The development of brain functional connectivity networks revealed by resting-state functional magnetic resonance imaging

Previous studies on brain functional connectivity networks in children have mainly focused on changes in function in specific brain regions, as opposed to whole brain connectivity in healthy children. By analyzing the independent components of activation and network connectivity between brain regions, we examined brain activity status and development trends in children aged 3 and 5 years. These data could provide a reference for brain function rehabilitation in children with illness or abnormal function. We acquired functional magnetic resonance images from 15 3-year-old children and 15 5-year-old children under natural sleep cond让ions. The participants were recruited from five kindergartens in the Nanshan District of Shenzhen City, China. The parents of the participants signed an informed consent form with the premise that they had been fully informed regarding the experimental protocol. We used masked independent component analysis and BrainNet Viewer software to explore the independent components of the brain and correlation connections between brain regions. We identified seven independent components in the two groups of children, including the executive control network, the dorsal attention network, the default mode network, the left frontoparietal network, the right frontoparietal network, the salience network, and the motor network. In the default mode network, the posterior cingulate cortex, medial frontal gyrus, and inferior parietal lobule were activated in both 3- and 5-year-old children, supporting the "three-brain region theory” of the default mode network. In the frontoparietal network, the frontal and parietal gyri were activated in the two groups of children, and functional connectivity was strengthened in 5-year-olds compared with 3-year-olds, although the nodes and network connections were not yet mature. The high-correlation network connections in the default mode networks and dorsal attention networks had been significantly strengthened in 5-year-olds vs. 3-year-olds. Further, the salience network in the 3-year-old children included an activated insula/inferior frontal gyrus-anterior cingulate cortex network circu让 and an activated thalamus-parahippocampal-posterior cingulate cortex-subcortical regions network circuit. By the age of 5 years, no des and high-correlation network connections (edges) were reduced in the salience network. Overall, activation of the dorsal attention network, default mode network, left frontoparietal network, and right frontoparietal network increased (the volume of activation increased, the signals strengthened, and the high-correlation connections increased and strengthened) in 5-year-olds compared with 3-year-olds, but activation in some brain nodes weakened or disappeared in the salience network, and the network connections (edges) were reduced. Between the ages of 3 and 5 years, we observed a tendency for function in some brain regions to be strengthened and for the generalization of activation to be reduced, indicating that specialization begins to develop at this time. The study protocol was approved by the local ethics committee of the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences in China with approval No. SIAT-IRB- 131115-H0075 on November 15, 2013.

Effective doctor-patient communication skills training optimizes functional organization of intrinsic brain architecture:a restingstate functional MRI study

We studied the influence of doctor-patient communication skills training on brain functional architecture using resting-state functional MRI（rs-fMRI） with a regional homogeneity（ReHo） method. Ten medical students participated in the study. A 1-year long doctor-patient communication skills training program was conducted. RsfMRI data were collected at baseline, one month and one year after training. There was a significant increase in the communication skills test average scores between baseline and 1-month duration of training（P〈0.001）. After one month of communication skills training, medical students had decreased ReHo in the right superior temporal gyrus compared with the baseline. After one year of communication skills training, students had increased ReHo in multiple regions and decreased ReHo in several regions（P 〈0.05, Alphasim corrected）. The change of ReHo values in the superior temporal gyrus negatively correlated with the change of communication skills scale score between one month after communication skills training and baseline（r=-0.734, P= 0.036）. The training program we used can be an effective approach of improving doctor-patient communication skills, and the training resulted in functional plasticity of the brain’s architecture toward optimizing locally functional organization.

Brain functional network connectivity based on a visual task: visual information processing-related brain regions are significantly activated in the task state

It is not clear whether the method used in functional brain-network related research can be applied to explore the feature binding mechanism of visual perception. In this study, we inves-tigated feature binding of color and shape in visual perception. Functional magnetic resonance imaging data were collected from 38 healthy volunteers at rest and while performing a visual perception task to construct brain networks active during resting and task states. Results showed that brain regions involved in visual information processing were obviously activated during the task. The components were partitioned using a greedy algorithm, indicating the visual network existed during the resting state.Z-values in the vision-related brain regions were calculated, conifrming the dynamic balance of the brain network. Connectivity between brain regions was determined, and the result showed that occipital and lingual gyri were stable brain regions in the visual system network, the parietal lobe played a very important role in the binding process of color features and shape features, and the fusiform and inferior temporal gyri were crucial for processing color and shape information. Experimental ifndings indicate that understanding visual feature binding and cognitive processes will help establish computational models of vision, improve image recognition technology, and provide a new theoretical mechanism for feature binding in visual perception.

