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The Role of RNA Epitranscriptomics and the RNA Fat Mass and Obesity-Associated Demethylase in Triple Negative Breast Cancer
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作者 Emilija Sagaityte Richard S. Dowd +2 位作者 Kendall Lane Stephanie L. Graff Steven A. Toms 《Advances in Breast Cancer Research》 CAS 2023年第2期27-50,共24页
Breast cancer is one of the most commonly diagnosed cancers and one of the most significant sources of cancer mortality. Triple negative breast cancer (TNBC) is a particularly aggressive subtype that has proven diffic... Breast cancer is one of the most commonly diagnosed cancers and one of the most significant sources of cancer mortality. Triple negative breast cancer (TNBC) is a particularly aggressive subtype that has proven difficult to treat with standard chemotherapies. Obesity has also been shown to exacerbate breast cancer, and diagnoses of these two diseases frequently overlap. Both conditions are regulated in part by the fat mass and obesity-associated (FTO) demethylase, an RNA demethylase which may drive breast cancers through epigenetic alterations to gene expression. Methods of inhibiting FTO have been researched in vitro and in vivo as an alternative or adjunct to chemotherapies in multiple cancers, including breast cancer. Translating knowledge of the role of FTO in breast cancer and the development of novel agents may allow for improvements in the treatment of this refractory cancer. This review therefore aims to provide an overview of existing and developing chemical inhibitors of FTO that could be innovatively studied for the treatment of TNBC and associated comorbidity. 展开更多
关键词 breast cancer OBESITY Fat mass and Obesity-Associated CHEMOTHERAPY Ep-igenetics RNA
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Body Mass Index and Breast Cancer Risk: A Retrospective Multi-Institutional Analysis in Saudi Arabia 被引量:2
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作者 Volker Rudat Nuha Birido +1 位作者 Saleh Tuwaijri Mousa A. Al-Abbadi 《Advances in Breast Cancer Research》 2013年第1期7-10,共4页
Background: The purpose of this study was to evaluate the association between the body mass index (BMI) of breast cancer patients and non-cancer females of the Eastern Province of Saudi Arabia. Methods: The weight, he... Background: The purpose of this study was to evaluate the association between the body mass index (BMI) of breast cancer patients and non-cancer females of the Eastern Province of Saudi Arabia. Methods: The weight, height and age was obtained from the patient records of 706 newly diagnosed breast cancer patients and of 20,872 non-cancer female patients who consulted the two largest hospitals in the Eastern Province of Saudi Arabia between 2006 and 2012. Factorial analysis of variance (ANOVA) was used to assess the association between the BMI, age and breast cancer status. Results: The mean BMI of the non-cancer females was 29.4 and the percentage of obese patients of the different age groups ranged from 23.9% to 66.5%. The BMI increased significantly with age. The ANOVA revealed that breast cancer patients older than 50 years had a significantly lower BMI compared to their non-cancer counterparts (p = 0.01). Conclusion: