Brainstem auditory evoked potentials in patients with delayed encephalopathy after acute carbon monoxide poisoning

Objective:To evaluate the changes of brainstem auditory evoked potential (BAEP) in patients with delayed encephalopathy after acute carbon monoxide poisoning. Methods: BAEPs were performed in 32 controls and 40 patients. Wave Ⅰ , Ⅱ , Ⅲ ,Ⅳ, Ⅴ latencies and Ⅰ-Ⅲ , Ⅲ-Ⅴ , Ⅰ-Ⅴ interpeak latencies were measured, respectively. Results: Abnormalities of BAEPs in 13 patients (13/40, 32 ％). Among the13 abnormal BAEPs, 3 displayed prolongation of latency to waves in one side, no potential in another side; 5 displayed a similar abnormality which was bilateral prolongation of latency to waves ;and another 5 displayed unilateral latency delay. Compared wave Ⅰ , Ⅱ , Ⅲ , Ⅳ, Ⅴ latencies and Ⅰ-Ⅲ , Ⅲ-Ⅴ , Ⅰ-Ⅴ interpeak latencies in the patients and the controls, there were no significant differences (P＞0.05). Conclusion: BAEPs can be used for evaluating the diagnostic and prognostic values in the cases of delayed encephalopathy after acute carbon monoxide poisoning.

Effect of Acupuncture on the Auditory Evoked Brain Stem Potential in Parkinson's Disease

Under the auditory evoked brain stem potential (ABP) examination, the latent period of V wave and the intermittent periods of III-V peak and I-V peak were significantly shortened in Parkinson's disease patients of the treatment group (N=29) after acupuncture treatment. The difference of cumulative scores in Webster's scale was also decreased in correlation analysis. The increase of dopamine in the brain and the excitability of the dopamine neurons may contribute to the therapeutic effects, in TCM terms, of subduing the pathogenic wind and tranquilizing the mind.……

Characteristics of brainstem auditory evoked potentials of students studying folk dance

BACKGROUND: Previous experiments have demonstrated that brainstem auditory evoked potential is affected by exercise,exercise duration,and frequency. OBJECTIVE: Comparing the brainstem auditory evoked potential of students studying folk dance to students studying other subjects. DESIGN: Observational contrast study. SETTING: Physical Education College,Shandong Normal University PARTICIPANTS: Fifty-five female students were enrolled at Shandong Normal University between September and December in 2005,including 21 students that studied folk dance and 34 students that studied other subjects. The age of the folk dance students averaged (19 ± 1) years and dance training length was (6.0 ± 1.5) years. The students that studied other subjects had never taken part in dance training or other physical training,and their age averaged (22 ± 1) years,body height averaged (162 ± 5) cm,body mass averaged (51 ± 6) kg. All subjects had no prior ear disease or history of other neurological disorders. All students provided informed consent for the experimental project. METHODS: The neural electricity tester,NDI-200 (Shanghai Poseidon Medical Electronic Instrument Factory) was used to examine and record Brainstem Auditory Evoked Potential values of the subjects during silence,as well as to transversally analyze the Brainstem Auditory Evoked Potential values. The electrode positions were cleaned and degreased with soapy water,followed by ethanol. The selected bipolar electrodes were situated on the head: recording electrodes were placed at the Baihui acupoint,and the reference electrode was placed at the mastoid of the measured ear,with grounding electrodes in the center of the forehead. Brainstem Auditory Evoked Potential values were elicited by monaural stimulation of a "click" though an earphone; the other ear was sheltered by the white noise. The click intensity was 102 db,the stimulation frequency was 30 Hz,the bandpass filters were 1 000-3 000 Hz,the sensitivity was 5 μV,and a total of 2 000 sweeps were averaged. Waveform identification and analysis: various components of the Brainstem Auditory Evoked Potential values were identified,and the peak latencies and peak-peak values were analyzed. MAIN OUTCOME MEASURES: Latency of Ⅰ,Ⅱ,Ⅲ,Ⅳ,Ⅴ and Peak-Peak Value of Ⅰ,Ⅲ,Ⅴ were measured. RESULTS: Fifty-five subjects were enrolled in the final analysis,without any loss. Compared to the students who studied other subjects ①Ⅰ-Ⅴ peak latencies (PL): Ⅳ PL of the right ear of the folk dance students was obviously longer (P < 0.05); ②Ⅰ,Ⅲ,Ⅴ peak-peak values: Ⅰ peak-peak values of the right ear were obviously higher (P < 0.05). CONCUSION: ① PL of the right ear of the folk dance students was obviously longer,which indicates that dancing results in a stronger sensibility to auditory stimuli. ②P?eak-peak values were obviously higher,which indicates that long-term exercise enhances the music senses and synchrony of auditory nerve impulses.

