厚裂凤仙花总黄酮提取工艺参数。 展开更多
关键词 厚裂凤仙花 总黄酮 central composite Desig响应面法 提取工艺
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Optimization of Process Parameters for in High-Energy Ball Milling of CNTs/Al2024 Composites Through Response Surface Methodology 被引量:3
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作者 Li Guo Xiaolan Cai +5 位作者 Lei Zhou Cui Hu Changjiang Yang Ziyang Wang Wenzhong Zhang Gang Peng 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2016年第1期53-59,共7页
The mathematical models are developed to evaluate the ultimate tensile strength( UTS) and hardness of CNTs / Al2024 composites fabricated by high-energy ball milling. The effects of the preparation variables which are... The mathematical models are developed to evaluate the ultimate tensile strength( UTS) and hardness of CNTs / Al2024 composites fabricated by high-energy ball milling. The effects of the preparation variables which are milling time,rotational speed,mass fraction of CNTs and ball to powder ratio on UST and hardness of CNTs / Al2024 composites are investigated. Based on the central composite design( CCD),a quadratic model is developed to correlate the fabrication variables to the UST and hardness. From the analysis of variance( ANOVA),the most influential factor on each experimental design response is identified. The optimum conditions for preparing CNTs / Al2024 composites are found as follows: 1. 53 h milling time,900 r / min rotational speed,mass fraction of CNTs 2. 87% and Ball to powder ratio 25 ∶ 1. The predicted maximum UST and hardness are 273.30 MPa and 261.36 HV,respectively. And the experimental values are 283.25 MPa and256.8 HV,respectively. It is indicated that the predicted UST and hardness after process optimization are found to agree satisfactory with the experimental values. 展开更多
关键词 high-energy ball milling CNTs/Al2024 central composite design OPTIMIZATION
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Determination of Optimal Temperature,Blend Ratio and Plasticity Properties of Composite Bread Product Using Response Surface Methodology
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作者 S.C.Nwanya B.C.Okonkwo 《Journal of Energy and Power Engineering》 2018年第8期385-394,共10页
Adaption of cassava composite flour to conventional process technology faces various engineering issues.The underlying goal of this study is how to plan a trade-off between cassava-wheat-soy composite materials and th... Adaption of cassava composite flour to conventional process technology faces various engineering issues.The underlying goal of this study is how to plan a trade-off between cassava-wheat-soy composite materials and their operating conditions with a view to enhance the acceptability and improve quality of the composite bread product.Consequently,RSM(response surface methodology)comprising of central composite design to determine the optimal temperature,blend ratio and corresponding response variables of wheat-cassava bread was carried out.By using Design