Altered spontaneous brain activity pattern in patients with ophthalmectomy: an resting-state fMRI study

●AIM:To use the voxel-wise degree centrality(DC)method to explore the underlying functional network brain-activity in patients with ophthalmectomy.●METHODS:A total of 32 ophthalmic surgery patients(10 women and 22 men),and 32 healthy subjects(10 women and 22 men)highly matched in gender,age,and the same operation method.Everyone experienced a restingstate functional magnetic resonance imaging scan.The spontaneous brain activity could be assessed by DC.Correlation analysis was used to explore the relationships between the average DC signal values and behavior performance in different regions.Receiver operating characteristic(ROC)cur ve analysis was utilized to differentiate between ophthalmectomy patients and healthy controls(HCs).●RESULTS:Compared with HCs,ophthalmectomy patients had greatly reduced DC values in left lingual gyrus,bilateral lingual lobe,left cingulate gyrus,and increased DC values of left cerebellum posterior lobe,left middle frontal gyrus1,right supramarginal gyrus,left middle frontal gyrus2,right middle frontal gyrus.However,we did not find that there was a correlation between the average DC values from various brain regions and clinical manifestations.●CONCLUSION:Dysfunction may be caused by ophthalmectomy in lots of cerebral areas,which may show the potential pathological mechanism of ophthalmectomy and it is beneficial to clinical diagnosis.

基于CCA融合FFT的SSVEP脑机接口分类算法

为解决多目标刺激范式的稳态视觉诱发电位脑电信号识别准确率低和信息传输率低的问题,提出了一种快速傅里叶变换同典型相关分析相结合的方法,通过快速傅里叶变换将信号训练成对应频率的训练模板,并作为参考信号与实时采集的信号进行典型相关分析来计算频率的识别准确率。6名受试者参与并完成了180组实验,在时间窗口长度为1.5 s的条件下,基于快速傅里叶变换-典型相关分析的稳态视觉诱发电位信号识别算法的平均识别准确率为93.98%,比典型相关分析算法提升了14.75%,信息传输率为62.30 bit·min^(-1),比典型相关分析算法提升了55.63%。实验结果表明,快速傅里叶变换-典型相关分析算法性能更优。

混合现实场景下结合SSVEP与眼动追踪的脑控机械臂系统

针对混合现实场景下脑控机械臂系统交互性差、指令集小的问题,设计了一种结合稳态视觉诱发电位(SSVEP)和眼动追踪技术的混合现实脑控机械臂系统。该系统通过眼动追踪技术实现目标区域的初选,而SSVEP信号则被用于在初选区域内识别最终的目标指令。在不增加刺激类别数量的前提下扩大了指令集,并根据受试者的视线停留区域实现异步控制。离线实验结果表明,在使用相同刺激类别数量的情况下,增加视觉刺激目标数量不会对分类准确率产生显著影响。通过在线实验验证了系统的适用性,相较于使用单一SSVEP范式的机械臂控制系统,所提出的系统具有更好的交互性和更大的指令集。