Enhanced auditory evoked potentials in musicians:A review of recent findings

Auditory evoked potentials serve as an objective mode for assessment to check the functioning of the auditory system and neuroplasticity.Literature has reported enhanced electrophysiological responses in musicians, which shows neuroplasticity in musicians. Various databases including Pub Med, Google, Google Scholar and Medline were searched for references related to auditory evoked potentials in musicians from 1994 till date. Different auditory evoked potentials in musicians have been summarized in the present article. The findings of various studies may support as evidences for music-induced neuroplasticity which can be used for the treatment of various clinical disorders. The search results showed enhanced auditory evoked potentials in musicians compared to non-musicians from brainstem to cortical levels. Also, the present review showed enhanced attentive and pre-attentive skills in musicians compared to non-musicians.

Intraoperative Auditory Evoked Potential Monitoring for Anaesthesia Depth and Utilization of Inhaled Isoflurane

Background: Hypnosis monitoring has been shown to reduce the incidence of awareness. A-line ARX-IndexTM (AAI) derived from auditory evoked potentials (AEP) represents as a numerical variable depth of anaesthesia. Objectives: To study the efficacy of AEP as an indicator of anaesthetic depth and monitor intraoperative awareness in neurosurgical patients by using the AAI scale. Design: Prospective cohort study is used. Setting: The study is in Neurosurgical centre of Tertiary care hospital. Participants: Neurosurgical patients requiring general anaesthesia with duration of surgery between 90 - 150 minutes were enrolled for the study. Intervention: Patients in Group 1 (control) were monitored by conventional methods. Patients in Group 2 (study) underwent intraoperative monitoring by using the AEP monitor. Primary outcome: To study the efficacy of AEP monitoring and AAI index for monitoring the depth of anaesthesia and reducing the incidence of awareness. Results: There was no significant difference in the intraoperative haemodynamic responses measured between the two study groups (p > 0.5). There was no significant difference in the identification of intraoperative awareness by using conventional parameters between the two groups (p > 0.5). There was also a significantly faster time to recovery for patients in Group 2 (p < 0.05). Conclusion: Hypnosis monitoring using AEP monitor/AAI in neurosurgical patients under general anaesthesia did not show any significant difference in haemodynamic response and intraoperative awareness but had significant lower consumption of volatile anaesthetic with cost sparing effect and a faster recovery time as compared to conventional monitoring.

Characteristics of brainstem auditory evoked potential of neonates with mild or moderate hyperbilirubinemia