Our data confirm the high BMI of the Saudi Arabian female population. The reason for our finding of a lower BMI of postmenopausal breast cancer patients compared to their non-cancer counterparts is unclear. Future studies are warranted to assess the impact of possible confounding factors on the association between obesity and breast cancer risk. An interesting factor to investigate in future studies would particularly be the use of the anti-diabetic and cancer-protective drug metformin considering that diabetes mellitus is endemic in Saudi Arabia with a prevalence of 30%. 展开更多
关键词 breast cancer Body mass Index ADOLESCENT FEMALE SAUDI ARABIA
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Analysis of Machine Learning Techniques Applied to the Classification of Masses and Microcalcification Clusters in Breast Cancer Computer-Aided Detection
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作者 Edén A. Alanís-Reyes José L. Hernández-Cruz +3 位作者 Jesús S. Cepeda Camila Castro Hugo Terashima-Marín Santiago E. Conant-Pablos 《Journal of Cancer Therapy》 2012年第6期1020-1028,共9页
Breast cancer is one of the most common and deadliest types of cancer among women and early detection is of major importance to decrease mortality rates. Microcalcification clusters and masses are two major indicators... Breast cancer is one of the most common and deadliest types of cancer among women and early detection is of major importance to decrease mortality rates. Microcalcification clusters and masses are two major indicators of malignancy in the early stages of this disease, when mammography is typically used as the screening technology. Computer-Aided Diagnosis (CAD) systems can support the radiologists’ work, by performing a double-reading process, which provides a second opinion that the physician can take into account in the detection process. This paper presents a CAD model based on computer vision procedures for locating suspicious regions that are later analyzed by artificial neural networks, support vector machines and linear discriminant analysis, to classify them into benign or malignant, based on a set of features that are extracted from lesions to characterize their visual content. A genetic algorithm is used to find the subset of features that provide the greatest discriminant power. Our results show that the SVM presented the highest overall accuracy and specificity for classifying microcalcification clusters, while the NN outperformed the rest for mass-classification in the same parameters. Overall accuracy, sensitivity and specificity were measured. 展开更多
关键词 Computer-Aided DIAGNOSIS breast cancer Detection breast cancer DIAGNOSIS mass-Segmentation CALCIFICATION SEGMENTATION Digital Mammography
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Novel Approach for Quantitative Measurement of Matrix Metalloprotease-1 (MMP1) in Human Breast Cancer Cells Using Mass Spectrometry
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作者 Ming Fa Kathleen Hoch +3 位作者 Xuejun Fan William P. Dubinsky Zhiqiang An Ningyan Zhang 《Journal of Analytical Sciences, Methods and Instrumentation》 2013年第1期54-61,共8页
