Effect of Acupuncture on the Auditory Evoked Brain Stem Potential in Parkinson's Disease

Under the auditory evoked brain stem potential (ABP) examination, the latent period of V wave and the intermittent periods of III-V peak and I-V peak were significantly shortened in Parkinson's disease patients of the treatment group (N=29) after acupuncture treatment. The difference of cumulative scores in Webster's scale was also decreased in correlation analysis. The increase of dopamine in the brain and the excitability of the dopamine neurons may contribute to the therapeutic effects, in TCM terms, of subduing the pathogenic wind and tranquilizing the mind.……

Effect of Qiangli Dingxuan Tablet on Cerebral Hemodynamics and Brainstem Auditory Evoked Potentials in Vertigo Patients with Posterior Circulation Ischemia

OBJECTIVE: To observe the effect of Qiangli Dingxuan Tablet on cerebral hemodynamics and brainstem auditory evoked potentials in vertigo patients with posterior circulation ischemia. METHODS: A total of 120 vertigo patients with posterior circulation ischemia were randomly divided into observation group and control group. 60 patients in the control group were treated with conventional western medicine. 60 patients in the observation group were treated with Qiangli Dingxuan Tablet on the basis of the control group. After 2 weeks of treatment, the improvement of vertigo(dizziness handicap inventory(DHI), dizziness handicap inventory(DHI)), the hemodynamic index(Basilar artery blood flow velocity(BA), left vertebroarterial artery(LVA), and the average blood flow velocity of right vertebroarterial artery(RVA)) and the changes in brain stem auditory evoked potential(BAEP) of two groups were observed. And statistical analysis was conducted for the clinical efficacy and adverse reactions during treatment of two groups. RESULTS: The total effective rate of the observation group was significantly higher than that of the control group(P < 0.05). The DHI and DARS scores of the two groups were significantly lower than those before treatment(P < 0.05), and the degree of reduction was more obvious in the observation group(P < 0.05). The levels of BA, LVA and RVA in the two groups were significantly higher than those before treatment(P < 0.05), and the levels of BA, LVA and RVA in the observation group were significantly higher than those in the control group(P < 0.05). The indexes of BAEP latency I, II, III and indexes of BAEP peak latency I-III, III-V, IV were obviously lower than those before treatment(P < 0.05). Besides, the decrease of BAEP index in the observation group was significantly lower than that in the control group(P < 0.05). No adverse reactions occurred during the treatment of the two groups. CONCLUSION: Qiangli Dingxuan Tablet is able to significantly improve the cerebral hemodynamics and brainstem auditory evoked potentials of patients with PCIV, and quickly relieve vertigo. It is safe and reliable and worthy of clinical application.

RELATIONS OF INTRACRANIAL PRESSURE, CREATINE KINASE AND BRAINSTEM AUDITORY EVOKED POTENTIAL IN PATIENTS WITH TRAUMATIC BRAIN EDEMA

We studied the relations of intracranial pressure (ICP),creatine kinase (CK) and bralnstem auditory evoked potential (BAEP) in 44 patients with traumatic brain edema who were admitted to our hospital from June 1990 to February 1991. There were 30 males and 14 females, with age range from 9 to 67 years. The results showed that the abnormal BAEP could reflect the severity of cerebral edema in acute head injury and was related to ICP and serum CK levels. When ICP>30 mmHg (4kPa), the abnormality of BAEP was more obvious than that of the control group (P<0.05); the serum CK levels were also elevated markedly. In patients with ICP over and below 4kPa, the rate of abnormal BAEP was 38.46% and 77.78% respectively (P<0.05). The serum CK level in the normal group or in the group with moderate abnormality of BAEP was significantly different from that in the group with severe abnormality or lack of BAEP (274.8± 98.24 U/L vs 705.3± 364.27 U/L; P<0.001). After treatment, the ICP returned to normal, and the BAEP norm

Brainstem auditory evoked potential combined with high resolution cranial base CT can optimize the diagnosis of auditory nerve injury