急性轻度创伤性脑损伤患者静息态功能MRI多模式研究

目的 采用静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)测量急性轻度创伤性脑损伤(mild traumatic brain injury,mTBI)患者与健康对照者(health control,HC)基于体素的指标,观察mTBI患者认知功能是否发生改变及其与蒙特利尔认知评估(Montreal Cognitive Assessment,MoCA)量表评分之间是否存在相关性。材料与方法前瞻性纳入31例单侧颅脑损伤11天内的急性mTBI患者,同期招募31例年龄、性别及受教育年限相匹配的HC,对所有受试者进行rs-fMRI扫描,并对mTBI组进行了临床评分。使用SPM 12和DPABI软件对图像进行预处理及基于体素的双样本t检验。使用高斯随机场(Gaussian random-field,GRF)校正。采用卡方检验估计两组性别构成的分布,两组间年龄的影响采用双样本t检验,两组间受教育年限的影响采用U检验。此外,对mTBI组损伤后纳入研究的时间及临床评分采用单样本t检验。采用Spearman相关系数分析mTBI组基于体素的指标与的MoCA量表评分评分的相关性。结果 mTBI组与HC组年龄(t=1.587,P>0.05)、性别(χ^(2)<0.001,P>0.05)和受教育年限(U=448,P>0.05)差异无统计学意义。与HC组相比,急性mTBI患者左侧脑岛、左侧中央后回和左侧中央前回的低频振幅(amplitude of low-frequency fluctuations,ALFF)增加(体素P值<0.005,GRF校正);右侧中央后回和右侧中央前回的分数低频振幅(fractional ALFF,fALFF)增加(体素P值<0.005,GRF校正);右侧楔叶和左侧中央后回的局部一致性(regional homogeneity,ReHo)增加(体素P值<0.005,GRF校正)。右侧中央后回与右侧枕中回和右侧楔叶的功能连接(functional connectivity,FC)增强(体素P值<0.005,GRF校正);右侧楔叶与右侧楔前叶的FC增强(体素P值<0.005,GRF校正),右侧楔叶与右侧尾状核的FC减弱(体素P值<0.005,GRF校正)。相关性分析显示,MoCA量表评分与基于种子的FC之间存在显著相关性。结论 研究结果表明,在脑损伤后的急性阶段,认知表现与静息状态下自发的大脑活动有关,特别是在默认模式网络(default mode network,DMN)、显著网络(salience network,SAN)和视觉网络中。此外,这项研究证明认知表现与MoCA量表评分之间存在相关性。

基于fMRI时变特征的大脑状态研究综述

功能磁共振成像技术已被广泛应用于人脑功能活动的研究,使用大脑状态(Brain State)研究大脑动力学得到了研究人员的广泛关注。以往关于大脑状态的综述,通常从状态定义方法的角度进行比较和总结,忽略了底层数据形式的不一致,可能导致对大脑状态的解读多样化。此外,现有综述也缺少对大脑状态分析应用方法的探讨。基于不同的数据形式,回顾了大脑状态的不同定义方法,总结了基于大脑状态进行大脑动力学分析的不同方法,并从大脑状态应用于认知、精神疾病、生理状态等方面的研究,总结出典型的研究方法。最后,发现了大脑元状态的定义与深度学习在特征提取方面具有相似性,从而提出将深度学习应用于大脑状态的识别以及大脑动力学的研究,这是一个有希望的未来方向。

定量脑电图趋势图在颈内动脉重度狭窄患者脑功能状态评估中的应用及其对短期内发生急性闭塞风险的预测价值(附1例报告)

目的探讨定量EEG趋势图在颈内动脉重度狭窄患者脑功能状态评估中的应用及其对短期内发生急性闭塞风险的预测价值。方法回顾性分析1例左侧颈内动脉重度狭窄患者临床和影像学资料,通过定量EEG趋势图评估其脑功能状态。结果定量EEG趋势图中节律性频谱图、振幅整合EEG和快速傅里叶转化频谱、功率谱能快速、直观地显示颈内动脉重度狭窄侧半球θ活动持续较健侧增多,且波幅增高。3 d后患者出现左侧颈内动脉急性闭塞、大动脉粥样硬化型脑梗死。结论作为神经影像学检查的补充,定量EEG趋势图可能有助于早期、快速识别颈内动脉重度狭窄患者缺血状态下的脑功能损伤,甚至对患者短期内发生急性闭塞具有潜在的预测价值。

基于PSD特征的FBCCA脑电信号识别方法

当前基于稳态视觉诱发电位(steady-state visual evoked potential,SSVEP)的脑机接口(brain-computer interfaces,BCIs)使用的都是单一识别算法,针对不同时间长度的识别准确率较低。提出了一种基于滤波器组的典型相关分析(filter bank canonical correlation analysis,FBCCA)与功率谱密度(power spectral density,PSD)分析相结合的SSVEP识别算法,可以提高SSVEP识别的普适性与准确率。该方法使用FBCCA寻找高相似度的参考频率信号,再通过多组PSD分析来锁定最终的响应频率,完成频率识别。该方法无需经过训练就能得到较高的识别准确率。实验结果表明:在刺激时长为1 s时,该方法能达到86.61%的准确率,比PSD分析方法提升了5.44%,比典型相关性分析方法(canonical correlation analysis,CCA)提升了10.38%的准确率,比FBCCA提升了8.86%的准确率。