BACKGROUND:Brainstem auditory evoked potential(BAEP) has been widely used to evaluate the functional integrity and development of injured auditory system and brain,especially to objectively evaluate the function of auditory system and brain stem of very young babies,such as neonates and sick babies. OBJECTIVE:To observe the changes of BAEP of neonates with hyperbilirubinemia,and to investigate the relationship of bilirubin concentration and BAEP. DESIGN:An observation experiment. SETTING:Department of Pediatrics,the 309 Clinical Division,General Hospital of Chinese PLA. PARTICIPANTS:Fifty-eight neonates with mild or moderate hyperbilirubinemia exhibiting jaundice within 24 hours after born,who received the treatment in the Department of Pediatrics,the 309 Clinical Division,General Hospital of Chinese PLA between January 2004 and May 2007,were recruited in this study. The involved neonates,31 boys and 27 girls,had gestational age of 37 to 46 weeks. They had no history of birth asphyxia,and were scored 8 to 10 points when born. Written informed consents of examination and treatment were obtained from the guardians of the neonates. This study was approved by the Hospital Ethics Committee. According to serum total bilirubin value,the neonates were assigned into 3 groups:low-concentration bilirubin group(n =16),moderate-concentration bilirubin group(n =27) and high-concentration bilirubin group(n =15). According to mean daily bilirubin increase,the subjects were sub-assigned into bilirubin rapid increase group(n =39) and bilirubin slow increase group(n =19). METHODS:After admission,all the neonates received drug treatment. Meanwhile,their 116 ears were examined with a myoelectricity evoked potential equipment(KEYPOINT) in latency,wave duration,amplitude and wave shape differentiation of each wave of BAEP. BAEP abnormal type was observed and abnormal rate of BAEP was calculated. MAIN OUTCOME MEASURES:① Abnormal rate and abnormal type of BAEP. ② Latency of waves Ⅰ,Ⅲ and Ⅴ,and wave duration of waves Ⅰ to Ⅲ,Ⅲ to Ⅴ,and Ⅰ to Ⅴ. RESULTS:Fifty-eight neonates with mild or moderate hyperbilirubinemia were involved in the final analysis. ①Abnormal type and abnormal rate of BAEP of neonates with hyperbilirubinemia:Among the 116 ears,unilateral or bilateral waves Ⅰ,Ⅲ,Ⅴ still existed. The latency of waves Ⅰ,Ⅲ and Ⅴ was +2.5 s longer than the normal level in 8,4 and 15 ears,respectively. The wave duration of waves Ⅰ to Ⅲ and waves Ⅲ to Ⅴ was +2.5 s longer than the normal level in 6 and 14 ears,respectively. The wave duration of waves Ⅲ to Ⅴ was longer than that of ipsilateral waves Ⅰ to Ⅲ in 24 ears. The latency difference of wave Ⅴ between two ears was larger than 0.4 ms in 31 neonates with hyperbilirubinemia;The amplitude of wave Ⅴ to that of ipsilateral wave I was lower than 0.5 in 29 neonates. Totally 52 ears were abnormal,and the abnormal rate was 44.8%. One to two months later,98% abnormal neonates with hyperbilirubinemia recovered. The abnormal rate in the low-,moderate-,and high-concentration bilirubin groups was 37.5%,44.4% and 53.3%,respectively. ② Comparison of latency and wave duration of each wave of BAEP:Latency of waves Ⅰ,Ⅲ and Ⅴ,and wave duration of waves Ⅰ to Ⅲ and Ⅲ to Ⅴ were gradually prolonged in low-,moderate-,and high-concentration bilirubin groups,but significant difference did not exist between two groups(P > 0.05). ③ There were no significant differences in latency of waves Ⅰ,Ⅲ and Ⅴ,and wave duration of waves Ⅰ to Ⅲ,Ⅲ to Ⅴ and Ⅰ to Ⅴ between bilirubin rapid increase group and bilirubin slow increase group(P > 0.05). CONCLUSION:Auditory acuity and brainstem of neonates with mild or moderate hyperbilirubinemia are damaged to some extent. High-concentration bilirubin causes BAEP abnormality easily. Bilirubin increase and its concentration change are not consistent with nervous lesion degree.