Purpose:Auditory nerve injury is one of the most common nerve injury complications of skull base fractures.However,there is currently a lack of auxiliary examination methods for its direct diagnosis.The purpose of this study was to find a more efficient and accurate means of diagnosis for auditory nerve injury.Methods:Through retrospectively analyzing the results of brainstem auditory evoked potential(BAEP)and high-resolution CT(HRCT)in 37 patients with hearing impairment following trauma from January 1,2018 to July 31,2020,the role of the two inspection methods in the diagnosis of auditory nerve injury was studied.Inclusion criteria were patient had a clear history of trauma and unilateral hearing impairment after trauma;while exclusion criteria were:(1)severe patient with a Glasgow coma scale score<5 because these patients were classified as severe head injury and admitted to the intensive care unit,(2)patient in the subacute stage admitted 72 h after trauma,and(3)patient with prior hearing impairment before trauma.According to Goodman's classification of hearing impairment,the patients were divided into low/medium/severe injury groups.In addition,patients were divided into HRCT-positive and negative groups for further investigation with their BAEP results.The positive rates of BEAP for each group were observed,and the results were analyzed by Chi-square test(p<0.05,regarded as statistical difference).Results:A total of 37 patients were included,including 21 males and 16 females.All of them were hospitalized patients with GCS score of 6-15 at the time of admission.The BAEP positive rate in the medium and severe injury group was 100%,which was significantly higher than that in the low injury group(27.27%)(p<0.01).The rate of BEAP positivity was significantly higher in the HRCT-positive group(20/30,66.7%)than in the HRCT-negative group(1/7,14.3%)(p<0.05).Twenty patients(54.05%)were both positive for BEAP and HRCT test,and considered to have auditory nerve damage.Six patients(16.22%)were both negative for BEAP and HRCT test,and 10 patients(27.03%)were BAEP-negative but HRCT-positive:all the 16 patients were considered as non-neurological injury.The rest 1 case(2.70%)was BAEP-positive but HRCT-negative,which we speculate may have auditory nerve concussion.Conclusion:By way of BAEP combining with skull base HRCT,we may improve the accuracy of the diagnosis of auditory nerve injury.Such a diagnostic strategy may be beneficial to guiding treatment plans and evaluating prognosis.

柴胡疏肝散对原发性抑郁症患者BAEP、VEP的影响

目的:观察柴胡疏肝散对原发性抑郁症患者脑干听觉诱发电位(BAEP)和视觉诱发电位(VEP)的影响。方法:将100例原发性抑郁症患者随机分为中药组、西药组,分别给予中药柴胡疏肝散和盐酸帕罗西汀治疗,采用脑诱发电位仪,记录治疗前后BAEP和VEP。结果:两组经治疗后,BAEP的I、V波治疗前后无明显改变(P>0.05),Ⅲ波潜伏期较治疗前明显缩短(P<0.05),VEP各波潜伏期均显著缩短(P<0.05);治疗后两组BAEP、VEP相比无统计学差异(P>0.05)。结论:柴胡疏肝散可缩短原发性抑郁症患者BAEP和VEP的潜伏期,减轻患者临床症状,具有应用价值。

家兔椎基底动脉供血不足动物模型的BAEP变化

目的 为了探讨家兔椎基底动脉缺血后的脑干听觉诱发电位 (brainstem auditory evoked poten-tials,BAEP)变化及其在临床工作中的意义。方法 通过结扎家兔单侧椎动脉从而造成脑干缺血 ,并连续记录结扎后一小时内的 BAEP的变化过程。结果 、 、 潜伏期逐渐延长 ,以 波延长最明显 , ～ 、 ～ 、 ～ 峰间期均明显延长 , 波、 波波幅改变无统计意义。结论 本实验表明在椎基底动脉供血不全时 BAEP有显著异常 ,可作为椎基底动脉梗死溶栓治疗后脑干功能变化的观察指标。

闭合性颅脑损伤后大鼠BAEP及脑损伤的动态变化

目的观察大鼠闭合性弥漫性颅脑损伤后脑干听觉诱发电位(BAEP)的动态改变及脑组织病理学变化,探讨BAEP在颅脑损伤后评估听觉功能障碍的价值。方法使用自制弹簧式小型生物打击机打击大鼠颅顶部,制造闭合性弥漫性轻型颅脑损伤模型。观察对照组以及伤后15min和1,3,6,12h及1,2,4,7,10,14,21d等时间点大鼠脑组织病理学改变,干/湿法检测脑组织含水量。分别于伤前、伤后各时间点以50Hz刺激率记录大鼠BAEP,对其结果进行比较。结果损伤后15min,BAEP的Ⅰ～Ⅴ、Ⅲ～ⅤIPL即较损伤前延长(P<0.05),至6～12h,Ⅲ、ⅤPL较损伤前延长。损伤后1～2d,Ⅲ、ⅤPL和Ⅰ～Ⅲ、Ⅰ～Ⅴ、Ⅲ～ⅤIPL均较损伤前显著延长(P<0.001),14d后BAEP逐渐恢复正常。伤后15min脑组织含水量开始升高,伤后1d达高峰,持续至4d后逐渐下降,至10d后降至正常水平。结论BAEP可作为闭合性弥漫性轻型颅脑损伤后听觉功能障碍的客观评价指标。