基于模式识别的高水平运动员RS-fMRI数据分类研究

为弥补传统的广义线性模型(generalized linear model,GLM)方法的不足,并探索模式识别在运动脑科学当中的应用价值。使用支持向量机(support vector machine,SVM)模式识别算法,以低频振幅(fractional amplitude of low-frequency fluctuations,fALFF)、局部一致性(regional homogeneity,ReHo)和度中心度(degree centrality,DC)作为学习特征,对射击运动组和滑冰运动组(分类1)、射击运动组和对照组(分类2)以及速滑运动组和对照组(分类3)之间进行二分类,并计算每一个脑区在分类算法当中的权重。使用留一交叉验证法计算分类正确率,使用总的准确率、接受者操作特性曲线(receiver operating characteristic curve,ROC)、以及预测准确率来衡量机器分类算法的优劣性。结果表明:分类1中SVM算法的正确率较高且分类效果更稳定,总的准确率(total accuracy,tACC)可以维持在96.67%以上,曲线下面积(area under curve,AUC)均为1,说明SVM算法对区分不同项目运动员脑静息态功能特征时更有优势;在分类2和分类3中,SVM算法效果取决于使用的指标。其中,使用fALFF或者综合使用三个静息态指标的分类效果较稳定(tACC均在80%以上,AUC均在0.88以上);小脑在分类1算法中占较多的权重,提示不同运动项目运动员的脑功能活动之间差异最明显的部位主要在小脑上。而分类2和3中,除了小脑,还有一些与运动执行和控制及其他功能活动相关的脑区参与了算法的构成。通过SVM分类算法的应用获得较为理想的结果,展示了模式识别方法在运动科学领域的应用价值。研究成果有助于体育科学研究者从新的角度更加全面地理解运动与脑的关系。

急性轻度创伤性脑损伤与记忆障碍相关默认模式网络分析

目的观察轻度创伤性脑损伤(mTBI)患者记忆功能是否发生改变;在mTBI队列中探讨功能连通性(FC)变化与蒙特利尔认知评估(MoCA)量表评分之间是否存在相关性。方法前瞻性收集39例急性mTBI患者(急性mTBI组)和39例健康对照者(HC),对所有受试者进行rs-fMRI扫描,并计算两组FC的值。结果与HC组相比,急性mTBI组左后扣带回与左楔叶和右距状裂周围皮层的FC增强;左眶内额上回与右颞上回和右中央后回的FC增强,右海马旁回与右内侧和旁扣带脑回、右丘脑及右尾状核的FC减弱。相关性分析显示,MoCA量表评分与基于DMN网络节点的FC之间未发现显著相关性。结论急性mTBI患者的DMN网络受到破坏,患者记忆功能发生障碍。FC异常与MoCA量表评分之间未发现相关性。

观察电针健康受试者不同经穴对Resting-state fMRI脑功能连接的影响

目的:观察比较电针心经穴与心包经穴时激活脑区的功能连接变化差异,为临床运用针刺心经、心包经穴治疗相关疾病提供实验依据。方法:将符合纳入标准的29例健康受试者随机分为电针心经穴组14例和电针心包经穴组15例,以双侧后扣带回为种子点,采用功能连接作为观察指标,分析两组电针刺激状态下脑功能连接的差异。结果:两组电针前静息状态下的脑功能连接比较未发现存在明显差异的脑区。电针心经穴与心包经穴时脑内功能网络均发生改变,前者出现功能连接增强的区域为右侧额下回、左侧颞下回、右侧顶下小叶、右侧海马旁回,新激活脑区为双侧中央后回、左侧中央前回、右侧楔前叶、左侧角回、左侧枕下回、左侧脑岛(P<0.05);后者出现功能连接增强的区域为右侧顶上小叶,新激活脑区为左侧小脑舌、左侧顶叶楔前叶、右侧枕下回、左侧豆状核、右侧脑岛(P<0.05)。结论:(1)大脑在无任务的安静、清醒状态下存在一定的功能活动。(2)电针心经、心包经穴广泛激活的脑区主要与精神、神志、智力等密切相关,为临床上选用二者治疗与上述脑区相关的精神、神志类疾病提供了重要的客观依据。电针心经激活的中央前回为皮质运动前区,与对侧肢体运动功能密切相关,它的激活为临床上治疗中风肢体功能障碍选用手少阴心经穴提供了佐证。两组均激活的脑岛与心血管的功能关系密切,为临床上选用心经、心包经穴治疗心血管病提供了部分影像学依据。两条经脉的主治有交叉性,均可用于治疗心脑相关疾病,同时又各有偏颇,心包经多用于治疗与心相关疾病,而心经更多用于治疗精神神志类疾病。