Identification and quantification of low abundance growth factors and regulators in complex biological samples still present a challenging task in analytical biochemistry. Immunoassays are often used for such purpose ... Identification and quantification of low abundance growth factors and regulators in complex biological samples still present a challenging task in analytical biochemistry. Immunoassays are often used for such purpose but immunoassays face limitation of both availability and qualities of antibody reagents that are necessary for development of immune assays. With genomics data base available, mass spectrometry (MS) can analyze protein tryptic peptides directly for quantitative determination of proteins. In this study, we report a method for detection of matrix metalloproteinase 1 (MMP1), an important extracellular matrix modulator, in human breast cancer cells by quadrupole time-of-flight (Q-TOF) MS. Absolute quantification of MMP1 was conducted using the selected reaction monitoring (SRM) on a triple quadrupole (Triple-Quad) MS via transitions selected from MMP1 tryptic peptides using non isotope labeled MMP1 protein as a titration standard. In comparison with immune based assay, this MS method showed picogram level sensitivity for quantitative determination of MMP1 intotal cell lysates. Our results demonstrated the feasibility of absolute quantification of low abundance proteins using label-free protein standard by mass spectrometry. Therefore, this method provides not only advantages of high sensitivity but also cost saving in comparison with the commonly used mass spectrometry that currently employs isotype labeled proteins for quantitative analysis. 展开更多
关键词 Matrix Metalloprotease-1 (MMP1) SKBR3 breast cancer Cells mass SPECTROMETRY Selected Reaction Monitoring ABSOLUTE Quantification
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The Effect of Body Mass Index on Survival in Breast Cancer
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作者 Aiat Morsy Samir Shehata 《Journal of Cancer Therapy》 2019年第12期883-894,共12页
Background: Obesity is a well-known risk factor for breast cancer recurrence and poor prognosis. The objective of this study was to evaluate the effect of body mass index (BMI) on survival in breast cancer patients. M... Background: Obesity is a well-known risk factor for breast cancer recurrence and poor prognosis. The objective of this study was to evaluate the effect of body mass index (BMI) on survival in breast cancer patients. Methods: We performed a retrospective analysis of 50 breast cancer patients treated in our hospital from January 2012 to December 2013. Patients were divided according to body mass index when diagnosed into: normal weight BMI 25 Kg/m2, over weight BMI ≥ 25 Kg/m2 to 2, obesity BMI ≥ 30 Kg/m2. In this study the effect of body mass index on progression free survival (PFS) and overall survival (OS) was evaluated. Results: The disease free survival (DFS) and overall survival (OS) decreased in overweight and obese patients. Both overweight and obesity were predictors for increased risks of breast cancer relapse and mortality with a median disease free survival for overweight 29 mons and obese patients 11 mons and a median overall survival for overweight patients 49 mons and obese patients 39 mons. Conclusion: Obesity and overweight are associated with poorer disease free survival and overall survival in patients with breast cancer. 展开更多