实验性脑室出血BAEP的改变及其病理基础

本实验系采用侧脑室恒压(5.2kPa)注血建立兔脑室出血动物模型来研究BAEP在各个时期的变化,并探讨其变化的病理基础。结果显示:注血后BAEPⅠ、Ⅲ、Ⅴ波PL及Ⅰ-Ⅲ,Ⅲ-Ⅴ波IPL在3小时内可以正常或轻度缩短,而后随时间逐渐延长,12小时后,Ⅰ、Ⅲ、Ⅴ波PL及Ⅰ-Ⅱ,Ⅲ-Ⅴ波IPL进一步延长,波幅逐渐降低,Ⅴ至Ⅰ波先后消失。其延长的可能机制:①髓鞘周期线分离;②神经细胞内外Na^+,K^+浓度差下降;③神经递质含量减少。

针刺对椎-基底动脉供血不足患者TCD和BAEP的影响

目的:探讨针刺治疗椎-基底动脉供血不足(VBI)的作用机理。方法:将40例VBI患者分为针刺组20例和常规组20例,另设正常对照组30例。针刺组在常规治疗的基础上加用针刺治疗,治疗前及治疗2w后检查多普勒(TCD)及脑干听觉诱发电位(BAEP),观察针刺对VBI患者血流速度及脑电生理的影响。结果:治疗前VBI患者双侧椎动脉及基底动脉峰速度明显低于对照组,TCD异常率为75.0%;BAEP异常率为70.0%,以脑干型异常为主。治疗后两组推动脉及基底动脉峰速度均有改善,TCD异常率为47.5%;治疗后BAEP异常率为45.0%,神经传导功能有明显改善,与常规组相比,针刺组Ⅴ波峰潜伏期、Ⅲ-Ⅴ和Ⅰ-Ⅴ峰间潜伏期改善更显著(P<0.05)。结论:针刺治疗可改善VBI患者的椎-基底动脉血流速度及脑干神经传导功能。

听神经瘤术中面部肌肉肌电图及BAEP的监测与面听神经功能保留:400例临床研究

目的总结听神经瘤术中监测面部肌肉自发与诱发肌电图和脑干听觉诱发电位(BAEP)的经验,分析术中面、听神经解剖功能保留的方法及影响因素。方法使用美国Nicolet公司生产的Viking-IV型和Axon公司的EpochXP型多导术中监测仪,对收治的400例听神经瘤患者进行了术中监测面部肌肉自发与诱发肌电图和BAEP。手术切除肿瘤,术后对患者进行面、听神经功能评估。结果肿瘤全切388例(97.70%),次全切9例,死亡3例。本组病人面神经解剖保留率为95.97%,功能保留率为91.94%。术后主要并发症包括完全性永久性面瘫11例,面部麻木23例,角膜溃疡18例,耳鸣29例,后经颅神经瘫痪28例,轻偏瘫3例,听力完全丧失139例。结论通过面部肌肉肌电图及BAEP的监测,可以准确判断颅神经的位置,最大程度避免颅神经的损伤。术中面部肌肉自发与诱发肌电图和BAEP监测,对听神经瘤外科手术的安全性提供了一定的保障,减少了手术的风险,使用得当可降低手术的致残率,应该成为听神经瘤手术的常规工作。

BAEP检测在脑震荡法医学鉴定中的应用

目的观察脑震荡伤者脑干听觉诱发电位(brainstem auditory evoked potential,BAEP)的变化。方法对19例脑震荡伤者进行BAEP检测,并与文献报道的正常人的异常率进行比较。结果脑震荡伤者BAEP的异常率为89.5%,明显高于正常对照组(P<0.05)。其中脑干段电反应异常率达73.7%,提示脑震荡伤者存在脑干功能障碍。结论BAEP对脑震荡损伤的认定有一定的价值。