基于静息态功能MRI的认知储备对脑网络的影响研究

目的:基于静息态功能磁共振成像(rest state functional magnetic resonance imaging,rsfMRI)图像,探究认知储备对脑网络的影响。方法:首先,在英国生物银行中选择7973名健康中老年人的rsfMRI图像,通过独立成分分析得到21个静息态网络。其次,采用图论分析方法提取网络节点效率、最短路径长度以及节点度中心性等参数。最后,比较并分析静息态网络的活跃程度、网络节点效率、节点最短路径长度以及节点度中心性4个指标,以及这4个指标与受教育程度、早期流体智力、体育运动、休闲活动和社交程度5个认知储备代理指标之间的关系。结果:研究结果表明,受教育程度、早期流体智力和体育运动3个认知储备代理指标与多个静息态网络的活跃程度以及大多数认知控制网络和默认模式网络中的节点效率、节点度中心性之间存在显著的正相关关系,但与大多数认知控制网络和默认模式网络中的最短路径长度之间存在显著的负相关关系。而休闲活动和社交程度2个认知储备代理指标与静息态网络的活跃程度呈负相关关系,且对功能网络整体拓扑特性的影响也相对较小。结论:受教育程度、早期流体智力和体育运动对静息态网络具有重要促进作用,而休闲活动和社交程度这2个认知储备代理指标可能对静息态网络产生负面影响。

动态功能性连接模式的状态判决与分类研究

针对动态脑网络分析中存在不同状态的连接模式,采用传统的聚类算法效果较差的问题,对神经疾病患者进行动态功能性连接分析,寻找稳定的状态特征来提高疾病分类准确率。阐述了脑网络构建、分析等基本理论,对现有研究存在的不足进行分析,介绍了动态功能性连接计算和有效特征提取过程。提出一种在交叉验证下微状态识别法,并与基于线性表达的维度压缩法结合,对原始动态功能连接进行稳定聚类与特征降维;引入类内距离准则对交叉验证下组内特征进行特征选择,对分类模型进行优化,提高了分类准确率。对比已有的聚类识别状态方法在公共数据集及轻度认知障碍识别分类中的应用,结果表明所提方法在稳定聚类和分类预测方面均表现较好,在特征选择后的分类准确率可以达到最优值86%。

静息态功能磁共振不同分析方法在意识障碍中的研究进展

意识障碍(DOC)是脑损伤后常见不良结局,通常导致严重医疗与经济负担。目前DOC的发病机制尚不明确,临床诊断及预后评估缺乏可靠标志物。神经功能成像因其客观性、可重复性在探究发病机制及疾病诊治方面发挥了重要作用。本文就静息态功能磁共振成像(rs-fMRI)不同分析技术对DOC的相关研究进展作一综述,旨在为探索DOC发病机制及临床诊治提供线索。

脑功能性近红外光谱技术在新生儿领域中的研究进展

功能性近红外光谱技术(functional near-infrared spectroscopy,fNIRS)是一种新兴的神经影像学检查工具,根据神经血管耦合机制,通过监测脑氧代谢的变化反映脑部神经元的活动功能,无创便捷,尤其适合新生儿脑功能监测。该文对新生儿语言、音乐和情绪的脑网络发育规律,新生儿护理的脑网络成像,静息态脑网络连接规律,以及疾病状态下脑功能成像特点等方面的fNIRS相关研究进行综述。

