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A Retrospective Study of Branch Atheromatous Disease: Analyses of Risk Factors and Prognosis 被引量:9
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作者 刘阳 范元腾 +4 位作者 刘煜敏 王涛 封红亮 刘广志 梅斌 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2017年第1期93-99,共7页
The theory of branch atheromatous disease(BAD) has been commonly underused in clinical practice and research since it was proposed in 1989. In this study, we sought to explore clinical characteristics of its substyp... The theory of branch atheromatous disease(BAD) has been commonly underused in clinical practice and research since it was proposed in 1989. In this study, we sought to explore clinical characteristics of its substypes and biomarkers for prognosis of BAD. A total of 176 consecutive patients with BAD were classified into two groups: paramedianpontine artery group(PPA group, n=70) and lenticulostriate artery group(LSA group, n=106). Bivariate analyses were used to explore the relationship between white matter hyperintensities(WMHs), National Institutes of Health Stroke Scale(NIHSS) scores and prognosis evaluated by the modified Rank Scale(m RS) at 6th month after stroke. The differences in prevalence of diabetes mellitus and a history of ischemic heart disease were statistically significant between PPA group and LSA group(χ~2=8.255, P=0.004; χ~2=13.402, P〈0.001). The bivariate analyses demonstrated a positive correlation between NIHSS and poor prognosis in patients with BAD and in the two subtype groups, and a positive correlation between WMHs and poor prognosis in the PPA group. It is concluded that a significantly higher prevalence of diabetes mellitus and a history of ischemic heart disease exist in the PPA group than in the LSA group. In addition, high grades of NIHSS scores imply poor prognosis in patients with BAD and in the two subtype groups. Moreover, WMHs are a positive predictor for poor prognosis in patients in the PPA group. 展开更多
关键词 branch atheromatous disease diabetes mellitus white matter hyperintensities prognosis National Institutes of Health Stroke Scale
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Comparative Analysis of General Characteristics of Ischemic Stroke of BAD and non-BAD CISS Subtypes 被引量:7
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作者 梅斌 刘广志 +3 位作者 杨阳 刘煜敏 曹江慧 章军建 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2015年第6期885-890,共6页
Summary: Based on the recently proposed Chinese ischemic stroke subclassification (CISS) system, intracranial branch atheromatous disease (BAD) is divided into large artery atherosclerosis (LAA) and penetrating... Summary: Based on the recently proposed Chinese ischemic stroke subclassification (CISS) system, intracranial branch atheromatous disease (BAD) is divided into large artery atherosclerosis (LAA) and penetrating artery disease (PAD). In the current retrospective analysis, we compared the general charac- teristics of BAD-LAA with BAD-PAD, BAD-LAA with non-BAD-LAA and BAD-PAD with non-BAD-PAD. The study included a total of 80 cases, including 45 cases of BAD and 35 cases of non-BAD. Subjects were classified using CISS system: BAD-LAA, BAD-PAD, non-BAD-LAA and non-BAD-PAD. In addition to analysis of general characteristics, the correlation between the factors and the two subtypes of BAD was evaluated. The number of cases included in the analysis was: 32 cases of BAD-LAA, 13 cases of BAD-PAD, 21 cases of non-BAD-LAA, and 14 cases of non-BAD-PAD. Dia- betes mellitus affected more non-BAD-LAA patients than BAD-LAA patients (P=0.035). In comparison with non-BAD-PAD, patients with BAD-PAD were younger (P=-0.040), had higher initial NIHSS score (P〈0.001) and morbidity of ischemic heart disease (P=0.033). Within patients with BAD, the PAD sub- type was associated with smoking (OR=0.043; P=0.011), higher low-density lipoprotein (OR=5.339; P=0.029), ischemic heart disease (OR=9.383; P=0.047) and diabetes mellitus (OR=12.59;P=-0.020). It was concluded that large artery atherosclerosis was the primary mechanism of BAD. The general char- acteristics showed no significant differences between the CISS subtypes of LAA and PAD within BAD, as well as between the BAD and non-BAD within LAA subtype. Several differences between PAD sub- types of BAD and non-BAD were revealed. 展开更多
关键词 branch atheromatous disease Chinese ischemic stroke subclassification HR-MRI ischemic stroke SUBTYPES large artery atherosclerosis penetrating artery disease
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