关键词 Body mass Index breast cancer OBESITY OVERWEIGHT RELAPSE MORTALITY
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Increased Cellular Invasion and Proliferation via Estrogen Receptor after 17-<i>β</i>-Estradiol Treatment in Breast Cancer Cells Using Stable Isotopic Labeling with Amino Acids in Cell Culture (SILAC) 被引量:1
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作者 Alimatou M. Tchafa Zhijiu Zhong +2 位作者 Rong Meng Judy N. Quong Andrew A. Quong 《Advances in Breast Cancer Research》 2013年第2期32-43,共12页
17-β-estradiol (estrogen) is a steroid hormone important to human development;however, high levels of this molecule are associated with increased risk of breast cancer primarily due to estrogen’s ability to bind and... 17-β-estradiol (estrogen) is a steroid hormone important to human development;however, high levels of this molecule are associated with increased risk of breast cancer primarily due to estrogen’s ability to bind and activate the estrogen receptor (ER) and initiate gene transcription. Currently, estrogen mechanisms of action are classified as genomic and non-genomic and occur in an ER-dependent and ER-independent manner. In this study, we examine estrogen signaling pathways, by measuring changes in protein expression as a function of time of exposure to estrogen in both ER-positive (MCF-7) and ER-negative (MDA-MB-231) cell lines. Using a robust experimental design utilizing isotopic labeling, two-dimensional LC-MS, and bioinformatics analysis, we report genomic and non-genomic ER regulated estrogen responsive proteins. We find a little over 200 proteins differentially expressed after estrogen treatment. Cell proliferation, transcription, actin filament capping and cell to cell signaling are significantly enriched in the MCF-7 cell line alone. Translational elongation and proteolysis are enriched in both cell lines. Subsets of the proteins presented in this study are for the first time directly associated with estrogen signaling in mammary carcinoma cells. We find that estrogen affected the expression of proteins involved in numerous processes that are related to tumorigenesis such as increased cellular division and invasion in an ER-dependent manner. Moreover, we identified negative regulation of apoptosis as a non-genomic process of estrogen. This study complements gene expression studies and highlights the need for both genomic and proteomic analyses in unraveling the complex mechanisms by which estrogen affects progression of breast cancer. 展开更多
关键词 17-Β-ESTRADIOL breast cancer Estrogen Receptor mass Spectrometry SILAC
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THE CLINICAL SIGNIFICANCE OF ^(99m)Tc-MIBI BREAST IMAGING IN THE DIAGNOSIS OF EARLY BREAST CANCER
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作者 任长才 金少津 +3 位作者 邹强 朱汇庆 王红鹰 梁春立 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2001年第2期128-131,共4页