397例听神经瘤听力特征分析

目的 分析听神经瘤患者听力学特征,为筛查听神经瘤提供参考依据。方法 回顾性分析2019年8月—2022年4月诊治的397例单侧听神经瘤患者临床资料,所有患者均行纯音测听、声导抗测试、言语识别率(SDS)、畸变产物耳声发射(DPOAE)、听性脑干诱发电位(ABR)和颅脑增强MRI。结果 以典型症状就诊者312例,非典型症状就诊者85例。以突发性聋就诊者25例;患耳听力正常者54例,包含大型甚至特大型肿瘤,99例全聋者亦包含内听道和中型肿瘤。5例全聋者言语识别能力未完全消失。DPOAE一致型245例,耳蜗型72例,蜗后型79例。ABR阳性率98.0%(389/397),8例ABR波形正常者中3例为双侧非对称听力损失。结论 非典型症状就诊者占比21.4%,以突发性聋就诊、听力正常或ABR正常者不能排除听神经瘤;DPOAE和ABR可作为筛查听神经瘤的重要检查方法。

糖尿病大鼠蜗神经核和上橄榄核形态变化与BAEP的关系

目的 研究糖尿病大鼠脑干听觉诱发电位 (brainstemauditoryevokedpotential,BAEP)和蜗神经核、上橄榄核形态学的变化。方法 采用腹腔注射链脲佐菌素诱导糖尿病大鼠模型 ,动态观测BAEP变化 ,并结合BAEP起源 ,应用光镜对脑干蜗神经核、上橄榄核进行形态学观察。结果 成模后 4周实验性糖尿病 (ED)组BAEP的Ⅰ、Ⅱ、Ⅳ、Ⅴ波PL和Ⅰ Ⅲ、Ⅲ Ⅴ延长(P <0 0 5 ) ,成模 6周 ,ED组BAEP各波PL、IPL均出现明显延长 (P <0 0 1)。成模 8周糖尿病大鼠出现脑干蜗神经核、上橄榄核神经元胞体萎缩、胞核内结构不清等表现 ,成模 10周后糖尿病大鼠上述核团神经元变性明显 ,并伴有神经元减少。结论 BAEP在糖尿病早期出现变化且早于中枢形态学变化 ,是临床早期诊断糖尿病中枢神经病变的客观灵敏指标。

BAEP与MRA在椎基底动系统TIA中的应用研究

目的:探讨脑干听觉诱发电位(BAEP)及磁共振血管成像(MRA)检查对椎基底动脉系统TIA的早期诊断价值。方法:对60例椎基底动脉系统TIA患者进行BAEP和MRA检查。BAEP异常患者治疗1周后复查,分析其前后变化。同时选取36例健康人行BAEP检查作对照。结果:治疗前患者组BAEP异常44例(73.3%),MRA异常35例(58.3%);治疗后患者组BAEP异常14例(23.3%)。对照组两项检查均正常。结论:BAEP、MRA对椎基底动脉系统TIA早期诊断具有重要价值,二者联合检测有助于缺血定位。

TSEP和BAEP监测在三叉神经痛微血管减压术中的应用价值

目的：探讨三叉神经痛微血管减压术（MVD）中联合应用三叉神经诱发电位（TSEP）、脑干听觉诱发电位（BAEP）监测的价值。方法：2007年2月至2009年11月我院采用MVD治疗58例三叉神经痛病人，以术中使用电生理监测的30例患者为试验组，未使用这两种电生理监测的28例患者为对照组，对比分析两组有效率（三叉神经痛症状缓解或消失）及眩晕、听力下降等并发症的发生率。结果：试验组术后有效率为93％（28例），发生眩晕1例（3％）和听力下降1例（3％）；对照组术后有效率为68％（19例），发生眩晕8例（29％）和听力下降9例（32％）。两组MVD治疗疗效差异及并发症发生率比较差异均有统计学意义（P〈0．05）。结论：三叉神经痛MVD中，联合应用TSEP和BAEP作术中监测能较好地控制并发症的发生及提高三叉神经MVD的治疗效果。

后循环梗死患者的BAEP、BR、TSEP检测

目的：探讨后循环脑梗死（PCI）患者脑干听觉诱发电位（BAEP）、瞬目反射（BR）、三叉神经诱发电位（TSEP）三种电生理变化。方法：选择60例经头颅MRI检查证实为PCI患者（病例组），分别于入院一周之内行BAEP、BR、TSEP检查，观察BAEP波形及I、Ⅲ、V波潜伏期（PL）、峰间期（IPL），计算BR既R1、R2、R2波平均PI。、波幅及TSEP各成分PL，并与40例健康体检者作对照。结果：病例组60例中BAEP异常35例（58％），异常主要表现为I、V波的PL、I—V波的IPL延长和I／V波幅比〉1。BR异常33例（55％），异常主要表现为R2波的PL延长，R2、R2’波幅下降。TSEP检查病例组与对照组PL比较未见明显差异。结论：BAEP、BR两种电生理检查方法能够较好地检测出PCI患者神经功能异常，联合应用BAEP及BR能够为PCI患者的神经功能的判断提供重要参考。