Electroencephalogram and brainstem auditory evoked potential in 539 patients with central coordination disorder

BACKGROUND: Electroencephalogram (EEG) and brainstem auditory evoked potential (BAEP) are objective non-invasive means of measuring brain electrophysiology. OBJECTIVE: To analyze the value of EEG and BAEP in early diagnosis, treatment and prognostic evaluation of central coordination disorder. DESIGN, TIME AND SETTING: This case analysis study was performed at the Rehabilitation Center of Hunan Children’s Hospital from January 2002 to January 2006. PARTICIPANTS: A total of 593 patients with severe central coordination disorder, comprising 455 boys and 138 girls, aged 1–6 months were enrolled for this study. METHODS: EEG was monitored using electroencephalography. BAEP was recorded using a Keypoint electromyogram device. Intelligence was tested by professionals using the Gesell scale. MAIN OUTCOME MEASURES: (1) The rate of abnormal EEG and BAEP, (2) correlation of abnormalities of EEG and BAEP with associated injuries, (3) correlation of abnormalities of EEG and BAEP with high risk factors. RESULTS: The rate of abnormal EEG was 68.6% (407/593 patients), and was increased in patients who also had mental retardation (P < 0.05). The rate of abnormal BAEP was 21.4% (127/593 patients). These 127 patients included 67 patients (52.8%) with peripheral auditory damage and 60 patients (47.2%) with central and mixed auditory damage. The rate of abnormal BAEP was significantly increased in patients who also had mental retardation (P < 0.01). Logistic regression analysis showed that asphyxia (P < 0.05), jaundice, preterm delivery, low birth weight and the umbilical cord around the neck were closely correlated with abnormal EEG in patients with central coordination disorder. Intracranial hemorrhage, jaundice (P < 0.05), low birth weight and intrauterine infection (P < 0.05) were closely correlated with abnormal BAEP in patients with central coordination disorder. CONCLUSION: Central coordination disorder is often associated with abnormal EEG and BAEP. The rate of EEG or BAEP abnormality is positively associated with the size of the brain injury. Asphyxia is a high risk factor for abnormal EEG in central coordination disorder. Jaundice and intrauterine infection are high risk factors for abnormal BAEP in central coordination disorder.

Clinical Study on Effect of Electro-acupuncture Combined with Different Anesthetics on Auditory-evoked Potential Index

Objective: To observe the effect of electro-acupuncture (EA) on auto regressive with exogenous input model (ARX-model) auditory evoked index (AAI) in patients anesthetized with different anesthetics. Methods: Forty-eight adult patients undergoing scheduled surgical operation were enrolled and divided into two groups (24 in each group) according to the anesthetics applied, Group A was anesthetized with propofol sedation and Group B with Isoflurane-epidural anesthesia. Group A was subdivided into three groups of low, middle and high concentration of target effect-site of 1.0 μg/ml, 1.5 μg/ml and 2.0 μg/ml through target controlled infusion (TCI) and Group B into 3 subgroups of minimum alveolar effective concentration of isoflurane (0.4 MAC, 0.6 MAC and 0.8 MAC for B1, B2 and B3 subgroups) respectively, with 8 patients in every subgroup. EA on acupoints of Hegu (LI4) and Neiguan (P6) was applied on all the patients during anesthesia, and the change of AAI at various time points was recorded. Results: In the three subgroups of Group A, levels of AAI were significantly elevated in the first few minutes after EA, and significantly lowered 20 min after EA in subgroup A2. While in the subgroups of Group B, except the elevating in Group B1 1- 2 min after EA, levels of AAI remained unchanged at other time points. Conclusion: Pain response could be reflected by AAI during EA. EA could enhance the sedative effect of propofol in middle concentration, but its effect on isoflurane epidural anesthesia is insignificant.

Effect of Qiangli Dingxuan Tablet on Cerebral Hemodynamics and Brainstem Auditory Evoked Potentials in Vertigo Patients with Posterior Circulation Ischemia