Expert,Version 8,contour plots were developed.The study reveals that wheat-cassava ratio of 80:20 percent at temperature of 220±2°C and time of 15±2 min gives the desired quality.Also,the plastic limit of the loaf responds to changes in cassava concentration,time and temperature.This experiment has shown that lower CMC(cassava mix concentration)(15%)improves bread volume(620 cm3),moisture content(7.1%)and plasticity(14%).The implication is that greater plasticity increases the malleability at which bread can be produced.Thus,the study is useful in interpreting the baking conditions of composite-wheat-cassava-soy(CWCS)breads and its acceptability.Design of the mix formulation on large scale requires huge investment capital.The particular findings could be of interest to food industry and a wider audience,hence constitute baseline for performance analysis by master bakers and policymakers.The outcome of this study helps to set malleability criteria for the dough which ensures acceptable bread quality. 展开更多
关键词 BREAD policy CMC central composite design PLASTICITY RSM
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Box-Behnken中心组合设计优化酶法提取马齿苋多糖的工艺 被引量:6
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作者 陈凌 曹巧巧 张建群 《江苏农业学报》 CSCD 北大核心 2020年第2期500-506,共7页
采用Box-Behnken中心组合试验设计,以果胶酶添加量、酶解温度、料液比为自变量,以多糖得率和羟基自由基(·OH)清除率为因变量,利用响应面法优化果胶酶酶解提取马齿苋多糖的工艺。结果表明,料液比1∶37(g/ml)、果胶酶添加量10.67 g/k... 采用Box-Behnken中心组合试验设计,以果胶酶添加量、酶解温度、料液比为自变量,以多糖得率和羟基自由基(·OH)清除率为因变量,利用响应面法优化果胶酶酶解提取马齿苋多糖的工艺。结果表明,料液比1∶37(g/ml)、果胶酶添加量10.67 g/kg、酶解温度36.4℃、pH值5.0、酶解时间80 min条件下,马齿苋多糖得率预测值与测定值的相对标准偏差为2.29%,模型拟合度较高。体外抗氧化试验结果表明,马齿苋多糖具有较好的抗氧化性。因此,采用响应面法优化酶法提取马齿苋多糖工艺条件是可行的。 展开更多
关键词 box-behnken中心组合设计 马齿苋 多糖 酶解提取
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Box-Behnken效应面法优化丹皮酚纳米结构脂质载体温敏型原位凝胶处方及其体外释放性能考察 被引量:5
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作者 龙凯花 黄昕玥 +2 位作者 王春柳 穆珺 李晔 《中国中医药信息杂志》 CAS CSCD 2018年第6期73-76,共4页
目的采用Box-Behnken效应面法优化丹皮酚纳米结构脂质载体(NLC)温度敏感型原位凝胶的处方,并对其体外释放性能进行考察,为经皮给药制剂的研究提供参考。方法以泊洛沙姆407和泊洛沙姆188质量分数为考察因素,胶凝温度为考察指标,通过二项... 目的采用Box-Behnken效应面法优化丹皮酚纳米结构脂质载体(NLC)温度敏感型原位凝胶的处方,并对其体外释放性能进行考察,为经皮给药制剂的研究提供参考。方法以泊洛沙姆407和泊洛沙姆188质量分数为考察因素,胶凝温度为考察指标,通过二项式模型及多元线性回归模型拟合并建立胶凝温度与2个考察因素之间的数学关系,采用Box-Behnken效应面法,对丹皮酚NLC温敏型原位凝胶的处方进行优化,并考察该制剂的体外释药特性。结果胶凝温度与2个考察因素之间存在可信定量关系,且二项式模型较多元线性模型置信度高。丹皮酚NLC温敏型原位凝胶的最佳处方为22.90%泊洛沙姆407和3.34%泊洛沙姆188,胶凝温度为(33.4±0.1)℃,24 h内丹皮酚NLC原位凝胶的累积释放量为51.19%。结论该方法适用于丹皮酚NLC温敏型原位凝胶的处方优化,建立的数学模型预测性良好,优选的处方可为丹皮酚经皮给药制剂的开发提供参考。 展开更多
关键词 温敏型原位凝胶 丹皮酚 纳米结构脂质载体 星点设计-效应面法 经皮给药
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Effect of Variable Selection on Multidisciplinary Design Optimization:a Flight Vehicle Example 被引量:7
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作者 J.Roshanian Z.Keshavarz 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2007年第1期86-96,共11页