原发性脑干病变BAEP与CT、MRI对比研究

目的：探讨ＣＴ、ＭＲＩ、ＢＡＥＰ对脑干病变诊断的敏感性及ＢＡＥＰ与脑干病损严重程度和预后的关系。方法：对３２例脑干病变的患者同时进行了ＣＴ、ＭＲＩ及ＢＡＥＰ检查，并对患者进行格拉斯哥昏迷计分（ＧＣＳ）及神经功能缺损评分（ＳＳＳ）。根据ＢＡＥＰ异常情况分为３组：Ⅰ组：ＢＡＥＰ正常组；Ⅱ组：ＢＡＥＰ异常或双侧不对称，但各波存在；Ⅲ组：除Ⅰ波外，其余各波消失。病后３月对患者进行预后评价。结果：脑干病变ＣＴ阳性率５３１３％，ＭＲＩ阳性率９０６２％，ＢＡＥＰ阳性率３４３８％。ＭＲＩ及ＢＡＥＰ阳性率高于头颅ＣＴ，有显著性差异，Ｐ＜００５。Ⅰ组及Ⅱ组患者ＧＣＳ计分高于Ⅲ组，ＳＳＳ评分低于Ⅲ组。Ⅲ组患者全部预后不良，与Ⅰ组及Ⅱ组比较有显著差异，Ｐ＜００５。结论：对脑干病变ＭＲＩ和ＢＡＥＰ阳性率较高，若同时进行ＭＲＩ和ＢＡＥＰ检查达１００％；ＢＡＥＰ是判断脑干病变严重程度及预后较为可靠的指标。

脑干听觉诱发电位(BAEP)用于监测小儿全麻深度及觉醒的研究

目的:研究应用脑干听觉诱发电位（BAEP）作为监测小儿全麻深度与觉醒的客观指标。方法:选择非神经外科无听力障碍的择期手术患儿45例,ASAI～Ⅱ级,分别施行异丙酚、芬太尼静脉麻醉及异氟醚吸入全身麻醉,观察各波潜伏期（PL）和波间期（IPL）随时间推移及麻醉剂量变化之间的关系。结果:（1）异丙酚静脉麻醉和异氟醚吸入麻醉与剂量呈良好的正相关,即随着麻醉药的浓度（或剂量）的增高,BAEP各波PL及IPL逐渐延长,反之逐渐缩短。（2）I波的潜伏期特性对于控制麻醉深度极为重要。（3）V波监测麻醉具有最佳的稳定性及相关性。（4）停用麻醉药一段时间或患儿基本清醒时,BAEP各波PL和IPL有的仍高于正常值,这是滞后（延迟）反应。（5）BAEP对芬太尼术中的觉醒监测不太敏感,即相关性较差。结论:BAEP各波的潜伏期及峰间期变化,可判断小儿全身麻醉深度,在一定程度上可作为判断觉醒的参考,但应考虑有延迟反应的可能。

CTLA-4Ig对大鼠实验性自身免疫性脑脊髓炎的BAEP、SEP的影响

目的探索CTLA-4Ig转基因治疗实验性自身免疫性脑脊髓炎(experimentalautoimmuneencephalomyelitis,EAE)的疗效和安全性。方法用AdCTLA-4Ig注射到Wistar大鼠EAE模型侧脑室内,观察临床发病情况和电生理改变,以判断其疗效。结果EAE大鼠侧脑室注射AdCTLA-4Ig后,大鼠EAE发病时间延迟,发病率显著下降。且脑干听觉诱发电位和体感诱发电位反映的中枢传导功能显著改善。结论CTLA-4Ig对EAE有明显疗效。

新生儿缺氧缺血性脑病与BAEP

目的:了解新生儿缺氧缺血性脑病(HIE)急性期BAEP的变化及其意义。方法:对22例HIE患儿进行BAEP及头颅CT检查,并和20例正常对照组进行比较分析。结果:患儿组BAEP异常率77.3％,CT异常率81.8％,二者无显著差异(P>0.05),并且,BAEP异常以中枢型为主。结论:BAEP为HlE急性期观察脑功能变化的敏感指标。