OBJECTIVE: To observe the effect of Qiangli Dingxuan Tablet on cerebral hemodynamics and brainstem auditory evoked potentials in vertigo patients with posterior circulation ischemia. METHODS: A total of 120 vertigo patients with posterior circulation ischemia were randomly divided into observation group and control group. 60 patients in the control group were treated with conventional western medicine. 60 patients in the observation group were treated with Qiangli Dingxuan Tablet on the basis of the control group. After 2 weeks of treatment, the improvement of vertigo(dizziness handicap inventory(DHI), dizziness handicap inventory(DHI)), the hemodynamic index(Basilar artery blood flow velocity(BA), left vertebroarterial artery(LVA), and the average blood flow velocity of right vertebroarterial artery(RVA)) and the changes in brain stem auditory evoked potential(BAEP) of two groups were observed. And statistical analysis was conducted for the clinical efficacy and adverse reactions during treatment of two groups. RESULTS: The total effective rate of the observation group was significantly higher than that of the control group(P < 0.05). The DHI and DARS scores of the two groups were significantly lower than those before treatment(P < 0.05), and the degree of reduction was more obvious in the observation group(P < 0.05). The levels of BA, LVA and RVA in the two groups were significantly higher than those before treatment(P < 0.05), and the levels of BA, LVA and RVA in the observation group were significantly higher than those in the control group(P < 0.05). The indexes of BAEP latency I, II, III and indexes of BAEP peak latency I-III, III-V, IV were obviously lower than those before treatment(P < 0.05). Besides, the decrease of BAEP index in the observation group was significantly lower than that in the control group(P < 0.05). No adverse reactions occurred during the treatment of the two groups. CONCLUSION: Qiangli Dingxuan Tablet is able to significantly improve the cerebral hemodynamics and brainstem auditory evoked potentials of patients with PCIV, and quickly relieve vertigo. It is safe and reliable and worthy of clinical application.

EFFECTS OF ACUPUNCTURE ON SENSORY EVOKED CORTICAL POTENTIALS IN RABBITS

The effects of acupuncture on the sensory evoked cortical potentials were investigated in 31 rabbits anaesthetized with urethane of conscious, so as to see what happened to the functional state of cerebral cortex in the meantime. The visual, auditory and somatosensory evoked potentials as well as raw EEGs were recorded from the animal’s scalp. In most cases, an electro-acupuncture instrument was used instead of manual acupuncture. The main component amplitudes of evoked potentials,the frequency band powers and the total integral values of raw EEGs were analyzed. Results showed that during acupuncture the main components of evoked potentials were significantly depressed and the raw EEGs appeared desynchronized while the experimental animals were slightly activated. Moreover,both the total integral values of raw EEGs and the powers of lower frequency waves (1 - 3. 99 Hz)were decreased and positively correlated well with the amplitudes of main components of the evoked potentials. Therefore, the possibility that the effects of acupuncture on the evoked potentials are secondary to the changes of raw EEGs remains to be ruled out, and it is suggested that the inhibition of evoked potentials during acupuncture does not necessarily mean that the cerebral cortex is in an inhibitory

Otoacoustic Emissions and Evoked Potentials in Infants after Breast-Feeding Jaundice——Hearing Dysfunction in Breast-Feeding Jaundice

We study hearing in a group of infants with Breast-feeding jaundice (BFJ) by means of Transient-evoked otoacoustic emissions (T-EOE) and Brainstem auditory evoked potentials (BAEP) searching for relationship between bilirubin serum levels and auditory dysfunction. Eleven infants born at-term with BFJ were selected for the study. We studied also 11 control age- and gender matched healthy at-term infants without signs of jaundice. T-EOAE studies were performed between 5-7 days after birth, and 3 months later. BAEP studies were performed once. BFJ group infants exhibited lower amplitudes in T-EOE than infants in the control group. These differences disappear at the 3-month evaluation. In BAEP, we observed a significant latency delay of waves I and V in Breast-feeding jaundice group infants. All infants in both groups demonstrated reproducible wave V response at 30 decibels. No significant correlation values were observed between bilirubin serum levels and T-EOE and BAEP variables. Our data suggest that BFJ can result in transient peripheral and central auditory dysfunction. Dysfunction is reversible after treatment of infants with BFJ.

Normalization of auditory evoked potential and visual evoked potential in patients with idiot savant

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Can bispectral index or auditory evoked potential index predict implicit memory during propofol-induced sedation?