Objective: To find an effective, sensitive, specific and noninvasive diagnostic method of breast cancer. Methods: 109 masses of 102 patients with breast lesions smaller than 2 cm in diameter were divided into three gr... Objective: To find an effective, sensitive, specific and noninvasive diagnostic method of breast cancer. Methods: 109 masses of 102 patients with breast lesions smaller than 2 cm in diameter were divided into three groups to undergo 99mTc-MIBI imaging and compared with the results of pathology examination. 20 cases without breast lesions were selected as control. Abnormal condensation of 99mTc-MIBI in the breast reaching 10% higher than that in the counterpart of the healthy breast was regarded as positive. Results: Of 32 breast cancers, positive imaging appeared in 25. Negative imaging were found in 31 of 38 benign breast lesions. Of 39 occult breast lesions, positive imaging appeared in 6 and 3 of them were breast cancer, 2 of 3 patients with slightly increased 99mTc-MIBI imaging threshold were breast cancer also. No positive imaging was found in the control group. The diagnostic accuracy, sensitivity, specificity, positive predictive value, negative predictive value of 99mTc-MIBI was 88.4%, 89.2%, 88.0%, 75.0% and 95.3%, respectively. Conclusion: 99mTc-MIBI imaging had higher sensitivity and accuracy in the diagnosis of breast cancer and differentiation between benign and malignant breast lesions. It could provide useful information for the diagnosis of clinically suspected breast cancer. 展开更多
关键词 breast mass 99MTC-MIBI breast imaging breast cancer
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GZMB在乳腺癌和乳腺良性肿物患者中的表达及与T淋巴细胞水平的关系研究
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作者 杨卫 李媛媛 +1 位作者 张丽柯 徐全晓 《黑龙江医药科学》 2024年第2期56-59,共4页
目的:探讨颗粒酶B(granzyme B,GZMB)在乳腺癌和乳腺良性肿物患者中的表达及与T淋巴细胞水平的关系。方法:选取2022年1月至2023年8月南阳市第一人民医院收治的乳腺癌患者63例为观察组,根据肿瘤分期分为T_(1)N_(0)M_(0)组、T_(2)N_(0)M_(0... 目的:探讨颗粒酶B(granzyme B,GZMB)在乳腺癌和乳腺良性肿物患者中的表达及与T淋巴细胞水平的关系。方法:选取2022年1月至2023年8月南阳市第一人民医院收治的乳腺癌患者63例为观察组,根据肿瘤分期分为T_(1)N_(0)M_(0)组、T_(2)N_(0)M_(0)组、T_(2)N_(1)M_(0)组、T_(3)N_(0)M_(0)组及T_(3)N_(1)M_(0)组;选择同期治疗的乳腺良性肿物患者9例为对照组;采用流式细胞仪测定各组GZMB及T淋巴细胞水平;对乳腺癌患者GZMB与T淋巴细胞参数完成相关性分析。结果:观察组乳腺癌患者GZMB水平高于对照组(P<0.05);CD_(3)^(+)、CD_(4)^(+)及CD_(4)^(+)/CD_(8)^(+)水平低于对照组(P<0.05);乳腺癌不同分期下CD_(8)^(+)水平无统计差异(P>0.05);乳腺癌患者中T_(3)N_(1)M_(0)组GZMB水平高于其余4组(P<0.05),CD_(3)^(+)、CD_(4)^(+)及CD_(4)^(+)/CD_(8)^(+)水平低于其余4组(P<0.05);乳腺癌患者分期越高,GZMB水平越高,CD_(3)^(+)、CD_(4)^(+)及CD_(4)^(+)/CD_(8)^(+)水平越低;Pearson相关性结果表明,乳腺癌患者GZMB水平与CD_(3)^(+)、CD_(4)^(+)及CD_(4)^(+)/CD_(8)^(+)水平呈负相关(P<0.05)。结论:GZMB在乳腺癌患者中呈高表达,其表达水平在不同分期中存在差异,且与T淋巴细胞水平存在相关性,可指导临床诊疗。 展开更多
关键词 颗粒酶B 乳腺癌 乳腺良性肿物 T淋巴细胞水平 相关性 流式细胞仪
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分子分型在肿块型及非肿块型乳腺癌中的差异及其与X线征像关系研究 被引量:2
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作者 张文婷 姚远 周炜根 《全科医学临床与教育》 2024年第2期117-122,共6页
目的 探讨肿块型及非肿块型乳腺癌的临床及分子分型差异、X线征象与分子分型的关系。方法 纳入372例乳腺X线表现为肿块型或非肿块型并经病理证实为乳腺癌的女性患者的临床、病理及影像资料,其中肿块型共210例,非肿块型共162例,回顾分析... 目的 探讨肿块型及非肿块型乳腺癌的临床及分子分型差异、X线征象与分子分型的关系。方法 纳入372例乳腺X线表现为肿块型或非肿块型并经病理证实为乳腺癌的女性患者的临床、病理及影像资料,其中肿块型共210例,非肿块型共162例,回顾分析两组临床及分子分型差异及不同分子分型乳腺癌X线征象差异。结果非肿块型病灶发生于相对低龄者,非浸润性癌占比高;肿块型患者相对高龄,以浸润性癌占比更高。Luminal B型多见于肿块型,Luminal HER-2型多见于非肿块型。不同分子分型的肿块型乳腺癌的影像特征如肿块是否伴随不对称及非肿块型乳腺癌的影像特征如结构扭曲、钙化等征象发生率、钙化形态等差异有统计学意义(P均<0.05)。结论 肿块型及非肿块型乳腺癌临床、病理特征及分子分型不同,部分X线征象与肿瘤分子分型有关,对治疗方案选择、预后判断等有一定价值。 展开更多
关键词 肿块型乳腺癌 非肿块型乳腺癌 乳腺X线摄影 免疫组织化学 乳腺癌分子分型
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南疆地区女性BMI与乳腺癌临床特征、分子分型的相关性研究
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作者 耿永勇 尹颜新 +5 位作者 赖国威 赵丹 郑锐年 李坊铭 尚玉芝 杨晓燕 《临床医学研究与实践》 2024年第26期38-41,共4页
