Because delayed diagnosis is one of the causes of poor prognosis in pancreatic ductal adenocarcinoma(PDAC), early detection is a key for overall improvement of prognosis. Towards this end, periodic screening is recomm...Because delayed diagnosis is one of the causes of poor prognosis in pancreatic ductal adenocarcinoma(PDAC), early detection is a key for overall improvement of prognosis. Towards this end, periodic screening is recommended for individuals considered high-risk for PDAC. Advances in diagnostic imaging modalities have increased the frequency of incidental findings of pancreatic cysts,including the intraductal papillary mucinous neoplasm(IPMN)-a major risk factor of PDAC, having 1% annual prevalence of concomitance with IPMN.Proper retainment of patients with IPMN and regular follow-up by routine imaging examination will likely improve early detection and better prognosis of PDAC. Unfortunately, current guidelines only address management of PDAC derived from IPMN and overlook PDAC concomitant with IPMN. Screening of patients with IPMN, by endoscopic ultrasonography(currently the most reliable modality for detecting small PDAC), may facilitate early detection of both IPMNderived and-concomitant PDAC. Prospective studies to evaluate the usefulness of endoscopic ultrasonography in screening of IPMN-concomitant PDAC will also help in determining the optimal surveillance strategy for more widespread applications.展开更多
目的:探讨不同类型乳腺黏液腺癌的超声声像图特点和病理学特征,并分析超声误诊的原因。方法:回顾性分析68例乳腺黏液腺癌患者共70个病灶的超声声像图表现、临床资料及病理检查结果。结果:68例乳腺黏液腺癌患者的平均发病年龄为(54.5...目的:探讨不同类型乳腺黏液腺癌的超声声像图特点和病理学特征,并分析超声误诊的原因。方法:回顾性分析68例乳腺黏液腺癌患者共70个病灶的超声声像图表现、临床资料及病理检查结果。结果:68例乳腺黏液腺癌患者的平均发病年龄为(54.5±23.3岁)(30~86岁),其中40例(58.8%)患者为50岁以上。病理检查结果提示,单纯型黏液腺癌占57.4%(39/68),混合型占42.6%(29/68);16.2%(11/68)的患者发生了淋巴结转移。本组共70个病灶中,位于右侧乳房的占41.4%(29/70),位于左侧乳房的占58.6%(41/70),病灶位置以外上象限多见41.4%(29/70)。单纯型黏液腺癌患者中,病灶形态不规则形占76.9%(30/39),混合型患者中病灶呈不规则形占80.6%(25/31);与混合型黏液腺癌相比,单纯型黏液腺癌病灶形态不规则病灶中呈分叶状者较多(25例比7例)(P<0.05);单纯型黏液腺癌病灶边界欠清者占48.7%(19/39),混合型黏液腺癌病灶则以边界不清为主77.4%(24/31);单纯型及混合型病灶均以后方回声增强最为多见,分别为74.4%(29/39)、48.4%(15/31)。单纯型病灶探及血流信号者占71.8%(28/39),混合型病灶探及血流信号占80.6%(25/31)。单纯型及混合型黏液腺癌中乳腺影像报告和数据系统(Breast Imaging Reporting and Data System,BI-RADS)分类为可疑恶性者分别占87.2%(34/39)和93.5%(29/31),误诊率分别为12.8%(5/39)、6.5%(2/31),均是因肿块多表现为形态规则、边界尚清晰、后方回声无改变等类似良性病变特征而被误诊。结论:乳腺黏液腺癌超声表现与病理分型间有一定相关性,单纯型乳腺黏液腺癌病灶多呈分叶状,边界欠清,后方回声增强,有时与良性肿瘤难以鉴别;混合型黏液腺癌则常有浸润性生长的影像学特征。展开更多
文摘Because delayed diagnosis is one of the causes of poor prognosis in pancreatic ductal adenocarcinoma(PDAC), early detection is a key for overall improvement of prognosis. Towards this end, periodic screening is recommended for individuals considered high-risk for PDAC. Advances in diagnostic imaging modalities have increased the frequency of incidental findings of pancreatic cysts,including the intraductal papillary mucinous neoplasm(IPMN)-a major risk factor of PDAC, having 1% annual prevalence of concomitance with IPMN.Proper retainment of patients with IPMN and regular follow-up by routine imaging examination will likely improve early detection and better prognosis of PDAC. Unfortunately, current guidelines only address management of PDAC derived from IPMN and overlook PDAC concomitant with IPMN. Screening of patients with IPMN, by endoscopic ultrasonography(currently the most reliable modality for detecting small PDAC), may facilitate early detection of both IPMNderived and-concomitant PDAC. Prospective studies to evaluate the usefulness of endoscopic ultrasonography in screening of IPMN-concomitant PDAC will also help in determining the optimal surveillance strategy for more widespread applications.
文摘目的:探讨不同类型乳腺黏液腺癌的超声声像图特点和病理学特征,并分析超声误诊的原因。方法:回顾性分析68例乳腺黏液腺癌患者共70个病灶的超声声像图表现、临床资料及病理检查结果。结果:68例乳腺黏液腺癌患者的平均发病年龄为(54.5±23.3岁)(30~86岁),其中40例(58.8%)患者为50岁以上。病理检查结果提示,单纯型黏液腺癌占57.4%(39/68),混合型占42.6%(29/68);16.2%(11/68)的患者发生了淋巴结转移。本组共70个病灶中,位于右侧乳房的占41.4%(29/70),位于左侧乳房的占58.6%(41/70),病灶位置以外上象限多见41.4%(29/70)。单纯型黏液腺癌患者中,病灶形态不规则形占76.9%(30/39),混合型患者中病灶呈不规则形占80.6%(25/31);与混合型黏液腺癌相比,单纯型黏液腺癌病灶形态不规则病灶中呈分叶状者较多(25例比7例)(P<0.05);单纯型黏液腺癌病灶边界欠清者占48.7%(19/39),混合型黏液腺癌病灶则以边界不清为主77.4%(24/31);单纯型及混合型病灶均以后方回声增强最为多见,分别为74.4%(29/39)、48.4%(15/31)。单纯型病灶探及血流信号者占71.8%(28/39),混合型病灶探及血流信号占80.6%(25/31)。单纯型及混合型黏液腺癌中乳腺影像报告和数据系统(Breast Imaging Reporting and Data System,BI-RADS)分类为可疑恶性者分别占87.2%(34/39)和93.5%(29/31),误诊率分别为12.8%(5/39)、6.5%(2/31),均是因肿块多表现为形态规则、边界尚清晰、后方回声无改变等类似良性病变特征而被误诊。结论:乳腺黏液腺癌超声表现与病理分型间有一定相关性,单纯型乳腺黏液腺癌病灶多呈分叶状,边界欠清,后方回声增强,有时与良性肿瘤难以鉴别;混合型黏液腺癌则常有浸润性生长的影像学特征。