Different multidisciplinary design optimization (MDO) problems are formulated and compared. Two MDO formulations are applied to a sounding rocket in order to optimize the performance of the rocket. In the MDO of the... Different multidisciplinary design optimization (MDO) problems are formulated and compared. Two MDO formulations are applied to a sounding rocket in order to optimize the performance of the rocket. In the MDO of the referred vehicle, three disciplines have been considered, which are trajectory, propulsion and aerodynamics. A special design structure matrix is developed to assist data exchange between disciplines. This design process uses response surface method (RSM) for multidisciplinary optimization of the rocket. The RSM is applied to the design in two categories: the propulsion model and the system level. In the propulsion model, RSM determines an approximate mathematical model of the engine output parameters as a function of design variables. In the system level, RSM fits a surface of objective function versus design variables. In the first MDO problem formulation, two design variables are selected to form propulsion discipline. In the second one, three new design variables from geometry are added and finally, an optimization method is applied to the response surface in the system level in order to find the best result. Application of the first developed multidisciplinary design optimization procedure increased accessible altitude (performance index) of the referred sounding rocket by twenty five percents and the second one twenty nine. 展开更多
关键词 multidisciplinary design optimization sounding rocket central composite design response surface method equation of motion of a rocket
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Box-Behnken设计-响应面法优选复方三七降脂滴丸成型工艺 被引量:2
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作者 李婷 刘婵 +1 位作者 凌佳琦 张水寒 《中国药师》 CAS 2022年第7期1259-1262,1301,共5页
目的:优选复方三七降脂滴丸成型工艺。方法:运用Box-Behnken中心组合设计试验,在单因素试验的基础上,以滴速、滴制温度、滴距为自变量,滴丸的溶散时限、重量差异、外观评分的总评归一化值(OD)为因变量,利用响应曲面法进行分析,选出最佳... 目的:优选复方三七降脂滴丸成型工艺。方法:运用Box-Behnken中心组合设计试验,在单因素试验的基础上,以滴速、滴制温度、滴距为自变量,滴丸的溶散时限、重量差异、外观评分的总评归一化值(OD)为因变量,利用响应曲面法进行分析,选出最佳成型工艺条件并进行验证试验。结果:复方三七降脂滴丸最优成型工艺条件为:PEG4000与PEG6000配比为3∶1,药物与基质配比1∶4,滴速为30~40滴/min,滴制温度80℃,滴距4 cm。结论:本试验采用Box-Behnken设计-响应面法优选的复方三七降脂滴丸成型工艺方法稳定、可行。 展开更多
关键词 复方三七降脂滴丸 box-behnken中心组合设计 响应面法 成型工艺
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用Box-Behnken效应面法优化穿心莲内酯纳米乳原位凝胶处方工艺研究 被引量:1
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作者 龙凯花 张红 +5 位作者 王春柳 刘洋 周洁 安玉叶 胡晓佳 李晔 《世界中医药》 CAS 2023年第12期1653-1656,共4页
目的:采用Box-Behnken效应面法优化穿心莲内酯纳米乳原位凝胶的处方,为中药经皮给药制剂的研究与开发提供参考。方法:以泊洛沙姆188(P188)和泊洛沙姆407(P407)为凝胶基质,采用凝胶基质的质量分数为考察因素,凝胶温度为考察指标,通过二... 目的:采用Box-Behnken效应面法优化穿心莲内酯纳米乳原位凝胶的处方,为中药经皮给药制剂的研究与开发提供参考。方法:以泊洛沙姆188(P188)和泊洛沙姆407(P407)为凝胶基质,采用凝胶基质的质量分数为考察因素,凝胶温度为考察指标,通过二项式拟合分析得到方程,并建立胶凝温度与2个考察因素之间的数学关系,采用星点设计-效应面法优化穿心莲内酯纳米乳原位凝胶的处方,并对优化处方进行验证。结果:凝胶温度与考察因素存在可信定量关系,且二项式拟合方程置信度高。穿心莲内酯纳米乳原位凝胶的最佳处方为20.00%泊洛沙姆407和5.00%泊洛沙姆188;凝胶温度为(33.8±0.2)℃,处方制备重复性高。结论:该方法适用于穿心莲内酯纳米乳原位凝胶的处方优化,建立的模型预测性良好,优化的制备方法稳定,胶凝温度适宜,可为穿心莲内酯经皮给药制剂的开发提供参考。 展开更多
关键词 穿心莲内酯 纳米乳 星点设计-效应面法 原位凝胶 经皮给药 泊洛沙姆188 泊洛沙姆407
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