目的探讨南疆地区女性体质指数(BMI)与乳腺癌临床特征、分子分型的相关性。方法回顾性选取2020年1月至2022年12月在新疆生产建设兵团第三师总医院进行治疗的165例女性乳腺癌患者为研究对象,依据住院时的BMI将其分为消瘦组(BMI<18.5 k... 目的探讨南疆地区女性体质指数(BMI)与乳腺癌临床特征、分子分型的相关性。方法回顾性选取2020年1月至2022年12月在新疆生产建设兵团第三师总医院进行治疗的165例女性乳腺癌患者为研究对象,依据住院时的BMI将其分为消瘦组(BMI<18.5 kg/m2)、正常组(BMI 18.5~23.9 kg/m2)、超重组(BMI24.0~27.9 kg/m2)以及肥胖组(BMI≥28.0 kg/m2)。比较四组患者的一般资料、病理特征以及主要分子分型。结果四组患者的高血脂、绝经状态比较,差异具有统计学意义(P<0.05)。四组患者的淋巴结转移情况比较,差异具有统计学意义(P<0.05)。四组患者的人表皮生长因子受体-2(HER-2)阳性占比比较,差异具有统计学意义(P<0.05)。结论南疆地区女性BMI与乳腺癌患者的高血脂、绝经状态、淋巴结转移以及HER-2阳性有关。 展开更多
关键词 南疆地区 乳腺癌 体质指数 淋巴结转移 分子分型
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浸润性乳腺癌患者非肿块强化和肿块强化的动态增强MRI特征分析
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作者 程世德 吴海峰 +2 位作者 钱超鹏 潘鑫 赵红 《医学影像学杂志》 2024年第3期53-56,共4页
目的探讨分析动态增强MRI特征为非肿块强化和肿块强化的浸润性乳腺癌患者影像特征。方法选取浸润性乳腺癌患者55例,行乳腺动态增强MRI检查显示为非肿块强化和肿块强化患者,分别作为观察组和对照组均经手术或病理活检证实,评估两组表观... 目的探讨分析动态增强MRI特征为非肿块强化和肿块强化的浸润性乳腺癌患者影像特征。方法选取浸润性乳腺癌患者55例,行乳腺动态增强MRI检查显示为非肿块强化和肿块强化患者,分别作为观察组和对照组均经手术或病理活检证实,评估两组表观扩散系数(ADC)值、早期强化率、肿块边界清晰、增强平台类型,病灶大小、雌激素受体(ER)、人表皮生长因子受体-2(HER-2)阳性、T分期、N分期结果。结果观察组表观扩散系数(ADC)值为(1.29±0.20)×10^(-3) mm^(2)/s,高于对照组(0.89±0.18)×10^(-3) mm^(2)/s,差异具有统计学意义(P<0.05),观察组肿块边界不清晰发生率为80.52%,高于对照组20.59%,差异具有统计学意义(P<0.05),观察组病灶体积为(25.50±4.21)cm^(3),高于对照组(16.65±3.92)cm^(3),差异具有统计学意义(P<0.05),观察组HER-2阳性率为76.19%,高于对照组26.47%,两组T分期、N分期比较,差异具有统计学意义(P<0.05)。结论对非肿块强化和肿块强化浸润性乳腺癌患者,动态增强MRI通过多参数、多方位成像进行鉴别,非肿块强化病灶ADC值、边界不清晰发生率及ER、HER-2阳性率表现为增高。 展开更多
关键词 浸润性乳腺癌 肿块 非肿块 磁共振成像
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曲妥珠单抗新辅助化疗治疗HER-2阳性乳腺癌中体重指数与病理完全缓解的关系
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作者 谢炉峰 缪继东 +2 位作者 蒋朝阳 李家伟 冯江 《河北医药》 CAS 2024年第15期2286-2290,共5页
目的 分析体重指数(BMI)与人表皮生长因子受体2(HER-2)阳性乳腺癌曲妥珠单抗新辅助化疗病理完全缓解(pCR)的关系。方法 收集2018年5月至2022年6月曲妥珠单抗新辅助治疗HER-2阳性乳腺癌患者136例临床资料,分析不同BMI的HER-2阳性乳腺癌... 目的 分析体重指数(BMI)与人表皮生长因子受体2(HER-2)阳性乳腺癌曲妥珠单抗新辅助化疗病理完全缓解(pCR)的关系。方法 收集2018年5月至2022年6月曲妥珠单抗新辅助治疗HER-2阳性乳腺癌患者136例临床资料,分析不同BMI的HER-2阳性乳腺癌临床病理特征,采用单因素及多因素Logistic分析BMI与pCR的关系。结果 136例HER-2阳性乳腺癌患者中,获得pCR 43例(31.62%)。BMI≥24组T分期(Ⅲ~Ⅳ期)、孕激素受体(PR)(阳性)、细胞核增殖抗原(Ki-67)(≥14)、淋巴结转移(阳性)高于BMI<24组(P<0.05)。pCR组与非pCR组年龄、月经状态、Ki-67比较(P>0.05);pCR组T分期(Ⅲ~Ⅳ期)、ER(阴性)、PR(阴性)、淋巴结转移(阳性)、BMI(≥24)低于非pCR组(P<0.05)。孕激素受体(PR)、淋巴结转移、BMI是影响ER-2阳性乳腺癌pCR的危险因素(P<0.05)。结论 曲妥珠单抗新辅助化疗治疗HER-2阳性乳腺癌pCR与PR、淋巴结转移、BMI明显相关,结合BMI与HER-2阳性乳腺癌临床病理特征的关系,BMI是HER-2阳性乳腺癌曲妥珠单抗新辅助化疗pCR的独立危险因素。 展开更多
关键词 HER-2阳性乳腺癌 曲妥珠单抗 新辅助化疗 体重指数 病理完全缓解
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基于多模态超声影像组学构建乳腺良恶性病变的预测模型
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作者 王晓梅 李俏然 +2 位作者 李雪莉 郑慧 陶鹏 《医学影像学杂志》 2024年第9期55-57,61,共4页
目的探讨基于多模态超声影像组学构建乳腺良恶性病变的预测模型实现乳腺病变术前评估。方法选取78例乳腺X线摄影和乳腺影像报告与数据系统(BI-RADS)4类乳腺肿块型病变患者,以手术病理结果为金标准,将患者分别纳入恶性组和良性组,均接受... 目的探讨基于多模态超声影像组学构建乳腺良恶性病变的预测模型实现乳腺病变术前评估。方法选取78例乳腺X线摄影和乳腺影像报告与数据系统(BI-RADS)4类乳腺肿块型病变患者,以手术病理结果为金标准,将患者分别纳入恶性组和良性组,均接受多模态超声检查,比较两组患者CDFI、SWE参数。结果78例乳腺肿块型病变患者中乳腺癌共52例,占比66.67%;乳腺纤维腺瘤26例,占比33.33%。CDFI检查结果显示,恶性组PSV、PI均高于良性组,差异有统计学意义(P<0.05)。SWE检查结果显示恶性组E_(max)、E_(mean)均大于良性组,差异有统计学意义(P<0.05)。ROC曲线显示PSV、RI、E_(max)、E_(mean)单独及联合检查预测乳腺肿块型病变良恶性的AUC值均≥0.70,且联合检查的预测价值更高(Z=2.102、2.841、2.770、1.984,P=0.018、0.002、0.003、0.024)。结论基于乳腺肿块型病变PSV、RI、E_(max)、E_(mean)的多模态超声影像组学模型,可用于鉴别乳腺良恶性病变。 展开更多
关键词 乳腺肿块 乳腺癌 多模态超声检查 影像组学 预测模型
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高频超声引导下粗针穿刺活检及肿瘤标志物检测在乳腺肿块良恶性鉴别诊断中的价值研究 被引量:1