Background Some patients still suffer from implicit memory of intraoperative events under adequate depth of anaesthesia. The elimination of implicit memory should be a necessary aim of clinical general anaesthesia. However, implicit memory cannot be tested during anaesthesia yet. We propose bispectral index (BIS) and auditory evoked potential index (AEPI), as predictors of implicit memory during anaesthesia. Methods Thirty-six patients were equally divided into 3 groups according to the Observer’s Assessment of Alertness/Sedation Score: A, level 3; B, level 2 ;and C, level 1. Every patient was given the first auditory stimulus before sedation. Then every patient received the second auditory stimulus after the target level of sedation had been reached. BIS and AEPI were monitored before and after the second auditory stimulus presentation. Four hours later, the inclusion test and exclusion test were performed on the ward using process dissociation procedure and the scores of implicit memory estimated. Results In groups A and B but not C, implicit memory estimates were statistically greater than zero (P<0.05). The implicit memory scores in group A did not differ significantly from those in group B (P>0.05). Implicit memory scores correlated with BIS and AEPI (P<0.01). The area under ROC curve is BIS> AEPI. The 95% cutoff points of BIS and AEPI for predicting implicit memory are 47 and 28, respectively. Conclusions Implicit memory does not disappear until the depth of sedation increases to level 1 of OAA/S score. Implicit memory scores correlate well with BIS and AEPI during sedation. BIS is a better index for predicting implicit memory than AEPI during propofol induced sedation.

The effect of lead on brainstem auditory evoked potentials in children

To determine whether lead affects brainstem auditory evoked potentials (BAEPs) in low-to-moderate lead exposed children Methods BAEPs were recorded from 114 asymptomatic children aged 1-6 years Average values were calculated for peak latency (PL) and amplitude (Amp) Whole blood lead (PbB) levels were assessed by graphite furnace atomic absorption spectroscopy Based on their PbB levels, subjects were divided into low lead (PbB<100 μg/L) and high lead subgroups (PbB ≥100 μg/L) Results The PbB levels of the 114 subjects ranged from 32 0 to 380 0 μg/L in a positively skewed distribution The median of PbB levels was 90 0 μg/L while the arithmetic average was 88 0 μg/L Of the subjects, 43 0% (49/114) had levels equal to or greater than 100 μg/L Bilateral PLs Ⅰ, Ⅴ, and Ⅲ of the left ear in the high lead subgroup were significantly longer than those in the low lead subgroup (P<0 05) A positive correlation was found between PbB levels and bilateral PLs Ⅰ, Ⅴ and Ⅲ of the left ear (P<0 05), after controlling for age and gender as confounding factors A significant and positive correlation between PbB levels and PL Ⅰ of the left ear, even when PbB levels were lower than 100 μg/L, in the low subgroup (r=0 295, P=0 019) was also found Conclusions Lead poisoning in children younger than 6 years old is a very serious problem to which close attention should be paid The indications that lead prolongs partial PLs may imply that lead, even at PbB levels lower than 100 μg/L, impairs both the peripheral and the central portions of the auditory system BAEPs may be a sensitive detector of subclinical lead exposure effects on the nervous system in

Brainstem auditory evoked potential combined with high resolution cranial base CT can optimize the diagnosis of auditory nerve injury