δ-连环蛋白高表达状态对乳腺癌患者化疗后短期脑认知功能影响的静息态功能MRI研究

目的利用静息态功能MRI探讨δ-连环蛋白(catenin)不同表达状态的乳腺癌患者采用蒽环联合环磷酰胺(anthracyclines cyclophosphamide,AC)化疗方案2个周期后的脑认知功能改变。材料与方法前瞻性收集66例经病理证实乳腺癌并首次进行标准化化疗患者,根据组织血清δ-catenin水平,分为δ-catenin高表达组31例和低表达组35例,同时收集健康对照(healthy control,HC)组36例。所有受试者在化疗前及2个化疗周期后进行神经心理学评分并行脑静息态功能MRI、3D-T1加权成像,分析脑静息态功能MRI指标,包括低频振幅(amplitude of low frequency fluctuation,ALFF)值、分数低频振幅(fractional amplitude of low frequency fluctuation,fALFF)值、局部一致性(regional homogeneity,ReHo)值,并对患者化疗前后神经心理学评分以及脑静息态功能MRI指标进行对比分析。结果化疗前δ-catenin高表达组人表皮生长因子受体2(human epidermal growth factor receptor 2,HER-2)显著高于低表达组,差异有统计学意义(P<0.05)。乳腺癌患者化疗前后神经心理学评分显示,δ-catenin高表达组患者化疗后癌症治疗认知功能评估(Functional Assessment of Cancer Therapy-Cognitive,FACT-Cog)总分、感知认知能力(Perceived Cognitive Abilities,PCA)、简易智力状态检查评分(Mini Mental State Examination,MMSE)、蒙特利尔认知评估评分(Montreal Cognitive Assessment,MOCA)、数字符号转化测验(Digital Symbol Substitution Test,DSST)以及中文听觉词语学习测验(Auditory Verbal Learning Test,AVLT)、数字连线实验B(Line-B)评分较化疗前差异有统计学意义,而低表达组只有AVLT-长时记忆(AVLT-long)评分差异有统计学意义(P均<0.05)。与化疗前相比,化疗2周期后部分脑区ALFF及ReHo值改变差异有统计学意义(P<0.05)。δ-catenin低表达组患者化疗后右侧前扣带和旁扣带脑回ALFF值下降,而δ-catenin高表达组右侧小脑半球4-5区、双侧脑岛、左侧舌回化疗后ALFF值下降。ReHo指标中,δ-catenin低表达组患者化疗后左侧眶部额下回ReHo值下降;而δ-catenin高表达组则左侧缘上回、左侧三角部额下回ReHo值下降(P均<0.05)。结论δ-catenin高表达进一步加重化疗对乳腺癌患者脑认知功能的损伤,主要涉及执行认知功能调控等相关脑区。

中西医结合治疗颅脑外伤后微小意识状态

微小意识状态(MCS)是重度意识障碍的表现形式之一,表现为意识内容缺失,觉醒程度降低,常见于脑血管病以及颅脑外伤患者。笔者所在科室在西医常规治疗及康复手法的基础上,根据颅脑外伤意识障碍患者长期卧床,气机不畅,酿生痰湿,郁而化热以及外伤后瘀滞于脑,经络不畅,清窍失养的辨证特点,分阶段予涤痰汤涤痰开窍、益气扶正或麝香四黄汤清热豁痰、逐瘀通经、开窍醒神。该患者前期体质较弱,不能耐受攻伐,以化痰通络、益气扶正为主,经过一段时间治疗后,原发症及营养状况极大改善且伴有郁热之象,以清热豁痰、醒脑开窍、祛瘀通络为治疗原则。最终使微小意识状态半年之久的患者意识障碍显著好转,并恢复一定自理能力。

抑郁症患者肝-脑功能区rfMRI影像学特征及与其相关性

目的 探讨抑郁症患者肝-脑功能区静息态功能磁共振成像(rfMRI)影像学特征及与其相关性。方法 将2022年11月-2023年7月医院精神科门诊确诊的40例抑郁症发作期患者依据病情严重程度分为轻中度组、重度组,采用rfMRI记录脑区影像学信息,比较轻中度组、重度组肝-脑功能区域的影像学特征。同期选取医院进行体检的20名健康志愿者作为对照,比较健康志愿者、抑郁症患者肝-脑功能区域的影像学特征,Pearson相关性分析法评估肝-脑功能区域异常影像学特征值与抑郁症的相关性。结果 轻中度组左侧枕中回ReHo值较重度组降低,双侧楔前叶、中扣带回、杏仁核ReHo值较重度组升高,差异具有统计学意义(P<0.05)。健康志愿者左侧枕中回ReHo值较抑郁症患者降低,双侧楔前叶、中扣带回、杏仁核ReHo值较抑郁症患者升高,差异具有统计学意义(P<0.05)。Pearson相关性分析结果显示,肝-脑功能区域中左侧枕中回ReHo值与HAMD-24评分呈正相关(r=0.506,P<0.05),右侧楔前叶、左侧楔前叶、右侧中扣带回、左侧中扣带回、右侧杏仁核、左侧杏仁核ReHo值与HAMD-24评分呈负相关(r=-0.446、-0.452、-0.462、-0.481-、0.520、-0.531,P<0.05)。结论 症患者肝-脑功能异常改变的区域分布于楔前叶、枕中回、中扣带回、杏仁核,且随着抑郁症患者病情进展,枕中回ReHo值逐渐升高,楔前叶、中扣带回、杏仁核ReHo值逐渐降低,枕中回、楔前叶、中扣带回、杏仁核区域异常与抑郁症病情具有一定相关性。