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作者 沈勤红 《中国现代药物应用》 2024年第5期68-71,共4页
目的 探讨高频超声引导下粗针穿刺活检及肿瘤标志物检测在乳腺肿块良恶性鉴别诊断中的价值。方法 选择140例乳腺肿块患者作为研究对象,经手术术后病理检查确诊乳腺癌72例、乳腺良性病变68例,所有患者术前均接受高频超声检查、高频超声... 目的 探讨高频超声引导下粗针穿刺活检及肿瘤标志物检测在乳腺肿块良恶性鉴别诊断中的价值。方法 选择140例乳腺肿块患者作为研究对象,经手术术后病理检查确诊乳腺癌72例、乳腺良性病变68例,所有患者术前均接受高频超声检查、高频超声引导下粗针穿刺活检及肿瘤标志物[癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原125(CA125)]检测。比较不同检查方法 (高频超声、高频超声引导下粗针穿刺活检)对乳腺癌的诊断效能,乳腺癌和乳腺良性病变患者的肿瘤标志物(CEA、CA199、CA125)水平,不同高频超声引导下粗针穿刺活检结果患者的超声表现特征及肿瘤标志物水平。结果 高频超声引导下粗针穿刺活检将4例乳腺癌误诊为乳腺良性病变,将1例乳腺纤维瘤和2例纤维样囊肿误诊为乳腺癌。高频超声引导下粗针穿刺活检诊断乳腺癌的灵敏度、特异度及准确率分别为94.44%、95.59%、95.00%,均明显高于高频超声的68.06%、79.41%、73.57%(P<0.05)。乳腺癌患者CEA、CA199、CA125水平分别为(4.55±1.22)ng/ml、(31.86±9.56)U/ml、(26.12±6.18)U/ml,均明显高于乳腺良性病变患者的(1.68±0.52)ng/ml、(12.10±4.33)U/ml、(11.54±4.83)U/ml(P<0.05)。高频超声引导下粗针穿刺活检良性与恶性患者的肿块最大直径、形态、边界、内部回声、淋巴结肿大、钙化、血流信号等超声特征比较差异有统计学意义(P<0.05)。高频超声引导下粗针穿刺活检良性患者的CEA、CA199、CA125水平分别为(1.74±0.55)ng/ml、(12.43±4.40)U/ml、(11.62±4.88)U/ml,均低于恶性患者的(4.53±1.26)ng/ml、(31.88±9.68)U/ml、(26.25±6.20)U/ml(P<0.05)。结论 高频超声引导下粗针穿刺活检能够较好的鉴别诊断乳腺癌与乳腺良性病变,其诊断效能明显优于单纯高频超声,穿刺活检结果与肿瘤标志物、超声表现特征存在明显关系,能够为乳腺肿块治疗提供指导依据。 展开更多
关键词 超声引导下粗针穿刺活检 乳腺肿块 乳腺癌 乳腺良性病变 肿瘤标志物
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MRI预测乳腺肿块良恶性的研究进展
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作者 胡朝(综述) 罗光华(审校) 《现代医药卫生》 2024年第8期1383-1386,1392,共5页
随着医疗水平的进步,乳腺疾病的检出率越来越高,特别是乳腺肿块。早期对肿块良恶性进行精准预测,不仅可以提高患者生存率,而且可以降低治疗成本。随着动态对比增强磁共振成像、扩散加权成像和磁共振光谱等各种技术的出现,早期预测乳腺... 随着医疗水平的进步,乳腺疾病的检出率越来越高,特别是乳腺肿块。早期对肿块良恶性进行精准预测,不仅可以提高患者生存率,而且可以降低治疗成本。随着动态对比增强磁共振成像、扩散加权成像和磁共振光谱等各种技术的出现,早期预测乳腺肿块良恶性成为可能。该文主要对磁共振成像预测乳腺肿块良恶性的研究进展进行综述。 展开更多
关键词 乳腺肿块 乳腺癌 磁共振成像 超快速动态增强 磁共振波谱 影像组学
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乳腺癌术后调强放疗患者体质情况与摆位误差的关系研究
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作者 姜玉玲 成俊 周春 《中国肿瘤外科杂志》 CAS 2024年第3期276-280,共5页
目的探讨乳腺癌术后调强放疗患者体质量指数(BMI)、胸围、乳腺体积与摆位误差的关系。方法选取2019年1月至2022年10月在南通市第三人民医院接受调强放疗的乳腺癌患者63例,比较不同BMI、胸围、乳腺体积等患者摆位误差差异。结果63例乳腺... 目的探讨乳腺癌术后调强放疗患者体质量指数(BMI)、胸围、乳腺体积与摆位误差的关系。方法选取2019年1月至2022年10月在南通市第三人民医院接受调强放疗的乳腺癌患者63例,比较不同BMI、胸围、乳腺体积等患者摆位误差差异。结果63例乳腺癌患者中,左右方向(X轴)摆位误差为(2.61±0.72)mm,头脚方向(Y轴)摆位误差为(2.84±0.80)mm,前后方向(Z轴)摆位误差为(2.89±0.78)mm。随着BMI增加,X轴、Y轴和Z轴摆位误差逐渐增加(P<0.05),其中BMI≥24.0 kg/m^(2)患者X轴、Y轴和Z轴摆位误差分别为(3.13±0.53)mm、(3.60±0.63)mm和(3.88±0.66)mm,明显高于BMI<18.5 kg/m^(2)和18.5~23.9 kg/m^(2)患者(P<0.05)。胸围≥89 cm患者X轴和Y轴摆位误差分别为(2.84±0.52)mm和(3.07±0.56)mm,明显高于胸围<89 cm患者。随着乳腺体积增加,X轴摆位误差逐渐增加(P<0.05),其中乳腺体积>800 cm^(3)患者X轴摆位误差为(3.16±0.68)mm,明显高于乳腺体积<500 cm^(3)和500~800 cm^(3)患者(P<0.05)。不同年龄患者X轴、Y轴和Z轴摆位误差比较差异无统计学意义(P>0.05)。结论乳腺癌术后调强放疗摆位误差受患者BMI、胸围及乳腺体积的影响,与患者年龄无明显关系。 展开更多
关键词 乳腺癌 术后调强放疗 体质量指数 胸围 乳腺体积 摆位误差
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肿块型乳腺癌患者肿瘤组织中Ki-67表达与超声特征的相关性
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作者 马新乐 徐杰 秦金霞 《新乡医学院学报》 CAS 2024年第3期240-244,共5页
