Through literature and clinical research,the current status of Mongolian medicine treatment for breast hyperplasia is discussed,such as oral administration of Mongolian medicine for treatment,oral administration of Mo...Through literature and clinical research,the current status of Mongolian medicine treatment for breast hyperplasia is discussed,such as oral administration of Mongolian medicine for treatment,oral administration of Mongolian medicine combined with external application for treatment,combination of Mongolian medicine acupuncture therapy and oral administration of Mongolian medicine for treatment,integrated treatment of Mongolian and Western medicine,and combination therapy of Mongolian and traditional Chinese medicine,providing new ideas and choices for clinical research.展开更多
Objective: This study aimed to investigate the anti-inflammatory and analgesic mechanisms of a breast lump resolution detergent in a rat model of breast hyperplasia. Methods: A rat model of breast hyperplasia was esta...Objective: This study aimed to investigate the anti-inflammatory and analgesic mechanisms of a breast lump resolution detergent in a rat model of breast hyperplasia. Methods: A rat model of breast hyperplasia was established using injections of estradiol benzoate combined with progesterone. The effects of the breast lump resolution detergent on nipple height and diameter in the rat model were observed, along with its impact on serum levels of estradiol (E2), prolactin (PRL), and progesterone (P). Additionally, the study examined the morphological changes in breast tissue. The impact of the breast nodule detergent on blood rheology parameters was also observed. Furthermore, the anti-inflammatory effect of the breast nodule detergent was assessed using the cotton ball granuloma experiment, and the analgesic effect was observed using the writhing test. Results: The breast lump resolution detergent reduced nipple height and diameter in the rat model, decreased serum levels of E2, PRL, and P, and alleviated pathological changes in breast tissue. It also lowered hemorheological parameters including whole blood high, medium, and low shear viscosity, plasma viscosity, red blood cell hematocrit, red blood cell aggregation index, red blood cell deformability index, red blood cell electrophoresis time, and erythrocyte sedimentation rate in the acute “blood stasis” rat model. The detergent reduced the weight of cotton ball granulomas in mice and decreased the number of writhing episodes caused by acetic acid. Conclusion: The breast lump resolution detergent demonstrates favorable therapeutic effects in treating breast hyperplasia, promoting blood circulation and removing blood stasis, exerting anti-inflammatory properties, and providing analgesic effects. The downregulation of serum E2 and PRL levels and the upregulation of P levels may be critical mechanisms underlying its efficacy.展开更多
OBJECTIVE To explore the relationship of high S-phase kinase associ- ated protein 2 (Skp2) expression with the characteristics of breast cancer. METHODS Using a immunohistochemical method, Skp2 expression was detected...OBJECTIVE To explore the relationship of high S-phase kinase associ- ated protein 2 (Skp2) expression with the characteristics of breast cancer. METHODS Using a immunohistochemical method, Skp2 expression was detected and evaluated in 30 normal tissues, 30 atypical ductal hy- perplasias (ADH), 30 ductal carcinomas in situ (DCIS) and 56 invasive carcinomas (including invasive specific carcinoma and invasive nonspe- cific carcinoma). The relationship between Skp2 expression and the characteristics of breast cancer was analyzed. RESULTS Skp2 expression varied among normal tissue, ADH, DCIS and invasive carcinomas (χ2=54.02, P<0.005). The positive level of Skp2 ex- pression in DCIS was higher than that of normal tissue (χ2=21.82, P< 0.005) and there was a significant difference in Skp2 between DCIS and ADH (χ2=5.08, P<0.025) as well as between invasive carcinomas and DCIS (χ2=6.52, P<0.01). The positive expression level of Skp2 in invasive carcinomas with positive lymph nodes was remarkably higher compared to those with negative lymph nodes. A significant difference in Skp2 ex- pression was found between combined histological Grades I and II ver- sus Grade III of invasive carcinomas (χ2=6.66, P<0.01). CONCLUSION High Skp2 expression may play an important role in car- cinogenesis and biological behavior of breast cancer.展开更多
文摘Through literature and clinical research,the current status of Mongolian medicine treatment for breast hyperplasia is discussed,such as oral administration of Mongolian medicine for treatment,oral administration of Mongolian medicine combined with external application for treatment,combination of Mongolian medicine acupuncture therapy and oral administration of Mongolian medicine for treatment,integrated treatment of Mongolian and Western medicine,and combination therapy of Mongolian and traditional Chinese medicine,providing new ideas and choices for clinical research.
文摘Objective: This study aimed to investigate the anti-inflammatory and analgesic mechanisms of a breast lump resolution detergent in a rat model of breast hyperplasia. Methods: A rat model of breast hyperplasia was established using injections of estradiol benzoate combined with progesterone. The effects of the breast lump resolution detergent on nipple height and diameter in the rat model were observed, along with its impact on serum levels of estradiol (E2), prolactin (PRL), and progesterone (P). Additionally, the study examined the morphological changes in breast tissue. The impact of the breast nodule detergent on blood rheology parameters was also observed. Furthermore, the anti-inflammatory effect of the breast nodule detergent was assessed using the cotton ball granuloma experiment, and the analgesic effect was observed using the writhing test. Results: The breast lump resolution detergent reduced nipple height and diameter in the rat model, decreased serum levels of E2, PRL, and P, and alleviated pathological changes in breast tissue. It also lowered hemorheological parameters including whole blood high, medium, and low shear viscosity, plasma viscosity, red blood cell hematocrit, red blood cell aggregation index, red blood cell deformability index, red blood cell electrophoresis time, and erythrocyte sedimentation rate in the acute “blood stasis” rat model. The detergent reduced the weight of cotton ball granulomas in mice and decreased the number of writhing episodes caused by acetic acid. Conclusion: The breast lump resolution detergent demonstrates favorable therapeutic effects in treating breast hyperplasia, promoting blood circulation and removing blood stasis, exerting anti-inflammatory properties, and providing analgesic effects. The downregulation of serum E2 and PRL levels and the upregulation of P levels may be critical mechanisms underlying its efficacy.
基金This work was supported by the NationalScientific Foundation of China (No.30471967).
文摘OBJECTIVE To explore the relationship of high S-phase kinase associ- ated protein 2 (Skp2) expression with the characteristics of breast cancer. METHODS Using a immunohistochemical method, Skp2 expression was detected and evaluated in 30 normal tissues, 30 atypical ductal hy- perplasias (ADH), 30 ductal carcinomas in situ (DCIS) and 56 invasive carcinomas (including invasive specific carcinoma and invasive nonspe- cific carcinoma). The relationship between Skp2 expression and the characteristics of breast cancer was analyzed. RESULTS Skp2 expression varied among normal tissue, ADH, DCIS and invasive carcinomas (χ2=54.02, P<0.005). The positive level of Skp2 ex- pression in DCIS was higher than that of normal tissue (χ2=21.82, P< 0.005) and there was a significant difference in Skp2 between DCIS and ADH (χ2=5.08, P<0.025) as well as between invasive carcinomas and DCIS (χ2=6.52, P<0.01). The positive expression level of Skp2 in invasive carcinomas with positive lymph nodes was remarkably higher compared to those with negative lymph nodes. A significant difference in Skp2 ex- pression was found between combined histological Grades I and II ver- sus Grade III of invasive carcinomas (χ2=6.66, P<0.01). CONCLUSION High Skp2 expression may play an important role in car- cinogenesis and biological behavior of breast cancer.