Purpose:Auditory nerve injury is one of the most common nerve injury complications of skull base fractures.However,there is currently a lack of auxiliary examination methods for its direct diagnosis.The purpose of this study was to find a more efficient and accurate means of diagnosis for auditory nerve injury.Methods:Through retrospectively analyzing the results of brainstem auditory evoked potential(BAEP)and high-resolution CT(HRCT)in 37 patients with hearing impairment following trauma from January 1,2018 to July 31,2020,the role of the two inspection methods in the diagnosis of auditory nerve injury was studied.Inclusion criteria were patient had a clear history of trauma and unilateral hearing impairment after trauma;while exclusion criteria were:(1)severe patient with a Glasgow coma scale score<5 because these patients were classified as severe head injury and admitted to the intensive care unit,(2)patient in the subacute stage admitted 72 h after trauma,and(3)patient with prior hearing impairment before trauma.According to Goodman's classification of hearing impairment,the patients were divided into low/medium/severe injury groups.In addition,patients were divided into HRCT-positive and negative groups for further investigation with their BAEP results.The positive rates of BEAP for each group were observed,and the results were analyzed by Chi-square test(p<0.05,regarded as statistical difference).Results:A total of 37 patients were included,including 21 males and 16 females.All of them were hospitalized patients with GCS score of 6-15 at the time of admission.The BAEP positive rate in the medium and severe injury group was 100%,which was significantly higher than that in the low injury group(27.27%)(p<0.01).The rate of BEAP positivity was significantly higher in the HRCT-positive group(20/30,66.7%)than in the HRCT-negative group(1/7,14.3%)(p<0.05).Twenty patients(54.05%)were both positive for BEAP and HRCT test,and considered to have auditory nerve damage.Six patients(16.22%)were both negative for BEAP and HRCT test,and 10 patients(27.03%)were BAEP-negative but HRCT-positive:all the 16 patients were considered as non-neurological injury.The rest 1 case(2.70%)was BAEP-positive but HRCT-negative,which we speculate may have auditory nerve concussion.Conclusion:By way of BAEP combining with skull base HRCT,we may improve the accuracy of the diagnosis of auditory nerve injury.Such a diagnostic strategy may be beneficial to guiding treatment plans and evaluating prognosis.

Influence of a preceding auditory stimulus on evoked potential of the succeeding stimulus

In the present study, we investigated the influ.ence of the preceding auditory stimulus on the audi-tory-evoked potential (AEP) of the succeeding stimuli, whenthe human subjects were presented with a pair of auditorystimuli. We found that the evoked potential of the succeedingstimulus was inhibited completely by the preceding stimulus,as the inter-stimulus interval (ISI) was shorter than 150 ms.This influence was dependent on the IS1 of two stimuli, theshorter the ISI the stronger the influence would be. The in-hibitory influence of the preceding stimulus might be causedby the neural refractory effect.

Influence of Electroacupuncture on Auditory Evoked Potential Index During Propofol Sedation

目的:观察丙泊酚镇静时电针对听觉诱发电位指数(AAI)的影响。方法:择期手术患音24例,根据丙泊酚效应室浓度随机分为Ⅰ组(1.0μg/mL)、Ⅱ组(1.5 μg/mL)、Ⅲ组(2.0 μg/mL)三组。静脉输入丙泊酚,电针合谷、内关穴,记录 AAI 变化。结果:电针后最初几分钟均有显著性升高,Ⅱ组电针20 min 时有显著降低(P<0.05)。结论:AAI 能灵敏地反映电针针刺时引起的疼痛反应,在中等浓度丙泊酚镇静中电针可加强其镇静水平。

长潜伏期听觉诱发电位在轻度认知障碍和阿尔茨海默病中的研究现状

长潜伏期听觉诱发电位不仅能反映大脑对声音信号的被动感觉处理过程,也能反应大脑在不同任务模式下的主动认识处理过程,因此被应用于认知功能的评估。本文就长潜伏期听觉诱发电位中的外源性成分(P1、N1、P2)和内源性成分(MMN/N2a、N2b、P3a、P3b)在轻度认知障碍和阿尔茨海默病中的研究现状进行综述,为国内开展相关研究提供一定的借鉴。

自闭症谱系障碍儿童的听觉诱发电位研究进展

自闭症谱系障碍儿童通常表现出对声音刺激的异常反应,前期针对其听觉功能的研究多采用客观听觉电生理测试,主要包含听性脑干反应及一系列皮层听觉诱发电位。综合这些研究中的结果提示,与正常发育儿童相比,自闭症谱系障碍儿童存在一定程度的中枢听觉信息处理障碍。本文对此进行综述。