目的分析肿块型乳腺癌患者肿瘤组织中Ki-67表达与超声特征的相关性。方法选择2020年1月至2022年12月新乡市中心医院收治的肿块型乳腺癌患者90例(90个肿块)为研究对象,根据肿瘤组织中Ki-67表达情况将患者分为Ki-67高表达组(n=53)和Ki-67... 目的分析肿块型乳腺癌患者肿瘤组织中Ki-67表达与超声特征的相关性。方法选择2020年1月至2022年12月新乡市中心医院收治的肿块型乳腺癌患者90例(90个肿块)为研究对象,根据肿瘤组织中Ki-67表达情况将患者分为Ki-67高表达组(n=53)和Ki-67低表达组(n=37)。比较2组患者的超声造影(CEUS)定性、定量特征,剪切波弹性成像(SWE)定性、定量特征,以及彩色多普勒血流显像(CDFI)特征;并采用多因素logistic回归分析肿块型乳腺癌患者Ki-67表达与超声特征的相关性。结果Ki-67高表达组CEUS灌注缺损患者占比显著高于Ki-67低表达组(P<0.05);2组患者的CEUS边界、均匀性、增强水平、增强后病灶范围、方向比较差异无统计学意义(P>0.05)。Ki-67高表达组患者的峰值强度、上升时间、半降时间显著高于Ki-67低表达组(P<0.05);2组患者的到达时间、达峰时间、平均通过时间比较差异无统计学意义(P>0.05)。Ki-67高表达组具有SWE硬环征患者占比显著高于Ki-67低表达组(P<0.05);2组具有SWE黑洞征患者占比比较差异无统计学意义(P>0.05)。Ki-67高表达组患者病灶与周围组织弹性模量比值水平显著高于Ki-67低表达组(P<0.05);2组患者的最大弹性模量值、平均弹性模量值、最小弹性模量值比较差异无统计学意义(P>0.05)。Ki-67高表达组CDFI下病灶大小为2~5 cm、边缘有毛刺患者占比显著高于Ki-67低表达组(P<0.05);2组患者CDFI下病灶形状、方位、钙化情况比较差异无统计学意义(P>0.05)。灌注缺损、硬环征、边缘有毛刺与肿块型乳腺癌患者Ki-67高表达有关(P<0.05)。结论肿块型乳腺癌的超声特征对Ki-67表达有预测作用,其中灌注缺损、硬环征、边缘有毛刺与Ki-67阳性表达具有相关性。 展开更多
关键词 肿块型乳腺癌 KI-67表达 超声影像
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超声双模态弹性成像在非肿块型乳腺病变中的诊断价值
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作者 王福霞 张茜 +4 位作者 朱珊 赵威 崔海欧 马莉琼 王文 《宁夏医学杂志》 CAS 2024年第1期31-33,I0001,共4页
目的 探讨超声剪切波弹性成像(SWE)与应变式弹性成像(SE)对非肿块型乳腺病变(NML)的诊断价值。方法 前瞻性纳入60个非肿块型乳腺病变病灶,术前进行SWE与SE双模态超声弹性成像检查,并与穿刺活检、旋切或手术后病理结果对照,得出这两种诊... 目的 探讨超声剪切波弹性成像(SWE)与应变式弹性成像(SE)对非肿块型乳腺病变(NML)的诊断价值。方法 前瞻性纳入60个非肿块型乳腺病变病灶,术前进行SWE与SE双模态超声弹性成像检查,并与穿刺活检、旋切或手术后病理结果对照,得出这两种诊断方法的敏感度、特异度、准确度、阳性似然比、阴性似然比。结果 60个NML病灶病理结果中有33个是恶性、27个是良性。SE诊断恶性有34个,良性有26个;SWE诊断恶性有29个,良性有31个。SE诊断非肿块型乳腺恶性病变的灵敏度、特异度、准确度、阳性似然比、阴性似然比分别是81.8%、74.1%、78.3%、79.4%、76.9%;SWE诊断分别是75.8%、85.2%、80.0%、86.2%、74.2%。2种诊断方法ROC曲线下面积分别为0.805、0.779,SE较SWE诊断效能高,但两者比较差异无统计学意义(P>0.05)。结论 SWE与SE两种弹性成像方法对乳腺NML良、恶性诊断均具有较好的诊断效能,二者联合使用,可在诊断中相互补充。 展开更多
关键词 剪切波弹性成像 应变弹性成像 非肿块型乳腺病变 乳腺癌
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体质量指数与女性乳腺癌患病风险的关系
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作者 程言磊 《中国现代药物应用》 2024年第18期43-46,共4页
目的探讨体质量指数(BMI)与女性乳腺癌患病风险的关系。方法纳入120例因乳腺疾病行相关治疗的女性患者为研究对象,其中60例乳腺癌患者记作研究组,60例乳腺良性疾病患者记作对照组。统计并比较两组患者基本情况,不同BMI(BMI<18.5 kg/m... 目的探讨体质量指数(BMI)与女性乳腺癌患病风险的关系。方法纳入120例因乳腺疾病行相关治疗的女性患者为研究对象,其中60例乳腺癌患者记作研究组,60例乳腺良性疾病患者记作对照组。统计并比较两组患者基本情况,不同BMI(BMI<18.5 kg/m^(2)、18.5~24.0 kg/m^(2)、24.1~28.0 kg/m^(2)和≥28 kg/m^(2)分别表示偏瘦、正常、超重、肥胖)患者乳腺癌患病风险多因素Logistics回归分析结果,比较各分子亚型(Luminal A型、Luminal B型、人表皮生长因子受体-2(HER-2)阳性型和三阴性)乳腺癌患者的BMI分布情况。结果研究组母乳喂养46例(76.67%)与BMI(23.99±3.11)kg/m^(2)与对照组的55例(91.67%)、(22.64±2.92)kg/m^(2)比较存在差异(P<0.05);两组年龄、月经状态、初潮年龄、初产年龄、怀孕次数、饮酒、吸烟、乳腺癌家族史、激素药物使用史情况比较无差异(P>0.05)。根据月经状态进行Logistics回归分析,随着BMI的增高,乳腺癌患病风险增高,特别是绝经后的女性人群(P<0.05)。60例乳腺癌患者中Luminal A型24例,Luminal B型21例,HER-2阳性型9例,三阴性6例,其中激素受体阳性患者所占比例最高,占75%。各分子亚型乳腺癌患者的BMI分布情况比较存在差异(P<0.008)。其中Luminal A型乳腺癌患者超重和肥胖占比较高。Luminal A型与其他三种亚型的BMI分布情况比较存在差异(P<0.008)。结论体重增加导致乳腺癌患病风险增加,特别是绝经后的女性;且Luminal A型乳腺癌的患病风险与体重增加的关系更加密切。 展开更多
关键词 体质量指数 乳腺癌 分子亚型 绝经
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乳腺X线摄影联合MRI-DWI对非肿块型乳腺癌的评估分析
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作者 赵玉乔 陈永亚 赵亮 《医学影像学杂志》 2024年第6期51-54,共4页
目的探讨乳腺X线摄影联合磁共振弥散加权成像(MRI-DWI)对非肿块型乳腺癌(NMBC)的评估分析。方法选取高度疑似NMBC的患者110例,所有患者均接受乳腺X线摄影、MRI-DWI及乳腺穿刺活检检查。以乳腺穿刺活检结果作为金标准,探讨乳腺X线摄影联... 目的探讨乳腺X线摄影联合磁共振弥散加权成像(MRI-DWI)对非肿块型乳腺癌(NMBC)的评估分析。方法选取高度疑似NMBC的患者110例,所有患者均接受乳腺X线摄影、MRI-DWI及乳腺穿刺活检检查。以乳腺穿刺活检结果作为金标准,探讨乳腺X线摄影联合MRI-DWI对NMBC的评估分析。结果经乳腺穿刺活检确诊,110例高度疑似NMBC患者中,NMBC患者90例(81.82%),非NMBC患者20例(19.18%)。乳腺X线摄影、MRI-DWI诊断NMBC与金标准的一致性Kappa值分别为0.572、0.622,一致性一般。乳腺X线摄影联合MRI-DWI诊断NMBC与金标准的一致性Kappa值为0.809,一致性好。三组灵敏度、准确度比较,乳腺X线摄影联合MRI-DWI>MRI-DWI>乳腺X线摄影,差异有统计学意义(P<0.05)。NMBC组微小钙化、结构扭曲占比显著高于非NMBC,ADC值低于非NMBC组,差异有统计学意义(P<0.05)。结论乳腺X线摄影联合MRI-DWI评估NMBC效能较高,可为临床NMBC诊治提供参考。 展开更多
关键词 非肿块型乳腺癌 乳腺X线摄影 磁共振弥散加权成像
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